DUF1935 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania braziliensis

UniProt:

E9AII2_LEIBR

TriTrypDb:

LbrM.20.5490 , LBRM2903_200069800

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AII2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AII2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.279
CLV_PCSK_SKI1_1	48	52	PF00082	0.468
DOC_CKS1_1	62	67	PF01111	0.354
DOC_MAPK_gen_1	145	152	PF00069	0.231
DOC_MAPK_MEF2A_6	55	63	PF00069	0.305
DOC_PP1_RVXF_1	46	52	PF00149	0.472
DOC_PP4_FxxP_1	67	70	PF00568	0.567
DOC_USP7_MATH_1	12	16	PF00917	0.666
DOC_WW_Pin1_4	131	136	PF00397	0.509
DOC_WW_Pin1_4	61	66	PF00397	0.338
LIG_14-3-3_CanoR_1	171	175	PF00244	0.231
LIG_APCC_ABBA_1	38	43	PF00400	0.511
LIG_APCC_ABBAyCdc20_2	97	103	PF00400	0.338
LIG_deltaCOP1_diTrp_1	94	101	PF00928	0.316
LIG_FHA_1	44	50	PF00498	0.579
LIG_FHA_1	54	60	PF00498	0.475
LIG_Integrin_isoDGR_2	143	145	PF01839	0.231
LIG_LIR_Apic_2	64	70	PF02991	0.530
LIG_LIR_Gen_1	28	38	PF02991	0.466
LIG_LIR_Gen_1	58	67	PF02991	0.300
LIG_LIR_Gen_1	95	103	PF02991	0.350
LIG_LIR_Nem_3	28	33	PF02991	0.486
LIG_LIR_Nem_3	58	63	PF02991	0.281
LIG_LIR_Nem_3	95	101	PF02991	0.350
LIG_SH3_3	147	153	PF00018	0.502
LIG_SH3_3	158	164	PF00018	0.377
LIG_SH3_3	34	40	PF00018	0.514
LIG_TRAF2_1	15	18	PF00917	0.612
LIG_TRAF2_1	82	85	PF00917	0.582
LIG_TRAF2_1	92	95	PF00917	0.647
MOD_CK1_1	106	112	PF00069	0.430
MOD_CK2_1	12	18	PF00069	0.623
MOD_CK2_1	71	77	PF00069	0.521
MOD_CK2_1	78	84	PF00069	0.506
MOD_GlcNHglycan	5	8	PF01048	0.671
MOD_GSK3_1	106	113	PF00069	0.391
MOD_N-GLC_1	101	106	PF02516	0.330
MOD_NEK2_1	101	106	PF00069	0.330
MOD_NEK2_2	96	101	PF00069	0.219
MOD_NMyristoyl	1	7	PF02799	0.548
MOD_PK_1	20	26	PF00069	0.624
MOD_PK_1	55	61	PF00069	0.307
MOD_PKA_2	170	176	PF00069	0.231
MOD_PKA_2	96	102	PF00069	0.418
MOD_Plk_1	106	112	PF00069	0.344
MOD_Plk_2-3	80	86	PF00069	0.551
MOD_Plk_4	110	116	PF00069	0.336
MOD_Plk_4	170	176	PF00069	0.243
MOD_Plk_4	55	61	PF00069	0.422
MOD_ProDKin_1	131	137	PF00069	0.509
MOD_ProDKin_1	61	67	PF00069	0.344
MOD_SPalmitoyl_4	1	7	PF01529	0.548
MOD_SUMO_for_1	146	149	PF00179	0.241
MOD_SUMO_rev_2	15	22	PF00179	0.525
MOD_SUMO_rev_2	173	179	PF00179	0.323
MOD_SUMO_rev_2	81	91	PF00179	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE64	Leptomonas seymouri	45%	100%
A0A3S7WW30	Leishmania donovani	74%	100%
A4HYX0	Leishmania infantum	74%	100%
E9AUR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QCR9	Leishmania major	73%	100%