DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIG2_LEIBR

TriTrypDb:

LbrM.20.5290 , LBRM2903_200067600

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIG2

Function

Biological processes
Term	Name	Level	Count
GO:0006450	regulation of translational fidelity	3	11
GO:0006457	protein folding	2	11
GO:0006458	'de novo' protein folding	3	11
GO:0009987	cellular process	1	11
GO:0051083	'de novo' cotranslational protein folding	4	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0030544	Hsp70 protein binding	4	11
GO:0031072	heat shock protein binding	3	11
GO:0043021	ribonucleoprotein complex binding	3	11
GO:0043022	ribosome binding	4	11
GO:0044877	protein-containing complex binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.265
CLV_C14_Caspase3-7	27	31	PF00656	0.501
CLV_C14_Caspase3-7	89	93	PF00656	0.569
CLV_NRD_NRD_1	122	124	PF00675	0.507
CLV_NRD_NRD_1	162	164	PF00675	0.256
CLV_NRD_NRD_1	315	317	PF00675	0.364
CLV_NRD_NRD_1	325	327	PF00675	0.396
CLV_NRD_NRD_1	354	356	PF00675	0.435
CLV_NRD_NRD_1	359	361	PF00675	0.462
CLV_NRD_NRD_1	411	413	PF00675	0.384
CLV_NRD_NRD_1	442	444	PF00675	0.486
CLV_PCSK_FUR_1	321	325	PF00082	0.399
CLV_PCSK_KEX2_1	161	163	PF00082	0.256
CLV_PCSK_KEX2_1	286	288	PF00082	0.395
CLV_PCSK_KEX2_1	306	308	PF00082	0.254
CLV_PCSK_KEX2_1	323	325	PF00082	0.457
CLV_PCSK_KEX2_1	332	334	PF00082	0.455
CLV_PCSK_KEX2_1	353	355	PF00082	0.469
CLV_PCSK_KEX2_1	361	363	PF00082	0.483
CLV_PCSK_KEX2_1	411	413	PF00082	0.408
CLV_PCSK_KEX2_1	442	444	PF00082	0.503
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.395
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.206
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.464
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.460
CLV_PCSK_PC7_1	321	327	PF00082	0.411
CLV_PCSK_SKI1_1	126	130	PF00082	0.386
CLV_PCSK_SKI1_1	332	336	PF00082	0.507
CLV_PCSK_SKI1_1	340	344	PF00082	0.462
CLV_PCSK_SKI1_1	432	436	PF00082	0.434
CLV_PCSK_SKI1_1	541	545	PF00082	0.498
CLV_PCSK_SKI1_1	613	617	PF00082	0.420
CLV_PCSK_SKI1_1	626	630	PF00082	0.390
CLV_PCSK_SKI1_1	634	638	PF00082	0.364
CLV_Separin_Metazoa	251	255	PF03568	0.454
DEG_Nend_UBRbox_3	1	3	PF02207	0.579
DOC_MAPK_gen_1	123	130	PF00069	0.411
DOC_MAPK_gen_1	306	312	PF00069	0.427
DOC_MAPK_gen_1	338	347	PF00069	0.521
DOC_PP1_RVXF_1	14	21	PF00149	0.686
DOC_USP7_MATH_1	112	116	PF00917	0.459
DOC_USP7_MATH_1	238	242	PF00917	0.388
DOC_USP7_MATH_1	444	448	PF00917	0.577
DOC_USP7_MATH_1	560	564	PF00917	0.538
DOC_USP7_MATH_1	582	586	PF00917	0.685
DOC_USP7_MATH_1	592	596	PF00917	0.604
DOC_USP7_UBL2_3	12	16	PF12436	0.614
DOC_USP7_UBL2_3	125	129	PF12436	0.402
DOC_USP7_UBL2_3	302	306	PF12436	0.445
DOC_USP7_UBL2_3	529	533	PF12436	0.408
DOC_USP7_UBL2_3	619	623	PF12436	0.422
DOC_WW_Pin1_4	33	38	PF00397	0.504
DOC_WW_Pin1_4	397	402	PF00397	0.542
DOC_WW_Pin1_4	580	585	PF00397	0.674
DOC_WW_Pin1_4	588	593	PF00397	0.579
LIG_14-3-3_CanoR_1	117	127	PF00244	0.559
LIG_14-3-3_CanoR_1	196	200	PF00244	0.284
LIG_14-3-3_CanoR_1	445	454	PF00244	0.538
LIG_14-3-3_CanoR_1	550	559	PF00244	0.424
LIG_BIR_III_2	207	211	PF00653	0.493
LIG_BIR_III_2	514	518	PF00653	0.397
LIG_BRCT_BRCA1_1	201	205	PF00533	0.383
LIG_Clathr_ClatBox_1	274	278	PF01394	0.479
LIG_deltaCOP1_diTrp_1	257	265	PF00928	0.324
LIG_FHA_1	27	33	PF00498	0.489
LIG_FHA_1	383	389	PF00498	0.276
LIG_FHA_1	400	406	PF00498	0.451
LIG_FHA_1	564	570	PF00498	0.467
LIG_FHA_1	57	63	PF00498	0.501
LIG_FHA_2	129	135	PF00498	0.300
LIG_FHA_2	165	171	PF00498	0.280
LIG_FHA_2	25	31	PF00498	0.488
LIG_FHA_2	518	524	PF00498	0.521
LIG_FHA_2	633	639	PF00498	0.476
LIG_LIR_Gen_1	138	145	PF02991	0.291
LIG_LIR_Gen_1	217	227	PF02991	0.315
LIG_LIR_Gen_1	247	256	PF02991	0.461
LIG_LIR_Gen_1	267	275	PF02991	0.362
LIG_LIR_Gen_1	540	549	PF02991	0.392
LIG_LIR_Gen_1	622	631	PF02991	0.362
LIG_LIR_Gen_1	638	646	PF02991	0.342
LIG_LIR_Nem_3	138	143	PF02991	0.286
LIG_LIR_Nem_3	177	183	PF02991	0.265
LIG_LIR_Nem_3	217	223	PF02991	0.335
LIG_LIR_Nem_3	247	252	PF02991	0.473
LIG_LIR_Nem_3	257	262	PF02991	0.323
LIG_LIR_Nem_3	264	268	PF02991	0.302
LIG_LIR_Nem_3	45	50	PF02991	0.599
LIG_LIR_Nem_3	540	545	PF02991	0.351
LIG_LIR_Nem_3	622	627	PF02991	0.362
LIG_LIR_Nem_3	638	643	PF02991	0.334
LIG_PCNA_PIPBox_1	213	222	PF02747	0.270
LIG_PCNA_PIPBox_1	384	393	PF02747	0.413
LIG_PCNA_yPIPBox_3	377	391	PF02747	0.421
LIG_Pex14_1	43	47	PF04695	0.601
LIG_Pex14_2	219	223	PF04695	0.322
LIG_Pex14_2	255	259	PF04695	0.302
LIG_PTAP_UEV_1	576	581	PF05743	0.489
LIG_SH2_CRK	47	51	PF00017	0.622
LIG_SH2_SRC	249	252	PF00017	0.490
LIG_SH2_STAP1	249	253	PF00017	0.467
LIG_SH2_STAP1	256	260	PF00017	0.248
LIG_SH3_3	234	240	PF00018	0.465
LIG_SH3_3	407	413	PF00018	0.361
LIG_SH3_3	574	580	PF00018	0.764
LIG_SH3_3	584	590	PF00018	0.591
LIG_Sin3_3	466	473	PF02671	0.484
LIG_SUMO_SIM_par_1	2	7	PF11976	0.628
LIG_SUMO_SIM_par_1	273	280	PF11976	0.467
LIG_SUMO_SIM_par_1	58	64	PF11976	0.534
LIG_TRAF2_1	282	285	PF00917	0.319
LIG_TRAF2_1	348	351	PF00917	0.452
LIG_TRAF2_1	372	375	PF00917	0.420
LIG_TRAF2_1	87	90	PF00917	0.546
LIG_TYR_ITSM	245	252	PF00017	0.486
LIG_WRC_WIRS_1	220	225	PF05994	0.407
MOD_CDK_SPxxK_3	397	404	PF00069	0.553
MOD_CK1_1	241	247	PF00069	0.448
MOD_CK1_1	26	32	PF00069	0.490
MOD_CK1_1	563	569	PF00069	0.571
MOD_CK1_1	585	591	PF00069	0.707
MOD_CK2_1	245	251	PF00069	0.387
MOD_CK2_1	592	598	PF00069	0.603
MOD_CK2_1	632	638	PF00069	0.489
MOD_GlcNHglycan	114	117	PF01048	0.650
MOD_GlcNHglycan	12	15	PF01048	0.652
MOD_GlcNHglycan	573	576	PF01048	0.597
MOD_GlcNHglycan	587	590	PF01048	0.646
MOD_GSK3_1	195	202	PF00069	0.305
MOD_GSK3_1	20	27	PF00069	0.588
MOD_GSK3_1	241	248	PF00069	0.371
MOD_GSK3_1	444	451	PF00069	0.482
MOD_GSK3_1	56	63	PF00069	0.566
MOD_GSK3_1	571	578	PF00069	0.569
MOD_GSK3_1	588	595	PF00069	0.637
MOD_N-GLC_1	173	178	PF02516	0.361
MOD_N-GLC_1	423	428	PF02516	0.535
MOD_N-GLC_1	598	603	PF02516	0.511
MOD_NEK2_1	219	224	PF00069	0.430
MOD_NEK2_1	56	61	PF00069	0.556
MOD_NEK2_1	630	635	PF00069	0.479
MOD_NEK2_1	645	650	PF00069	0.427
MOD_PIKK_1	20	26	PF00454	0.695
MOD_PIKK_1	446	452	PF00454	0.449
MOD_PIKK_1	61	67	PF00454	0.568
MOD_PK_1	232	238	PF00069	0.462
MOD_PKA_1	231	237	PF00069	0.366
MOD_PKA_2	195	201	PF00069	0.287
MOD_PKA_2	444	450	PF00069	0.537
MOD_PKA_2	551	557	PF00069	0.550
MOD_Plk_1	244	250	PF00069	0.302
MOD_Plk_1	266	272	PF00069	0.340
MOD_Plk_1	277	283	PF00069	0.410
MOD_Plk_1	522	528	PF00069	0.434
MOD_Plk_1	598	604	PF00069	0.455
MOD_Plk_2-3	149	155	PF00069	0.275
MOD_Plk_2-3	245	251	PF00069	0.321
MOD_ProDKin_1	33	39	PF00069	0.495
MOD_ProDKin_1	397	403	PF00069	0.550
MOD_ProDKin_1	580	586	PF00069	0.673
MOD_ProDKin_1	588	594	PF00069	0.574
MOD_SUMO_for_1	143	146	PF00179	0.387
MOD_SUMO_rev_2	298	308	PF00179	0.504
MOD_SUMO_rev_2	327	334	PF00179	0.487
MOD_SUMO_rev_2	364	370	PF00179	0.466
TRG_DiLeu_BaEn_2	640	646	PF01217	0.434
TRG_DiLeu_BaEn_4	329	335	PF01217	0.408
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.431
TRG_ENDOCYTIC_2	140	143	PF00928	0.291
TRG_ENDOCYTIC_2	249	252	PF00928	0.471
TRG_ENDOCYTIC_2	47	50	PF00928	0.595
TRG_ER_diArg_1	160	163	PF00400	0.256
TRG_ER_diArg_1	307	310	PF00400	0.543
TRG_ER_diArg_1	320	323	PF00400	0.371
TRG_ER_diArg_1	324	326	PF00400	0.427
TRG_ER_diArg_1	353	355	PF00400	0.409
TRG_ER_diArg_1	359	362	PF00400	0.431
TRG_ER_diArg_1	410	412	PF00400	0.322
TRG_ER_diArg_1	442	445	PF00400	0.583
TRG_ER_diArg_1	549	552	PF00400	0.532
TRG_NES_CRM1_1	177	192	PF08389	0.335
TRG_NLS_MonoCore_2	122	127	PF00514	0.575
TRG_NLS_MonoExtN_4	123	128	PF00514	0.441
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT7	Leptomonas seymouri	73%	100%
A0A0S4KI36	Bodo saltans	48%	100%
A0A1X0NWB2	Trypanosomatidae	50%	97%
A0A3Q8IAL4	Leishmania donovani	86%	100%
A0A422NLR6	Trypanosoma rangeli	57%	100%
A4HYV5	Leishmania infantum	86%	100%
C9ZID5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AUQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q1RMH9	Bos taurus	28%	100%
Q4QCT3	Leishmania major	85%	100%
Q4R8H2	Macaca fascicularis	28%	100%
Q7TQ20	Rattus norvegicus	29%	100%
Q99543	Homo sapiens	28%	100%