Putative axoneme central apparatus protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paralyzed flagella protein 16

Species:

Leishmania braziliensis

UniProt:

E9AIJ7_LEIBR

TriTrypDb:

LbrM.20.5640 , LBRM2903_200071200

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005930	axoneme	2	1
GO:0015630	microtubule cytoskeleton	6	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AIJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIJ7

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0001578	microtubule bundle formation	4	1
GO:0003341	cilium movement	4	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0035082	axoneme assembly	5	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060294	cilium movement involved in cell motility	5	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.470
CLV_C14_Caspase3-7	362	366	PF00656	0.276
CLV_PCSK_KEX2_1	327	329	PF00082	0.251
CLV_PCSK_KEX2_1	369	371	PF00082	0.328
CLV_PCSK_KEX2_1	544	546	PF00082	0.360
CLV_PCSK_KEX2_1	591	593	PF00082	0.372
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.251
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.367
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.337
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.372
CLV_PCSK_SKI1_1	147	151	PF00082	0.533
CLV_PCSK_SKI1_1	190	194	PF00082	0.343
CLV_PCSK_SKI1_1	398	402	PF00082	0.311
CLV_PCSK_SKI1_1	520	524	PF00082	0.242
CLV_PCSK_SKI1_1	544	548	PF00082	0.324
DEG_APCC_DBOX_1	519	527	PF00400	0.241
DOC_CYCLIN_RxL_1	187	196	PF00134	0.345
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.338
DOC_MAPK_DCC_7	309	317	PF00069	0.251
DOC_MAPK_MEF2A_6	309	317	PF00069	0.251
DOC_MAPK_RevD_3	313	328	PF00069	0.251
DOC_PP1_RVXF_1	158	164	PF00149	0.334
DOC_PP1_RVXF_1	38	44	PF00149	0.412
DOC_PP1_RVXF_1	46	52	PF00149	0.416
DOC_PP2B_LxvP_1	74	77	PF13499	0.409
DOC_PP2B_LxvP_1	89	92	PF13499	0.398
DOC_PP4_FxxP_1	4	7	PF00568	0.478
DOC_PP4_FxxP_1	64	67	PF00568	0.427
DOC_USP7_MATH_1	136	140	PF00917	0.393
DOC_USP7_MATH_1	212	216	PF00917	0.421
DOC_USP7_MATH_1	380	384	PF00917	0.333
DOC_USP7_MATH_1	533	537	PF00917	0.382
DOC_USP7_MATH_1	610	614	PF00917	0.444
DOC_USP7_MATH_1	7	11	PF00917	0.476
DOC_USP7_UBL2_3	544	548	PF12436	0.343
DOC_WW_Pin1_4	112	117	PF00397	0.483
DOC_WW_Pin1_4	128	133	PF00397	0.521
DOC_WW_Pin1_4	254	259	PF00397	0.359
DOC_WW_Pin1_4	3	8	PF00397	0.485
DOC_WW_Pin1_4	338	343	PF00397	0.421
DOC_WW_Pin1_4	422	427	PF00397	0.322
DOC_WW_Pin1_4	59	64	PF00397	0.471
DOC_WW_Pin1_4	631	636	PF00397	0.365
DOC_WW_Pin1_4	87	92	PF00397	0.432
LIG_14-3-3_CanoR_1	210	218	PF00244	0.418
LIG_14-3-3_CanoR_1	328	337	PF00244	0.266
LIG_14-3-3_CanoR_1	40	46	PF00244	0.438
LIG_14-3-3_CanoR_1	412	421	PF00244	0.453
LIG_Actin_WH2_2	312	329	PF00022	0.251
LIG_APCC_ABBA_1	17	22	PF00400	0.477
LIG_BRCT_BRCA1_1	244	248	PF00533	0.295
LIG_CtBP_PxDLS_1	58	62	PF00389	0.438
LIG_deltaCOP1_diTrp_1	46	51	PF00928	0.430
LIG_EVH1_1	74	78	PF00568	0.405
LIG_EVH1_2	67	71	PF00568	0.404
LIG_FHA_1	227	233	PF00498	0.474
LIG_FHA_1	423	429	PF00498	0.312
LIG_FHA_1	467	473	PF00498	0.303
LIG_FHA_2	115	121	PF00498	0.465
LIG_FHA_2	150	156	PF00498	0.446
LIG_FHA_2	164	170	PF00498	0.308
LIG_FHA_2	281	287	PF00498	0.266
LIG_FHA_2	331	337	PF00498	0.266
LIG_FHA_2	360	366	PF00498	0.266
LIG_FHA_2	638	644	PF00498	0.385
LIG_LIR_Apic_2	2	7	PF02991	0.476
LIG_LIR_Apic_2	528	533	PF02991	0.372
LIG_LIR_Apic_2	62	67	PF02991	0.426
LIG_LIR_Apic_2	631	635	PF02991	0.503
LIG_LIR_LC3C_4	388	391	PF02991	0.295
LIG_LIR_Nem_3	152	156	PF02991	0.510
LIG_LIR_Nem_3	394	399	PF02991	0.300
LIG_MYND_1	558	562	PF01753	0.325
LIG_MYND_1	59	63	PF01753	0.431
LIG_MYND_3	557	561	PF01753	0.312
LIG_PCNA_yPIPBox_3	182	190	PF02747	0.262
LIG_Pex14_1	290	294	PF04695	0.291
LIG_Pex14_1	47	51	PF04695	0.433
LIG_Pex14_2	396	400	PF04695	0.294
LIG_Pex14_2	43	47	PF04695	0.410
LIG_PTB_Apo_2	619	626	PF02174	0.408
LIG_SH2_CRK	580	584	PF00017	0.451
LIG_SH2_GRB2like	530	533	PF00017	0.297
LIG_SH2_SRC	530	533	PF00017	0.297
LIG_SH2_SRC	556	559	PF00017	0.460
LIG_SH2_STAP1	580	584	PF00017	0.451
LIG_SH2_STAP1	637	641	PF00017	0.377
LIG_SH2_STAT3	648	651	PF00017	0.508
LIG_SH2_STAT5	294	297	PF00017	0.251
LIG_SH2_STAT5	444	447	PF00017	0.333
LIG_SH2_STAT5	462	465	PF00017	0.278
LIG_SH2_STAT5	530	533	PF00017	0.367
LIG_SH2_STAT5	556	559	PF00017	0.445
LIG_SH2_STAT5	575	578	PF00017	0.185
LIG_SH3_3	110	116	PF00018	0.468
LIG_SH3_3	126	132	PF00018	0.417
LIG_SH3_3	316	322	PF00018	0.251
LIG_SH3_3	53	59	PF00018	0.431
LIG_SH3_3	552	558	PF00018	0.327
LIG_SH3_3	563	569	PF00018	0.319
LIG_SH3_3	69	75	PF00018	0.382
LIG_SUMO_SIM_anti_2	95	100	PF11976	0.439
LIG_SUMO_SIM_par_1	190	196	PF11976	0.346
LIG_SUMO_SIM_par_1	95	100	PF11976	0.439
LIG_TRAF2_1	214	217	PF00917	0.440
LIG_WRC_WIRS_1	1	6	PF05994	0.478
LIG_WRC_WIRS_1	150	155	PF05994	0.515
MOD_CDK_SPxxK_3	112	119	PF00069	0.469
MOD_CK1_1	196	202	PF00069	0.432
MOD_CK1_1	332	338	PF00069	0.233
MOD_CK1_1	464	470	PF00069	0.379
MOD_CK2_1	149	155	PF00069	0.517
MOD_CK2_1	211	217	PF00069	0.421
MOD_CK2_1	280	286	PF00069	0.284
MOD_CK2_1	610	616	PF00069	0.439
MOD_CK2_1	637	643	PF00069	0.395
MOD_GlcNHglycan	202	205	PF01048	0.315
MOD_GlcNHglycan	223	226	PF01048	0.361
MOD_GlcNHglycan	244	247	PF01048	0.293
MOD_GlcNHglycan	286	289	PF01048	0.224
MOD_GlcNHglycan	463	466	PF01048	0.373
MOD_GlcNHglycan	509	512	PF01048	0.375
MOD_GSK3_1	123	130	PF00069	0.481
MOD_GSK3_1	196	203	PF00069	0.335
MOD_GSK3_1	280	287	PF00069	0.267
MOD_GSK3_1	3	10	PF00069	0.472
MOD_GSK3_1	444	451	PF00069	0.436
MOD_GSK3_1	610	617	PF00069	0.433
MOD_LATS_1	21	27	PF00433	0.477
MOD_N-GLC_1	212	217	PF02516	0.410
MOD_N-GLC_2	622	624	PF02516	0.328
MOD_NEK2_1	163	168	PF00069	0.328
MOD_NEK2_1	193	198	PF00069	0.405
MOD_NEK2_1	231	236	PF00069	0.365
MOD_NEK2_1	344	349	PF00069	0.490
MOD_NEK2_1	466	471	PF00069	0.302
MOD_NEK2_1	614	619	PF00069	0.478
MOD_NEK2_2	322	327	PF00069	0.263
MOD_PIKK_1	102	108	PF00454	0.444
MOD_PIKK_1	226	232	PF00454	0.471
MOD_PIKK_1	264	270	PF00454	0.252
MOD_PKA_2	448	454	PF00069	0.305
MOD_PKA_2	507	513	PF00069	0.336
MOD_Plk_1	123	129	PF00069	0.467
MOD_Plk_1	322	328	PF00069	0.251
MOD_Plk_2-3	488	494	PF00069	0.384
MOD_Plk_4	344	350	PF00069	0.447
MOD_Plk_4	637	643	PF00069	0.380
MOD_ProDKin_1	112	118	PF00069	0.485
MOD_ProDKin_1	128	134	PF00069	0.518
MOD_ProDKin_1	254	260	PF00069	0.286
MOD_ProDKin_1	3	9	PF00069	0.485
MOD_ProDKin_1	338	344	PF00069	0.416
MOD_ProDKin_1	422	428	PF00069	0.317
MOD_ProDKin_1	59	65	PF00069	0.470
MOD_ProDKin_1	631	637	PF00069	0.362
MOD_ProDKin_1	87	93	PF00069	0.432
MOD_SUMO_for_1	590	593	PF00179	0.359
MOD_SUMO_for_1	606	609	PF00179	0.377
MOD_SUMO_rev_2	363	368	PF00179	0.317
TRG_DiLeu_BaEn_1	34	39	PF01217	0.423
TRG_DiLeu_BaEn_1	385	390	PF01217	0.294
TRG_DiLeu_BaEn_1	427	432	PF01217	0.312
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.330
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.305
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.359
TRG_DiLeu_BaLyEn_6	559	564	PF01217	0.318
TRG_ENDOCYTIC_2	580	583	PF00928	0.456
TRG_ER_diArg_1	160	163	PF00400	0.427
TRG_ER_diArg_1	47	50	PF00400	0.429
TRG_NES_CRM1_1	34	46	PF08389	0.415
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	190	195	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE96	Leptomonas seymouri	94%	100%
A0A0S4J9K3	Bodo saltans	81%	100%
A0A1X0NXK0	Trypanosomatidae	85%	100%
A0A3Q8IEY0	Leishmania donovani	97%	100%
A0A3R7K990	Trypanosoma rangeli	85%	100%
A4HYY3	Leishmania infantum	97%	100%
C1JZ66	Bos taurus	23%	100%
C9ZIJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E9AUS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O75602	Homo sapiens	62%	100%
Q4QCQ4	Leishmania major	96%	100%
Q9JLI7	Mus musculus	63%	100%
V5D560	Trypanosoma cruzi	86%	100%