Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AIK4_LEIBR

TriTrypDb:

LbrM.20.5710 , LBRM2903_200071900 , LBRM2903_200072000

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.637
CLV_NRD_NRD_1	350	352	PF00675	0.679
CLV_NRD_NRD_1	442	444	PF00675	0.538
CLV_PCSK_KEX2_1	350	352	PF00082	0.679
CLV_PCSK_KEX2_1	442	444	PF00082	0.538
CLV_PCSK_KEX2_1	77	79	PF00082	0.525
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.491
CLV_PCSK_SKI1_1	107	111	PF00082	0.474
CLV_PCSK_SKI1_1	11	15	PF00082	0.383
CLV_PCSK_SKI1_1	157	161	PF00082	0.448
CLV_PCSK_SKI1_1	339	343	PF00082	0.619
CLV_PCSK_SKI1_1	374	378	PF00082	0.541
CLV_PCSK_SKI1_1	413	417	PF00082	0.310
DEG_APCC_DBOX_1	156	164	PF00400	0.648
DEG_Nend_Nbox_1	1	3	PF02207	0.669
DEG_SPOP_SBC_1	213	217	PF00917	0.656
DOC_CKS1_1	416	421	PF01111	0.310
DOC_CKS1_1	434	439	PF01111	0.637
DOC_CYCLIN_RxL_1	215	223	PF00134	0.643
DOC_CYCLIN_RxL_1	335	344	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.310
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.641
DOC_MAPK_HePTP_8	134	146	PF00069	0.565
DOC_MAPK_MEF2A_6	137	146	PF00069	0.588
DOC_PP2B_LxvP_1	503	506	PF13499	0.383
DOC_PP2B_LxvP_1	93	96	PF13499	0.696
DOC_USP7_MATH_1	164	168	PF00917	0.766
DOC_USP7_MATH_1	214	218	PF00917	0.660
DOC_USP7_MATH_1	236	240	PF00917	0.603
DOC_USP7_MATH_1	33	37	PF00917	0.683
DOC_USP7_MATH_1	396	400	PF00917	0.474
DOC_USP7_MATH_1	83	87	PF00917	0.677
DOC_WW_Pin1_4	206	211	PF00397	0.701
DOC_WW_Pin1_4	415	420	PF00397	0.310
DOC_WW_Pin1_4	433	438	PF00397	0.632
DOC_WW_Pin1_4	510	515	PF00397	0.216
DOC_WW_Pin1_4	541	546	PF00397	0.403
LIG_14-3-3_CanoR_1	230	235	PF00244	0.576
LIG_14-3-3_CanoR_1	255	264	PF00244	0.711
LIG_14-3-3_CanoR_1	359	365	PF00244	0.350
LIG_14-3-3_CanoR_1	92	96	PF00244	0.724
LIG_BIR_III_4	183	187	PF00653	0.739
LIG_BRCT_BRCA1_1	35	39	PF00533	0.589
LIG_Clathr_ClatBox_1	340	344	PF01394	0.311
LIG_FAT_LD_1	548	556	PF03623	0.429
LIG_FHA_1	128	134	PF00498	0.573
LIG_FHA_1	145	151	PF00498	0.640
LIG_FHA_1	327	333	PF00498	0.331
LIG_FHA_1	416	422	PF00498	0.271
LIG_FHA_1	453	459	PF00498	0.618
LIG_FHA_1	465	471	PF00498	0.549
LIG_FHA_1	531	537	PF00498	0.431
LIG_FHA_1	7	13	PF00498	0.629
LIG_FHA_2	195	201	PF00498	0.635
LIG_FHA_2	271	277	PF00498	0.595
LIG_FHA_2	288	294	PF00498	0.662
LIG_FHA_2	47	53	PF00498	0.633
LIG_FHA_2	493	499	PF00498	0.571
LIG_IRF3_LxIS_1	70	75	PF10401	0.632
LIG_LIR_Gen_1	143	154	PF02991	0.688
LIG_LIR_Gen_1	197	206	PF02991	0.633
LIG_LIR_Gen_1	26	35	PF02991	0.652
LIG_LIR_Gen_1	289	299	PF02991	0.636
LIG_LIR_Gen_1	557	566	PF02991	0.448
LIG_LIR_Gen_1	567	572	PF02991	0.412
LIG_LIR_Nem_3	143	149	PF02991	0.637
LIG_LIR_Nem_3	197	201	PF02991	0.629
LIG_LIR_Nem_3	289	295	PF02991	0.639
LIG_LIR_Nem_3	557	562	PF02991	0.388
LIG_LIR_Nem_3	567	572	PF02991	0.431
LIG_PDZ_Class_1	567	572	PF00595	0.367
LIG_Pex14_1	288	292	PF04695	0.581
LIG_Pex14_1	424	428	PF04695	0.310
LIG_Pex14_2	201	205	PF04695	0.632
LIG_Pex14_2	292	296	PF04695	0.576
LIG_PTAP_UEV_1	168	173	PF05743	0.633
LIG_SH2_CRK	311	315	PF00017	0.383
LIG_SH2_CRK	559	563	PF00017	0.439
LIG_SH2_PTP2	189	192	PF00017	0.676
LIG_SH2_STAP1	311	315	PF00017	0.383
LIG_SH2_STAT5	189	192	PF00017	0.676
LIG_SH2_STAT5	372	375	PF00017	0.429
LIG_SH2_STAT5	477	480	PF00017	0.585
LIG_SH2_STAT5	565	568	PF00017	0.410
LIG_SH3_1	189	195	PF00018	0.688
LIG_SH3_2	169	174	PF14604	0.636
LIG_SH3_3	147	153	PF00018	0.628
LIG_SH3_3	166	172	PF00018	0.662
LIG_SH3_3	187	193	PF00018	0.704
LIG_SH3_3	377	383	PF00018	0.468
LIG_SH3_CIN85_PxpxPR_1	437	442	PF14604	0.635
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.569
LIG_SUMO_SIM_anti_2	223	228	PF11976	0.634
LIG_SUMO_SIM_anti_2	51	60	PF11976	0.641
LIG_SUMO_SIM_par_1	223	228	PF11976	0.679
LIG_SUMO_SIM_par_1	70	76	PF11976	0.632
LIG_TRAF2_1	16	19	PF00917	0.695
LIG_TRAF2_1	495	498	PF00917	0.569
LIG_TRFH_1	189	193	PF08558	0.725
LIG_WRC_WIRS_1	202	207	PF05994	0.571
MOD_CDK_SPxK_1	541	547	PF00069	0.403
MOD_CK1_1	167	173	PF00069	0.697
MOD_CK1_1	257	263	PF00069	0.624
MOD_CK1_1	267	273	PF00069	0.650
MOD_CK1_1	368	374	PF00069	0.443
MOD_CK1_1	391	397	PF00069	0.486
MOD_CK1_1	399	405	PF00069	0.483
MOD_CK1_1	451	457	PF00069	0.681
MOD_CK1_1	508	514	PF00069	0.301
MOD_CK1_1	51	57	PF00069	0.727
MOD_CK1_1	73	79	PF00069	0.658
MOD_CK2_1	194	200	PF00069	0.570
MOD_CK2_1	270	276	PF00069	0.621
MOD_CK2_1	287	293	PF00069	0.663
MOD_CK2_1	469	475	PF00069	0.607
MOD_CK2_1	492	498	PF00069	0.570
MOD_Cter_Amidation	348	351	PF01082	0.632
MOD_GlcNHglycan	21	24	PF01048	0.416
MOD_GlcNHglycan	227	230	PF01048	0.583
MOD_GlcNHglycan	264	267	PF01048	0.493
MOD_GlcNHglycan	347	350	PF01048	0.635
MOD_GlcNHglycan	394	397	PF01048	0.690
MOD_GlcNHglycan	4	7	PF01048	0.426
MOD_GlcNHglycan	401	404	PF01048	0.699
MOD_GlcNHglycan	450	453	PF01048	0.466
MOD_GlcNHglycan	46	49	PF01048	0.494
MOD_GlcNHglycan	472	475	PF01048	0.439
MOD_GlcNHglycan	98	101	PF01048	0.549
MOD_GSK3_1	196	203	PF00069	0.630
MOD_GSK3_1	2	9	PF00069	0.650
MOD_GSK3_1	254	261	PF00069	0.638
MOD_GSK3_1	287	294	PF00069	0.632
MOD_GSK3_1	388	395	PF00069	0.513
MOD_GSK3_1	44	51	PF00069	0.756
MOD_GSK3_1	448	455	PF00069	0.714
MOD_GSK3_1	457	464	PF00069	0.799
MOD_GSK3_1	535	542	PF00069	0.322
MOD_GSK3_1	72	79	PF00069	0.697
MOD_N-GLC_1	327	332	PF02516	0.539
MOD_N-GLC_2	367	369	PF02516	0.539
MOD_NEK2_1	1	6	PF00069	0.657
MOD_NEK2_1	201	206	PF00069	0.568
MOD_NEK2_1	258	263	PF00069	0.722
MOD_NEK2_1	264	269	PF00069	0.699
MOD_NEK2_1	291	296	PF00069	0.578
MOD_NEK2_1	365	370	PF00069	0.431
MOD_NEK2_1	450	455	PF00069	0.694
MOD_NEK2_1	457	462	PF00069	0.619
MOD_NEK2_1	50	55	PF00069	0.744
MOD_NEK2_1	72	77	PF00069	0.637
MOD_NEK2_2	236	241	PF00069	0.596
MOD_OFUCOSY	502	509	PF10250	0.358
MOD_PIKK_1	113	119	PF00454	0.599
MOD_PIKK_1	144	150	PF00454	0.688
MOD_PIKK_1	518	524	PF00454	0.411
MOD_PIKK_1	6	12	PF00454	0.646
MOD_PK_1	230	236	PF00069	0.571
MOD_PKA_2	254	260	PF00069	0.586
MOD_PKA_2	358	364	PF00069	0.378
MOD_PKA_2	392	398	PF00069	0.613
MOD_PKA_2	44	50	PF00069	0.702
MOD_PKA_2	530	536	PF00069	0.432
MOD_PKA_2	60	66	PF00069	0.718
MOD_PKA_2	91	97	PF00069	0.751
MOD_Plk_1	105	111	PF00069	0.783
MOD_Plk_1	33	39	PF00069	0.613
MOD_Plk_1	51	57	PF00069	0.683
MOD_Plk_2-3	492	498	PF00069	0.570
MOD_Plk_4	118	124	PF00069	0.699
MOD_Plk_4	201	207	PF00069	0.569
MOD_Plk_4	230	236	PF00069	0.597
MOD_Plk_4	287	293	PF00069	0.596
MOD_Plk_4	368	374	PF00069	0.338
MOD_Plk_4	452	458	PF00069	0.683
MOD_Plk_4	564	570	PF00069	0.415
MOD_ProDKin_1	206	212	PF00069	0.701
MOD_ProDKin_1	415	421	PF00069	0.310
MOD_ProDKin_1	433	439	PF00069	0.636
MOD_ProDKin_1	510	516	PF00069	0.216
MOD_ProDKin_1	541	547	PF00069	0.403
MOD_SUMO_for_1	341	344	PF00179	0.314
TRG_DiLeu_BaEn_1	336	341	PF01217	0.296
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.585
TRG_DiLeu_LyEn_5	336	341	PF01217	0.296
TRG_ENDOCYTIC_2	311	314	PF00928	0.310
TRG_ENDOCYTIC_2	559	562	PF00928	0.402
TRG_ER_diArg_1	350	352	PF00400	0.486
TRG_ER_diArg_1	432	435	PF00400	0.599
TRG_ER_diArg_1	441	443	PF00400	0.699
TRG_NES_CRM1_1	143	158	PF08389	0.702
TRG_Pf-PMV_PEXEL_1	339	344	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ42	Leptomonas seymouri	52%	100%
A0A3Q8IAX6	Leishmania donovani	75%	99%
A4HYZ0	Leishmania infantum	75%	97%
E9AUT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	97%
Q4QCP7	Leishmania major	76%	99%