Triosephosphate isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

triosephosphate isomerase

Species:

Leishmania braziliensis

UniProt:

E9AIG9_LEIBR

TriTrypDb:

LbrM.20.5360 , LBRM2903_240014600

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

E9AIG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIG9

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0005996	monosaccharide metabolic process	3	12
GO:0006006	glucose metabolic process	5	12
GO:0006066	alcohol metabolic process	3	1
GO:0006071	glycerol metabolic process	5	1
GO:0006081	cellular aldehyde metabolic process	3	1
GO:0006082	organic acid metabolic process	3	12
GO:0006090	pyruvate metabolic process	7	12
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006094	gluconeogenesis	6	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004807	triose-phosphate isomerase activity	5	12
GO:0016853	isomerase activity	2	12
GO:0016860	intramolecular oxidoreductase activity	3	12
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.492
CLV_NRD_NRD_1	191	193	PF00675	0.316
CLV_NRD_NRD_1	99	101	PF00675	0.246
CLV_PCSK_KEX2_1	99	101	PF00082	0.246
CLV_PCSK_SKI1_1	142	146	PF00082	0.336
CLV_PCSK_SKI1_1	177	181	PF00082	0.246
DOC_CKS1_1	178	183	PF01111	0.446
DOC_MAPK_gen_1	157	165	PF00069	0.391
DOC_USP7_UBL2_3	154	158	PF12436	0.430
DOC_WW_Pin1_4	177	182	PF00397	0.446

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX95	Leptomonas seymouri	81%	100%
A0A0S4J0S4	Bodo saltans	67%	100%
A0A1L5YRA2	Scylla paramamosain	46%	100%
A0A1X0NVW6	Trypanosomatidae	67%	97%
A0A3Q8IMM9	Leishmania donovani	91%	100%
A0A422NHP8	Trypanosoma rangeli	69%	100%
A0KTZ2	Shewanella sp. (strain ANA-3)	41%	97%
A0L8V0	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	47%	98%
A0PYP2	Clostridium novyi (strain NT)	42%	100%
A0Q8C4	Francisella tularensis subsp. novicida (strain U112)	38%	99%

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