Putative RNA-binding regulatory protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein, putative

Species:

Leishmania braziliensis

UniProt:

E9AIJ1_LEIBR

TriTrypDb:

LbrM.20.5580 , LBRM2903_200070800

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AIJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIJ1

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	18
GO:0003723	RNA binding	4	18
GO:0005488	binding	1	18
GO:0097159	organic cyclic compound binding	2	18
GO:1901363	heterocyclic compound binding	2	18
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.494
CLV_NRD_NRD_1	120	122	PF00675	0.485
CLV_NRD_NRD_1	236	238	PF00675	0.371
CLV_NRD_NRD_1	449	451	PF00675	0.638
CLV_NRD_NRD_1	5	7	PF00675	0.561
CLV_PCSK_KEX2_1	111	113	PF00082	0.494
CLV_PCSK_KEX2_1	120	122	PF00082	0.485
CLV_PCSK_KEX2_1	236	238	PF00082	0.371
CLV_PCSK_KEX2_1	277	279	PF00082	0.500
CLV_PCSK_KEX2_1	303	305	PF00082	0.587
CLV_PCSK_KEX2_1	448	450	PF00082	0.671
CLV_PCSK_KEX2_1	5	7	PF00082	0.561
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.500
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.615
CLV_PCSK_SKI1_1	166	170	PF00082	0.463
CLV_PCSK_SKI1_1	236	240	PF00082	0.400
CLV_PCSK_SKI1_1	284	288	PF00082	0.458
CLV_PCSK_SKI1_1	37	41	PF00082	0.416
CLV_Separin_Metazoa	163	167	PF03568	0.382
DEG_APCC_DBOX_1	110	118	PF00400	0.409
DEG_APCC_DBOX_1	165	173	PF00400	0.382
DEG_APCC_DBOX_1	236	244	PF00400	0.483
DEG_APCC_DBOX_1	375	383	PF00400	0.521
DEG_Nend_UBRbox_4	1	3	PF02207	0.380
DOC_CYCLIN_RxL_1	233	242	PF00134	0.416
DOC_CYCLIN_yCln2_LP_2	328	334	PF00134	0.562
DOC_MAPK_FxFP_2	412	415	PF00069	0.542
DOC_PP2B_LxvP_1	328	331	PF13499	0.632
DOC_PP4_FxxP_1	412	415	PF00568	0.775
DOC_PP4_FxxP_1	459	462	PF00568	0.643
DOC_USP7_UBL2_3	295	299	PF12436	0.458
DOC_WW_Pin1_4	30	35	PF00397	0.463
DOC_WW_Pin1_4	441	446	PF00397	0.668
LIG_14-3-3_CanoR_1	194	202	PF00244	0.503
LIG_14-3-3_CanoR_1	20	27	PF00244	0.540
LIG_Actin_WH2_1	236	253	PF00022	0.428
LIG_Actin_WH2_1	48	66	PF00022	0.438
LIG_Actin_WH2_2	49	66	PF00022	0.437
LIG_AP2alpha_2	178	180	PF02296	0.290
LIG_BIR_III_4	69	73	PF00653	0.195
LIG_CaM_IQ_9	287	303	PF13499	0.455
LIG_EH1_1	260	268	PF00400	0.434
LIG_FHA_1	86	92	PF00498	0.373
LIG_FHA_2	331	337	PF00498	0.565
LIG_FHA_2	76	82	PF00498	0.437
LIG_LIR_Apic_2	410	415	PF02991	0.637
LIG_LIR_Nem_3	178	183	PF02991	0.357
LIG_LIR_Nem_3	255	261	PF02991	0.391
LIG_LIR_Nem_3	275	279	PF02991	0.442
LIG_LIR_Nem_3	410	414	PF02991	0.454
LIG_PDZ_Class_2	462	467	PF00595	0.514
LIG_Pex14_2	459	463	PF04695	0.650
LIG_SH2_CRK	96	100	PF00017	0.484
LIG_SH2_STAP1	397	401	PF00017	0.525
LIG_SH2_STAP1	96	100	PF00017	0.426
LIG_SH2_STAT3	183	186	PF00017	0.347
LIG_SH2_STAT3	397	400	PF00017	0.529
LIG_SH2_STAT5	109	112	PF00017	0.498
LIG_SH2_STAT5	138	141	PF00017	0.393
LIG_SH2_STAT5	200	203	PF00017	0.406
LIG_SH2_STAT5	332	335	PF00017	0.757
LIG_SH2_STAT5	369	372	PF00017	0.791
LIG_SH2_STAT5	411	414	PF00017	0.455
LIG_SH3_2	355	360	PF14604	0.520
LIG_SH3_3	241	247	PF00018	0.546
LIG_SH3_3	267	273	PF00018	0.566
LIG_SH3_3	302	308	PF00018	0.729
LIG_SH3_3	337	343	PF00018	0.724
LIG_SH3_3	352	358	PF00018	0.819
LIG_SH3_3	359	365	PF00018	0.536
LIG_SH3_3	437	443	PF00018	0.689
LIG_UBA3_1	209	216	PF00899	0.371
MOD_CDK_SPxxK_3	30	37	PF00069	0.458
MOD_CDK_SPxxK_3	441	448	PF00069	0.665
MOD_CK1_1	107	113	PF00069	0.481
MOD_CK1_1	192	198	PF00069	0.377
MOD_CK1_1	403	409	PF00069	0.521
MOD_CK2_1	75	81	PF00069	0.394
MOD_GlcNHglycan	124	128	PF01048	0.542
MOD_GlcNHglycan	384	387	PF01048	0.522
MOD_GlcNHglycan	402	405	PF01048	0.696
MOD_GSK3_1	189	196	PF00069	0.403
MOD_GSK3_1	345	352	PF00069	0.752
MOD_GSK3_1	81	88	PF00069	0.388
MOD_N-GLC_2	102	104	PF02516	0.391
MOD_NEK2_1	139	144	PF00069	0.411
MOD_NEK2_1	210	215	PF00069	0.404
MOD_NEK2_1	345	350	PF00069	0.527
MOD_NEK2_1	95	100	PF00069	0.392
MOD_PIKK_1	104	110	PF00454	0.419
MOD_PIKK_1	139	145	PF00454	0.396
MOD_PIKK_1	317	323	PF00454	0.685
MOD_PIKK_1	349	355	PF00454	0.583
MOD_PIKK_1	363	369	PF00454	0.519
MOD_PIKK_1	43	49	PF00454	0.477
MOD_PKA_2	19	25	PF00069	0.438
MOD_PKA_2	193	199	PF00069	0.511
MOD_PKA_2	345	351	PF00069	0.670
MOD_Plk_1	123	129	PF00069	0.435
MOD_Plk_4	330	336	PF00069	0.559
MOD_Plk_4	95	101	PF00069	0.404
MOD_ProDKin_1	30	36	PF00069	0.458
MOD_ProDKin_1	441	447	PF00069	0.663
MOD_SUMO_for_1	294	297	PF00179	0.496
TRG_ENDOCYTIC_2	258	261	PF00928	0.486
TRG_ENDOCYTIC_2	332	335	PF00928	0.486
TRG_ENDOCYTIC_2	411	414	PF00928	0.455
TRG_ENDOCYTIC_2	96	99	PF00928	0.419
TRG_ER_diArg_1	111	113	PF00400	0.343
TRG_ER_diArg_1	235	237	PF00400	0.371
TRG_ER_diArg_1	282	285	PF00400	0.455
TRG_ER_diArg_1	448	450	PF00400	0.704
TRG_ER_diArg_1	5	7	PF00400	0.563
TRG_ER_diArg_1	61	64	PF00400	0.451
TRG_NES_CRM1_1	167	178	PF08389	0.382
TRG_NES_CRM1_1	57	69	PF08389	0.426
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P473	Leptomonas seymouri	23%	84%
A0A0N1ILR0	Leptomonas seymouri	56%	71%
A0A3Q8IA47	Leishmania donovani	85%	79%
A0A3R7NFN9	Trypanosoma rangeli	52%	86%
A0A3R7NHA6	Trypanosoma rangeli	24%	82%
A0A3S7WW64	Leishmania donovani	91%	86%
A4HNL0	Leishmania braziliensis	24%	85%
A4HYX9	Leishmania infantum	85%	79%
A4HYY0	Leishmania infantum	92%	86%
C9ZII7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	69%
E8NHJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9ASC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	84%
E9AUS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QCQ8	Leishmania major	90%	100%
Q4QCQ9	Leishmania major	82%	100%
V5B1W9	Trypanosoma cruzi	24%	83%