Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIL4_LEIBR

TriTrypDb:

LbrM.20.5820 , LBRM2903_200073400

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AIL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.444
CLV_NRD_NRD_1	241	243	PF00675	0.355
CLV_NRD_NRD_1	385	387	PF00675	0.579
CLV_PCSK_FUR_1	239	243	PF00082	0.438
CLV_PCSK_KEX2_1	241	243	PF00082	0.371
CLV_PCSK_KEX2_1	384	386	PF00082	0.547
DEG_Nend_UBRbox_3	1	3	PF02207	0.687
DOC_CKS1_1	225	230	PF01111	0.649
DOC_MAPK_gen_1	10	18	PF00069	0.623
DOC_MAPK_gen_1	256	264	PF00069	0.512
DOC_MAPK_MEF2A_6	373	382	PF00069	0.616
DOC_PP2B_LxvP_1	278	281	PF13499	0.727
DOC_PP2B_LxvP_1	319	322	PF13499	0.732
DOC_PP2B_PxIxI_1	189	195	PF00149	0.248
DOC_USP7_MATH_1	352	356	PF00917	0.654
DOC_USP7_MATH_1	366	370	PF00917	0.728
DOC_USP7_MATH_1	389	393	PF00917	0.773
DOC_USP7_MATH_1	85	89	PF00917	0.307
DOC_WW_Pin1_4	224	229	PF00397	0.677
DOC_WW_Pin1_4	387	392	PF00397	0.726
DOC_WW_Pin1_4	62	67	PF00397	0.424
LIG_14-3-3_CanoR_1	15	19	PF00244	0.491
LIG_14-3-3_CanoR_1	239	248	PF00244	0.488
LIG_14-3-3_CanoR_1	384	389	PF00244	0.624
LIG_APCC_ABBA_1	22	27	PF00400	0.348
LIG_BRCT_BRCA1_1	296	300	PF00533	0.583
LIG_BRCT_BRCA1_1	48	52	PF00533	0.279
LIG_CaM_NSCaTE_8	145	152	PF13499	0.491
LIG_FHA_1	117	123	PF00498	0.372
LIG_FHA_1	162	168	PF00498	0.311
LIG_FHA_1	205	211	PF00498	0.396
LIG_FHA_1	34	40	PF00498	0.396
LIG_FHA_1	363	369	PF00498	0.771
LIG_FHA_1	63	69	PF00498	0.421
LIG_FHA_2	126	132	PF00498	0.434
LIG_FHA_2	225	231	PF00498	0.646
LIG_FHA_2	241	247	PF00498	0.527
LIG_GBD_Chelix_1	212	220	PF00786	0.306
LIG_LIR_Apic_2	291	295	PF02991	0.576
LIG_LIR_Apic_2	302	306	PF02991	0.560
LIG_LIR_Gen_1	355	362	PF02991	0.723
LIG_LIR_Gen_1	74	85	PF02991	0.361
LIG_LIR_Nem_3	138	142	PF02991	0.482
LIG_LIR_Nem_3	186	191	PF02991	0.345
LIG_LIR_Nem_3	297	303	PF02991	0.594
LIG_LIR_Nem_3	74	80	PF02991	0.429
LIG_Pex14_2	135	139	PF04695	0.571
LIG_PTB_Apo_2	138	145	PF02174	0.536
LIG_SH2_CRK	303	307	PF00017	0.710
LIG_SH2_GRB2like	215	218	PF00017	0.510
LIG_SH2_NCK_1	296	300	PF00017	0.632
LIG_SH2_NCK_1	303	307	PF00017	0.632
LIG_SH2_SRC	303	306	PF00017	0.638
LIG_SH2_STAP1	296	300	PF00017	0.583
LIG_SH2_STAT3	159	162	PF00017	0.408
LIG_SH2_STAT5	143	146	PF00017	0.621
LIG_SH2_STAT5	159	162	PF00017	0.342
LIG_SH2_STAT5	177	180	PF00017	0.216
LIG_SH2_STAT5	188	191	PF00017	0.311
LIG_SH2_STAT5	205	208	PF00017	0.241
LIG_SH2_STAT5	215	218	PF00017	0.369
LIG_SH3_3	222	228	PF00018	0.620
LIG_SH3_3	284	290	PF00018	0.695
LIG_SH3_3	302	308	PF00018	0.678
LIG_SH3_3	314	320	PF00018	0.695
LIG_SH3_3	369	375	PF00018	0.770
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.356
LIG_TRAF2_1	227	230	PF00917	0.606
LIG_TRAF2_1	243	246	PF00917	0.542
LIG_TRFH_1	62	66	PF08558	0.356
LIG_WRC_WIRS_1	136	141	PF05994	0.666
LIG_WRC_WIRS_1	34	39	PF05994	0.348
LIG_WW_1	396	399	PF00397	0.691
MOD_CK1_1	240	246	PF00069	0.527
MOD_CK1_1	312	318	PF00069	0.663
MOD_CK1_1	46	52	PF00069	0.273
MOD_CK1_1	76	82	PF00069	0.433
MOD_CK2_1	147	153	PF00069	0.294
MOD_CK2_1	224	230	PF00069	0.591
MOD_CK2_1	240	246	PF00069	0.605
MOD_CK2_1	352	358	PF00069	0.723
MOD_GlcNHglycan	149	152	PF01048	0.332
MOD_GlcNHglycan	296	299	PF01048	0.503
MOD_GlcNHglycan	311	314	PF01048	0.534
MOD_GlcNHglycan	332	335	PF01048	0.420
MOD_GlcNHglycan	345	348	PF01048	0.416
MOD_GlcNHglycan	369	372	PF01048	0.525
MOD_GlcNHglycan	45	48	PF01048	0.425
MOD_GSK3_1	339	346	PF00069	0.765
MOD_GSK3_1	352	359	PF00069	0.617
MOD_GSK3_1	362	369	PF00069	0.748
MOD_GSK3_1	69	76	PF00069	0.360
MOD_GSK3_1	85	92	PF00069	0.273
MOD_N-GLC_1	125	130	PF02516	0.295
MOD_N-GLC_1	216	221	PF02516	0.318
MOD_N-GLC_1	265	270	PF02516	0.438
MOD_N-GLC_1	89	94	PF02516	0.452
MOD_NEK2_1	135	140	PF00069	0.611
MOD_NEK2_1	161	166	PF00069	0.202
MOD_NEK2_1	216	221	PF00069	0.537
MOD_NEK2_1	329	334	PF00069	0.604
MOD_NEK2_1	356	361	PF00069	0.680
MOD_NEK2_1	38	43	PF00069	0.293
MOD_NEK2_1	91	96	PF00069	0.407
MOD_NEK2_2	116	121	PF00069	0.196
MOD_PIKK_1	389	395	PF00454	0.711
MOD_PIKK_1	91	97	PF00454	0.358
MOD_PKA_1	384	390	PF00069	0.623
MOD_PKA_2	14	20	PF00069	0.644
MOD_PKA_2	240	246	PF00069	0.527
MOD_PKA_2	384	390	PF00069	0.623
MOD_Plk_1	125	131	PF00069	0.303
MOD_Plk_1	216	222	PF00069	0.579
MOD_Plk_1	73	79	PF00069	0.452
MOD_Plk_1	89	95	PF00069	0.264
MOD_Plk_4	116	122	PF00069	0.326
MOD_Plk_4	163	169	PF00069	0.224
MOD_Plk_4	184	190	PF00069	0.437
MOD_Plk_4	204	210	PF00069	0.363
MOD_Plk_4	280	286	PF00069	0.682
MOD_Plk_4	339	345	PF00069	0.685
MOD_Plk_4	352	358	PF00069	0.649
MOD_ProDKin_1	224	230	PF00069	0.673
MOD_ProDKin_1	387	393	PF00069	0.727
MOD_ProDKin_1	62	68	PF00069	0.420
MOD_SUMO_rev_2	230	236	PF00179	0.599
MOD_SUMO_rev_2	253	258	PF00179	0.626
TRG_ENDOCYTIC_2	188	191	PF00928	0.341
TRG_ENDOCYTIC_2	223	226	PF00928	0.610
TRG_ENDOCYTIC_2	357	360	PF00928	0.774
TRG_ER_diArg_1	238	241	PF00400	0.605
TRG_ER_diArg_1	383	386	PF00400	0.779
TRG_NLS_MonoExtN_4	10	16	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH38	Leptomonas seymouri	55%	98%
A0A0N1PA63	Leptomonas seymouri	22%	69%
A0A1X0NHW5	Trypanosomatidae	22%	96%
A0A3S7WW58	Leishmania donovani	77%	99%
C9ZIN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AGU2	Leishmania infantum	77%	100%
E9AUU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4QCN6	Leishmania major	76%	100%
V5ASX9	Trypanosoma cruzi	43%	100%