Protein YIF1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein YIF1

Gene product:

protein transport protein YIF1, putative

Species:

Leishmania braziliensis

UniProt:

E9AIG3_LEIBR

TriTrypDb:

LbrM.20.5300 , LBRM2903_200067700

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	11
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0098588	bounding membrane of organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9AIG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIG3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0048193	Golgi vesicle transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	82	84	PF00675	0.236
CLV_NRD_NRD_1	97	99	PF00675	0.246
CLV_PCSK_KEX2_1	82	84	PF00082	0.235
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.240
CLV_PCSK_SKI1_1	243	247	PF00082	0.276
CLV_PCSK_SKI1_1	299	303	PF00082	0.361
DEG_COP1_1	150	158	PF00400	0.351
DEG_Nend_UBRbox_3	1	3	PF02207	0.636
DOC_MAPK_gen_1	82	90	PF00069	0.406
DOC_MAPK_MEF2A_6	243	251	PF00069	0.241
DOC_MAPK_MEF2A_6	82	90	PF00069	0.417
DOC_MAPK_NFAT4_5	83	91	PF00069	0.453
DOC_PP2B_LxvP_1	168	171	PF13499	0.241
DOC_PP2B_LxvP_1	88	91	PF13499	0.510
DOC_PP4_FxxP_1	11	14	PF00568	0.624
DOC_PP4_FxxP_1	124	127	PF00568	0.504
DOC_PP4_FxxP_1	153	156	PF00568	0.453
DOC_PP4_FxxP_1	256	259	PF00568	0.151
DOC_USP7_MATH_1	154	158	PF00917	0.514
DOC_USP7_MATH_1	171	175	PF00917	0.417
DOC_USP7_MATH_1	191	195	PF00917	0.253
DOC_USP7_UBL2_3	95	99	PF12436	0.510
DOC_WW_Pin1_4	123	128	PF00397	0.433
DOC_WW_Pin1_4	133	138	PF00397	0.470
DOC_WW_Pin1_4	187	192	PF00397	0.310
LIG_14-3-3_CanoR_1	299	304	PF00244	0.562
LIG_14-3-3_CterR_2	319	324	PF00244	0.225
LIG_Actin_WH2_2	206	221	PF00022	0.284
LIG_BRCT_BRCA1_1	149	153	PF00533	0.370
LIG_BRCT_BRCA1_1	263	267	PF00533	0.386
LIG_BRCT_BRCA1_1	7	11	PF00533	0.621
LIG_eIF4E_1	80	86	PF01652	0.473
LIG_FHA_1	150	156	PF00498	0.411
LIG_FHA_1	175	181	PF00498	0.268
LIG_FHA_1	190	196	PF00498	0.217
LIG_FHA_1	201	207	PF00498	0.267
LIG_FHA_1	277	283	PF00498	0.423
LIG_FHA_1	4	10	PF00498	0.673
LIG_FHA_1	92	98	PF00498	0.514
LIG_LIR_Apic_2	121	127	PF02991	0.504
LIG_LIR_Apic_2	150	156	PF02991	0.446
LIG_LIR_Apic_2	254	259	PF02991	0.151
LIG_LIR_Apic_2	8	14	PF02991	0.621
LIG_LIR_Gen_1	177	186	PF02991	0.242
LIG_LIR_Gen_1	313	322	PF02991	0.339
LIG_LIR_Nem_3	166	172	PF02991	0.410
LIG_LIR_Nem_3	177	181	PF02991	0.241
LIG_LIR_Nem_3	264	270	PF02991	0.298
LIG_LIR_Nem_3	276	280	PF02991	0.293
LIG_LIR_Nem_3	313	318	PF02991	0.350
LIG_NRBOX	248	254	PF00104	0.222
LIG_REV1ctd_RIR_1	25	32	PF16727	0.627
LIG_REV1ctd_RIR_1	275	285	PF16727	0.300
LIG_REV1ctd_RIR_1	90	99	PF16727	0.398
LIG_SH2_CRK	242	246	PF00017	0.241
LIG_SH2_CRK	263	267	PF00017	0.386
LIG_SH2_CRK	270	274	PF00017	0.386
LIG_SH2_NCK_1	135	139	PF00017	0.554
LIG_SH2_NCK_1	270	274	PF00017	0.164
LIG_SH2_PTP2	169	172	PF00017	0.274
LIG_SH2_PTP2	178	181	PF00017	0.195
LIG_SH2_PTP2	244	247	PF00017	0.275
LIG_SH2_SRC	270	273	PF00017	0.164
LIG_SH2_STAP1	223	227	PF00017	0.448
LIG_SH2_STAP1	263	267	PF00017	0.365
LIG_SH2_STAP1	270	274	PF00017	0.406
LIG_SH2_STAT5	169	172	PF00017	0.241
LIG_SH2_STAT5	178	181	PF00017	0.241
LIG_SH2_STAT5	184	187	PF00017	0.241
LIG_SH2_STAT5	244	247	PF00017	0.241
LIG_SH2_STAT5	303	306	PF00017	0.302
LIG_SH2_STAT5	73	76	PF00017	0.452
LIG_SH2_STAT5	80	83	PF00017	0.459
LIG_SH2_STAT5	96	99	PF00017	0.514
LIG_SH3_3	153	159	PF00018	0.478
LIG_SH3_3	225	231	PF00018	0.450
LIG_SH3_3	292	298	PF00018	0.390
LIG_SUMO_SIM_anti_2	214	219	PF11976	0.335
LIG_SUMO_SIM_par_1	84	89	PF11976	0.510
LIG_TYR_ITIM	176	181	PF00017	0.241
LIG_TYR_ITIM	261	266	PF00017	0.248
LIG_TYR_ITIM	268	273	PF00017	0.188
LIG_UBA3_1	236	243	PF00899	0.330
LIG_WW_3	294	298	PF00397	0.390
MOD_CK1_1	128	134	PF00069	0.469
MOD_CK1_1	136	142	PF00069	0.474
MOD_CK1_1	174	180	PF00069	0.386
MOD_CK1_1	190	196	PF00069	0.284
MOD_CK1_1	199	205	PF00069	0.298
MOD_CK1_1	276	282	PF00069	0.403
MOD_GlcNHglycan	109	112	PF01048	0.211
MOD_GlcNHglycan	127	130	PF01048	0.314
MOD_GlcNHglycan	132	135	PF01048	0.139
MOD_GSK3_1	103	110	PF00069	0.506
MOD_GSK3_1	123	130	PF00069	0.377
MOD_GSK3_1	187	194	PF00069	0.313
MOD_GSK3_1	196	203	PF00069	0.264
MOD_GSK3_1	40	47	PF00069	0.543
MOD_NEK2_1	200	205	PF00069	0.253
MOD_NEK2_1	261	266	PF00069	0.368
MOD_NEK2_1	40	45	PF00069	0.489
MOD_PIKK_1	251	257	PF00454	0.306
MOD_PKB_1	297	305	PF00069	0.453
MOD_Plk_1	289	295	PF00069	0.462
MOD_Plk_1	76	82	PF00069	0.510
MOD_Plk_4	139	145	PF00069	0.361
MOD_Plk_4	171	177	PF00069	0.321
MOD_Plk_4	196	202	PF00069	0.279
MOD_Plk_4	262	268	PF00069	0.356
MOD_Plk_4	273	279	PF00069	0.326
MOD_Plk_4	310	316	PF00069	0.394
MOD_Plk_4	44	50	PF00069	0.367
MOD_Plk_4	76	82	PF00069	0.461
MOD_ProDKin_1	123	129	PF00069	0.433
MOD_ProDKin_1	133	139	PF00069	0.470
MOD_ProDKin_1	187	193	PF00069	0.310
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.453
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.398
TRG_ENDOCYTIC_2	169	172	PF00928	0.241
TRG_ENDOCYTIC_2	178	181	PF00928	0.241
TRG_ENDOCYTIC_2	242	245	PF00928	0.241
TRG_ENDOCYTIC_2	263	266	PF00928	0.266
TRG_ENDOCYTIC_2	270	273	PF00928	0.231
TRG_ENDOCYTIC_2	63	66	PF00928	0.422
TRG_ENDOCYTIC_2	73	76	PF00928	0.386
TRG_ER_diArg_1	296	299	PF00400	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEI6	Leptomonas seymouri	58%	100%
A0A0S4KG55	Bodo saltans	35%	100%
A0A1X0NW97	Trypanosomatidae	39%	100%
A0A3Q8IDN8	Leishmania donovani	85%	100%
A0A3R7RL55	Trypanosoma rangeli	36%	100%
A4HYV6	Leishmania infantum	85%	100%
C9ZID7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AUQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O95070	Homo sapiens	27%	100%
Q3T196	Bos taurus	27%	100%
Q4QCT2	Leishmania major	82%	100%
Q5BJH7	Homo sapiens	26%	100%
Q5U3G6	Danio rerio	25%	100%
Q6PC24	Danio rerio	27%	100%
Q91XB7	Mus musculus	29%	100%
V5C052	Trypanosoma cruzi	40%	100%