Putative glutaredoxin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaredoxin, putative

Species:

Leishmania braziliensis

UniProt:

E9AIF1_LEIBR

TriTrypDb:

LbrM.20.5180 , LBRM2903_200066300

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AIF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIF1

Function

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Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034599	cellular response to oxidative stress	4	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0062197	cellular response to chemical stress	4	1
GO:0070887	cellular response to chemical stimulus	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	1
GO:0003824	catalytic activity	1	12
GO:0015035	protein-disulfide reductase activity	3	12
GO:0015036	disulfide oxidoreductase activity	4	12
GO:0015038	glutathione disulfide oxidoreductase activity	5	1
GO:0016491	oxidoreductase activity	2	12
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	12
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.341
CLV_PCSK_KEX2_1	19	21	PF00082	0.374
CLV_PCSK_SKI1_1	22	26	PF00082	0.319
CLV_PCSK_SKI1_1	38	42	PF00082	0.185
CLV_PCSK_SKI1_1	60	64	PF00082	0.249
DOC_CYCLIN_RxL_1	35	43	PF00134	0.249
DOC_MAPK_gen_1	19	26	PF00069	0.292
DOC_MAPK_gen_1	36	44	PF00069	0.249
DOC_MAPK_gen_1	45	53	PF00069	0.251
DOC_MAPK_MEF2A_6	36	44	PF00069	0.257

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIF5	Leptomonas seymouri	26%	100%
A0A0N1PD78	Leptomonas seymouri	93%	100%
A0A0S4JTJ5	Bodo saltans	37%	86%
A0A0S4JUD4	Bodo saltans	36%	100%
A0A0S4JWT8	Bodo saltans	82%	100%
A0A0S4KNN2	Bodo saltans	81%	100%
A0A1X0NXP8	Trypanosomatidae	85%	100%
A0A3Q8IG95	Leishmania donovani	29%	99%
A0A3S7WVZ7	Leishmania donovani	93%	100%
A0A422NLI8	Trypanosoma rangeli	81%	100%

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