Cell division cycle protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell division cycle protein-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIL0_LEIBR

TriTrypDb:

LbrM.20.5780 , LBRM2903_200072700

Length:

823

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AIL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIL0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	9
GO:0051301	cell division	2	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	610	614	PF00656	0.279
CLV_C14_Caspase3-7	639	643	PF00656	0.279
CLV_MEL_PAP_1	372	378	PF00089	0.524
CLV_NRD_NRD_1	397	399	PF00675	0.493
CLV_NRD_NRD_1	493	495	PF00675	0.498
CLV_NRD_NRD_1	560	562	PF00675	0.297
CLV_NRD_NRD_1	695	697	PF00675	0.461
CLV_NRD_NRD_1	707	709	PF00675	0.669
CLV_PCSK_FUR_1	781	785	PF00082	0.463
CLV_PCSK_KEX2_1	397	399	PF00082	0.493
CLV_PCSK_KEX2_1	470	472	PF00082	0.645
CLV_PCSK_KEX2_1	493	495	PF00082	0.496
CLV_PCSK_KEX2_1	559	561	PF00082	0.298
CLV_PCSK_KEX2_1	694	696	PF00082	0.456
CLV_PCSK_KEX2_1	706	708	PF00082	0.653
CLV_PCSK_KEX2_1	783	785	PF00082	0.474
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.645
CLV_PCSK_PC1ET2_1	694	696	PF00082	0.419
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.474
CLV_PCSK_SKI1_1	135	139	PF00082	0.483
CLV_PCSK_SKI1_1	151	155	PF00082	0.512
CLV_PCSK_SKI1_1	161	165	PF00082	0.409
CLV_PCSK_SKI1_1	183	187	PF00082	0.441
CLV_PCSK_SKI1_1	382	386	PF00082	0.427
CLV_PCSK_SKI1_1	397	401	PF00082	0.338
CLV_PCSK_SKI1_1	551	555	PF00082	0.302
DEG_SPOP_SBC_1	483	487	PF00917	0.500
DOC_CYCLIN_RxL_1	319	328	PF00134	0.263
DOC_CYCLIN_RxL_1	53	63	PF00134	0.520
DOC_CYCLIN_RxL_1	557	566	PF00134	0.410
DOC_CYCLIN_yClb5_NLxxxL_5	264	272	PF00134	0.423
DOC_MAPK_gen_1	397	408	PF00069	0.324
DOC_MAPK_gen_1	434	442	PF00069	0.303
DOC_MAPK_gen_1	671	681	PF00069	0.279
DOC_MAPK_JIP1_4	671	677	PF00069	0.279
DOC_MAPK_MEF2A_6	397	406	PF00069	0.332
DOC_MAPK_MEF2A_6	436	444	PF00069	0.307
DOC_MAPK_MEF2A_6	671	679	PF00069	0.279
DOC_PP2B_LxvP_1	10	13	PF13499	0.606
DOC_PP2B_LxvP_1	272	275	PF13499	0.558
DOC_PP2B_LxvP_1	287	290	PF13499	0.530
DOC_PP2B_LxvP_1	406	409	PF13499	0.351
DOC_PP2B_LxvP_1	442	445	PF13499	0.327
DOC_PP2B_LxvP_1	533	536	PF13499	0.581
DOC_PP2B_LxvP_1	562	565	PF13499	0.410
DOC_PP2B_LxvP_1	615	618	PF13499	0.279
DOC_USP7_MATH_1	416	420	PF00917	0.278
DOC_USP7_MATH_1	483	487	PF00917	0.689
DOC_USP7_MATH_1	546	550	PF00917	0.317
DOC_USP7_MATH_1	758	762	PF00917	0.728
DOC_USP7_MATH_2	450	456	PF00917	0.482
DOC_WW_Pin1_4	210	215	PF00397	0.544
DOC_WW_Pin1_4	230	235	PF00397	0.548
DOC_WW_Pin1_4	244	249	PF00397	0.472
DOC_WW_Pin1_4	311	316	PF00397	0.548
DOC_WW_Pin1_4	680	685	PF00397	0.424
DOC_WW_Pin1_4	760	765	PF00397	0.672
DOC_WW_Pin1_4	791	796	PF00397	0.600
LIG_14-3-3_CanoR_1	135	140	PF00244	0.583
LIG_14-3-3_CanoR_1	142	150	PF00244	0.476
LIG_14-3-3_CanoR_1	241	251	PF00244	0.385
LIG_14-3-3_CanoR_1	632	638	PF00244	0.291
LIG_14-3-3_CanoR_1	64	70	PF00244	0.483
LIG_14-3-3_CanoR_1	706	716	PF00244	0.604
LIG_14-3-3_CanoR_1	804	812	PF00244	0.470
LIG_Actin_WH2_2	136	153	PF00022	0.433
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_BRCT_BRCA1_1	225	229	PF00533	0.388
LIG_BRCT_BRCA1_1	688	692	PF00533	0.446
LIG_BRCT_BRCA1_2	688	694	PF00533	0.445
LIG_CSL_BTD_1	15	18	PF09270	0.500
LIG_FHA_1	124	130	PF00498	0.621
LIG_FHA_1	160	166	PF00498	0.542
LIG_FHA_1	245	251	PF00498	0.504
LIG_FHA_1	3	9	PF00498	0.560
LIG_FHA_1	308	314	PF00498	0.543
LIG_FHA_1	337	343	PF00498	0.377
LIG_FHA_1	360	366	PF00498	0.380
LIG_FHA_1	390	396	PF00498	0.508
LIG_FHA_1	413	419	PF00498	0.489
LIG_FHA_1	449	455	PF00498	0.631
LIG_FHA_1	486	492	PF00498	0.511
LIG_FHA_1	523	529	PF00498	0.428
LIG_FHA_1	537	543	PF00498	0.334
LIG_FHA_1	550	556	PF00498	0.245
LIG_FHA_1	57	63	PF00498	0.661
LIG_FHA_1	741	747	PF00498	0.546
LIG_FHA_1	766	772	PF00498	0.578
LIG_FHA_1	797	803	PF00498	0.779
LIG_FHA_2	128	134	PF00498	0.647
LIG_FHA_2	136	142	PF00498	0.599
LIG_FHA_2	271	277	PF00498	0.535
LIG_FHA_2	384	390	PF00498	0.503
LIG_FHA_2	513	519	PF00498	0.268
LIG_FHA_2	620	626	PF00498	0.378
LIG_FHA_2	637	643	PF00498	0.242
LIG_LIR_Gen_1	176	185	PF02991	0.445
LIG_LIR_Gen_1	501	509	PF02991	0.563
LIG_LIR_Nem_3	176	181	PF02991	0.445
LIG_LIR_Nem_3	501	506	PF02991	0.454
LIG_LIR_Nem_3	72	78	PF02991	0.574
LIG_LIR_Nem_3	84	89	PF02991	0.516
LIG_MYND_1	760	764	PF01753	0.621
LIG_MYND_3	274	278	PF01753	0.320
LIG_NRBOX	223	229	PF00104	0.438
LIG_NRBOX	238	244	PF00104	0.305
LIG_NRBOX	633	639	PF00104	0.279
LIG_Pex14_2	88	92	PF04695	0.476
LIG_SH2_CRK	503	507	PF00017	0.407
LIG_SH2_GRB2like	195	198	PF00017	0.298
LIG_SH2_PTP2	178	181	PF00017	0.276
LIG_SH2_SRC	101	104	PF00017	0.399
LIG_SH2_STAP1	380	384	PF00017	0.336
LIG_SH2_STAP1	503	507	PF00017	0.464
LIG_SH2_STAT5	101	104	PF00017	0.424
LIG_SH2_STAT5	178	181	PF00017	0.276
LIG_SH2_STAT5	195	198	PF00017	0.317
LIG_SH2_STAT5	394	397	PF00017	0.446
LIG_SH2_STAT5	738	741	PF00017	0.600
LIG_SH3_3	21	27	PF00018	0.609
LIG_SH3_3	283	289	PF00018	0.468
LIG_SH3_3	442	448	PF00018	0.618
LIG_SH3_3	492	498	PF00018	0.549
LIG_SH3_3	666	672	PF00018	0.410
LIG_SH3_3	754	760	PF00018	0.664
LIG_SH3_3	88	94	PF00018	0.487
LIG_SH3_3	97	103	PF00018	0.498
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.449
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.341
LIG_SUMO_SIM_anti_2	525	532	PF11976	0.522
LIG_SUMO_SIM_anti_2	576	582	PF11976	0.279
LIG_SUMO_SIM_anti_2	650	656	PF11976	0.410
LIG_SUMO_SIM_par_1	102	107	PF11976	0.531
LIG_SUMO_SIM_par_1	402	407	PF11976	0.344
LIG_SUMO_SIM_par_1	439	446	PF11976	0.397
LIG_SUMO_SIM_par_1	525	532	PF11976	0.451
LIG_SUMO_SIM_par_1	652	658	PF11976	0.409
LIG_SUMO_SIM_par_1	723	730	PF11976	0.542
LIG_TRAF2_1	515	518	PF00917	0.268
LIG_UBA3_1	317	322	PF00899	0.254
LIG_UBA3_1	775	783	PF00899	0.424
LIG_WRC_WIRS_1	358	363	PF05994	0.462
LIG_WW_3	616	620	PF00397	0.279
LIG_WW_3	756	760	PF00397	0.606
MOD_CDK_SPK_2	210	215	PF00069	0.619
MOD_CK1_1	220	226	PF00069	0.519
MOD_CK1_1	295	301	PF00069	0.695
MOD_CK1_1	306	312	PF00069	0.643
MOD_CK1_1	459	465	PF00069	0.690
MOD_CK1_1	549	555	PF00069	0.288
MOD_CK1_1	658	664	PF00069	0.399
MOD_CK1_1	683	689	PF00069	0.376
MOD_CK1_1	710	716	PF00069	0.644
MOD_CK1_1	796	802	PF00069	0.686
MOD_CK2_1	135	141	PF00069	0.563
MOD_CK2_1	146	152	PF00069	0.595
MOD_CK2_1	270	276	PF00069	0.453
MOD_CK2_1	357	363	PF00069	0.462
MOD_CK2_1	383	389	PF00069	0.423
MOD_CK2_1	416	422	PF00069	0.429
MOD_CK2_1	512	518	PF00069	0.263
MOD_CK2_1	619	625	PF00069	0.410
MOD_CK2_1	745	751	PF00069	0.478
MOD_CK2_1	760	766	PF00069	0.586
MOD_GlcNHglycan	123	126	PF01048	0.548
MOD_GlcNHglycan	294	297	PF01048	0.701
MOD_GlcNHglycan	458	461	PF01048	0.756
MOD_GlcNHglycan	546	549	PF01048	0.282
MOD_GlcNHglycan	657	660	PF01048	0.333
MOD_GlcNHglycan	686	689	PF01048	0.579
MOD_GlcNHglycan	748	751	PF01048	0.620
MOD_GSK3_1	123	130	PF00069	0.721
MOD_GSK3_1	159	166	PF00069	0.582
MOD_GSK3_1	218	225	PF00069	0.427
MOD_GSK3_1	242	249	PF00069	0.340
MOD_GSK3_1	295	302	PF00069	0.666
MOD_GSK3_1	303	310	PF00069	0.640
MOD_GSK3_1	330	337	PF00069	0.574
MOD_GSK3_1	389	396	PF00069	0.409
MOD_GSK3_1	412	419	PF00069	0.524
MOD_GSK3_1	421	428	PF00069	0.526
MOD_GSK3_1	448	455	PF00069	0.693
MOD_GSK3_1	549	556	PF00069	0.324
MOD_GSK3_1	56	63	PF00069	0.522
MOD_GSK3_1	594	601	PF00069	0.420
MOD_GSK3_1	619	626	PF00069	0.321
MOD_GSK3_1	632	639	PF00069	0.300
MOD_GSK3_1	65	72	PF00069	0.426
MOD_GSK3_1	679	686	PF00069	0.504
MOD_GSK3_1	789	796	PF00069	0.521
MOD_N-GLC_1	121	126	PF02516	0.460
MOD_N-GLC_1	626	631	PF02516	0.402
MOD_NEK2_1	112	117	PF00069	0.608
MOD_NEK2_1	242	247	PF00069	0.557
MOD_NEK2_1	292	297	PF00069	0.676
MOD_NEK2_1	299	304	PF00069	0.678
MOD_NEK2_1	334	339	PF00069	0.459
MOD_NEK2_1	357	362	PF00069	0.285
MOD_NEK2_1	383	388	PF00069	0.557
MOD_NEK2_1	404	409	PF00069	0.570
MOD_NEK2_1	595	600	PF00069	0.357
MOD_NEK2_1	60	65	PF00069	0.544
MOD_NEK2_1	775	780	PF00069	0.481
MOD_PIKK_1	152	158	PF00454	0.386
MOD_PIKK_1	232	238	PF00454	0.459
MOD_PIKK_1	253	259	PF00454	0.352
MOD_PIKK_1	43	49	PF00454	0.456
MOD_PIKK_1	636	642	PF00454	0.410
MOD_PIKK_1	786	792	PF00454	0.555
MOD_PIKK_1	796	802	PF00454	0.591
MOD_PKA_1	397	403	PF00069	0.306
MOD_PKA_1	707	713	PF00069	0.614
MOD_PKA_2	143	149	PF00069	0.480
MOD_PKA_2	397	403	PF00069	0.355
MOD_PKA_2	620	626	PF00069	0.322
MOD_PKA_2	707	713	PF00069	0.626
MOD_PKA_2	758	764	PF00069	0.669
MOD_PKA_2	803	809	PF00069	0.564
MOD_Plk_1	389	395	PF00069	0.324
MOD_Plk_1	630	636	PF00069	0.279
MOD_Plk_2-3	270	276	PF00069	0.498
MOD_Plk_4	223	229	PF00069	0.362
MOD_Plk_4	246	252	PF00069	0.517
MOD_Plk_4	330	336	PF00069	0.437
MOD_Plk_4	576	582	PF00069	0.302
MOD_Plk_4	633	639	PF00069	0.279
MOD_ProDKin_1	210	216	PF00069	0.545
MOD_ProDKin_1	230	236	PF00069	0.544
MOD_ProDKin_1	244	250	PF00069	0.472
MOD_ProDKin_1	311	317	PF00069	0.537
MOD_ProDKin_1	680	686	PF00069	0.427
MOD_ProDKin_1	760	766	PF00069	0.668
MOD_ProDKin_1	791	797	PF00069	0.599
TRG_DiLeu_BaEn_1	176	181	PF01217	0.421
TRG_DiLeu_BaEn_1	730	735	PF01217	0.523
TRG_DiLeu_BaEn_4	176	182	PF01217	0.423
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.511
TRG_ENDOCYTIC_2	101	104	PF00928	0.551
TRG_ENDOCYTIC_2	178	181	PF00928	0.470
TRG_ENDOCYTIC_2	380	383	PF00928	0.442
TRG_ENDOCYTIC_2	503	506	PF00928	0.431
TRG_ER_diArg_1	142	145	PF00400	0.534
TRG_ER_diArg_1	397	399	PF00400	0.428
TRG_ER_diArg_1	433	436	PF00400	0.406
TRG_ER_diArg_1	493	495	PF00400	0.496
TRG_ER_diArg_1	558	561	PF00400	0.298
TRG_ER_diArg_1	618	621	PF00400	0.297
TRG_ER_diArg_1	695	698	PF00400	0.472
TRG_ER_diArg_1	706	708	PF00400	0.542
TRG_NES_CRM1_1	518	532	PF08389	0.531
TRG_NLS_MonoExtC_3	693	698	PF00514	0.423
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	695	699	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E7	Leptomonas seymouri	50%	100%
A0A1X0NXH5	Trypanosomatidae	33%	100%
A0A3Q8IBN9	Leishmania donovani	76%	100%
A0A3R7NWG6	Trypanosoma rangeli	35%	100%
A4HZ08	Leishmania infantum	76%	100%
C9ZIP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AUU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QCP1	Leishmania major	76%	100%
V5BCV9	Trypanosoma cruzi	34%	100%