Kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinase-like protein

Gene product:

kinase-like protein

Species:

Leishmania braziliensis

UniProt:

E9AII8_LEIBR

TriTrypDb:

LbrM.20.5550 , LBRM2903_200070500

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AII8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AII8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0046777	protein autophosphorylation	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0004674	protein serine/threonine kinase activity	4	9
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004683	calmodulin-dependent protein kinase activity	5	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	1
GO:0010857	calcium-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.201
CLV_C14_Caspase3-7	218	222	PF00656	0.192
CLV_MEL_PAP_1	48	54	PF00089	0.458
CLV_NRD_NRD_1	119	121	PF00675	0.424
CLV_NRD_NRD_1	246	248	PF00675	0.193
CLV_NRD_NRD_1	34	36	PF00675	0.625
CLV_NRD_NRD_1	342	344	PF00675	0.318
CLV_NRD_NRD_1	86	88	PF00675	0.348
CLV_NRD_NRD_1	95	97	PF00675	0.345
CLV_PCSK_KEX2_1	119	121	PF00082	0.424
CLV_PCSK_KEX2_1	246	248	PF00082	0.378
CLV_PCSK_KEX2_1	34	36	PF00082	0.625
CLV_PCSK_KEX2_1	341	343	PF00082	0.361
CLV_PCSK_KEX2_1	86	88	PF00082	0.282
CLV_PCSK_KEX2_1	91	93	PF00082	0.325
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.400
CLV_PCSK_PC7_1	87	93	PF00082	0.277
CLV_PCSK_SKI1_1	191	195	PF00082	0.292
CLV_PCSK_SKI1_1	348	352	PF00082	0.268
CLV_PCSK_SKI1_1	35	39	PF00082	0.529
CLV_Separin_Metazoa	106	110	PF03568	0.212
DEG_APCC_DBOX_1	342	350	PF00400	0.263
DOC_CKS1_1	249	254	PF01111	0.352
DOC_CKS1_1	59	64	PF01111	0.496
DOC_MAPK_FxFP_2	162	165	PF00069	0.378
DOC_MAPK_gen_1	34	42	PF00069	0.359
DOC_MAPK_MEF2A_6	138	146	PF00069	0.352
DOC_MAPK_MEF2A_6	272	281	PF00069	0.217
DOC_MAPK_MEF2A_6	34	42	PF00069	0.359
DOC_MAPK_NFAT4_5	35	43	PF00069	0.349
DOC_PP1_RVXF_1	226	233	PF00149	0.378
DOC_PP1_RVXF_1	33	40	PF00149	0.476
DOC_PP4_FxxP_1	162	165	PF00568	0.378
DOC_USP7_MATH_1	296	300	PF00917	0.485
DOC_USP7_MATH_1	303	307	PF00917	0.521
DOC_USP7_MATH_1	329	333	PF00917	0.410
DOC_WW_Pin1_4	121	126	PF00397	0.370
DOC_WW_Pin1_4	248	253	PF00397	0.352
DOC_WW_Pin1_4	58	63	PF00397	0.487
LIG_14-3-3_CanoR_1	100	108	PF00244	0.234
LIG_14-3-3_CanoR_1	283	290	PF00244	0.193
LIG_14-3-3_CanoR_1	92	96	PF00244	0.322
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BIR_III_2	221	225	PF00653	0.193
LIG_CSL_BTD_1	59	62	PF09270	0.495
LIG_deltaCOP1_diTrp_1	273	282	PF00928	0.292
LIG_eIF4E_1	164	170	PF01652	0.193
LIG_FHA_1	306	312	PF00498	0.421
LIG_FHA_2	59	65	PF00498	0.308
LIG_HP1_1	166	170	PF01393	0.285
LIG_LIR_Apic_2	251	257	PF02991	0.292
LIG_LIR_Nem_3	286	292	PF02991	0.305
LIG_LYPXL_yS_3	164	167	PF13949	0.193
LIG_SH3_3	246	252	PF00018	0.321
LIG_SH3_3	295	301	PF00018	0.478
LIG_SH3_3	356	362	PF00018	0.375
LIG_SUMO_SIM_par_1	165	171	PF11976	0.378
LIG_SUMO_SIM_par_1	311	316	PF11976	0.407
LIG_SUMO_SIM_par_1	71	76	PF11976	0.264
LIG_TRAF2_1	28	31	PF00917	0.388
LIG_TRAF2_1	61	64	PF00917	0.315
MOD_CK2_1	25	31	PF00069	0.564
MOD_CK2_1	58	64	PF00069	0.397
MOD_GlcNHglycan	101	104	PF01048	0.406
MOD_GlcNHglycan	316	320	PF01048	0.486
MOD_GlcNHglycan	331	334	PF01048	0.291
MOD_GlcNHglycan	44	47	PF01048	0.407
MOD_GlcNHglycan	9	12	PF01048	0.568
MOD_GSK3_1	273	280	PF00069	0.301
MOD_GSK3_1	311	318	PF00069	0.422
MOD_GSK3_1	38	45	PF00069	0.405
MOD_N-GLC_1	303	308	PF02516	0.448
MOD_NEK2_1	277	282	PF00069	0.352
MOD_NEK2_1	38	43	PF00069	0.459
MOD_PKA_1	342	348	PF00069	0.272
MOD_PKA_1	91	97	PF00069	0.378
MOD_PKA_2	282	288	PF00069	0.361
MOD_PKA_2	342	348	PF00069	0.383
MOD_PKA_2	7	13	PF00069	0.570
MOD_PKA_2	91	97	PF00069	0.322
MOD_PKA_2	99	105	PF00069	0.234
MOD_Plk_4	277	283	PF00069	0.348
MOD_Plk_4	331	337	PF00069	0.385
MOD_Plk_4	38	44	PF00069	0.389
MOD_ProDKin_1	121	127	PF00069	0.370
MOD_ProDKin_1	248	254	PF00069	0.352
MOD_ProDKin_1	58	64	PF00069	0.488
TRG_ENDOCYTIC_2	164	167	PF00928	0.242
TRG_ER_diArg_1	245	247	PF00400	0.193
TRG_ER_diArg_1	340	343	PF00400	0.444
TRG_ER_diArg_1	85	87	PF00400	0.260
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H5	Leptomonas seymouri	25%	100%
A0A0N1HVN6	Leptomonas seymouri	26%	97%
A0A0N1HY86	Leptomonas seymouri	24%	70%
A0A0N1ILF4	Leptomonas seymouri	41%	71%
A0A0S4J842	Bodo saltans	23%	68%
A0A0S4J9Q7	Bodo saltans	26%	80%
A0A0S4JK24	Bodo saltans	24%	84%
A0A0S4JU73	Bodo saltans	25%	77%
A0A0S4JZV2	Bodo saltans	27%	100%
A0A0S4KFT7	Bodo saltans	26%	100%
A0A0S4KMV7	Bodo saltans	29%	100%
A0A1X0NKA1	Trypanosomatidae	27%	82%
A0A1X0NWB9	Trypanosomatidae	22%	76%
A0A1X0P3J5	Trypanosomatidae	26%	79%
A0A1X0P919	Trypanosomatidae	24%	98%
A0A2I0BVG8	Plasmodium falciparum (isolate NF54)	24%	69%
A0A3Q8IB30	Leishmania donovani	26%	100%
A0A3Q8IBT5	Leishmania donovani	76%	100%
A0A3R7K681	Trypanosoma rangeli	27%	71%
A0A3S5H5U5	Leishmania donovani	26%	80%
A0A3S5H789	Leishmania donovani	67%	95%
A0A3S7X2W3	Leishmania donovani	26%	98%
A0A3S7XAL3	Leishmania donovani	25%	73%
A0A422N3Y6	Trypanosoma rangeli	24%	82%
A0A422N701	Trypanosoma rangeli	25%	82%
A0A422P0N6	Trypanosoma rangeli	25%	100%
A2BD05	Sus scrofa	24%	100%
A4H9L8	Leishmania braziliensis	27%	100%
A4HHN1	Leishmania braziliensis	25%	98%
A4HXY2	Leishmania infantum	26%	100%
A4HYX6	Leishmania infantum	67%	95%
A4I4U6	Leishmania infantum	26%	98%
A4IDC1	Leishmania infantum	25%	71%
A8WXF6	Caenorhabditis briggsae	26%	68%
A9RWC9	Physcomitrium patens	25%	100%
D0A2R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	96%
D0N4E2	Phytophthora infestans (strain T30-4)	28%	91%
E9AG71	Leishmania infantum	26%	80%
E9ALJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	98%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ASS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	72%
E9AUS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	96%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	73%
G5EFM9	Caenorhabditis elegans	24%	100%
G5EFU0	Caenorhabditis elegans	25%	70%
O09110	Mus musculus	28%	100%
O14733	Homo sapiens	25%	87%
O22932	Arabidopsis thaliana	26%	84%
O43293	Homo sapiens	23%	80%
O54784	Mus musculus	21%	81%
O77708	Oryctolagus cuniculus	26%	68%
O88643	Mus musculus	23%	67%
O88764	Rattus norvegicus	21%	81%
O94768	Homo sapiens	24%	98%
O95747	Homo sapiens	25%	69%
O96017	Homo sapiens	27%	67%
P11730	Rattus norvegicus	26%	69%
P15791	Rattus norvegicus	26%	68%
P27466	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	82%
P28582	Daucus carota	27%	68%
P32491	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	72%
P35465	Rattus norvegicus	22%	67%
P36506	Rattus norvegicus	26%	91%
P36507	Homo sapiens	26%	91%
P46734	Homo sapiens	28%	100%
P49101	Zea mays	27%	71%
P52564	Homo sapiens	26%	100%
P53682	Oryza sativa subsp. japonica	28%	68%
P53683	Oryza sativa subsp. japonica	27%	68%
P59895	Rattus norvegicus	24%	100%
P62343	Plasmodium falciparum (isolate K1 / Thailand)	24%	69%
P62344	Plasmodium falciparum (isolate 3D7)	24%	69%
P70236	Mus musculus	26%	100%
Q08E52	Bos taurus	22%	67%
Q10292	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	82%
Q13153	Homo sapiens	22%	67%
Q13163	Homo sapiens	24%	81%
Q13177	Homo sapiens	21%	69%
Q13557	Homo sapiens	26%	73%
Q1HG70	Canis lupus familiaris	25%	91%
Q1PFH8	Arabidopsis thaliana	26%	66%
Q20347	Caenorhabditis elegans	27%	100%
Q24324	Drosophila melanogaster	24%	92%
Q27687	Leishmania major	26%	100%
Q2HJF7	Bos taurus	26%	75%
Q2RAV0	Oryza sativa subsp. japonica	28%	67%
Q32PP3	Danio rerio	27%	100%
Q38868	Arabidopsis thaliana	26%	67%
Q3E9C0	Arabidopsis thaliana	27%	70%
Q3Y416	Caenorhabditis elegans	22%	67%
Q42396	Arabidopsis thaliana	27%	74%
Q42479	Arabidopsis thaliana	28%	69%
Q4KSH7	Rattus norvegicus	25%	87%
Q4Q1S4	Leishmania major	25%	72%
Q4QCR2	Leishmania major	73%	100%
Q4QCR3	Leishmania major	68%	100%
Q4QIV8	Leishmania major	26%	80%
Q54JG7	Dictyostelium discoideum	21%	75%
Q54QD5	Dictyostelium discoideum	24%	75%
Q54SJ5	Dictyostelium discoideum	24%	100%
Q55GV3	Dictyostelium discoideum	21%	76%
Q5E9X2	Bos taurus	26%	100%
Q5JLQ9	Oryza sativa subsp. japonica	26%	76%
Q5R495	Pongo abelii	25%	69%
Q5ZKI0	Gallus gallus	26%	76%
Q60EY8	Oryza sativa subsp. japonica	31%	78%
Q62829	Rattus norvegicus	21%	67%
Q62862	Rattus norvegicus	24%	81%
Q63932	Mus musculus	25%	91%
Q6AVM3	Oryza sativa subsp. japonica	25%	71%
Q6P9R2	Mus musculus	24%	69%
Q6PA14	Xenopus laevis	22%	75%
Q6PHZ2	Mus musculus	26%	73%
Q6YY75	Oryza sativa subsp. japonica	24%	68%
Q7XSQ5	Oryza sativa subsp. japonica	26%	68%
Q863I2	Sus scrofa	24%	69%
Q8BG48	Mus musculus	25%	98%
Q8CE90	Mus musculus	25%	68%
Q8VDF3	Mus musculus	22%	98%
Q90891	Gallus gallus	25%	91%
Q91XS8	Rattus norvegicus	25%	98%
Q923T9	Mus musculus	26%	69%
Q95266	Sus scrofa	26%	73%
Q9C6P3	Arabidopsis thaliana	26%	70%
Q9ES70	Mus musculus	24%	100%
Q9FJV0	Arabidopsis thaliana	25%	100%
Q9GM70	Oryctolagus cuniculus	25%	92%
Q9HC98	Homo sapiens	24%	100%
Q9LT35	Arabidopsis thaliana	25%	88%
Q9S9V0	Arabidopsis thaliana	24%	75%
Q9SJ61	Arabidopsis thaliana	23%	70%
Q9SZM3	Arabidopsis thaliana	26%	75%
Q9UEE5	Homo sapiens	25%	88%
Q9UEW8	Homo sapiens	25%	67%
Q9UIK4	Homo sapiens	21%	98%
Q9WVS7	Mus musculus	24%	81%
Q9Y077	Leishmania major	26%	98%
Q9Z265	Mus musculus	26%	67%
Q9ZSA2	Arabidopsis thaliana	24%	69%
Q9ZSA4	Arabidopsis thaliana	25%	75%
V5B8E0	Trypanosoma cruzi	32%	100%
V5BAZ8	Trypanosoma cruzi	26%	95%
V5BFI8	Trypanosoma cruzi	23%	82%
V5BI43	Trypanosoma cruzi	28%	73%
V5BMH5	Trypanosoma cruzi	27%	100%
V5DUH0	Trypanosoma cruzi	26%	66%