Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AII1_LEIBR

TriTrypDb:

LbrM.20.5480 , LBRM2903_200069700

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AII1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AII1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.601
CLV_C14_Caspase3-7	354	358	PF00656	0.777
CLV_C14_Caspase3-7	9	13	PF00656	0.553
CLV_NRD_NRD_1	330	332	PF00675	0.797
CLV_NRD_NRD_1	365	367	PF00675	0.769
CLV_NRD_NRD_1	686	688	PF00675	0.701
CLV_NRD_NRD_1	83	85	PF00675	0.540
CLV_PCSK_FUR_1	363	367	PF00082	0.771
CLV_PCSK_KEX2_1	279	281	PF00082	0.593
CLV_PCSK_KEX2_1	365	367	PF00082	0.769
CLV_PCSK_KEX2_1	503	505	PF00082	0.459
CLV_PCSK_KEX2_1	686	688	PF00082	0.701
CLV_PCSK_KEX2_1	72	74	PF00082	0.525
CLV_PCSK_KEX2_1	83	85	PF00082	0.598
CLV_PCSK_KEX2_1	87	89	PF00082	0.606
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.593
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.459
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.525
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.598
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.606
CLV_PCSK_SKI1_1	173	177	PF00082	0.549
CLV_PCSK_SKI1_1	282	286	PF00082	0.594
CLV_PCSK_SKI1_1	381	385	PF00082	0.621
CLV_PCSK_SKI1_1	426	430	PF00082	0.580
CLV_PCSK_SKI1_1	455	459	PF00082	0.488
CLV_PCSK_SKI1_1	553	557	PF00082	0.614
CLV_PCSK_SKI1_1	561	565	PF00082	0.551
CLV_PCSK_SKI1_1	578	582	PF00082	0.500
CLV_Separin_Metazoa	558	562	PF03568	0.506
DEG_APCC_DBOX_1	364	372	PF00400	0.768
DEG_APCC_DBOX_1	575	583	PF00400	0.718
DEG_SCF_FBW7_2	489	495	PF00400	0.689
DEG_SPOP_SBC_1	183	187	PF00917	0.547
DEG_SPOP_SBC_1	3	7	PF00917	0.571
DOC_CKS1_1	188	193	PF01111	0.745
DOC_CKS1_1	489	494	PF01111	0.686
DOC_CKS1_1	554	559	PF01111	0.703
DOC_MAPK_gen_1	363	373	PF00069	0.764
DOC_MAPK_gen_1	564	572	PF00069	0.633
DOC_MAPK_gen_1	573	582	PF00069	0.706
DOC_MAPK_MEF2A_6	310	318	PF00069	0.562
DOC_PP1_RVXF_1	576	582	PF00149	0.552
DOC_PP2B_LxvP_1	374	377	PF13499	0.532
DOC_PP2B_LxvP_1	742	745	PF13499	0.535
DOC_PP4_FxxP_1	288	291	PF00568	0.596
DOC_PP4_FxxP_1	330	333	PF00568	0.596
DOC_PP4_FxxP_1	627	630	PF00568	0.561
DOC_PP4_MxPP_1	610	613	PF00568	0.568
DOC_USP7_MATH_1	252	256	PF00917	0.793
DOC_USP7_MATH_1	296	300	PF00917	0.795
DOC_USP7_MATH_1	3	7	PF00917	0.571
DOC_USP7_MATH_1	319	323	PF00917	0.726
DOC_USP7_MATH_1	325	329	PF00917	0.671
DOC_USP7_MATH_1	393	397	PF00917	0.691
DOC_USP7_MATH_1	420	424	PF00917	0.576
DOC_USP7_MATH_1	595	599	PF00917	0.562
DOC_USP7_MATH_1	630	634	PF00917	0.622
DOC_USP7_MATH_1	65	69	PF00917	0.602
DOC_USP7_MATH_1	671	675	PF00917	0.549
DOC_USP7_MATH_1	691	695	PF00917	0.555
DOC_USP7_UBL2_3	162	166	PF12436	0.584
DOC_USP7_UBL2_3	173	177	PF12436	0.513
DOC_USP7_UBL2_3	689	693	PF12436	0.584
DOC_USP7_UBL2_3	83	87	PF12436	0.556
DOC_WW_Pin1_4	166	171	PF00397	0.774
DOC_WW_Pin1_4	187	192	PF00397	0.708
DOC_WW_Pin1_4	204	209	PF00397	0.533
DOC_WW_Pin1_4	225	230	PF00397	0.552
DOC_WW_Pin1_4	248	253	PF00397	0.869
DOC_WW_Pin1_4	260	265	PF00397	0.667
DOC_WW_Pin1_4	287	292	PF00397	0.671
DOC_WW_Pin1_4	310	315	PF00397	0.741
DOC_WW_Pin1_4	416	421	PF00397	0.675
DOC_WW_Pin1_4	429	434	PF00397	0.700
DOC_WW_Pin1_4	442	447	PF00397	0.531
DOC_WW_Pin1_4	488	493	PF00397	0.688
DOC_WW_Pin1_4	553	558	PF00397	0.721
DOC_WW_Pin1_4	618	623	PF00397	0.594
DOC_WW_Pin1_4	632	637	PF00397	0.540
LIG_14-3-3_CanoR_1	370	374	PF00244	0.763
LIG_14-3-3_CanoR_1	426	435	PF00244	0.556
LIG_14-3-3_CanoR_1	645	651	PF00244	0.587
LIG_14-3-3_CanoR_1	681	685	PF00244	0.741
LIG_APCC_ABBAyCdc20_2	381	387	PF00400	0.643
LIG_BRCT_BRCA1_1	118	122	PF00533	0.692
LIG_Clathr_ClatBox_1	539	543	PF01394	0.713
LIG_Clathr_ClatBox_1	579	583	PF01394	0.550
LIG_CtBP_PxDLS_1	640	644	PF00389	0.553
LIG_EVH1_1	246	250	PF00568	0.597
LIG_FHA_1	17	23	PF00498	0.523
LIG_FHA_1	219	225	PF00498	0.654
LIG_FHA_1	311	317	PF00498	0.768
LIG_FHA_1	481	487	PF00498	0.675
LIG_FHA_1	520	526	PF00498	0.665
LIG_FHA_1	535	541	PF00498	0.523
LIG_FHA_1	554	560	PF00498	0.457
LIG_FHA_1	633	639	PF00498	0.664
LIG_FHA_1	645	651	PF00498	0.596
LIG_FHA_1	777	783	PF00498	0.618
LIG_FHA_2	137	143	PF00498	0.655
LIG_FHA_2	303	309	PF00498	0.845
LIG_FHA_2	352	358	PF00498	0.574
LIG_FHA_2	417	423	PF00498	0.578
LIG_FHA_2	489	495	PF00498	0.689
LIG_FHA_2	619	625	PF00498	0.573
LIG_LIR_Apic_2	285	291	PF02991	0.596
LIG_LIR_Apic_2	328	333	PF02991	0.590
LIG_LIR_Apic_2	624	630	PF02991	0.567
LIG_LIR_Apic_2	708	713	PF02991	0.678
LIG_LIR_Gen_1	180	188	PF02991	0.554
LIG_LIR_Gen_1	468	479	PF02991	0.670
LIG_LIR_Gen_1	512	521	PF02991	0.632
LIG_LIR_Nem_3	180	184	PF02991	0.549
LIG_LIR_Nem_3	380	385	PF02991	0.719
LIG_LIR_Nem_3	468	474	PF02991	0.677
LIG_LIR_Nem_3	512	517	PF02991	0.624
LIG_MYND_1	112	116	PF01753	0.691
LIG_PDZ_Class_2	781	786	PF00595	0.724
LIG_SH2_CRK	710	714	PF00017	0.558
LIG_SH2_GRB2like	678	681	PF00017	0.552
LIG_SH2_NCK_1	710	714	PF00017	0.558
LIG_SH2_PTP2	471	474	PF00017	0.676
LIG_SH2_SRC	471	474	PF00017	0.676
LIG_SH2_STAT5	471	474	PF00017	0.676
LIG_SH2_STAT5	524	527	PF00017	0.713
LIG_SH3_2	249	254	PF14604	0.594
LIG_SH3_3	12	18	PF00018	0.721
LIG_SH3_3	185	191	PF00018	0.742
LIG_SH3_3	223	229	PF00018	0.627
LIG_SH3_3	244	250	PF00018	0.805
LIG_SH3_3	313	319	PF00018	0.597
LIG_SH3_3	356	362	PF00018	0.644
LIG_SH3_3	486	492	PF00018	0.689
LIG_SH3_3	513	519	PF00018	0.622
LIG_SH3_3	635	641	PF00018	0.640
LIG_SH3_4	406	413	PF00018	0.569
LIG_SUMO_SIM_anti_2	369	375	PF11976	0.762
LIG_SUMO_SIM_anti_2	547	552	PF11976	0.522
LIG_SUMO_SIM_par_1	190	196	PF11976	0.558
LIG_SUMO_SIM_par_1	221	228	PF11976	0.560
LIG_SUMO_SIM_par_1	646	652	PF11976	0.558
LIG_TRAF2_1	415	418	PF00917	0.702
LIG_TRAF2_1	492	495	PF00917	0.701
LIG_UBA3_1	579	584	PF00899	0.718
LIG_UBA3_1	752	758	PF00899	0.533
LIG_WW_3	360	364	PF00397	0.573
MOD_CDC14_SPxK_1	251	254	PF00782	0.597
MOD_CDK_SPK_2	166	171	PF00069	0.768
MOD_CDK_SPK_2	204	209	PF00069	0.588
MOD_CDK_SPK_2	618	623	PF00069	0.575
MOD_CDK_SPxK_1	248	254	PF00069	0.597
MOD_CDK_SPxxK_3	166	173	PF00069	0.566
MOD_CK1_1	117	123	PF00069	0.690
MOD_CK1_1	161	167	PF00069	0.694
MOD_CK1_1	169	175	PF00069	0.695
MOD_CK1_1	182	188	PF00069	0.564
MOD_CK1_1	225	231	PF00069	0.554
MOD_CK1_1	263	269	PF00069	0.607
MOD_CK1_1	287	293	PF00069	0.687
MOD_CK1_1	295	301	PF00069	0.626
MOD_CK1_1	343	349	PF00069	0.587
MOD_CK1_1	369	375	PF00069	0.750
MOD_CK1_1	424	430	PF00069	0.774
MOD_CK1_1	448	454	PF00069	0.673
MOD_CK1_1	463	469	PF00069	0.527
MOD_CK1_1	6	12	PF00069	0.732
MOD_CK1_1	603	609	PF00069	0.560
MOD_CK1_1	632	638	PF00069	0.757
MOD_CK1_1	646	652	PF00069	0.571
MOD_CK1_1	68	74	PF00069	0.622
MOD_CK1_1	776	782	PF00069	0.585
MOD_CK2_1	136	142	PF00069	0.651
MOD_CK2_1	302	308	PF00069	0.707
MOD_CK2_1	450	456	PF00069	0.513
MOD_CK2_1	467	473	PF00069	0.553
MOD_CK2_1	488	494	PF00069	0.689
MOD_GlcNHglycan	267	270	PF01048	0.666
MOD_GlcNHglycan	294	297	PF01048	0.667
MOD_GlcNHglycan	395	398	PF01048	0.555
MOD_GlcNHglycan	422	426	PF01048	0.769
MOD_GlcNHglycan	505	508	PF01048	0.517
MOD_GlcNHglycan	593	596	PF01048	0.710
MOD_GlcNHglycan	607	610	PF01048	0.613
MOD_GlcNHglycan	651	654	PF01048	0.568
MOD_GlcNHglycan	658	661	PF01048	0.616
MOD_GlcNHglycan	673	676	PF01048	0.556
MOD_GlcNHglycan	692	696	PF01048	0.647
MOD_GlcNHglycan	8	11	PF01048	0.698
MOD_GSK3_1	110	117	PF00069	0.689
MOD_GSK3_1	157	164	PF00069	0.687
MOD_GSK3_1	165	172	PF00069	0.720
MOD_GSK3_1	179	186	PF00069	0.574
MOD_GSK3_1	196	203	PF00069	0.570
MOD_GSK3_1	2	9	PF00069	0.728
MOD_GSK3_1	218	225	PF00069	0.635
MOD_GSK3_1	248	255	PF00069	0.809
MOD_GSK3_1	283	290	PF00069	0.721
MOD_GSK3_1	291	298	PF00069	0.726
MOD_GSK3_1	310	317	PF00069	0.621
MOD_GSK3_1	33	40	PF00069	0.508
MOD_GSK3_1	339	346	PF00069	0.592
MOD_GSK3_1	416	423	PF00069	0.689
MOD_GSK3_1	447	454	PF00069	0.693
MOD_GSK3_1	460	467	PF00069	0.527
MOD_GSK3_1	591	598	PF00069	0.608
MOD_GSK3_1	652	659	PF00069	0.684
MOD_GSK3_1	687	694	PF00069	0.580
MOD_GSK3_1	758	765	PF00069	0.663
MOD_GSK3_1	773	780	PF00069	0.601
MOD_N-GLC_1	385	390	PF02516	0.787
MOD_N-GLC_1	698	703	PF02516	0.576
MOD_NEK2_1	122	127	PF00069	0.484
MOD_NEK2_1	158	163	PF00069	0.714
MOD_NEK2_1	179	184	PF00069	0.740
MOD_NEK2_1	275	280	PF00069	0.698
MOD_NEK2_1	284	289	PF00069	0.770
MOD_NEK2_1	385	390	PF00069	0.757
MOD_NEK2_1	421	426	PF00069	0.578
MOD_NEK2_1	447	452	PF00069	0.672
MOD_NEK2_1	464	469	PF00069	0.502
MOD_NEK2_1	605	610	PF00069	0.761
MOD_NEK2_1	643	648	PF00069	0.678
MOD_NEK2_1	656	661	PF00069	0.563
MOD_NEK2_1	774	779	PF00069	0.540
MOD_NEK2_2	519	524	PF00069	0.691
MOD_NMyristoyl	1	7	PF02799	0.769
MOD_PK_1	222	228	PF00069	0.559
MOD_PK_1	544	550	PF00069	0.522
MOD_PK_1	566	572	PF00069	0.514
MOD_PK_1	758	764	PF00069	0.548
MOD_PKA_1	503	509	PF00069	0.460
MOD_PKA_2	338	344	PF00069	0.622
MOD_PKA_2	369	375	PF00069	0.762
MOD_PKA_2	503	509	PF00069	0.460
MOD_PKA_2	644	650	PF00069	0.587
MOD_PKA_2	680	686	PF00069	0.750
MOD_PKB_1	260	268	PF00069	0.594
MOD_Plk_1	200	206	PF00069	0.578
MOD_Plk_1	303	309	PF00069	0.687
MOD_Plk_1	339	345	PF00069	0.592
MOD_Plk_1	664	670	PF00069	0.560
MOD_Plk_1	758	764	PF00069	0.657
MOD_Plk_4	222	228	PF00069	0.750
MOD_Plk_4	319	325	PF00069	0.825
MOD_Plk_4	343	349	PF00069	0.587
MOD_Plk_4	519	525	PF00069	0.664
MOD_Plk_4	748	754	PF00069	0.524
MOD_ProDKin_1	166	172	PF00069	0.771
MOD_ProDKin_1	187	193	PF00069	0.707
MOD_ProDKin_1	204	210	PF00069	0.531
MOD_ProDKin_1	225	231	PF00069	0.554
MOD_ProDKin_1	248	254	PF00069	0.871
MOD_ProDKin_1	260	266	PF00069	0.666
MOD_ProDKin_1	287	293	PF00069	0.669
MOD_ProDKin_1	310	316	PF00069	0.741
MOD_ProDKin_1	416	422	PF00069	0.675
MOD_ProDKin_1	429	435	PF00069	0.696
MOD_ProDKin_1	442	448	PF00069	0.533
MOD_ProDKin_1	488	494	PF00069	0.689
MOD_ProDKin_1	553	559	PF00069	0.719
MOD_ProDKin_1	618	624	PF00069	0.594
MOD_ProDKin_1	632	638	PF00069	0.542
MOD_SUMO_rev_2	451	459	PF00179	0.490
MOD_SUMO_rev_2	494	499	PF00179	0.631
TRG_DiLeu_BaEn_1	130	135	PF01217	0.719
TRG_ENDOCYTIC_2	24	27	PF00928	0.701
TRG_ENDOCYTIC_2	471	474	PF00928	0.676
TRG_ER_diArg_1	362	365	PF00400	0.761
TRG_ER_diArg_1	379	382	PF00400	0.526
TRG_NLS_Bipartite_1	72	90	PF00514	0.633
TRG_NLS_MonoCore_2	278	283	PF00514	0.587
TRG_NLS_MonoCore_2	82	87	PF00514	0.446
TRG_NLS_MonoExtC_3	82	87	PF00514	0.644
TRG_NLS_MonoExtN_4	83	90	PF00514	0.650
TRG_Pf-PMV_PEXEL_1	553	558	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAM5	Leishmania donovani	56%	94%
A4HYW9	Leishmania infantum	56%	94%
E9AUR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	95%
Q4QCS0	Leishmania major	55%	100%