LeishMANIAdb
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Adaptin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Adaptin_N domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
E9AIK6_LEIBR
TriTrypDb:
LbrM.20.5740 , LBRM2903_200072300 *
Length:
975

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AIK6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIK6

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 1
GO:0009987 cellular process 1 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0003700 DNA-binding transcription factor activity 2 1
GO:0140110 transcription regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 289 293 PF00656 0.308
CLV_C14_Caspase3-7 378 382 PF00656 0.536
CLV_C14_Caspase3-7 797 801 PF00656 0.615
CLV_C14_Caspase3-7 828 832 PF00656 0.723
CLV_NRD_NRD_1 139 141 PF00675 0.638
CLV_NRD_NRD_1 313 315 PF00675 0.619
CLV_NRD_NRD_1 468 470 PF00675 0.671
CLV_NRD_NRD_1 490 492 PF00675 0.470
CLV_NRD_NRD_1 56 58 PF00675 0.544
CLV_NRD_NRD_1 602 604 PF00675 0.464
CLV_NRD_NRD_1 954 956 PF00675 0.591
CLV_PCSK_KEX2_1 139 141 PF00082 0.638
CLV_PCSK_KEX2_1 313 315 PF00082 0.619
CLV_PCSK_KEX2_1 468 470 PF00082 0.671
CLV_PCSK_KEX2_1 490 492 PF00082 0.470
CLV_PCSK_KEX2_1 557 559 PF00082 0.629
CLV_PCSK_KEX2_1 602 604 PF00082 0.464
CLV_PCSK_KEX2_1 683 685 PF00082 0.360
CLV_PCSK_PC1ET2_1 557 559 PF00082 0.629
CLV_PCSK_PC1ET2_1 683 685 PF00082 0.443
CLV_PCSK_SKI1_1 432 436 PF00082 0.621
CLV_PCSK_SKI1_1 495 499 PF00082 0.594
CLV_PCSK_SKI1_1 643 647 PF00082 0.663
DEG_APCC_DBOX_1 650 658 PF00400 0.361
DEG_MDM2_SWIB_1 551 559 PF02201 0.369
DEG_SPOP_SBC_1 270 274 PF00917 0.498
DEG_SPOP_SBC_1 531 535 PF00917 0.508
DEG_SPOP_SBC_1 849 853 PF00917 0.557
DOC_CDC14_PxL_1 296 304 PF14671 0.429
DOC_CDC14_PxL_1 878 886 PF14671 0.784
DOC_MAPK_DCC_7 561 571 PF00069 0.437
DOC_MAPK_DCC_7 666 675 PF00069 0.312
DOC_MAPK_gen_1 13 22 PF00069 0.397
DOC_MAPK_gen_1 313 320 PF00069 0.401
DOC_MAPK_gen_1 468 479 PF00069 0.298
DOC_MAPK_gen_1 57 67 PF00069 0.363
DOC_MAPK_gen_1 69 79 PF00069 0.298
DOC_MAPK_gen_1 955 963 PF00069 0.794
DOC_MAPK_HePTP_8 363 375 PF00069 0.281
DOC_MAPK_HePTP_8 55 67 PF00069 0.378
DOC_MAPK_JIP1_4 314 320 PF00069 0.357
DOC_MAPK_MEF2A_6 16 24 PF00069 0.270
DOC_MAPK_MEF2A_6 332 340 PF00069 0.425
DOC_MAPK_MEF2A_6 366 375 PF00069 0.286
DOC_MAPK_MEF2A_6 472 481 PF00069 0.286
DOC_MAPK_MEF2A_6 58 67 PF00069 0.361
DOC_MAPK_MEF2A_6 666 675 PF00069 0.312
DOC_MAPK_MEF2A_6 70 79 PF00069 0.306
DOC_MAPK_RevD_3 453 469 PF00069 0.433
DOC_MAPK_RevD_3 671 684 PF00069 0.465
DOC_PP2B_LxvP_1 887 890 PF13499 0.710
DOC_USP7_MATH_1 3 7 PF00917 0.523
DOC_USP7_MATH_1 438 442 PF00917 0.509
DOC_USP7_MATH_1 531 535 PF00917 0.446
DOC_USP7_MATH_1 794 798 PF00917 0.786
DOC_USP7_MATH_1 817 821 PF00917 0.683
DOC_USP7_MATH_1 830 834 PF00917 0.604
DOC_USP7_UBL2_3 14 18 PF12436 0.491
DOC_WW_Pin1_4 238 243 PF00397 0.721
DOC_WW_Pin1_4 440 445 PF00397 0.500
DOC_WW_Pin1_4 532 537 PF00397 0.558
DOC_WW_Pin1_4 564 569 PF00397 0.378
DOC_WW_Pin1_4 644 649 PF00397 0.461
DOC_WW_Pin1_4 800 805 PF00397 0.617
LIG_14-3-3_CanoR_1 283 288 PF00244 0.361
LIG_14-3-3_CanoR_1 332 336 PF00244 0.437
LIG_14-3-3_CanoR_1 344 354 PF00244 0.338
LIG_14-3-3_CanoR_1 413 417 PF00244 0.402
LIG_14-3-3_CanoR_1 643 648 PF00244 0.449
LIG_14-3-3_CanoR_1 714 724 PF00244 0.652
LIG_14-3-3_CanoR_1 74 80 PF00244 0.312
LIG_14-3-3_CanoR_1 792 797 PF00244 0.726
LIG_14-3-3_CanoR_1 826 830 PF00244 0.707
LIG_14-3-3_CanoR_1 955 961 PF00244 0.748
LIG_14-3-3_CanoR_1 970 975 PF00244 0.761
LIG_Actin_RPEL_3 67 86 PF02755 0.354
LIG_Actin_WH2_2 400 415 PF00022 0.438
LIG_Actin_WH2_2 445 463 PF00022 0.448
LIG_APCC_ABBA_1 22 27 PF00400 0.396
LIG_BRCT_BRCA1_1 300 304 PF00533 0.356
LIG_BRCT_BRCA1_1 805 809 PF00533 0.769
LIG_deltaCOP1_diTrp_1 748 758 PF00928 0.676
LIG_EH1_1 654 662 PF00400 0.485
LIG_eIF4E_1 15 21 PF01652 0.280
LIG_EVH1_1 881 885 PF00568 0.780
LIG_FHA_1 272 278 PF00498 0.401
LIG_FHA_1 283 289 PF00498 0.421
LIG_FHA_1 359 365 PF00498 0.334
LIG_FHA_1 445 451 PF00498 0.401
LIG_FHA_1 472 478 PF00498 0.413
LIG_FHA_1 496 502 PF00498 0.389
LIG_FHA_1 537 543 PF00498 0.546
LIG_FHA_1 561 567 PF00498 0.435
LIG_FHA_1 644 650 PF00498 0.466
LIG_FHA_1 868 874 PF00498 0.704
LIG_FHA_2 129 135 PF00498 0.284
LIG_FHA_2 284 290 PF00498 0.260
LIG_FHA_2 346 352 PF00498 0.261
LIG_FHA_2 542 548 PF00498 0.480
LIG_GBD_Chelix_1 183 191 PF00786 0.545
LIG_GBD_Chelix_1 404 412 PF00786 0.531
LIG_GBD_Chelix_1 574 582 PF00786 0.585
LIG_IRF3_LxIS_1 822 828 PF10401 0.720
LIG_LIR_Apic_2 292 297 PF02991 0.372
LIG_LIR_Apic_2 938 944 PF02991 0.709
LIG_LIR_Gen_1 172 180 PF02991 0.379
LIG_LIR_Gen_1 219 227 PF02991 0.589
LIG_LIR_Gen_1 301 311 PF02991 0.300
LIG_LIR_Gen_1 321 329 PF02991 0.198
LIG_LIR_Gen_1 650 661 PF02991 0.361
LIG_LIR_Gen_1 738 747 PF02991 0.579
LIG_LIR_Nem_3 172 177 PF02991 0.380
LIG_LIR_Nem_3 219 225 PF02991 0.593
LIG_LIR_Nem_3 301 307 PF02991 0.360
LIG_LIR_Nem_3 321 326 PF02991 0.198
LIG_LIR_Nem_3 738 742 PF02991 0.587
LIG_LIR_Nem_3 748 754 PF02991 0.617
LIG_NRBOX 430 436 PF00104 0.375
LIG_PCNA_yPIPBox_3 200 211 PF02747 0.437
LIG_PCNA_yPIPBox_3 782 792 PF02747 0.556
LIG_PDZ_Class_1 970 975 PF00595 0.761
LIG_Pex14_1 294 298 PF04695 0.350
LIG_Pex14_2 551 555 PF04695 0.453
LIG_Pex14_2 592 596 PF04695 0.387
LIG_SH2_CRK 174 178 PF00017 0.326
LIG_SH2_CRK 323 327 PF00017 0.431
LIG_SH2_CRK 668 672 PF00017 0.572
LIG_SH2_GRB2like 480 483 PF00017 0.433
LIG_SH2_SRC 298 301 PF00017 0.326
LIG_SH2_SRC 480 483 PF00017 0.433
LIG_SH2_SRC 668 671 PF00017 0.567
LIG_SH2_STAP1 174 178 PF00017 0.326
LIG_SH2_STAT5 298 301 PF00017 0.326
LIG_SH2_STAT5 459 462 PF00017 0.348
LIG_SH2_STAT5 480 483 PF00017 0.402
LIG_SH2_STAT5 708 711 PF00017 0.619
LIG_SH2_STAT5 715 718 PF00017 0.617
LIG_SH2_STAT5 741 744 PF00017 0.584
LIG_SH2_STAT5 971 974 PF00017 0.705
LIG_SH3_3 211 217 PF00018 0.520
LIG_SH3_3 241 247 PF00018 0.585
LIG_SH3_3 294 300 PF00018 0.388
LIG_SH3_3 452 458 PF00018 0.403
LIG_SH3_3 869 875 PF00018 0.777
LIG_SH3_3 879 885 PF00018 0.780
LIG_SUMO_SIM_anti_2 348 354 PF11976 0.418
LIG_SUMO_SIM_anti_2 567 573 PF11976 0.429
LIG_SUMO_SIM_anti_2 753 758 PF11976 0.672
LIG_SUMO_SIM_par_1 206 212 PF11976 0.419
LIG_SUMO_SIM_par_1 360 365 PF11976 0.268
LIG_SUMO_SIM_par_1 567 573 PF11976 0.404
LIG_SUMO_SIM_par_1 78 84 PF11976 0.395
LIG_TRAF2_1 544 547 PF00917 0.491
LIG_TRAF2_1 760 763 PF00917 0.691
LIG_TYR_ITSM 170 177 PF00017 0.476
LIG_WRC_WIRS_1 736 741 PF05994 0.482
LIG_WW_1 917 920 PF00397 0.761
LIG_WW_2 882 885 PF00397 0.748
MOD_CDK_SPK_2 800 805 PF00069 0.522
MOD_CDK_SPxxK_3 644 651 PF00069 0.573
MOD_CK1_1 234 240 PF00069 0.689
MOD_CK1_1 334 340 PF00069 0.590
MOD_CK1_1 345 351 PF00069 0.364
MOD_CK1_1 390 396 PF00069 0.431
MOD_CK1_1 43 49 PF00069 0.345
MOD_CK1_1 440 446 PF00069 0.557
MOD_CK1_1 530 536 PF00069 0.683
MOD_CK1_1 560 566 PF00069 0.594
MOD_CK1_1 647 653 PF00069 0.449
MOD_CK1_1 718 724 PF00069 0.577
MOD_CK1_1 740 746 PF00069 0.560
MOD_CK1_1 795 801 PF00069 0.663
MOD_CK1_1 803 809 PF00069 0.630
MOD_CK1_1 867 873 PF00069 0.762
MOD_CK1_1 901 907 PF00069 0.727
MOD_CK2_1 283 289 PF00069 0.300
MOD_CK2_1 44 50 PF00069 0.466
MOD_CK2_1 541 547 PF00069 0.662
MOD_CK2_1 689 695 PF00069 0.515
MOD_CK2_1 758 764 PF00069 0.524
MOD_CK2_1 81 87 PF00069 0.413
MOD_CK2_1 837 843 PF00069 0.511
MOD_GlcNHglycan 136 139 PF01048 0.569
MOD_GlcNHglycan 308 311 PF01048 0.492
MOD_GlcNHglycan 392 395 PF01048 0.677
MOD_GlcNHglycan 440 443 PF01048 0.593
MOD_GlcNHglycan 529 532 PF01048 0.639
MOD_GlcNHglycan 587 590 PF01048 0.502
MOD_GlcNHglycan 610 613 PF01048 0.721
MOD_GlcNHglycan 639 642 PF01048 0.674
MOD_GlcNHglycan 710 713 PF01048 0.446
MOD_GlcNHglycan 846 849 PF01048 0.660
MOD_GlcNHglycan 866 869 PF01048 0.427
MOD_GlcNHglycan 87 91 PF01048 0.358
MOD_GlcNHglycan 893 899 PF01048 0.743
MOD_GlcNHglycan 931 934 PF01048 0.792
MOD_GlcNHglycan 937 940 PF01048 0.673
MOD_GSK3_1 105 112 PF00069 0.440
MOD_GSK3_1 128 135 PF00069 0.543
MOD_GSK3_1 230 237 PF00069 0.608
MOD_GSK3_1 265 272 PF00069 0.405
MOD_GSK3_1 298 305 PF00069 0.317
MOD_GSK3_1 330 337 PF00069 0.522
MOD_GSK3_1 390 397 PF00069 0.613
MOD_GSK3_1 40 47 PF00069 0.454
MOD_GSK3_1 419 426 PF00069 0.551
MOD_GSK3_1 434 441 PF00069 0.525
MOD_GSK3_1 491 498 PF00069 0.454
MOD_GSK3_1 523 530 PF00069 0.679
MOD_GSK3_1 532 539 PF00069 0.715
MOD_GSK3_1 560 567 PF00069 0.511
MOD_GSK3_1 625 632 PF00069 0.774
MOD_GSK3_1 635 642 PF00069 0.706
MOD_GSK3_1 643 650 PF00069 0.556
MOD_GSK3_1 702 709 PF00069 0.502
MOD_GSK3_1 731 738 PF00069 0.504
MOD_GSK3_1 792 799 PF00069 0.644
MOD_GSK3_1 803 810 PF00069 0.703
MOD_GSK3_1 817 824 PF00069 0.511
MOD_GSK3_1 830 837 PF00069 0.510
MOD_GSK3_1 844 851 PF00069 0.532
MOD_GSK3_1 894 901 PF00069 0.734
MOD_N-GLC_1 109 114 PF02516 0.419
MOD_N-GLC_1 419 424 PF02516 0.599
MOD_N-GLC_1 629 634 PF02516 0.526
MOD_N-GLC_1 781 786 PF02516 0.522
MOD_N-GLC_1 792 797 PF02516 0.596
MOD_N-GLC_1 864 869 PF02516 0.692
MOD_N-GLC_1 927 932 PF02516 0.674
MOD_N-GLC_2 5 7 PF02516 0.602
MOD_NEK2_1 105 110 PF00069 0.436
MOD_NEK2_1 20 25 PF00069 0.516
MOD_NEK2_1 218 223 PF00069 0.583
MOD_NEK2_1 259 264 PF00069 0.444
MOD_NEK2_1 318 323 PF00069 0.328
MOD_NEK2_1 375 380 PF00069 0.651
MOD_NEK2_1 411 416 PF00069 0.436
MOD_NEK2_1 434 439 PF00069 0.411
MOD_NEK2_1 471 476 PF00069 0.457
MOD_NEK2_1 529 534 PF00069 0.494
MOD_NEK2_1 596 601 PF00069 0.375
MOD_NEK2_1 639 644 PF00069 0.673
MOD_NEK2_1 81 86 PF00069 0.533
MOD_NEK2_1 825 830 PF00069 0.655
MOD_NMyristoyl 1 7 PF02799 0.673
MOD_PIKK_1 128 134 PF00454 0.588
MOD_PIKK_1 419 425 PF00454 0.595
MOD_PIKK_1 834 840 PF00454 0.600
MOD_PIKK_1 867 873 PF00454 0.663
MOD_PK_1 366 372 PF00069 0.320
MOD_PKA_1 557 563 PF00069 0.558
MOD_PKA_1 70 76 PF00069 0.484
MOD_PKA_2 282 288 PF00069 0.554
MOD_PKA_2 331 337 PF00069 0.540
MOD_PKA_2 358 364 PF00069 0.448
MOD_PKA_2 394 400 PF00069 0.550
MOD_PKA_2 412 418 PF00069 0.487
MOD_PKA_2 471 477 PF00069 0.552
MOD_PKA_2 557 563 PF00069 0.558
MOD_PKA_2 825 831 PF00069 0.622
MOD_Plk_1 109 115 PF00069 0.413
MOD_Plk_1 234 240 PF00069 0.711
MOD_Plk_1 419 425 PF00069 0.498
MOD_Plk_1 629 635 PF00069 0.650
MOD_Plk_1 781 787 PF00069 0.606
MOD_Plk_1 792 798 PF00069 0.564
MOD_Plk_1 830 836 PF00069 0.736
MOD_Plk_2-3 387 393 PF00069 0.468
MOD_Plk_4 20 26 PF00069 0.510
MOD_Plk_4 218 224 PF00069 0.381
MOD_Plk_4 283 289 PF00069 0.438
MOD_Plk_4 298 304 PF00069 0.468
MOD_Plk_4 358 364 PF00069 0.568
MOD_Plk_4 366 372 PF00069 0.549
MOD_Plk_4 423 429 PF00069 0.504
MOD_Plk_4 538 544 PF00069 0.697
MOD_Plk_4 567 573 PF00069 0.543
MOD_Plk_4 75 81 PF00069 0.488
MOD_Plk_4 781 787 PF00069 0.506
MOD_Plk_4 956 962 PF00069 0.688
MOD_ProDKin_1 238 244 PF00069 0.653
MOD_ProDKin_1 440 446 PF00069 0.627
MOD_ProDKin_1 532 538 PF00069 0.723
MOD_ProDKin_1 564 570 PF00069 0.461
MOD_ProDKin_1 644 650 PF00069 0.578
MOD_ProDKin_1 800 806 PF00069 0.520
MOD_SUMO_rev_2 810 820 PF00179 0.693
TRG_DiLeu_BaLyEn_6 221 226 PF01217 0.410
TRG_DiLeu_BaLyEn_6 407 412 PF01217 0.452
TRG_DiLeu_BaLyEn_6 448 453 PF01217 0.556
TRG_ENDOCYTIC_2 174 177 PF00928 0.391
TRG_ENDOCYTIC_2 323 326 PF00928 0.545
TRG_ENDOCYTIC_2 971 974 PF00928 0.644
TRG_ER_diArg_1 139 141 PF00400 0.552
TRG_ER_diArg_1 313 315 PF00400 0.524
TRG_ER_diArg_1 490 492 PF00400 0.316
TRG_NES_CRM1_1 564 576 PF08389 0.300
TRG_Pf-PMV_PEXEL_1 139 144 PF00026 0.489
TRG_Pf-PMV_PEXEL_1 224 229 PF00026 0.386
TRG_Pf-PMV_PEXEL_1 432 436 PF00026 0.339
TRG_Pf-PMV_PEXEL_1 714 719 PF00026 0.525
TRG_Pf-PMV_PEXEL_1 722 727 PF00026 0.536
TRG_Pf-PMV_PEXEL_1 83 87 PF00026 0.417

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HU24 Leptomonas seymouri 60% 99%
A0A1X0NW53 Trypanosomatidae 31% 97%
A0A3R7NMU6 Trypanosoma rangeli 31% 100%
A0A3S7WW45 Leishmania donovani 80% 100%
A4HYZ2 Leishmania infantum 80% 100%
C9ZIP6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 99%
E9AUT8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4QCP5 Leishmania major 78% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS