Tegument protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tegument protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIJ8_LEIBR

TriTrypDb:

LbrM.20.5650 , LBRM2903_200071300

Length:

886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.528
CLV_NRD_NRD_1	106	108	PF00675	0.594
CLV_NRD_NRD_1	300	302	PF00675	0.578
CLV_NRD_NRD_1	74	76	PF00675	0.679
CLV_NRD_NRD_1	764	766	PF00675	0.782
CLV_PCSK_FUR_1	70	74	PF00082	0.682
CLV_PCSK_KEX2_1	106	108	PF00082	0.594
CLV_PCSK_KEX2_1	300	302	PF00082	0.578
CLV_PCSK_KEX2_1	72	74	PF00082	0.681
CLV_PCSK_KEX2_1	764	766	PF00082	0.782
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.672
CLV_PCSK_PC7_1	70	76	PF00082	0.779
CLV_PCSK_SKI1_1	275	279	PF00082	0.586
CLV_PCSK_SKI1_1	306	310	PF00082	0.571
CLV_PCSK_SKI1_1	86	90	PF00082	0.476
DEG_APCC_DBOX_1	171	179	PF00400	0.358
DEG_APCC_DBOX_1	305	313	PF00400	0.580
DEG_Nend_UBRbox_1	1	4	PF02207	0.523
DEG_SCF_FBW7_1	655	660	PF00400	0.791
DEG_SPOP_SBC_1	471	475	PF00917	0.769
DEG_SPOP_SBC_1	636	640	PF00917	0.765
DOC_CKS1_1	442	447	PF01111	0.603
DOC_CKS1_1	676	681	PF01111	0.573
DOC_CYCLIN_RxL_1	272	283	PF00134	0.581
DOC_CYCLIN_RxL_1	847	857	PF00134	0.766
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.498
DOC_MAPK_gen_1	246	255	PF00069	0.471
DOC_MAPK_gen_1	72	82	PF00069	0.555
DOC_MAPK_gen_1	764	771	PF00069	0.766
DOC_MAPK_MEF2A_6	196	205	PF00069	0.506
DOC_MAPK_MEF2A_6	246	255	PF00069	0.471
DOC_MAPK_MEF2A_6	75	84	PF00069	0.457
DOC_PP2B_LxvP_1	623	626	PF13499	0.601
DOC_USP7_MATH_1	130	134	PF00917	0.599
DOC_USP7_MATH_1	163	167	PF00917	0.646
DOC_USP7_MATH_1	267	271	PF00917	0.489
DOC_USP7_MATH_1	443	447	PF00917	0.758
DOC_USP7_MATH_1	509	513	PF00917	0.590
DOC_USP7_MATH_1	554	558	PF00917	0.517
DOC_USP7_MATH_1	686	690	PF00917	0.814
DOC_USP7_MATH_1	727	731	PF00917	0.781
DOC_USP7_MATH_1	794	798	PF00917	0.686
DOC_USP7_MATH_1	832	836	PF00917	0.645
DOC_WW_Pin1_4	196	201	PF00397	0.466
DOC_WW_Pin1_4	392	397	PF00397	0.545
DOC_WW_Pin1_4	402	407	PF00397	0.705
DOC_WW_Pin1_4	416	421	PF00397	0.628
DOC_WW_Pin1_4	441	446	PF00397	0.791
DOC_WW_Pin1_4	653	658	PF00397	0.782
DOC_WW_Pin1_4	672	677	PF00397	0.733
DOC_WW_Pin1_4	682	687	PF00397	0.815
DOC_WW_Pin1_4	689	694	PF00397	0.493
LIG_14-3-3_CanoR_1	134	143	PF00244	0.691
LIG_14-3-3_CanoR_1	24	33	PF00244	0.646
LIG_14-3-3_CanoR_1	317	324	PF00244	0.622
LIG_14-3-3_CanoR_1	55	65	PF00244	0.730
LIG_14-3-3_CanoR_1	600	610	PF00244	0.681
LIG_14-3-3_CanoR_1	691	697	PF00244	0.720
LIG_14-3-3_CanoR_1	73	82	PF00244	0.467
LIG_APCC_ABBA_1	88	93	PF00400	0.514
LIG_BRCT_BRCA1_1	875	879	PF00533	0.646
LIG_Clathr_ClatBox_1	164	168	PF01394	0.625
LIG_Clathr_ClatBox_2	5	10	PF01394	0.539
LIG_deltaCOP1_diTrp_1	617	621	PF00928	0.667
LIG_FHA_1	172	178	PF00498	0.579
LIG_FHA_1	200	206	PF00498	0.484
LIG_FHA_1	250	256	PF00498	0.532
LIG_FHA_1	339	345	PF00498	0.555
LIG_FHA_1	393	399	PF00498	0.549
LIG_FHA_1	508	514	PF00498	0.597
LIG_FHA_1	654	660	PF00498	0.733
LIG_FHA_1	726	732	PF00498	0.724
LIG_FHA_1	74	80	PF00498	0.560
LIG_FHA_1	750	756	PF00498	0.585
LIG_FHA_2	255	261	PF00498	0.678
LIG_FHA_2	772	778	PF00498	0.633
LIG_GBD_Chelix_1	571	579	PF00786	0.565
LIG_LIR_Gen_1	217	227	PF02991	0.574
LIG_LIR_Gen_1	315	325	PF02991	0.628
LIG_LIR_Gen_1	338	345	PF02991	0.413
LIG_LIR_Gen_1	452	459	PF02991	0.554
LIG_LIR_Gen_1	773	783	PF02991	0.654
LIG_LIR_Gen_1	87	95	PF02991	0.532
LIG_LIR_Nem_3	190	195	PF02991	0.574
LIG_LIR_Nem_3	217	223	PF02991	0.563
LIG_LIR_Nem_3	283	287	PF02991	0.592
LIG_LIR_Nem_3	315	321	PF02991	0.619
LIG_LIR_Nem_3	338	343	PF02991	0.414
LIG_LIR_Nem_3	452	458	PF02991	0.581
LIG_LIR_Nem_3	773	778	PF02991	0.636
LIG_LIR_Nem_3	842	848	PF02991	0.669
LIG_LIR_Nem_3	87	92	PF02991	0.521
LIG_NRBOX	308	314	PF00104	0.590
LIG_NRBOX	618	624	PF00104	0.567
LIG_NRBOX	825	831	PF00104	0.741
LIG_Pex14_1	559	563	PF04695	0.489
LIG_SH2_CRK	237	241	PF00017	0.430
LIG_SH2_CRK	318	322	PF00017	0.629
LIG_SH2_CRK	576	580	PF00017	0.580
LIG_SH2_NCK_1	726	730	PF00017	0.574
LIG_SH2_PTP2	220	223	PF00017	0.453
LIG_SH2_SRC	371	374	PF00017	0.628
LIG_SH2_STAP1	237	241	PF00017	0.612
LIG_SH2_STAP1	738	742	PF00017	0.579
LIG_SH2_STAP1	775	779	PF00017	0.614
LIG_SH2_STAT3	33	36	PF00017	0.591
LIG_SH2_STAT5	184	187	PF00017	0.459
LIG_SH2_STAT5	19	22	PF00017	0.734
LIG_SH2_STAT5	220	223	PF00017	0.453
LIG_SH2_STAT5	318	321	PF00017	0.732
LIG_SH2_STAT5	741	744	PF00017	0.838
LIG_SH2_STAT5	91	94	PF00017	0.526
LIG_SH3_3	137	143	PF00018	0.726
LIG_SH3_3	527	533	PF00018	0.506
LIG_SH3_3	670	676	PF00018	0.691
LIG_SH3_3	691	697	PF00018	0.695
LIG_SH3_3	760	766	PF00018	0.704
LIG_SH3_3	782	788	PF00018	0.706
LIG_SH3_3	845	851	PF00018	0.669
LIG_SUMO_SIM_anti_2	238	243	PF11976	0.354
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.586
LIG_SUMO_SIM_anti_2	341	348	PF11976	0.655
LIG_SUMO_SIM_par_1	251	257	PF11976	0.517
LIG_SUMO_SIM_par_1	307	315	PF11976	0.587
LIG_SUMO_SIM_par_1	341	348	PF11976	0.655
LIG_TRAF2_1	831	834	PF00917	0.737
LIG_TYR_ITIM	574	579	PF00017	0.521
LIG_UBA3_1	80	86	PF00899	0.417
MOD_CK1_1	133	139	PF00069	0.773
MOD_CK1_1	166	172	PF00069	0.484
MOD_CK1_1	199	205	PF00069	0.481
MOD_CK1_1	392	398	PF00069	0.580
MOD_CK1_1	454	460	PF00069	0.574
MOD_CK1_1	475	481	PF00069	0.566
MOD_CK1_1	583	589	PF00069	0.559
MOD_CK1_1	601	607	PF00069	0.675
MOD_CK1_1	637	643	PF00069	0.780
MOD_CK1_1	669	675	PF00069	0.726
MOD_CK1_1	689	695	PF00069	0.766
MOD_CK1_1	700	706	PF00069	0.814
MOD_CK1_1	710	716	PF00069	0.601
MOD_CK1_1	730	736	PF00069	0.715
MOD_CK1_1	797	803	PF00069	0.702
MOD_CK1_1	872	878	PF00069	0.648
MOD_CK2_1	608	614	PF00069	0.542
MOD_CMANNOS	618	621	PF00535	0.662
MOD_CMANNOS	7	10	PF00535	0.796
MOD_GlcNHglycan	152	156	PF01048	0.782
MOD_GlcNHglycan	160	163	PF01048	0.613
MOD_GlcNHglycan	168	171	PF01048	0.318
MOD_GlcNHglycan	445	448	PF01048	0.695
MOD_GlcNHglycan	460	463	PF01048	0.566
MOD_GlcNHglycan	58	61	PF01048	0.744
MOD_GlcNHglycan	582	585	PF01048	0.677
MOD_GlcNHglycan	66	69	PF01048	0.755
MOD_GlcNHglycan	745	748	PF01048	0.719
MOD_GlcNHglycan	882	885	PF01048	0.517
MOD_GSK3_1	130	137	PF00069	0.723
MOD_GSK3_1	267	274	PF00069	0.460
MOD_GSK3_1	36	43	PF00069	0.674
MOD_GSK3_1	454	461	PF00069	0.585
MOD_GSK3_1	471	478	PF00069	0.678
MOD_GSK3_1	542	549	PF00069	0.674
MOD_GSK3_1	554	561	PF00069	0.699
MOD_GSK3_1	634	641	PF00069	0.664
MOD_GSK3_1	642	649	PF00069	0.708
MOD_GSK3_1	653	660	PF00069	0.482
MOD_GSK3_1	671	678	PF00069	0.740
MOD_GSK3_1	682	689	PF00069	0.714
MOD_GSK3_1	700	707	PF00069	0.761
MOD_GSK3_1	710	717	PF00069	0.696
MOD_GSK3_1	725	732	PF00069	0.709
MOD_GSK3_1	789	796	PF00069	0.801
MOD_GSK3_1	868	875	PF00069	0.653
MOD_GSK3_1	91	98	PF00069	0.448
MOD_N-GLC_1	24	29	PF02516	0.546
MOD_N-GLC_1	5	10	PF02516	0.541
MOD_N-GLC_1	794	799	PF02516	0.552
MOD_N-GLC_1	809	814	PF02516	0.630
MOD_N-GLC_1	868	873	PF02516	0.653
MOD_NEK2_1	205	210	PF00069	0.512
MOD_NEK2_1	329	334	PF00069	0.597
MOD_NEK2_1	345	350	PF00069	0.614
MOD_NEK2_1	390	395	PF00069	0.789
MOD_NEK2_1	458	463	PF00069	0.560
MOD_NEK2_1	477	482	PF00069	0.679
MOD_NEK2_1	687	692	PF00069	0.664
MOD_NEK2_1	742	747	PF00069	0.722
MOD_NEK2_1	771	776	PF00069	0.677
MOD_NEK2_1	80	85	PF00069	0.512
MOD_NEK2_1	868	873	PF00069	0.755
MOD_NEK2_2	832	837	PF00069	0.652
MOD_PIKK_1	19	25	PF00454	0.756
MOD_PIKK_1	558	564	PF00454	0.740
MOD_PIKK_1	666	672	PF00454	0.790
MOD_PIKK_1	758	764	PF00454	0.575
MOD_PIKK_1	95	101	PF00454	0.592
MOD_PKA_1	73	79	PF00069	0.752
MOD_PKA_1	764	770	PF00069	0.770
MOD_PKA_2	133	139	PF00069	0.691
MOD_PKA_2	171	177	PF00069	0.470
MOD_PKA_2	316	322	PF00069	0.615
MOD_PKA_2	363	369	PF00069	0.621
MOD_PKA_2	599	605	PF00069	0.710
MOD_PKA_2	73	79	PF00069	0.524
MOD_PKA_2	764	770	PF00069	0.757
MOD_PKB_1	149	157	PF00069	0.546
MOD_Plk_1	451	457	PF00069	0.559
MOD_Plk_1	794	800	PF00069	0.513
MOD_Plk_1	839	845	PF00069	0.663
MOD_Plk_1	868	874	PF00069	0.654
MOD_Plk_2-3	840	846	PF00069	0.777
MOD_Plk_4	235	241	PF00069	0.527
MOD_Plk_4	330	336	PF00069	0.663
MOD_Plk_4	345	351	PF00069	0.499
MOD_Plk_4	454	460	PF00069	0.796
MOD_Plk_4	472	478	PF00069	0.801
MOD_Plk_4	509	515	PF00069	0.441
MOD_Plk_4	764	770	PF00069	0.770
MOD_Plk_4	840	846	PF00069	0.665
MOD_Plk_4	869	875	PF00069	0.532
MOD_ProDKin_1	196	202	PF00069	0.458
MOD_ProDKin_1	392	398	PF00069	0.546
MOD_ProDKin_1	402	408	PF00069	0.703
MOD_ProDKin_1	416	422	PF00069	0.625
MOD_ProDKin_1	441	447	PF00069	0.791
MOD_ProDKin_1	653	659	PF00069	0.782
MOD_ProDKin_1	672	678	PF00069	0.735
MOD_ProDKin_1	682	688	PF00069	0.816
MOD_ProDKin_1	689	695	PF00069	0.493
MOD_SUMO_rev_2	113	120	PF00179	0.566
TRG_DiLeu_BaEn_1	193	198	PF01217	0.530
TRG_DiLeu_BaEn_1	863	868	PF01217	0.760
TRG_DiLeu_BaEn_2	76	82	PF01217	0.461
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.676
TRG_DiLeu_BaLyEn_6	821	826	PF01217	0.507
TRG_DiLeu_LyEn_5	193	198	PF01217	0.530
TRG_DiLeu_LyEn_5	863	868	PF01217	0.643
TRG_ENDOCYTIC_2	220	223	PF00928	0.542
TRG_ENDOCYTIC_2	237	240	PF00928	0.508
TRG_ENDOCYTIC_2	318	321	PF00928	0.625
TRG_ENDOCYTIC_2	576	579	PF00928	0.588
TRG_ENDOCYTIC_2	775	778	PF00928	0.639
TRG_ER_diArg_1	106	108	PF00400	0.594
TRG_ER_diArg_1	245	248	PF00400	0.658
TRG_ER_diArg_1	300	302	PF00400	0.578
TRG_ER_diArg_1	73	75	PF00400	0.680
TRG_ER_diArg_1	763	765	PF00400	0.799
TRG_ER_diArg_1	879	882	PF00400	0.649
TRG_NLS_MonoCore_2	71	76	PF00514	0.775
TRG_NLS_MonoExtC_3	71	77	PF00514	0.668
TRG_NLS_MonoExtN_4	70	76	PF00514	0.677
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.688
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.581
TRG_PTS1	883	886	PF00515	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y6	Leptomonas seymouri	41%	84%
A0A3S7WW50	Leishmania donovani	73%	95%
A4HYY4	Leishmania infantum	73%	95%
E9AUT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	95%
Q4QCQ3	Leishmania major	72%	100%