Putative calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C2, putative

Species:

Leishmania braziliensis

UniProt:

E9AIH2_LEIBR

TriTrypDb:

LbrM.20.5390 , LBRM2903_200068600

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIH2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	59	61	PF00675	0.374
CLV_PCSK_KEX2_1	159	161	PF00082	0.294
CLV_PCSK_KEX2_1	189	191	PF00082	0.388
CLV_PCSK_KEX2_1	59	61	PF00082	0.407
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.294
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.388
DOC_ANK_TNKS_1	189	196	PF00023	0.381
DOC_CYCLIN_yCln2_LP_2	130	136	PF00134	0.407
DOC_USP7_UBL2_3	4	8	PF12436	0.346
DOC_WW_Pin1_4	43	48	PF00397	0.293
LIG_14-3-3_CanoR_1	96	105	PF00244	0.370
LIG_BIR_II_1	1	5	PF00653	0.360
LIG_BRCT_BRCA1_1	154	158	PF00533	0.301
LIG_Clathr_ClatBox_1	178	182	PF01394	0.350
LIG_deltaCOP1_diTrp_1	100	104	PF00928	0.576
LIG_FHA_1	30	36	PF00498	0.313
LIG_FHA_1	49	55	PF00498	0.482
LIG_LIR_Gen_1	99	110	PF02991	0.595
LIG_LIR_Nem_3	155	161	PF02991	0.412
LIG_LIR_Nem_3	169	174	PF02991	0.572
LIG_LIR_Nem_3	2	6	PF02991	0.521
LIG_LIR_Nem_3	46	52	PF02991	0.286
LIG_LIR_Nem_3	66	71	PF02991	0.598
LIG_LIR_Nem_3	82	87	PF02991	0.320
LIG_LIR_Nem_3	99	105	PF02991	0.373
LIG_PDZ_Class_3	201	206	PF00595	0.350
LIG_SH2_CRK	68	72	PF00017	0.365
LIG_SH2_CRK	84	88	PF00017	0.518
LIG_SH2_GRB2like	9	12	PF00017	0.376
LIG_SH2_PTP2	121	124	PF00017	0.303
LIG_SH2_STAP1	23	27	PF00017	0.282
LIG_SH2_STAT5	121	124	PF00017	0.504
LIG_SH2_STAT5	139	142	PF00017	0.302
LIG_SH2_STAT5	9	12	PF00017	0.617
LIG_SH3_3	130	136	PF00018	0.401
LIG_SH3_3	178	184	PF00018	0.514
LIG_SH3_3	41	47	PF00018	0.489
LIG_SH3_5	21	25	PF00018	0.290
LIG_SUMO_SIM_anti_2	109	114	PF11976	0.285
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.405
LIG_SUMO_SIM_par_1	37	43	PF11976	0.276
LIG_SUMO_SIM_par_1	69	74	PF11976	0.478
LIG_UBA3_1	112	120	PF00899	0.294
MOD_CK2_1	71	77	PF00069	0.278
MOD_GlcNHglycan	36	39	PF01048	0.274
MOD_GlcNHglycan	90	93	PF01048	0.364
MOD_GSK3_1	48	55	PF00069	0.521
MOD_GSK3_1	96	103	PF00069	0.498
MOD_N-GLC_1	63	68	PF02516	0.380
MOD_N-GLC_1	88	93	PF02516	0.561
MOD_NEK2_1	88	93	PF00069	0.334
MOD_PIKK_1	196	202	PF00454	0.372
MOD_PIKK_1	52	58	PF00454	0.341
MOD_PKA_2	95	101	PF00069	0.382
MOD_Plk_1	108	114	PF00069	0.290
MOD_Plk_1	152	158	PF00069	0.315
MOD_Plk_4	152	158	PF00069	0.354
MOD_ProDKin_1	43	49	PF00069	0.297
MOD_SUMO_for_1	172	175	PF00179	0.339
MOD_SUMO_rev_2	66	71	PF00179	0.328
TRG_ENDOCYTIC_2	121	124	PF00928	0.502
TRG_ENDOCYTIC_2	68	71	PF00928	0.588
TRG_ENDOCYTIC_2	84	87	PF00928	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E8NHK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	74%