SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIK0_LEIBR

TriTrypDb:

LbrM.20.5670 , LBRM2903_200071500

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	332	338	PF00089	0.452
CLV_NRD_NRD_1	190	192	PF00675	0.429
CLV_NRD_NRD_1	250	252	PF00675	0.601
CLV_PCSK_FUR_1	247	251	PF00082	0.569
CLV_PCSK_KEX2_1	190	192	PF00082	0.427
CLV_PCSK_KEX2_1	249	251	PF00082	0.526
CLV_PCSK_SKI1_1	163	167	PF00082	0.375
CLV_PCSK_SKI1_1	179	183	PF00082	0.331
CLV_PCSK_SKI1_1	208	212	PF00082	0.307
CLV_PCSK_SKI1_1	250	254	PF00082	0.541
DEG_APCC_DBOX_1	178	186	PF00400	0.352
DEG_APCC_DBOX_1	207	215	PF00400	0.333
DEG_COP1_1	265	275	PF00400	0.458
DEG_Nend_Nbox_1	1	3	PF02207	0.525
DEG_SCF_FBW7_1	279	286	PF00400	0.364
DOC_CDC14_PxL_1	269	277	PF14671	0.351
DOC_CKS1_1	195	200	PF01111	0.301
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.355
DOC_MAPK_DCC_7	161	171	PF00069	0.466
DOC_MAPK_MEF2A_6	163	172	PF00069	0.513
DOC_PP2B_LxvP_1	196	199	PF13499	0.355
DOC_PP4_MxPP_1	98	101	PF00568	0.423
DOC_USP7_MATH_1	14	18	PF00917	0.525
DOC_WW_Pin1_4	136	141	PF00397	0.448
DOC_WW_Pin1_4	191	196	PF00397	0.490
DOC_WW_Pin1_4	279	284	PF00397	0.481
LIG_14-3-3_CanoR_1	190	195	PF00244	0.535
LIG_14-3-3_CanoR_1	250	256	PF00244	0.647
LIG_14-3-3_CanoR_1	300	307	PF00244	0.279
LIG_14-3-3_CanoR_1	322	332	PF00244	0.460
LIG_14-3-3_CanoR_1	80	89	PF00244	0.328
LIG_Clathr_ClatBox_1	169	173	PF01394	0.501
LIG_DLG_GKlike_1	251	259	PF00625	0.485
LIG_FHA_1	110	116	PF00498	0.459
LIG_FHA_1	195	201	PF00498	0.297
LIG_FHA_1	27	33	PF00498	0.453
LIG_FHA_1	280	286	PF00498	0.412
LIG_FHA_1	316	322	PF00498	0.496
LIG_FHA_1	69	75	PF00498	0.255
LIG_FHA_2	18	24	PF00498	0.589
LIG_LIR_Gen_1	122	132	PF02991	0.356
LIG_LIR_Gen_1	142	153	PF02991	0.382
LIG_LIR_Gen_1	230	239	PF02991	0.533
LIG_LIR_Gen_1	267	277	PF02991	0.522
LIG_LIR_Nem_3	122	128	PF02991	0.356
LIG_LIR_Nem_3	142	148	PF02991	0.377
LIG_LIR_Nem_3	173	177	PF02991	0.387
LIG_LIR_Nem_3	230	236	PF02991	0.518
LIG_LIR_Nem_3	267	272	PF02991	0.448
LIG_LIR_Nem_3	45	49	PF02991	0.458
LIG_LIR_Nem_3	5	9	PF02991	0.617
LIG_MYND_1	273	277	PF01753	0.313
LIG_NRBOX	184	190	PF00104	0.473
LIG_PCNA_PIPBox_1	181	190	PF02747	0.402
LIG_Pex14_1	248	252	PF04695	0.635
LIG_Pex14_2	334	338	PF04695	0.455
LIG_SH2_CRK	145	149	PF00017	0.478
LIG_SH2_CRK	233	237	PF00017	0.516
LIG_SH2_CRK	269	273	PF00017	0.399
LIG_SH2_GRB2like	144	147	PF00017	0.485
LIG_SH2_STAT5	125	128	PF00017	0.354
LIG_SH2_STAT5	233	236	PF00017	0.513
LIG_SH3_3	134	140	PF00018	0.459
LIG_SH3_3	192	198	PF00018	0.442
LIG_SH3_5	140	144	PF00018	0.516
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.489
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.356
LIG_SUMO_SIM_par_1	167	173	PF11976	0.508
LIG_TRAF2_1	53	56	PF00917	0.404
LIG_TRFH_1	145	149	PF08558	0.478
LIG_TRFH_1	269	273	PF08558	0.384
LIG_TYR_ITIM	202	207	PF00017	0.443
LIG_TYR_ITIM	231	236	PF00017	0.472
LIG_WRC_WIRS_1	25	30	PF05994	0.437
MOD_CDK_SPK_2	136	141	PF00069	0.449
MOD_CK1_1	139	145	PF00069	0.420
MOD_CK1_1	17	23	PF00069	0.552
MOD_CK1_1	194	200	PF00069	0.461
MOD_CK1_1	229	235	PF00069	0.566
MOD_CK1_1	254	260	PF00069	0.675
MOD_CK2_1	17	23	PF00069	0.488
MOD_CK2_1	300	306	PF00069	0.278
MOD_GlcNHglycan	17	20	PF01048	0.540
MOD_GSK3_1	14	21	PF00069	0.530
MOD_GSK3_1	190	197	PF00069	0.405
MOD_GSK3_1	227	234	PF00069	0.526
MOD_GSK3_1	251	258	PF00069	0.652
MOD_GSK3_1	279	286	PF00069	0.351
MOD_GSK3_1	68	75	PF00069	0.355
MOD_N-GLC_1	323	328	PF02516	0.369
MOD_N-GLC_2	302	304	PF02516	0.270
MOD_NEK2_1	109	114	PF00069	0.505
MOD_NEK2_1	2	7	PF00069	0.570
MOD_NEK2_1	231	236	PF00069	0.491
MOD_NEK2_1	255	260	PF00069	0.629
MOD_NEK2_1	323	328	PF00069	0.398
MOD_PIKK_1	323	329	PF00454	0.398
MOD_PKA_1	190	196	PF00069	0.307
MOD_PKA_2	190	196	PF00069	0.307
MOD_PKB_1	249	257	PF00069	0.575
MOD_Plk_2-3	99	105	PF00069	0.282
MOD_Plk_4	180	186	PF00069	0.366
MOD_Plk_4	251	257	PF00069	0.624
MOD_Plk_4	271	277	PF00069	0.341
MOD_Plk_4	69	75	PF00069	0.319
MOD_ProDKin_1	136	142	PF00069	0.446
MOD_ProDKin_1	191	197	PF00069	0.482
MOD_ProDKin_1	279	285	PF00069	0.485
TRG_DiLeu_BaEn_1	267	272	PF01217	0.468
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.511
TRG_DiLeu_BaLyEn_6	274	279	PF01217	0.328
TRG_ENDOCYTIC_2	125	128	PF00928	0.367
TRG_ENDOCYTIC_2	144	147	PF00928	0.351
TRG_ENDOCYTIC_2	204	207	PF00928	0.391
TRG_ENDOCYTIC_2	233	236	PF00928	0.480
TRG_ENDOCYTIC_2	269	272	PF00928	0.415
TRG_ER_diArg_1	189	191	PF00400	0.435
TRG_ER_diArg_1	248	251	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5T0	Leptomonas seymouri	76%	100%
A0A0S4INP7	Bodo saltans	40%	88%
A0A1X0NW56	Trypanosomatidae	52%	98%
A0A3R7RG23	Trypanosoma rangeli	52%	99%
A0A3S7WW32	Leishmania donovani	89%	100%
A4HYY6	Leishmania infantum	92%	100%
C9ZIJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	96%
E9AUT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QCQ1	Leishmania major	87%	100%
V5BDU9	Trypanosoma cruzi	53%	100%