DUF3523 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIG5_LEIBR

TriTrypDb:

LbrM.20.5320 , LBRM2903_200067900

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AIG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	278	280	PF00675	0.408
CLV_PCSK_SKI1_1	123	127	PF00082	0.697
DEG_Nend_UBRbox_3	1	3	PF02207	0.499
DOC_CKS1_1	170	175	PF01111	0.421
DOC_MAPK_MEF2A_6	227	234	PF00069	0.322
DOC_PP1_RVXF_1	225	232	PF00149	0.286
DOC_PP4_FxxP_1	195	198	PF00568	0.520
DOC_PP4_FxxP_1	247	250	PF00568	0.376
DOC_USP7_MATH_1	134	138	PF00917	0.334
DOC_USP7_MATH_1	39	43	PF00917	0.309
DOC_WW_Pin1_4	169	174	PF00397	0.392
DOC_WW_Pin1_4	87	92	PF00397	0.430
LIG_14-3-3_CanoR_1	68	74	PF00244	0.712
LIG_Actin_WH2_2	100	117	PF00022	0.470
LIG_FHA_1	172	178	PF00498	0.390
LIG_FHA_1	236	242	PF00498	0.249
LIG_FHA_1	51	57	PF00498	0.377
LIG_FHA_1	68	74	PF00498	0.618
LIG_FHA_2	122	128	PF00498	0.402
LIG_LIR_Apic_2	246	250	PF02991	0.436
LIG_LIR_Gen_1	213	220	PF02991	0.413
LIG_LIR_Nem_3	160	166	PF02991	0.430
LIG_LIR_Nem_3	213	218	PF02991	0.488
LIG_LIR_Nem_3	255	259	PF02991	0.592
LIG_LYPXL_yS_3	163	166	PF13949	0.432
LIG_PCNA_PIPBox_1	204	213	PF02747	0.501
LIG_Pex14_2	210	214	PF04695	0.376
LIG_REV1ctd_RIR_1	192	197	PF16727	0.359
LIG_SH2_CRK	122	126	PF00017	0.432
LIG_SH2_STAP1	215	219	PF00017	0.430
LIG_SH2_STAT5	31	34	PF00017	0.367
LIG_SH2_STAT5	37	40	PF00017	0.354
LIG_SH3_3	167	173	PF00018	0.272
LIG_SUMO_SIM_anti_2	135	140	PF11976	0.496
LIG_SUMO_SIM_anti_2	238	243	PF11976	0.249
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.700
LIG_WRC_WIRS_1	211	216	PF05994	0.345
LIG_WRC_WIRS_1	244	249	PF05994	0.417
MOD_CK1_1	80	86	PF00069	0.705
MOD_CK1_1	92	98	PF00069	0.303
MOD_CK2_1	121	127	PF00069	0.394
MOD_CK2_1	210	216	PF00069	0.355
MOD_CK2_1	218	224	PF00069	0.384
MOD_CMANNOS	228	231	PF00535	0.610
MOD_GlcNHglycan	220	223	PF01048	0.561
MOD_GlcNHglycan	41	44	PF01048	0.431
MOD_GlcNHglycan	47	50	PF01048	0.319
MOD_GlcNHglycan	60	63	PF01048	0.486
MOD_GlcNHglycan	79	82	PF01048	0.486
MOD_GSK3_1	121	128	PF00069	0.431
MOD_GSK3_1	153	160	PF00069	0.510
MOD_GSK3_1	69	76	PF00069	0.608
MOD_N-GLC_1	128	133	PF02516	0.715
MOD_N-GLC_1	235	240	PF02516	0.249
MOD_NEK2_1	218	223	PF00069	0.481
MOD_NEK2_1	27	32	PF00069	0.366
MOD_NEK2_1	58	63	PF00069	0.417
MOD_NEK2_1	64	69	PF00069	0.627
MOD_NEK2_1	77	82	PF00069	0.467
MOD_PIKK_1	15	21	PF00454	0.511
MOD_PKA_2	67	73	PF00069	0.700
MOD_Plk_1	128	134	PF00069	0.483
MOD_Plk_1	235	241	PF00069	0.249
MOD_Plk_4	134	140	PF00069	0.501
MOD_Plk_4	210	216	PF00069	0.286
MOD_Plk_4	230	236	PF00069	0.359
MOD_Plk_4	27	33	PF00069	0.394
MOD_Plk_4	80	86	PF00069	0.617
MOD_Plk_4	89	95	PF00069	0.362
MOD_ProDKin_1	169	175	PF00069	0.389
MOD_ProDKin_1	87	93	PF00069	0.430
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.330
TRG_ENDOCYTIC_2	122	125	PF00928	0.428
TRG_ENDOCYTIC_2	163	166	PF00928	0.430
TRG_ENDOCYTIC_2	182	185	PF00928	0.212
TRG_ENDOCYTIC_2	191	194	PF00928	0.376
TRG_ENDOCYTIC_2	215	218	PF00928	0.376
TRG_ENDOCYTIC_2	256	259	PF00928	0.591
TRG_ER_diArg_1	10	13	PF00400	0.526
TRG_ER_diLys_1	295	299	PF00400	0.757
TRG_NLS_Bipartite_1	279	298	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W3	Leptomonas seymouri	53%	100%
A0A1X0NW94	Trypanosomatidae	23%	100%
A0A3Q8IAV6	Leishmania donovani	77%	100%
A4HYV8	Leishmania infantum	78%	100%
E9AUQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QCT0	Leishmania major	77%	100%