Putative calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C2, putative

Species:

Leishmania braziliensis

UniProt:

E9AIG7_LEIBR

TriTrypDb:

LbrM.20.5340 , LBRM2903_200068500

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIG7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	320	322	PF00675	0.749
CLV_PCSK_KEX2_1	320	322	PF00082	0.749
CLV_PCSK_SKI1_1	196	200	PF00082	0.745
CLV_PCSK_SKI1_1	321	325	PF00082	0.729
DEG_APCC_DBOX_1	319	327	PF00400	0.745
DEG_Nend_UBRbox_1	1	4	PF02207	0.825
DEG_SCF_FBW7_1	299	306	PF00400	0.822
DEG_SIAH_1	186	194	PF03145	0.761
DOC_CKS1_1	300	305	PF01111	0.823
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.782
DOC_MAPK_gen_1	2	12	PF00069	0.808
DOC_MAPK_gen_1	317	326	PF00069	0.752
DOC_MAPK_MEF2A_6	5	14	PF00069	0.794
DOC_MAPK_NFAT4_5	9	17	PF00069	0.788
DOC_PP1_RVXF_1	323	329	PF00149	0.752
DOC_PP4_FxxP_1	258	261	PF00568	0.549
DOC_USP7_MATH_1	126	130	PF00917	0.845
DOC_USP7_MATH_1	136	140	PF00917	0.659
DOC_USP7_MATH_1	319	323	PF00917	0.750
DOC_USP7_MATH_1	70	74	PF00917	0.857
DOC_USP7_MATH_1	95	99	PF00917	0.828
DOC_USP7_UBL2_3	5	9	PF12436	0.806
DOC_WW_Pin1_4	15	20	PF00397	0.784
DOC_WW_Pin1_4	299	304	PF00397	0.814
DOC_WW_Pin1_4	315	320	PF00397	0.509
LIG_14-3-3_CanoR_1	196	202	PF00244	0.727
LIG_14-3-3_CanoR_1	297	303	PF00244	0.803
LIG_14-3-3_CanoR_1	320	324	PF00244	0.733
LIG_14-3-3_CterR_2	338	341	PF00244	0.821
LIG_Actin_WH2_2	309	327	PF00022	0.780
LIG_BRCT_BRCA1_1	53	57	PF00533	0.855
LIG_BRCT_BRCA1_1	72	76	PF00533	0.524
LIG_FHA_1	193	199	PF00498	0.758
LIG_FHA_1	300	306	PF00498	0.826
LIG_FHA_2	38	44	PF00498	0.855
LIG_FHA_2	73	79	PF00498	0.850
LIG_LIR_Apic_2	162	168	PF02991	0.797
LIG_LIR_Apic_2	256	261	PF02991	0.549
LIG_LIR_Nem_3	274	278	PF02991	0.549
LIG_SH2_CRK	165	169	PF00017	0.793
LIG_SH2_CRK	7	11	PF00017	0.806
LIG_SH2_NCK_1	165	169	PF00017	0.793
LIG_SH2_NCK_1	172	176	PF00017	0.662
LIG_SH2_SRC	172	175	PF00017	0.789
LIG_SH2_SRC	179	182	PF00017	0.683
LIG_SH2_STAP1	149	153	PF00017	0.813
LIG_SH2_STAP1	172	176	PF00017	0.784
LIG_SH2_STAT5	134	137	PF00017	0.837
LIG_SH2_STAT5	157	160	PF00017	0.814
LIG_SH2_STAT5	179	182	PF00017	0.806
LIG_SH2_STAT5	315	318	PF00017	0.794
LIG_SH3_3	79	85	PF00018	0.813
LIG_TRAF2_1	113	116	PF00917	0.839
LIG_TRAF2_1	148	151	PF00917	0.825
LIG_TRAF2_1	171	174	PF00917	0.791
LIG_TRAF2_1	58	61	PF00917	0.837
LIG_TRAF2_1	77	80	PF00917	0.505
LIG_TYR_ITIM	263	268	PF00017	0.549
LIG_UBA3_1	263	272	PF00899	0.549
LIG_WW_1	131	134	PF00397	0.841
MOD_CDC14_SPxK_1	318	321	PF00782	0.764
MOD_CDK_SPK_2	315	320	PF00069	0.790
MOD_CDK_SPxK_1	315	321	PF00069	0.781
MOD_CK1_1	18	24	PF00069	0.788
MOD_CK1_1	293	299	PF00069	0.783
MOD_CK1_1	301	307	PF00069	0.688
MOD_CK2_1	212	218	PF00069	0.752
MOD_GlcNHglycan	187	190	PF01048	0.767
MOD_GlcNHglycan	333	336	PF01048	0.791
MOD_GlcNHglycan	53	56	PF01048	0.852
MOD_GSK3_1	234	241	PF00069	0.800
MOD_GSK3_1	26	33	PF00069	0.832
MOD_GSK3_1	299	306	PF00069	0.822
MOD_GSK3_1	315	322	PF00069	0.495
MOD_GSK3_1	327	334	PF00069	0.579
MOD_N-GLC_1	278	283	PF02516	0.549
MOD_N-GLC_2	23	25	PF02516	0.804
MOD_NEK2_1	10	15	PF00069	0.787
MOD_NEK2_1	219	224	PF00069	0.737
MOD_NEK2_1	31	36	PF00069	0.845
MOD_OFUCOSY	250	257	PF10250	0.549
MOD_PIKK_1	103	109	PF00454	0.849
MOD_PIKK_1	38	44	PF00454	0.855
MOD_PKA_1	271	277	PF00069	0.549
MOD_PKA_2	290	296	PF00069	0.773
MOD_PKA_2	319	325	PF00069	0.744
MOD_PKB_1	329	337	PF00069	0.794
MOD_Plk_1	238	244	PF00069	0.764
MOD_Plk_1	278	284	PF00069	0.549
MOD_Plk_1	70	76	PF00069	0.858
MOD_Plk_1	95	101	PF00069	0.828
MOD_Plk_2-3	234	240	PF00069	0.808
MOD_Plk_4	238	244	PF00069	0.764
MOD_ProDKin_1	15	21	PF00069	0.784
MOD_ProDKin_1	299	305	PF00069	0.819
MOD_ProDKin_1	315	321	PF00069	0.501
TRG_ENDOCYTIC_2	172	175	PF00928	0.789
TRG_ENDOCYTIC_2	265	268	PF00928	0.549
TRG_ENDOCYTIC_2	7	10	PF00928	0.805
TRG_ER_diArg_1	193	196	PF00400	0.768
TRG_ER_diArg_1	285	288	PF00400	0.728
TRG_ER_diArg_1	319	321	PF00400	0.763
TRG_ER_diArg_1	328	331	PF00400	0.635
TRG_NLS_MonoCore_2	1	6	PF00514	0.817
TRG_NLS_MonoExtN_4	2	7	PF00514	0.813
TRG_NLS_MonoExtN_4	270	275	PF00514	0.549