LeishMANIAdb
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DUF1935 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DUF1935 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
E9AIH7_LEIBR
TriTrypDb:
LbrM.20.5440 , LBRM2903_200069300
Length:
146

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Plasminogen binding proteins in secreted membrane vesicles of Leishmania mexicana
Publication 1st author(s): Figuera
Publication Identifier(s): 23178693
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: E9AUS1
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 2
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 1
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 15
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 24
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 52
NetGPI no yes: 0, no: 52
Cellular components
TermNameLevelCount
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 2
GO:0020018 ciliary pocket membrane 6 1
GO:0031090 organelle membrane 3 2
GO:0031253 cell projection membrane 4 2
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
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Expansion

Sequence features

E9AIH7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIH7

PDB structure(s): 1r75_A , 2fe0_A

Function

Biological processes
TermNameLevelCount
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0044000 movement in host 4 1
GO:0044403 biological process involved in symbiotic interaction 2 1
GO:0044409 entry into host 5 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 136 138 PF00675 0.531
CLV_PCSK_KEX2_1 136 138 PF00082 0.534
CLV_PCSK_SKI1_1 30 34 PF00082 0.458
CLV_PCSK_SKI1_1 63 67 PF00082 0.482
DOC_CYCLIN_RxL_1 60 70 PF00134 0.464
DOC_PP2B_LxvP_1 138 141 PF13499 0.574
DOC_USP7_MATH_1 89 93 PF00917 0.221
LIG_BRCT_BRCA1_1 142 146 PF00533 0.474
LIG_deltaCOP1_diTrp_1 46 51 PF00928 0.437
LIG_FHA_1 5 11 PF00498 0.604
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P6Y3 Leptomonas seymouri 39% 100%
A0A0N0P7C3 Leptomonas seymouri 73% 100%
A0A0N1HYV4 Leptomonas seymouri 33% 100%
A0A0N1I5S6 Leptomonas seymouri 41% 95%
A0A0N1I8U4 Leptomonas seymouri 35% 100%
A0A0N1P9P7 Leptomonas seymouri 38% 75%
A0A0N1PE11 Leptomonas seymouri 35% 100%
A0A1X0NW95 Trypanosomatidae 38% 100%
A0A1X0NWH2 Trypanosomatidae 58% 100%
A0A1X0NWV3 Trypanosomatidae 39% 98%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS