LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
E9AIK7_LEIBR
TriTrypDb:
LbrM.20.5750 , LBRM2903_200072400 *
Length:
975

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIK7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIK7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 417 421 PF00656 0.597
CLV_C14_Caspase3-7 465 469 PF00656 0.435
CLV_C14_Caspase3-7 648 652 PF00656 0.338
CLV_C14_Caspase3-7 825 829 PF00656 0.539
CLV_C14_Caspase3-7 854 858 PF00656 0.589
CLV_C14_Caspase3-7 885 889 PF00656 0.695
CLV_NRD_NRD_1 154 156 PF00675 0.684
CLV_NRD_NRD_1 332 334 PF00675 0.542
CLV_NRD_NRD_1 342 344 PF00675 0.641
CLV_NRD_NRD_1 471 473 PF00675 0.412
CLV_NRD_NRD_1 717 719 PF00675 0.740
CLV_NRD_NRD_1 813 815 PF00675 0.572
CLV_NRD_NRD_1 863 865 PF00675 0.623
CLV_NRD_NRD_1 960 962 PF00675 0.586
CLV_PCSK_KEX2_1 154 156 PF00082 0.684
CLV_PCSK_KEX2_1 332 334 PF00082 0.542
CLV_PCSK_KEX2_1 342 344 PF00082 0.641
CLV_PCSK_KEX2_1 471 473 PF00082 0.434
CLV_PCSK_KEX2_1 717 719 PF00082 0.748
CLV_PCSK_KEX2_1 813 815 PF00082 0.578
CLV_PCSK_KEX2_1 865 867 PF00082 0.674
CLV_PCSK_KEX2_1 960 962 PF00082 0.613
CLV_PCSK_KEX2_1 971 973 PF00082 0.574
CLV_PCSK_PC1ET2_1 865 867 PF00082 0.674
CLV_PCSK_PC1ET2_1 960 962 PF00082 0.671
CLV_PCSK_PC1ET2_1 971 973 PF00082 0.625
CLV_PCSK_SKI1_1 244 248 PF00082 0.476
CLV_PCSK_SKI1_1 333 337 PF00082 0.532
CLV_PCSK_SKI1_1 62 66 PF00082 0.384
CLV_PCSK_SKI1_1 675 679 PF00082 0.388
CLV_PCSK_SKI1_1 814 818 PF00082 0.535
CLV_PCSK_SKI1_1 86 90 PF00082 0.395
DEG_Nend_Nbox_1 1 3 PF02207 0.545
DEG_SCF_FBW7_1 943 949 PF00400 0.548
DEG_SCF_FBW7_2 111 117 PF00400 0.442
DOC_CDC14_PxL_1 264 272 PF14671 0.381
DOC_CKS1_1 111 116 PF01111 0.443
DOC_CKS1_1 943 948 PF01111 0.549
DOC_CYCLIN_RxL_1 632 642 PF00134 0.524
DOC_CYCLIN_RxL_1 83 90 PF00134 0.483
DOC_CYCLIN_yCln2_LP_2 637 643 PF00134 0.612
DOC_MAPK_DCC_7 471 479 PF00069 0.397
DOC_MAPK_DCC_7 86 96 PF00069 0.482
DOC_MAPK_gen_1 139 148 PF00069 0.415
DOC_MAPK_gen_1 202 210 PF00069 0.600
DOC_MAPK_gen_1 451 461 PF00069 0.465
DOC_MAPK_gen_1 471 479 PF00069 0.349
DOC_MAPK_gen_1 532 542 PF00069 0.450
DOC_MAPK_gen_1 62 70 PF00069 0.363
DOC_MAPK_gen_1 84 91 PF00069 0.495
DOC_MAPK_MEF2A_6 205 212 PF00069 0.503
DOC_MAPK_MEF2A_6 471 479 PF00069 0.397
DOC_MAPK_MEF2A_6 535 544 PF00069 0.524
DOC_PP1_RVXF_1 242 248 PF00149 0.468
DOC_PP2B_LxvP_1 252 255 PF13499 0.432
DOC_PP2B_LxvP_1 637 640 PF13499 0.489
DOC_PP2B_LxvP_1 89 92 PF13499 0.486
DOC_PP4_FxxP_1 543 546 PF00568 0.506
DOC_USP7_MATH_1 142 146 PF00917 0.585
DOC_USP7_MATH_1 191 195 PF00917 0.514
DOC_USP7_MATH_1 229 233 PF00917 0.476
DOC_USP7_MATH_1 290 294 PF00917 0.366
DOC_USP7_MATH_1 344 348 PF00917 0.715
DOC_USP7_MATH_1 369 373 PF00917 0.750
DOC_USP7_MATH_1 375 379 PF00917 0.508
DOC_USP7_MATH_1 47 51 PF00917 0.550
DOC_USP7_MATH_1 495 499 PF00917 0.598
DOC_USP7_MATH_1 608 612 PF00917 0.442
DOC_USP7_MATH_1 655 659 PF00917 0.497
DOC_USP7_MATH_1 716 720 PF00917 0.552
DOC_USP7_MATH_1 859 863 PF00917 0.697
DOC_USP7_MATH_1 912 916 PF00917 0.622
DOC_USP7_MATH_1 930 934 PF00917 0.570
DOC_USP7_MATH_1 938 942 PF00917 0.658
DOC_USP7_MATH_1 955 959 PF00917 0.506
DOC_USP7_MATH_1 967 971 PF00917 0.517
DOC_USP7_MATH_2 640 646 PF00917 0.507
DOC_USP7_UBL2_3 962 966 PF12436 0.574
DOC_WW_Pin1_4 110 115 PF00397 0.463
DOC_WW_Pin1_4 192 197 PF00397 0.510
DOC_WW_Pin1_4 807 812 PF00397 0.613
DOC_WW_Pin1_4 866 871 PF00397 0.720
DOC_WW_Pin1_4 939 944 PF00397 0.732
DOC_WW_Pin1_4 965 970 PF00397 0.659
LIG_14-3-3_CanoR_1 202 212 PF00244 0.498
LIG_14-3-3_CanoR_1 332 338 PF00244 0.495
LIG_14-3-3_CanoR_1 343 352 PF00244 0.602
LIG_14-3-3_CanoR_1 496 500 PF00244 0.593
LIG_14-3-3_CanoR_1 646 650 PF00244 0.489
LIG_14-3-3_CanoR_1 717 724 PF00244 0.631
LIG_14-3-3_CanoR_1 733 743 PF00244 0.691
LIG_14-3-3_CanoR_1 864 872 PF00244 0.843
LIG_14-3-3_CanoR_1 911 915 PF00244 0.587
LIG_14-3-3_CanoR_1 934 943 PF00244 0.622
LIG_CtBP_PxDLS_1 209 213 PF00389 0.306
LIG_DLG_GKlike_1 288 296 PF00625 0.308
LIG_eIF4E_1 435 441 PF01652 0.438
LIG_FHA_1 10 16 PF00498 0.491
LIG_FHA_1 106 112 PF00498 0.511
LIG_FHA_1 20 26 PF00498 0.374
LIG_FHA_1 361 367 PF00498 0.574
LIG_FHA_1 405 411 PF00498 0.530
LIG_FHA_1 506 512 PF00498 0.565
LIG_FHA_1 703 709 PF00498 0.459
LIG_FHA_1 730 736 PF00498 0.518
LIG_FHA_1 78 84 PF00498 0.416
LIG_FHA_1 845 851 PF00498 0.759
LIG_FHA_2 369 375 PF00498 0.607
LIG_FHA_2 425 431 PF00498 0.560
LIG_FHA_2 463 469 PF00498 0.433
LIG_FHA_2 489 495 PF00498 0.471
LIG_FHA_2 852 858 PF00498 0.687
LIG_LIR_Apic_2 541 546 PF02991 0.450
LIG_LIR_Gen_1 16 25 PF02991 0.401
LIG_LIR_Gen_1 498 506 PF02991 0.411
LIG_LIR_Gen_1 52 61 PF02991 0.546
LIG_LIR_Gen_1 66 74 PF02991 0.312
LIG_LIR_Nem_3 16 20 PF02991 0.407
LIG_LIR_Nem_3 390 395 PF02991 0.470
LIG_LIR_Nem_3 498 503 PF02991 0.382
LIG_LIR_Nem_3 52 57 PF02991 0.470
LIG_LIR_Nem_3 66 70 PF02991 0.351
LIG_LYPXL_S_1 434 438 PF13949 0.413
LIG_LYPXL_yS_3 392 395 PF13949 0.499
LIG_LYPXL_yS_3 435 438 PF13949 0.412
LIG_NRBOX 394 400 PF00104 0.521
LIG_NRBOX 437 443 PF00104 0.428
LIG_NRBOX 525 531 PF00104 0.471
LIG_NRP_CendR_1 972 975 PF00754 0.586
LIG_PCNA_yPIPBox_3 523 535 PF02747 0.465
LIG_SH2_CRK 2 6 PF00017 0.498
LIG_SH2_NCK_1 46 50 PF00017 0.419
LIG_SH2_NCK_1 756 760 PF00017 0.500
LIG_SH2_PTP2 67 70 PF00017 0.412
LIG_SH2_SRC 756 759 PF00017 0.484
LIG_SH2_STAP1 301 305 PF00017 0.360
LIG_SH2_STAT3 447 450 PF00017 0.283
LIG_SH2_STAT3 663 666 PF00017 0.470
LIG_SH2_STAT5 136 139 PF00017 0.459
LIG_SH2_STAT5 437 440 PF00017 0.427
LIG_SH2_STAT5 448 451 PF00017 0.402
LIG_SH2_STAT5 460 463 PF00017 0.323
LIG_SH2_STAT5 602 605 PF00017 0.466
LIG_SH2_STAT5 663 666 PF00017 0.470
LIG_SH2_STAT5 669 672 PF00017 0.459
LIG_SH2_STAT5 67 70 PF00017 0.339
LIG_SH3_2 808 813 PF14604 0.520
LIG_SH3_2 943 948 PF14604 0.549
LIG_SH3_3 108 114 PF00018 0.394
LIG_SH3_3 159 165 PF00018 0.604
LIG_SH3_3 190 196 PF00018 0.519
LIG_SH3_3 748 754 PF00018 0.406
LIG_SH3_3 792 798 PF00018 0.566
LIG_SH3_3 802 808 PF00018 0.638
LIG_SH3_3 873 879 PF00018 0.771
LIG_SH3_3 92 98 PF00018 0.520
LIG_SH3_3 940 946 PF00018 0.573
LIG_SH3_4 962 969 PF00018 0.534
LIG_SUMO_SIM_anti_2 16 22 PF11976 0.440
LIG_SUMO_SIM_anti_2 66 72 PF11976 0.416
LIG_SUMO_SIM_anti_2 900 905 PF11976 0.709
LIG_TRAF2_1 486 489 PF00917 0.536
LIG_TRAF2_1 514 517 PF00917 0.555
LIG_TRAF2_1 594 597 PF00917 0.470
LIG_UBA3_1 918 926 PF00899 0.644
LIG_WRC_WIRS_1 1 6 PF05994 0.458
LIG_WRC_WIRS_1 334 339 PF05994 0.545
MOD_CDC14_SPxK_1 810 813 PF00782 0.599
MOD_CDC14_SPxK_1 871 874 PF00782 0.583
MOD_CDC14_SPxK_1 968 971 PF00782 0.532
MOD_CDK_SPK_2 110 115 PF00069 0.463
MOD_CDK_SPxK_1 807 813 PF00069 0.737
MOD_CDK_SPxK_1 868 874 PF00069 0.579
MOD_CDK_SPxK_1 942 948 PF00069 0.550
MOD_CDK_SPxK_1 965 971 PF00069 0.540
MOD_CDK_SPxxK_3 807 814 PF00069 0.668
MOD_CDK_SPxxK_3 965 972 PF00069 0.661
MOD_CK1_1 105 111 PF00069 0.568
MOD_CK1_1 150 156 PF00069 0.576
MOD_CK1_1 194 200 PF00069 0.472
MOD_CK1_1 231 237 PF00069 0.431
MOD_CK1_1 257 263 PF00069 0.389
MOD_CK1_1 3 9 PF00069 0.494
MOD_CK1_1 360 366 PF00069 0.634
MOD_CK1_1 378 384 PF00069 0.520
MOD_CK1_1 45 51 PF00069 0.427
MOD_CK1_1 502 508 PF00069 0.562
MOD_CK1_1 645 651 PF00069 0.454
MOD_CK1_1 681 687 PF00069 0.470
MOD_CK1_1 729 735 PF00069 0.693
MOD_CK1_1 736 742 PF00069 0.725
MOD_CK1_1 855 861 PF00069 0.752
MOD_CK1_1 889 895 PF00069 0.689
MOD_CK1_1 917 923 PF00069 0.647
MOD_CK1_1 933 939 PF00069 0.531
MOD_CK1_1 941 947 PF00069 0.609
MOD_CK2_1 288 294 PF00069 0.319
MOD_CK2_1 368 374 PF00069 0.713
MOD_CK2_1 488 494 PF00069 0.403
MOD_CK2_1 608 614 PF00069 0.507
MOD_CK2_1 7 13 PF00069 0.426
MOD_Cter_Amidation 330 333 PF01082 0.543
MOD_GlcNHglycan 196 199 PF01048 0.483
MOD_GlcNHglycan 220 223 PF01048 0.386
MOD_GlcNHglycan 231 234 PF01048 0.347
MOD_GlcNHglycan 284 287 PF01048 0.498
MOD_GlcNHglycan 346 349 PF01048 0.630
MOD_GlcNHglycan 420 423 PF01048 0.541
MOD_GlcNHglycan 47 50 PF01048 0.379
MOD_GlcNHglycan 504 507 PF01048 0.377
MOD_GlcNHglycan 516 521 PF01048 0.311
MOD_GlcNHglycan 592 595 PF01048 0.347
MOD_GlcNHglycan 680 683 PF01048 0.525
MOD_GlcNHglycan 7 10 PF01048 0.443
MOD_GlcNHglycan 728 731 PF01048 0.719
MOD_GlcNHglycan 781 784 PF01048 0.543
MOD_GlcNHglycan 857 860 PF01048 0.687
MOD_GlcNHglycan 914 917 PF01048 0.734
MOD_GlcNHglycan 936 939 PF01048 0.760
MOD_GlcNHglycan 951 954 PF01048 0.705
MOD_GlcNHglycan 957 960 PF01048 0.655
MOD_GSK3_1 142 149 PF00069 0.489
MOD_GSK3_1 228 235 PF00069 0.405
MOD_GSK3_1 256 263 PF00069 0.461
MOD_GSK3_1 278 285 PF00069 0.488
MOD_GSK3_1 3 10 PF00069 0.537
MOD_GSK3_1 301 308 PF00069 0.547
MOD_GSK3_1 357 364 PF00069 0.641
MOD_GSK3_1 495 502 PF00069 0.540
MOD_GSK3_1 702 709 PF00069 0.389
MOD_GSK3_1 729 736 PF00069 0.764
MOD_GSK3_1 851 858 PF00069 0.640
MOD_GSK3_1 860 867 PF00069 0.722
MOD_GSK3_1 884 891 PF00069 0.701
MOD_GSK3_1 910 917 PF00069 0.586
MOD_GSK3_1 930 937 PF00069 0.747
MOD_GSK3_1 938 945 PF00069 0.760
MOD_GSK3_1 951 958 PF00069 0.583
MOD_GSK3_1 961 968 PF00069 0.559
MOD_N-GLC_1 123 128 PF02516 0.416
MOD_N-GLC_1 150 155 PF02516 0.661
MOD_N-GLC_1 260 265 PF02516 0.320
MOD_N-GLC_1 344 349 PF02516 0.479
MOD_N-GLC_1 418 423 PF02516 0.510
MOD_N-GLC_1 55 60 PF02516 0.457
MOD_N-GLC_1 851 856 PF02516 0.643
MOD_NEK2_1 102 107 PF00069 0.503
MOD_NEK2_1 123 128 PF00069 0.507
MOD_NEK2_1 147 152 PF00069 0.570
MOD_NEK2_1 218 223 PF00069 0.442
MOD_NEK2_1 271 276 PF00069 0.482
MOD_NEK2_1 305 310 PF00069 0.416
MOD_NEK2_1 357 362 PF00069 0.638
MOD_NEK2_1 4 9 PF00069 0.368
MOD_NEK2_1 42 47 PF00069 0.440
MOD_NEK2_1 499 504 PF00069 0.495
MOD_NEK2_1 678 683 PF00069 0.612
MOD_NEK2_1 707 712 PF00069 0.490
MOD_NEK2_1 74 79 PF00069 0.362
MOD_NEK2_2 495 500 PF00069 0.490
MOD_NEK2_2 608 613 PF00069 0.345
MOD_PIKK_1 47 53 PF00454 0.299
MOD_PIKK_1 615 621 PF00454 0.410
MOD_PIKK_1 717 723 PF00454 0.494
MOD_PIKK_1 890 896 PF00454 0.676
MOD_PK_1 538 544 PF00069 0.373
MOD_PKA_1 717 723 PF00069 0.494
MOD_PKA_1 864 870 PF00069 0.639
MOD_PKA_1 961 967 PF00069 0.566
MOD_PKA_2 361 367 PF00069 0.719
MOD_PKA_2 404 410 PF00069 0.479
MOD_PKA_2 495 501 PF00069 0.598
MOD_PKA_2 645 651 PF00069 0.443
MOD_PKA_2 716 722 PF00069 0.592
MOD_PKA_2 855 861 PF00069 0.751
MOD_PKA_2 910 916 PF00069 0.635
MOD_PKA_2 933 939 PF00069 0.553
MOD_Plk_1 123 129 PF00069 0.414
MOD_Plk_1 142 148 PF00069 0.504
MOD_Plk_1 260 266 PF00069 0.309
MOD_Plk_1 378 384 PF00069 0.631
MOD_Plk_1 74 80 PF00069 0.266
MOD_Plk_2-3 488 494 PF00069 0.465
MOD_Plk_4 102 108 PF00069 0.561
MOD_Plk_4 123 129 PF00069 0.396
MOD_Plk_4 142 148 PF00069 0.432
MOD_Plk_4 16 22 PF00069 0.449
MOD_Plk_4 266 272 PF00069 0.369
MOD_Plk_4 278 284 PF00069 0.434
MOD_Plk_4 301 307 PF00069 0.471
MOD_Plk_4 333 339 PF00069 0.465
MOD_Plk_4 488 494 PF00069 0.443
MOD_Plk_4 495 501 PF00069 0.477
MOD_Plk_4 538 544 PF00069 0.467
MOD_Plk_4 546 552 PF00069 0.446
MOD_Plk_4 556 562 PF00069 0.355
MOD_Plk_4 645 651 PF00069 0.395
MOD_Plk_4 791 797 PF00069 0.455
MOD_Plk_4 836 842 PF00069 0.656
MOD_Plk_4 914 920 PF00069 0.616
MOD_ProDKin_1 110 116 PF00069 0.456
MOD_ProDKin_1 192 198 PF00069 0.505
MOD_ProDKin_1 807 813 PF00069 0.617
MOD_ProDKin_1 866 872 PF00069 0.718
MOD_ProDKin_1 939 945 PF00069 0.731
MOD_ProDKin_1 965 971 PF00069 0.659
MOD_SUMO_for_1 816 819 PF00179 0.542
MOD_SUMO_rev_2 891 901 PF00179 0.719
TRG_DiLeu_BaEn_1 66 71 PF01217 0.416
TRG_DiLeu_BaEn_2 116 122 PF01217 0.414
TRG_DiLeu_BaLyEn_6 525 530 PF01217 0.310
TRG_DiLeu_LyEn_5 873 878 PF01217 0.557
TRG_ENDOCYTIC_2 2 5 PF00928 0.503
TRG_ENDOCYTIC_2 392 395 PF00928 0.499
TRG_ENDOCYTIC_2 435 438 PF00928 0.438
TRG_ENDOCYTIC_2 67 70 PF00928 0.352
TRG_ER_diArg_1 154 156 PF00400 0.746
TRG_ER_diArg_1 332 334 PF00400 0.542
TRG_ER_diArg_1 470 472 PF00400 0.391
TRG_ER_diArg_1 716 718 PF00400 0.611
TRG_ER_diArg_1 813 815 PF00400 0.578
TRG_ER_diArg_1 83 86 PF00400 0.472
TRG_ER_diArg_1 830 833 PF00400 0.501
TRG_ER_FFAT_1 582 593 PF00635 0.297
TRG_NES_CRM1_1 117 131 PF08389 0.393
TRG_NLS_Bipartite_1 960 975 PF00514 0.539
TRG_NLS_MonoExtC_3 970 975 PF00514 0.661
TRG_NLS_MonoExtN_4 969 975 PF00514 0.573
TRG_Pf-PMV_PEXEL_1 733 738 PF00026 0.623
TRG_Pf-PMV_PEXEL_1 814 818 PF00026 0.689
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.591

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB01 Leptomonas seymouri 50% 100%
A0A1X0NWS1 Trypanosomatidae 26% 100%
A0A3S5H790 Leishmania donovani 78% 100%
A4HZ05 Leishmania infantum 78% 100%
C9ZIP4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
E9AUT9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
Q4QCP4 Leishmania major 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS