Pre-mRNA-splicing factor 38

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pre-mRNA-splicing factor 38, putative

Species:

Leishmania braziliensis

UniProt:

E9AIG4_LEIBR

TriTrypDb:

LbrM.20.5310 , LBRM2903_200067800

Length:

268

Annotations

LeishMANIAdb annotations

A conserved eukaryotic pre-mRNA-splicing factor 38 protein. Non-TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0071011	precatalytic spliceosome	4	7
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7

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Expansion

Sequence features

E9AIG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIG4

Function

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Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008380	RNA splicing	7	7

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.346
CLV_PCSK_KEX2_1	166	168	PF00082	0.523
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.541
CLV_PCSK_SKI1_1	202	206	PF00082	0.372
CLV_PCSK_SKI1_1	34	38	PF00082	0.546
CLV_PCSK_SKI1_1	80	84	PF00082	0.346
CLV_Separin_Metazoa	199	203	PF03568	0.566
DEG_APCC_DBOX_1	201	209	PF00400	0.537
DEG_SCF_FBW7_1	242	249	PF00400	0.650
DOC_CKS1_1	234	239	PF01111	0.694

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I3	Leptomonas seymouri	54%	100%
A0A3S7WW05	Leishmania donovani	79%	100%
A4HYV7	Leishmania infantum	80%	100%
E9AUQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QCT1	Leishmania major	80%	100%

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