DUF1935 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIH7_LEIBR

TriTrypDb:

LbrM.20.5440 , LBRM2903_200069300

Length:

146

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Plasminogen binding proteins in secreted membrane vesicles of Leishmania mexicana
Publication 1st author(s): Figuera
Publication Identifier(s): 23178693
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: E9AUS1
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 15

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 52
NetGPI	no	yes: 0, no: 52

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0097542	ciliary tip	2	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	1
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2

Expansion

Sequence features

E9AIH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIH7

PDB structure(s): 1r75_A , 2fe0_A

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0009987	cellular process	1	2
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044000	movement in host	4	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044409	entry into host	5	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0044782	cilium organization	5	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.531
CLV_PCSK_KEX2_1	136	138	PF00082	0.534
CLV_PCSK_SKI1_1	30	34	PF00082	0.458
CLV_PCSK_SKI1_1	63	67	PF00082	0.482
DOC_CYCLIN_RxL_1	60	70	PF00134	0.464
DOC_PP2B_LxvP_1	138	141	PF13499	0.574
DOC_USP7_MATH_1	89	93	PF00917	0.221
LIG_BRCT_BRCA1_1	142	146	PF00533	0.474
LIG_deltaCOP1_diTrp_1	46	51	PF00928	0.437
LIG_FHA_1	5	11	PF00498	0.604
LIG_FHA_2	79	85	PF00498	0.342
LIG_LIR_Nem_3	31	37	PF02991	0.372
LIG_LIR_Nem_3	46	52	PF02991	0.425
LIG_SH2_CRK	21	25	PF00017	0.645
LIG_SH2_GRB2like	21	24	PF00017	0.625
LIG_SH2_STAP1	109	113	PF00017	0.407
LIG_SH2_STAP1	58	62	PF00017	0.331
LIG_SH2_STAT3	122	125	PF00017	0.485
LIG_SH2_STAT5	122	125	PF00017	0.485
LIG_SH2_STAT5	21	24	PF00017	0.573
LIG_SH2_STAT5	64	67	PF00017	0.371
LIG_TYR_ITIM	37	42	PF00017	0.344
MOD_CK1_1	6	12	PF00069	0.652
MOD_CK2_1	108	114	PF00069	0.423
MOD_N-GLC_1	4	9	PF02516	0.787
MOD_N-GLC_1	52	57	PF02516	0.388
MOD_NEK2_1	75	80	PF00069	0.353
MOD_NEK2_2	89	94	PF00069	0.304
MOD_NMyristoyl	1	7	PF02799	0.618
MOD_Plk_1	89	95	PF00069	0.267
MOD_Plk_4	89	95	PF00069	0.353
MOD_SUMO_rev_2	107	113	PF00179	0.388
MOD_SUMO_rev_2	92	101	PF00179	0.434
TRG_DiLeu_BaEn_2	96	102	PF01217	0.370
TRG_ENDOCYTIC_2	135	138	PF00928	0.505
TRG_ENDOCYTIC_2	39	42	PF00928	0.348
TRG_ER_diArg_1	135	137	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y3	Leptomonas seymouri	39%	100%
A0A0N0P7C3	Leptomonas seymouri	73%	100%
A0A0N1HYV4	Leptomonas seymouri	33%	100%
A0A0N1I5S6	Leptomonas seymouri	41%	95%
A0A0N1I8U4	Leptomonas seymouri	35%	100%
A0A0N1P9P7	Leptomonas seymouri	38%	75%
A0A0N1PE11	Leptomonas seymouri	35%	100%
A0A1X0NW95	Trypanosomatidae	38%	100%
A0A1X0NWH2	Trypanosomatidae	58%	100%
A0A1X0NWV3	Trypanosomatidae	39%	98%
A0A1X0NXS9	Trypanosomatidae	28%	100%
A0A1X0NXT9	Trypanosomatidae	39%	100%
A0A3Q8I9V9	Leishmania donovani	32%	100%
A0A3Q8IBM6	Leishmania donovani	35%	100%
A0A3Q8IBP3	Leishmania donovani	84%	100%
A0A3Q8IKN9	Leishmania donovani	43%	100%
A0A3R7MWC6	Trypanosoma rangeli	37%	100%
A0A3S7WW23	Leishmania donovani	36%	100%
A0A3S7WZ86	Leishmania donovani	36%	100%
A0A422MSY8	Trypanosoma rangeli	39%	87%
A0A422MSZ3	Trypanosoma rangeli	36%	100%
A0A422N035	Trypanosoma rangeli	50%	100%
A0A422N058	Trypanosoma rangeli	31%	95%
A4H7N9	Leishmania braziliensis	33%	100%
A4H7P0	Leishmania braziliensis	33%	100%
A4HW29	Leishmania infantum	32%	100%
A4HYW5	Leishmania infantum	83%	100%
A4HYW6	Leishmania infantum	35%	100%
A4HYX3	Leishmania infantum	36%	100%
A4HYX4	Leishmania infantum	36%	100%
A4I1M3	Leishmania infantum	36%	100%
C9ZIF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZIF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZIF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AIH8	Leishmania braziliensis	40%	100%
E9AII3	Leishmania braziliensis	36%	100%
E9AII5	Leishmania braziliensis	36%	100%
E9AII6	Leishmania braziliensis	41%	100%
E9APT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AUR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AUR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AUS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AUS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AXQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
P84150	Leishmania major	36%	100%
Q4Q9R4	Leishmania major	36%	100%
Q4QCS4	Leishmania major	81%	100%
Q4QFP8	Leishmania major	32%	100%
Q5SDH3	Leishmania major	37%	100%
Q5SDH4	Leishmania major	36%	100%
Q5SDH5	Leishmania major	42%	100%