Phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Suppressor of G2 allele of SKP1, putative

Species:

Leishmania braziliensis

UniProt:

E9AIL2_LEIBR

TriTrypDb:

LbrM.20.5800 , LBRM2903_200073200

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIL2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0051087	protein-folding chaperone binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.238
CLV_NRD_NRD_1	98	100	PF00675	0.712
CLV_PCSK_KEX2_1	171	173	PF00082	0.254
CLV_PCSK_SKI1_1	176	180	PF00082	0.262
CLV_PCSK_SKI1_1	39	43	PF00082	0.671
CLV_PCSK_SKI1_1	78	82	PF00082	0.581
DOC_MAPK_gen_1	132	141	PF00069	0.308
DOC_MAPK_gen_1	28	37	PF00069	0.549
DOC_MAPK_gen_1	78	86	PF00069	0.538
DOC_MAPK_MEF2A_6	134	143	PF00069	0.491

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVR6	Leptomonas seymouri	69%	98%
A0A0S4JRF8	Bodo saltans	57%	73%
A0A1X0NW51	Trypanosomatidae	54%	96%
A0A3Q8IEZ0	Leishmania donovani	89%	100%
A0A3R7M4C8	Trypanosoma rangeli	55%	99%
A4HYZ4	Leishmania infantum	89%	100%
C9ZIN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	96%
E9AUU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QCN8	Leishmania major	87%	100%
V5BCX0	Trypanosoma cruzi	55%	99%

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