Pre-mRNA-splicing factor 38

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pre-mRNA-splicing factor 38, putative

Species:

Leishmania braziliensis

UniProt:

E9AIG4_LEIBR

TriTrypDb:

LbrM.20.5310 , LBRM2903_200067800

Length:

268

Annotations

LeishMANIAdb annotations

A conserved eukaryotic pre-mRNA-splicing factor 38 protein. Non-TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0071011	precatalytic spliceosome	4	7
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

E9AIG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIG4

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.346
CLV_PCSK_KEX2_1	166	168	PF00082	0.523
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.541
CLV_PCSK_SKI1_1	202	206	PF00082	0.372
CLV_PCSK_SKI1_1	34	38	PF00082	0.546
CLV_PCSK_SKI1_1	80	84	PF00082	0.346
CLV_Separin_Metazoa	199	203	PF03568	0.566
DEG_APCC_DBOX_1	201	209	PF00400	0.537
DEG_SCF_FBW7_1	242	249	PF00400	0.650
DOC_CKS1_1	234	239	PF01111	0.694
DOC_CKS1_1	243	248	PF01111	0.683
DOC_CYCLIN_RxL_1	196	209	PF00134	0.544
DOC_CYCLIN_RxL_1	30	41	PF00134	0.346
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.647
DOC_CYCLIN_yCln2_LP_2	261	267	PF00134	0.660
DOC_MAPK_gen_1	89	99	PF00069	0.522
DOC_MAPK_MEF2A_6	30	39	PF00069	0.343
DOC_MAPK_MEF2A_6	58	67	PF00069	0.238
DOC_MAPK_MEF2A_6	92	101	PF00069	0.546
DOC_PP1_RVXF_1	32	39	PF00149	0.346
DOC_PP2B_LxvP_1	14	17	PF13499	0.419
DOC_PP4_FxxP_1	216	219	PF00568	0.522
DOC_USP7_MATH_1	185	189	PF00917	0.626
DOC_USP7_MATH_1	224	228	PF00917	0.776
DOC_USP7_MATH_1	241	245	PF00917	0.761
DOC_USP7_MATH_1	246	250	PF00917	0.740
DOC_WW_Pin1_4	233	238	PF00397	0.756
DOC_WW_Pin1_4	242	247	PF00397	0.741
LIG_14-3-3_CanoR_1	153	162	PF00244	0.802
LIG_BIR_II_1	1	5	PF00653	0.406
LIG_BRCT_BRCA1_1	186	190	PF00533	0.629
LIG_Clathr_ClatBox_1	205	209	PF01394	0.578
LIG_FHA_1	210	216	PF00498	0.586
LIG_FHA_1	51	57	PF00498	0.288
LIG_LIR_Apic_2	163	168	PF02991	0.622
LIG_LIR_Apic_2	213	219	PF02991	0.505
LIG_LIR_Nem_3	117	122	PF02991	0.546
LIG_LIR_Nem_3	149	155	PF02991	0.646
LIG_LIR_Nem_3	209	214	PF02991	0.559
LIG_LIR_Nem_3	257	261	PF02991	0.605
LIG_PDZ_Class_2	263	268	PF00595	0.627
LIG_SH2_CRK	119	123	PF00017	0.546
LIG_SH2_CRK	165	169	PF00017	0.630
LIG_SH2_STAT5	203	206	PF00017	0.640
LIG_SH2_STAT5	214	217	PF00017	0.584
LIG_SH2_STAT5	262	265	PF00017	0.507
LIG_SH2_STAT5	61	64	PF00017	0.353
LIG_SH2_STAT5	90	93	PF00017	0.546
LIG_SH3_3	195	201	PF00018	0.696
LIG_SH3_3	234	240	PF00018	0.756
LIG_TRAF2_1	129	132	PF00917	0.639
LIG_UBA3_1	159	166	PF00899	0.727
LIG_WW_1	200	203	PF00397	0.669
LIG_WW_3	199	203	PF00397	0.587
MOD_CK1_1	176	182	PF00069	0.726
MOD_CK1_1	222	228	PF00069	0.797
MOD_CK1_1	249	255	PF00069	0.732
MOD_GlcNHglycan	137	140	PF01048	0.420
MOD_GlcNHglycan	175	178	PF01048	0.561
MOD_GlcNHglycan	181	184	PF01048	0.516
MOD_GSK3_1	133	140	PF00069	0.754
MOD_GSK3_1	151	158	PF00069	0.718
MOD_GSK3_1	22	29	PF00069	0.346
MOD_GSK3_1	220	227	PF00069	0.658
MOD_GSK3_1	242	249	PF00069	0.750
MOD_GSK3_1	41	48	PF00069	0.238
MOD_N-GLC_1	179	184	PF02516	0.425
MOD_NEK2_1	155	160	PF00069	0.730
MOD_NEK2_2	148	153	PF00069	0.622
MOD_PIKK_1	22	28	PF00454	0.238
MOD_PIKK_1	222	228	PF00454	0.815
MOD_Plk_1	41	47	PF00069	0.300
MOD_Plk_4	155	161	PF00069	0.729
MOD_Plk_4	254	260	PF00069	0.693
MOD_ProDKin_1	233	239	PF00069	0.755
MOD_ProDKin_1	242	248	PF00069	0.742
MOD_SUMO_rev_2	127	136	PF00179	0.542
TRG_DiLeu_BaEn_4	41	47	PF01217	0.346
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.346
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.411
TRG_ENDOCYTIC_2	119	122	PF00928	0.546
TRG_ENDOCYTIC_2	203	206	PF00928	0.626
TRG_ER_diArg_1	19	22	PF00400	0.260
TRG_NLS_MonoCore_2	165	170	PF00514	0.652
TRG_NLS_MonoExtC_3	165	171	PF00514	0.739
TRG_Pf-PMV_PEXEL_1	21	26	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I3	Leptomonas seymouri	54%	100%
A0A3S7WW05	Leishmania donovani	79%	100%
A4HYV7	Leishmania infantum	80%	100%
E9AUQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QCT1	Leishmania major	80%	100%