Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIK2_LEIBR

TriTrypDb:

LbrM.20.5690

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.611
CLV_C14_Caspase3-7	77	81	PF00656	0.465
CLV_NRD_NRD_1	141	143	PF00675	0.623
CLV_NRD_NRD_1	151	153	PF00675	0.643
CLV_NRD_NRD_1	192	194	PF00675	0.557
CLV_PCSK_KEX2_1	141	143	PF00082	0.589
CLV_PCSK_KEX2_1	151	153	PF00082	0.608
CLV_PCSK_KEX2_1	191	193	PF00082	0.474
CLV_PCSK_KEX2_1	360	362	PF00082	0.481
CLV_PCSK_KEX2_1	99	101	PF00082	0.524
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.481
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.524
CLV_PCSK_SKI1_1	129	133	PF00082	0.468
CLV_PCSK_SKI1_1	151	155	PF00082	0.498
CLV_PCSK_SKI1_1	179	183	PF00082	0.435
DEG_COP1_1	236	246	PF00400	0.486
DEG_SPOP_SBC_1	300	304	PF00917	0.597
DOC_CKS1_1	18	23	PF01111	0.480
DOC_CYCLIN_RxL_1	348	358	PF00134	0.519
DOC_CYCLIN_RxL_1	43	54	PF00134	0.410
DOC_MAPK_gen_1	57	66	PF00069	0.352
DOC_MAPK_gen_1	76	86	PF00069	0.365
DOC_MAPK_gen_1	99	106	PF00069	0.495
DOC_MAPK_MEF2A_6	57	66	PF00069	0.352
DOC_MAPK_MEF2A_6	87	94	PF00069	0.387
DOC_MAPK_MEF2A_6	99	106	PF00069	0.379
DOC_PP1_RVXF_1	159	165	PF00149	0.345
DOC_USP7_MATH_1	235	239	PF00917	0.727
DOC_USP7_MATH_1	271	275	PF00917	0.573
DOC_USP7_MATH_1	300	304	PF00917	0.593
DOC_USP7_MATH_1	312	316	PF00917	0.405
DOC_USP7_MATH_1	44	48	PF00917	0.411
DOC_USP7_MATH_1	74	78	PF00917	0.411
DOC_WW_Pin1_4	17	22	PF00397	0.488
DOC_WW_Pin1_4	201	206	PF00397	0.681
DOC_WW_Pin1_4	233	238	PF00397	0.682
DOC_WW_Pin1_4	248	253	PF00397	0.568
DOC_WW_Pin1_4	274	279	PF00397	0.532
LIG_14-3-3_CanoR_1	151	160	PF00244	0.485
LIG_14-3-3_CanoR_1	191	197	PF00244	0.657
LIG_APCC_ABBAyCdc20_2	69	75	PF00400	0.502
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BIR_III_4	29	33	PF00653	0.445
LIG_FHA_1	112	118	PF00498	0.428
LIG_FHA_1	120	126	PF00498	0.462
LIG_FHA_1	18	24	PF00498	0.384
LIG_FHA_1	180	186	PF00498	0.456
LIG_FHA_1	306	312	PF00498	0.530
LIG_FHA_2	122	128	PF00498	0.382
LIG_FHA_2	300	306	PF00498	0.583
LIG_FHA_2	35	41	PF00498	0.474
LIG_FHA_2	4	10	PF00498	0.610
LIG_LIR_Apic_2	274	279	PF02991	0.597
LIG_LIR_Gen_1	89	98	PF02991	0.342
LIG_LIR_Nem_3	174	180	PF02991	0.353
LIG_LIR_Nem_3	53	58	PF02991	0.481
LIG_LIR_Nem_3	89	94	PF02991	0.344
LIG_NRBOX	93	99	PF00104	0.414
LIG_PCNA_PIPBox_1	49	58	PF02747	0.468
LIG_PCNA_yPIPBox_3	46	56	PF02747	0.463
LIG_SH2_CRK	276	280	PF00017	0.587
LIG_SH2_NCK_1	276	280	PF00017	0.587
LIG_SH2_PTP2	91	94	PF00017	0.348
LIG_SH2_SRC	333	336	PF00017	0.351
LIG_SH2_STAT5	115	118	PF00017	0.466
LIG_SH2_STAT5	242	245	PF00017	0.473
LIG_SH2_STAT5	276	279	PF00017	0.699
LIG_SH2_STAT5	34	37	PF00017	0.473
LIG_SH2_STAT5	55	58	PF00017	0.480
LIG_SH2_STAT5	91	94	PF00017	0.348
LIG_SH3_2	21	26	PF14604	0.411
LIG_SH3_3	18	24	PF00018	0.515
LIG_SH3_3	202	208	PF00018	0.640
LIG_SH3_3	275	281	PF00018	0.491
LIG_SH3_4	59	66	PF00018	0.463
LIG_Sin3_3	362	369	PF02671	0.443
LIG_SUMO_SIM_par_1	302	310	PF11976	0.510
LIG_SUMO_SIM_par_1	351	358	PF11976	0.514
LIG_TYR_ITIM	175	180	PF00017	0.355
LIG_UBA3_1	352	360	PF00899	0.457
MOD_CK1_1	195	201	PF00069	0.596
MOD_CK1_1	2	8	PF00069	0.663
MOD_CK1_1	204	210	PF00069	0.678
MOD_CK1_1	236	242	PF00069	0.683
MOD_CK1_1	274	280	PF00069	0.656
MOD_CK2_1	121	127	PF00069	0.397
MOD_CK2_1	248	254	PF00069	0.602
MOD_CK2_1	299	305	PF00069	0.597
MOD_CK2_1	3	9	PF00069	0.706
MOD_GlcNHglycan	194	197	PF01048	0.546
MOD_GlcNHglycan	2	5	PF01048	0.687
MOD_GlcNHglycan	238	241	PF01048	0.603
MOD_GlcNHglycan	273	276	PF01048	0.697
MOD_GlcNHglycan	287	290	PF01048	0.645
MOD_GSK3_1	13	20	PF00069	0.604
MOD_GSK3_1	147	154	PF00069	0.707
MOD_GSK3_1	195	202	PF00069	0.690
MOD_GSK3_1	203	210	PF00069	0.646
MOD_GSK3_1	281	288	PF00069	0.601
MOD_GSK3_1	301	308	PF00069	0.628
MOD_LATS_1	190	196	PF00433	0.554
MOD_N-GLC_1	212	217	PF02516	0.767
MOD_N-GLC_2	81	83	PF02516	0.349
MOD_NEK2_1	355	360	PF00069	0.476
MOD_NEK2_2	74	79	PF00069	0.381
MOD_PKA_1	151	157	PF00069	0.510
MOD_PKA_1	192	198	PF00069	0.709
MOD_PKA_2	151	157	PF00069	0.510
MOD_PKA_2	192	198	PF00069	0.665
MOD_PKA_2	341	347	PF00069	0.429
MOD_Plk_1	212	218	PF00069	0.634
MOD_Plk_1	355	361	PF00069	0.532
MOD_Plk_1	74	80	PF00069	0.362
MOD_Plk_2-3	121	127	PF00069	0.456
MOD_Plk_4	111	117	PF00069	0.399
MOD_Plk_4	121	127	PF00069	0.369
MOD_ProDKin_1	17	23	PF00069	0.471
MOD_ProDKin_1	201	207	PF00069	0.681
MOD_ProDKin_1	233	239	PF00069	0.682
MOD_ProDKin_1	248	254	PF00069	0.571
MOD_ProDKin_1	274	280	PF00069	0.527
MOD_SUMO_for_1	58	61	PF00179	0.479
MOD_SUMO_rev_2	121	131	PF00179	0.459
TRG_DiLeu_BaEn_1	158	163	PF01217	0.464
TRG_DiLeu_BaEn_1	61	66	PF01217	0.461
TRG_DiLeu_LyEn_5	158	163	PF01217	0.464
TRG_ENDOCYTIC_2	166	169	PF00928	0.366
TRG_ENDOCYTIC_2	177	180	PF00928	0.362
TRG_ENDOCYTIC_2	55	58	PF00928	0.480
TRG_ENDOCYTIC_2	91	94	PF00928	0.348
TRG_ER_diArg_1	151	153	PF00400	0.542
TRG_ER_diArg_1	159	162	PF00400	0.300
TRG_ER_diArg_1	191	193	PF00400	0.518
TRG_NES_CRM1_1	158	171	PF08389	0.472
TRG_NES_CRM1_1	40	54	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	351	356	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV9	Leptomonas seymouri	53%	92%
A0A1X0NWT1	Trypanosomatidae	37%	99%
A0A3S7WW52	Leishmania donovani	79%	96%
A0A422N975	Trypanosoma rangeli	37%	100%
A4HYY8	Leishmania infantum	79%	96%
C9ZIJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	94%
E9AUT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	96%
Q4QCP9	Leishmania major	82%	100%