Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TBC1 domain family member 20/GTPase, putative

Species:

Leishmania braziliensis

UniProt:

E9AIL1_LEIBR

TriTrypDb:

LbrM.20.5790 , LBRM2903_200073000 , LBRM2903_200073100

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIL1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0016192	vesicle-mediated transport	4	7
GO:0043085	positive regulation of catalytic activity	4	7
GO:0043087	regulation of GTPase activity	5	7
GO:0043547	positive regulation of GTPase activity	6	7
GO:0044093	positive regulation of molecular function	3	7
GO:0050790	regulation of catalytic activity	3	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051336	regulation of hydrolase activity	4	7
GO:0051345	positive regulation of hydrolase activity	5	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0009987	cellular process	1	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.822
CLV_C14_Caspase3-7	67	71	PF00656	0.664
CLV_C14_Caspase3-7	82	86	PF00656	0.629
CLV_NRD_NRD_1	131	133	PF00675	0.589
CLV_NRD_NRD_1	173	175	PF00675	0.539
CLV_NRD_NRD_1	181	183	PF00675	0.529
CLV_NRD_NRD_1	254	256	PF00675	0.328
CLV_NRD_NRD_1	520	522	PF00675	0.304
CLV_PCSK_FUR_1	307	311	PF00082	0.418
CLV_PCSK_FUR_1	518	522	PF00082	0.376
CLV_PCSK_FUR_1	7	11	PF00082	0.492
CLV_PCSK_KEX2_1	131	133	PF00082	0.589
CLV_PCSK_KEX2_1	172	174	PF00082	0.542
CLV_PCSK_KEX2_1	181	183	PF00082	0.529
CLV_PCSK_KEX2_1	253	255	PF00082	0.331
CLV_PCSK_KEX2_1	309	311	PF00082	0.362
CLV_PCSK_KEX2_1	520	522	PF00082	0.304
CLV_PCSK_KEX2_1	9	11	PF00082	0.494
CLV_PCSK_KEX2_1	97	99	PF00082	0.458
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.418
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.480
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.458
CLV_PCSK_PC7_1	249	255	PF00082	0.346
CLV_PCSK_SKI1_1	181	185	PF00082	0.529
CLV_PCSK_SKI1_1	254	258	PF00082	0.312
CLV_PCSK_SKI1_1	262	266	PF00082	0.319
CLV_PCSK_SKI1_1	520	524	PF00082	0.349
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DOC_CYCLIN_RxL_1	257	269	PF00134	0.546
DOC_MAPK_gen_1	181	190	PF00069	0.604
DOC_MAPK_gen_1	253	263	PF00069	0.549
DOC_MAPK_gen_1	493	501	PF00069	0.539
DOC_MAPK_HePTP_8	370	382	PF00069	0.427
DOC_MAPK_MEF2A_6	257	265	PF00069	0.539
DOC_MAPK_MEF2A_6	373	382	PF00069	0.427
DOC_MAPK_MEF2A_6	410	417	PF00069	0.680
DOC_PP1_RVXF_1	397	404	PF00149	0.463
DOC_PP1_RVXF_1	498	504	PF00149	0.539
DOC_PP1_RVXF_1	518	525	PF00149	0.572
DOC_PP2B_LxvP_1	138	141	PF13499	0.860
DOC_PP4_FxxP_1	72	75	PF00568	0.754
DOC_USP7_MATH_1	111	115	PF00917	0.680
DOC_USP7_MATH_1	143	147	PF00917	0.749
DOC_USP7_MATH_1	513	517	PF00917	0.777
DOC_USP7_UBL2_3	9	13	PF12436	0.639
DOC_WW_Pin1_4	121	126	PF00397	0.740
DOC_WW_Pin1_4	136	141	PF00397	0.668
DOC_WW_Pin1_4	161	166	PF00397	0.632
DOC_WW_Pin1_4	201	206	PF00397	0.826
DOC_WW_Pin1_4	285	290	PF00397	0.546
DOC_WW_Pin1_4	509	514	PF00397	0.654
DOC_WW_Pin1_4	71	76	PF00397	0.748
DOC_WW_Pin1_4	86	91	PF00397	0.707
LIG_14-3-3_CanoR_1	112	118	PF00244	0.857
LIG_14-3-3_CanoR_1	173	183	PF00244	0.731
LIG_14-3-3_CanoR_1	237	243	PF00244	0.614
LIG_14-3-3_CanoR_1	310	316	PF00244	0.549
LIG_14-3-3_CanoR_1	317	324	PF00244	0.550
LIG_14-3-3_CanoR_1	439	445	PF00244	0.511
LIG_14-3-3_CanoR_1	521	529	PF00244	0.244
LIG_APCC_ABBA_1	287	292	PF00400	0.546
LIG_CaM_IQ_9	40	55	PF13499	0.685
LIG_eIF4E_1	389	395	PF01652	0.530
LIG_FHA_1	324	330	PF00498	0.427
LIG_FHA_1	357	363	PF00498	0.538
LIG_FHA_1	389	395	PF00498	0.539
LIG_FHA_1	536	542	PF00498	0.628
LIG_FHA_2	158	164	PF00498	0.642
LIG_FHA_2	337	343	PF00498	0.427
LIG_FHA_2	453	459	PF00498	0.478
LIG_IRF3_LxIS_1	390	397	PF10401	0.427
LIG_LIR_Apic_2	218	223	PF02991	0.746
LIG_LIR_Apic_2	509	513	PF02991	0.681
LIG_LIR_Apic_2	70	75	PF02991	0.777
LIG_LIR_Gen_1	342	348	PF02991	0.427
LIG_LIR_Gen_1	376	382	PF02991	0.427
LIG_LIR_Gen_1	400	409	PF02991	0.588
LIG_LIR_Nem_3	218	222	PF02991	0.754
LIG_LIR_Nem_3	238	243	PF02991	0.383
LIG_LIR_Nem_3	306	311	PF02991	0.489
LIG_LIR_Nem_3	342	346	PF02991	0.546
LIG_LIR_Nem_3	376	380	PF02991	0.618
LIG_LIR_Nem_3	400	406	PF02991	0.584
LIG_MYND_1	136	140	PF01753	0.829
LIG_NRBOX	260	266	PF00104	0.546
LIG_Rb_pABgroove_1	369	377	PF01858	0.546
LIG_SH2_CRK	273	277	PF00017	0.546
LIG_SH2_CRK	434	438	PF00017	0.582
LIG_SH2_STAP1	324	328	PF00017	0.546
LIG_SH2_STAP1	352	356	PF00017	0.618
LIG_SH2_STAT3	463	466	PF00017	0.505
LIG_SH2_STAT5	285	288	PF00017	0.549
LIG_SH2_STAT5	361	364	PF00017	0.546
LIG_SH2_STAT5	377	380	PF00017	0.546
LIG_SH2_STAT5	389	392	PF00017	0.546
LIG_SH2_STAT5	463	466	PF00017	0.620
LIG_SH3_3	137	143	PF00018	0.779
LIG_SH3_3	210	216	PF00018	0.715
LIG_SH3_3	283	289	PF00018	0.427
LIG_SH3_3	330	336	PF00018	0.427
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.530
LIG_SUMO_SIM_anti_2	423	431	PF11976	0.671
LIG_SUMO_SIM_par_1	294	301	PF11976	0.546
LIG_SUMO_SIM_par_1	378	383	PF11976	0.530
LIG_TRAF2_1	471	474	PF00917	0.501
LIG_TRFH_1	285	289	PF08558	0.546
LIG_UBA3_1	402	410	PF00899	0.585
LIG_WRC_WIRS_1	69	74	PF05994	0.782
LIG_WW_3	139	143	PF00397	0.829
MOD_CDC14_SPxK_1	139	142	PF00782	0.667
MOD_CDC14_SPxK_1	512	515	PF00782	0.674
MOD_CDK_SPxK_1	136	142	PF00069	0.668
MOD_CDK_SPxK_1	509	515	PF00069	0.660
MOD_CK1_1	113	119	PF00069	0.743
MOD_CK1_1	177	183	PF00069	0.789
MOD_CK1_1	238	244	PF00069	0.576
MOD_CK1_1	68	74	PF00069	0.813
MOD_CK1_1	91	97	PF00069	0.679
MOD_CK2_1	157	163	PF00069	0.649
MOD_CK2_1	295	301	PF00069	0.526
MOD_CK2_1	336	342	PF00069	0.427
MOD_CK2_1	394	400	PF00069	0.557
MOD_CK2_1	444	450	PF00069	0.547
MOD_CK2_1	452	458	PF00069	0.485
MOD_GlcNHglycan	113	116	PF01048	0.569
MOD_GlcNHglycan	145	148	PF01048	0.531
MOD_GlcNHglycan	209	212	PF01048	0.556
MOD_GlcNHglycan	245	248	PF01048	0.332
MOD_GlcNHglycan	311	314	PF01048	0.346
MOD_GlcNHglycan	383	387	PF01048	0.409
MOD_GlcNHglycan	4	7	PF01048	0.607
MOD_GlcNHglycan	90	93	PF01048	0.509
MOD_GSK3_1	106	113	PF00069	0.768
MOD_GSK3_1	157	164	PF00069	0.704
MOD_GSK3_1	197	204	PF00069	0.746
MOD_GSK3_1	352	359	PF00069	0.618
MOD_GSK3_1	413	420	PF00069	0.725
MOD_GSK3_1	435	442	PF00069	0.580
MOD_GSK3_1	487	494	PF00069	0.643
MOD_GSK3_1	509	516	PF00069	0.673
MOD_GSK3_1	56	63	PF00069	0.741
MOD_LATS_1	58	64	PF00433	0.785
MOD_N-GLC_1	105	110	PF02516	0.460
MOD_N-GLC_1	201	206	PF02516	0.626
MOD_N-GLC_1	207	212	PF02516	0.532
MOD_NEK2_1	127	132	PF00069	0.779
MOD_NEK2_1	157	162	PF00069	0.649
MOD_NEK2_1	2	7	PF00069	0.708
MOD_NEK2_1	209	214	PF00069	0.721
MOD_NEK2_1	256	261	PF00069	0.448
MOD_NEK2_1	303	308	PF00069	0.546
MOD_NEK2_1	323	328	PF00069	0.383
MOD_NEK2_1	394	399	PF00069	0.538
MOD_NEK2_1	413	418	PF00069	0.648
MOD_NEK2_1	523	528	PF00069	0.408
MOD_NEK2_2	513	518	PF00069	0.589
MOD_PIKK_1	174	180	PF00454	0.730
MOD_PIKK_1	394	400	PF00454	0.538
MOD_PIKK_1	462	468	PF00454	0.551
MOD_PKA_1	309	315	PF00069	0.546
MOD_PKA_2	111	117	PF00069	0.800
MOD_PKA_2	309	315	PF00069	0.562
MOD_PKA_2	316	322	PF00069	0.527
MOD_PKA_2	467	473	PF00069	0.699
MOD_PKB_1	132	140	PF00069	0.787
MOD_PKB_1	172	180	PF00069	0.732
MOD_Plk_1	105	111	PF00069	0.814
MOD_Plk_1	235	241	PF00069	0.546
MOD_Plk_1	44	50	PF00069	0.699
MOD_Plk_1	449	455	PF00069	0.491
MOD_Plk_1	60	66	PF00069	0.686
MOD_Plk_2-3	295	301	PF00069	0.546
MOD_Plk_4	209	215	PF00069	0.722
MOD_Plk_4	256	262	PF00069	0.474
MOD_Plk_4	352	358	PF00069	0.618
MOD_Plk_4	440	446	PF00069	0.487
MOD_Plk_4	452	458	PF00069	0.500
MOD_Plk_4	523	529	PF00069	0.274
MOD_Plk_4	68	74	PF00069	0.707
MOD_ProDKin_1	121	127	PF00069	0.742
MOD_ProDKin_1	136	142	PF00069	0.669
MOD_ProDKin_1	161	167	PF00069	0.630
MOD_ProDKin_1	201	207	PF00069	0.824
MOD_ProDKin_1	285	291	PF00069	0.546
MOD_ProDKin_1	509	515	PF00069	0.660
MOD_ProDKin_1	71	77	PF00069	0.747
MOD_ProDKin_1	86	92	PF00069	0.707
MOD_SUMO_rev_2	404	412	PF00179	0.479
MOD_SUMO_rev_2	80	89	PF00179	0.664
TRG_DiLeu_BaEn_2	473	479	PF01217	0.617
TRG_DiLeu_BaEn_4	474	480	PF01217	0.617
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.427
TRG_DiLeu_BaLyEn_6	497	502	PF01217	0.529
TRG_ENDOCYTIC_2	273	276	PF00928	0.546
TRG_ENDOCYTIC_2	377	380	PF00928	0.618
TRG_ENDOCYTIC_2	434	437	PF00928	0.580
TRG_ER_diArg_1	131	134	PF00400	0.773
TRG_ER_diArg_1	171	174	PF00400	0.740
TRG_ER_diArg_1	181	183	PF00400	0.729
TRG_ER_diArg_1	253	255	PF00400	0.531
TRG_ER_diArg_1	517	520	PF00400	0.661
TRG_ER_FFAT_2	66	78	PF00635	0.659
TRG_NES_CRM1_1	369	383	PF08389	0.618
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P406	Leptomonas seymouri	54%	93%
A0A3S7WWA9	Leishmania donovani	75%	91%
A4HYZ3	Leishmania infantum	76%	91%
E9AUU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	91%
Q4QCN9	Leishmania major	75%	100%