C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AIK3_LEIBR

TriTrypDb:

LbrM.20.5700 , LBRM2903_200071800

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	76	80	PF00082	0.535
DEG_MDM2_SWIB_1	70	78	PF02201	0.516
DOC_CKS1_1	120	125	PF01111	0.451
DOC_MAPK_gen_1	66	73	PF00069	0.513
DOC_MAPK_gen_1	95	104	PF00069	0.512
DOC_MAPK_MEF2A_6	113	121	PF00069	0.482
DOC_MAPK_MEF2A_6	20	29	PF00069	0.524
DOC_MAPK_MEF2A_6	66	73	PF00069	0.508
DOC_MAPK_MEF2A_6	98	106	PF00069	0.612
DOC_PP2B_LxvP_1	150	153	PF13499	0.507
DOC_PP2B_LxvP_1	193	196	PF13499	0.665
DOC_PP2B_LxvP_1	221	224	PF13499	0.543
DOC_USP7_MATH_1	155	159	PF00917	0.690
DOC_USP7_MATH_1	222	226	PF00917	0.726
DOC_USP7_MATH_1	237	241	PF00917	0.537
DOC_USP7_MATH_1	41	45	PF00917	0.477
DOC_WW_Pin1_4	119	124	PF00397	0.549
DOC_WW_Pin1_4	145	150	PF00397	0.634
DOC_WW_Pin1_4	151	156	PF00397	0.594
DOC_WW_Pin1_4	159	164	PF00397	0.570
LIG_14-3-3_CanoR_1	20	24	PF00244	0.622
LIG_APCC_ABBAyCdc20_2	66	72	PF00400	0.508
LIG_deltaCOP1_diTrp_1	72	79	PF00928	0.523
LIG_FHA_1	114	120	PF00498	0.590
LIG_FHA_1	60	66	PF00498	0.593
LIG_FHA_1	73	79	PF00498	0.543
LIG_FHA_2	120	126	PF00498	0.544
LIG_FHA_2	146	152	PF00498	0.510
LIG_FHA_2	166	172	PF00498	0.608
LIG_LIR_Gen_1	85	96	PF02991	0.511
LIG_LIR_Nem_3	21	26	PF02991	0.523
LIG_Pex14_2	49	53	PF04695	0.532
LIG_Pex14_2	70	74	PF04695	0.500
LIG_PTB_Apo_2	64	71	PF02174	0.437
LIG_SH2_CRK	141	145	PF00017	0.681
LIG_SH2_NCK_1	156	160	PF00017	0.616
LIG_SH2_PTP2	26	29	PF00017	0.511
LIG_SH2_STAP1	156	160	PF00017	0.727
LIG_SH2_STAP1	198	202	PF00017	0.485
LIG_SH2_STAT5	161	164	PF00017	0.658
LIG_SH2_STAT5	26	29	PF00017	0.511
LIG_SH3_3	117	123	PF00018	0.453
LIG_SH3_3	166	172	PF00018	0.585
LIG_SH3_3	231	237	PF00018	0.540
LIG_SUMO_SIM_anti_2	114	122	PF11976	0.425
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.495
LIG_SUMO_SIM_par_1	114	122	PF11976	0.425
LIG_SUMO_SIM_par_1	148	154	PF11976	0.508
LIG_SUMO_SIM_par_1	2	7	PF11976	0.483
LIG_UBA3_1	69	76	PF00899	0.509
LIG_WW_1	195	198	PF00397	0.580
MOD_CK1_1	115	121	PF00069	0.464
MOD_CK1_1	154	160	PF00069	0.501
MOD_CK1_1	18	24	PF00069	0.480
MOD_CK1_1	7	13	PF00069	0.422
MOD_CK1_1	77	83	PF00069	0.511
MOD_CK2_1	145	151	PF00069	0.546
MOD_GlcNHglycan	157	160	PF01048	0.728
MOD_GlcNHglycan	209	212	PF01048	0.716
MOD_GlcNHglycan	42	46	PF01048	0.615
MOD_GlcNHglycan	9	12	PF01048	0.417
MOD_GSK3_1	111	118	PF00069	0.535
MOD_GSK3_1	14	21	PF00069	0.615
MOD_GSK3_1	151	158	PF00069	0.515
MOD_N-GLC_2	164	166	PF02516	0.653
MOD_NEK2_1	19	24	PF00069	0.601
MOD_NEK2_1	79	84	PF00069	0.604
MOD_NEK2_1	9	14	PF00069	0.516
MOD_NEK2_2	74	79	PF00069	0.504
MOD_PIKK_1	222	228	PF00454	0.716
MOD_PIKK_1	237	243	PF00454	0.549
MOD_PIKK_1	77	83	PF00454	0.518
MOD_PKA_2	12	18	PF00069	0.559
MOD_PKA_2	19	25	PF00069	0.605
MOD_Plk_1	4	10	PF00069	0.497
MOD_Plk_4	115	121	PF00069	0.414
MOD_Plk_4	165	171	PF00069	0.535
MOD_Plk_4	184	190	PF00069	0.630
MOD_Plk_4	4	10	PF00069	0.516
MOD_Plk_4	74	80	PF00069	0.502
MOD_ProDKin_1	119	125	PF00069	0.558
MOD_ProDKin_1	145	151	PF00069	0.634
MOD_ProDKin_1	159	165	PF00069	0.573
TRG_ENDOCYTIC_2	198	201	PF00928	0.571
TRG_ENDOCYTIC_2	26	29	PF00928	0.511
TRG_ER_diArg_1	65	68	PF00400	0.551
TRG_NES_CRM1_1	135	146	PF08389	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P409	Leptomonas seymouri	49%	86%
A0A3Q8IDQ9	Leishmania donovani	67%	100%
A4HYY9	Leishmania infantum	68%	100%
E9AUT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QCP8	Leishmania major	66%	100%