DUF1935 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania braziliensis

UniProt:

E9AII0_LEIBR

TriTrypDb:

LbrM.20.5470 , LBRM2903_200069600

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AII0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AII0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.552
CLV_PCSK_KEX2_1	192	194	PF00082	0.405
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.405
CLV_PCSK_SKI1_1	106	110	PF00082	0.555
CLV_PCSK_SKI1_1	238	242	PF00082	0.247
DEG_Kelch_Keap1_1	231	236	PF01344	0.247
DEG_SPOP_SBC_1	67	71	PF00917	0.520
DOC_USP7_MATH_1	215	219	PF00917	0.405
DOC_USP7_MATH_1	67	71	PF00917	0.533
DOC_WW_Pin1_4	155	160	PF00397	0.614
DOC_WW_Pin1_4	38	43	PF00397	0.766
DOC_WW_Pin1_4	47	52	PF00397	0.687
LIG_14-3-3_CanoR_1	176	186	PF00244	0.247
LIG_14-3-3_CanoR_1	208	214	PF00244	0.405
LIG_BRCT_BRCA1_1	209	213	PF00533	0.405
LIG_FHA_1	201	207	PF00498	0.430
LIG_FHA_1	223	229	PF00498	0.275
LIG_FHA_1	67	73	PF00498	0.578
LIG_FHA_2	115	121	PF00498	0.589
LIG_FHA_2	17	23	PF00498	0.587
LIG_FXI_DFP_1	271	275	PF00024	0.458
LIG_LIR_Apic_2	109	115	PF02991	0.547
LIG_LIR_Apic_2	158	163	PF02991	0.545
LIG_LIR_Gen_1	138	147	PF02991	0.474
LIG_LIR_Nem_3	138	143	PF02991	0.464
LIG_LIR_Nem_3	172	178	PF02991	0.344
LIG_LIR_Nem_3	255	259	PF02991	0.405
LIG_PCNA_yPIPBox_3	176	189	PF02747	0.405
LIG_SH2_CRK	160	164	PF00017	0.494
LIG_SH2_NCK_1	112	116	PF00017	0.545
LIG_SH2_STAT5	205	208	PF00017	0.429
LIG_SH3_2	51	56	PF14604	0.525
LIG_SH3_3	36	42	PF00018	0.733
LIG_SH3_3	48	54	PF00018	0.576
LIG_TRAF2_1	98	101	PF00917	0.543
LIG_UBA3_1	184	192	PF00899	0.405
LIG_WW_3	53	57	PF00397	0.521
MOD_CDC14_SPxK_1	53	56	PF00782	0.523
MOD_CDK_SPxK_1	50	56	PF00069	0.526
MOD_CK1_1	50	56	PF00069	0.704
MOD_CK1_1	78	84	PF00069	0.697
MOD_CK1_1	87	93	PF00069	0.627
MOD_CK2_1	114	120	PF00069	0.617
MOD_CK2_1	121	127	PF00069	0.604
MOD_CK2_1	14	20	PF00069	0.640
MOD_CK2_1	67	73	PF00069	0.554
MOD_CK2_1	95	101	PF00069	0.611
MOD_GlcNHglycan	123	126	PF01048	0.622
MOD_GlcNHglycan	47	50	PF01048	0.654
MOD_GlcNHglycan	91	94	PF01048	0.568
MOD_GSK3_1	34	41	PF00069	0.728
MOD_GSK3_1	74	81	PF00069	0.690
MOD_GSK3_1	83	90	PF00069	0.622
MOD_GSK3_1	96	103	PF00069	0.707
MOD_N-GLC_1	199	204	PF02516	0.405
MOD_N-GLC_1	83	88	PF02516	0.631
MOD_NEK2_1	102	107	PF00069	0.595
MOD_NEK2_1	207	212	PF00069	0.441
MOD_NEK2_1	222	227	PF00069	0.365
MOD_NEK2_1	74	79	PF00069	0.576
MOD_NEK2_2	215	220	PF00069	0.477
MOD_NEK2_2	258	263	PF00069	0.405
MOD_NMyristoyl	1	7	PF02799	0.559
MOD_PIKK_1	177	183	PF00454	0.247
MOD_PIKK_1	245	251	PF00454	0.405
MOD_PKA_1	14	20	PF00069	0.553
MOD_PKA_2	207	213	PF00069	0.405
MOD_PKB_1	12	20	PF00069	0.551
MOD_Plk_1	199	205	PF00069	0.322
MOD_Plk_1	215	221	PF00069	0.322
MOD_Plk_1	87	93	PF00069	0.697
MOD_Plk_2-3	16	22	PF00069	0.556
MOD_Plk_2-3	269	275	PF00069	0.445
MOD_Plk_4	200	206	PF00069	0.368
MOD_Plk_4	275	281	PF00069	0.467
MOD_ProDKin_1	155	161	PF00069	0.607
MOD_ProDKin_1	38	44	PF00069	0.768
MOD_ProDKin_1	47	53	PF00069	0.686
MOD_SPalmitoyl_4	1	7	PF01529	0.559
TRG_DiLeu_BaEn_2	246	252	PF01217	0.405
TRG_DiLeu_BaEn_2	254	260	PF01217	0.322
TRG_ENDOCYTIC_2	175	178	PF00928	0.405
TRG_ENDOCYTIC_2	256	259	PF00928	0.405
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEW9	Leishmania donovani	48%	100%
A4HYW8	Leishmania infantum	47%	100%
E9AUR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4QCS1	Leishmania major	47%	98%