Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIF0_LEIBR

TriTrypDb:

LbrM.20.5170 , LBRM2903_200066200

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.533
CLV_C14_Caspase3-7	327	331	PF00656	0.673
CLV_NRD_NRD_1	211	213	PF00675	0.753
CLV_NRD_NRD_1	216	218	PF00675	0.676
CLV_NRD_NRD_1	271	273	PF00675	0.537
CLV_NRD_NRD_1	312	314	PF00675	0.805
CLV_NRD_NRD_1	43	45	PF00675	0.559
CLV_NRD_NRD_1	485	487	PF00675	0.732
CLV_NRD_NRD_1	488	490	PF00675	0.719
CLV_NRD_NRD_1	591	593	PF00675	0.589
CLV_PCSK_FUR_1	388	392	PF00082	0.730
CLV_PCSK_KEX2_1	203	205	PF00082	0.706
CLV_PCSK_KEX2_1	211	213	PF00082	0.789
CLV_PCSK_KEX2_1	216	218	PF00082	0.742
CLV_PCSK_KEX2_1	271	273	PF00082	0.537
CLV_PCSK_KEX2_1	312	314	PF00082	0.793
CLV_PCSK_KEX2_1	343	345	PF00082	0.569
CLV_PCSK_KEX2_1	390	392	PF00082	0.730
CLV_PCSK_KEX2_1	43	45	PF00082	0.559
CLV_PCSK_KEX2_1	591	593	PF00082	0.589
CLV_PCSK_KEX2_1	75	77	PF00082	0.630
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.613
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.623
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.569
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.730
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.559
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.630
CLV_PCSK_PC7_1	212	218	PF00082	0.702
CLV_PCSK_SKI1_1	111	115	PF00082	0.589
CLV_PCSK_SKI1_1	12	16	PF00082	0.506
CLV_PCSK_SKI1_1	18	22	PF00082	0.504
CLV_PCSK_SKI1_1	216	220	PF00082	0.705
CLV_PCSK_SKI1_1	29	33	PF00082	0.603
CLV_PCSK_SKI1_1	416	420	PF00082	0.670
CLV_PCSK_SKI1_1	432	436	PF00082	0.566
CLV_PCSK_SKI1_1	44	48	PF00082	0.631
DEG_APCC_DBOX_1	271	279	PF00400	0.546
DEG_COP1_1	544	553	PF00400	0.575
DEG_Nend_UBRbox_2	1	3	PF02207	0.593
DEG_SCF_FBW7_2	238	243	PF00400	0.541
DEG_SPOP_SBC_1	183	187	PF00917	0.672
DEG_SPOP_SBC_1	639	643	PF00917	0.714
DOC_CKS1_1	118	123	PF01111	0.531
DOC_CKS1_1	515	520	PF01111	0.613
DOC_CKS1_1	536	541	PF01111	0.598
DOC_MAPK_gen_1	268	278	PF00069	0.621
DOC_MAPK_gen_1	312	321	PF00069	0.694
DOC_MAPK_gen_1	96	106	PF00069	0.349
DOC_MAPK_MEF2A_6	107	114	PF00069	0.499
DOC_PP1_RVXF_1	10	16	PF00149	0.511
DOC_PP1_RVXF_1	109	115	PF00149	0.518
DOC_PP2B_LxvP_1	276	279	PF13499	0.576
DOC_PP2B_PxIxI_1	123	129	PF00149	0.528
DOC_PP4_FxxP_1	235	238	PF00568	0.612
DOC_PP4_FxxP_1	689	692	PF00568	0.529
DOC_USP7_MATH_1	149	153	PF00917	0.650
DOC_USP7_MATH_1	183	187	PF00917	0.674
DOC_USP7_MATH_1	282	286	PF00917	0.571
DOC_USP7_MATH_1	299	303	PF00917	0.513
DOC_USP7_MATH_1	375	379	PF00917	0.809
DOC_USP7_MATH_1	399	403	PF00917	0.677
DOC_USP7_MATH_1	450	454	PF00917	0.561
DOC_USP7_MATH_1	485	489	PF00917	0.582
DOC_USP7_MATH_1	493	497	PF00917	0.636
DOC_USP7_MATH_1	501	505	PF00917	0.547
DOC_USP7_MATH_1	520	524	PF00917	0.585
DOC_USP7_MATH_1	558	562	PF00917	0.587
DOC_USP7_MATH_1	590	594	PF00917	0.585
DOC_USP7_MATH_1	635	639	PF00917	0.709
DOC_USP7_MATH_1	666	670	PF00917	0.699
DOC_USP7_UBL2_3	43	47	PF12436	0.574
DOC_USP7_UBL2_3	435	439	PF12436	0.579
DOC_WD40_RPTOR_TOS_1	707	713	PF00400	0.686
DOC_WW_Pin1_4	117	122	PF00397	0.572
DOC_WW_Pin1_4	134	139	PF00397	0.618
DOC_WW_Pin1_4	236	241	PF00397	0.737
DOC_WW_Pin1_4	242	247	PF00397	0.812
DOC_WW_Pin1_4	423	428	PF00397	0.705
DOC_WW_Pin1_4	477	482	PF00397	0.746
DOC_WW_Pin1_4	514	519	PF00397	0.683
DOC_WW_Pin1_4	535	540	PF00397	0.704
DOC_WW_Pin1_4	549	554	PF00397	0.654
DOC_WW_Pin1_4	562	567	PF00397	0.724
DOC_WW_Pin1_4	571	576	PF00397	0.673
DOC_WW_Pin1_4	623	628	PF00397	0.737
DOC_WW_Pin1_4	647	652	PF00397	0.800
DOC_WW_Pin1_4	654	659	PF00397	0.705
DOC_WW_Pin1_4	688	693	PF00397	0.684
LIG_14-3-3_CanoR_1	18	28	PF00244	0.643
LIG_14-3-3_CanoR_1	258	264	PF00244	0.678
LIG_14-3-3_CanoR_1	283	289	PF00244	0.547
LIG_14-3-3_CanoR_1	312	321	PF00244	0.730
LIG_14-3-3_CanoR_1	564	570	PF00244	0.734
LIG_14-3-3_CanoR_1	591	598	PF00244	0.622
LIG_14-3-3_CanoR_1	637	647	PF00244	0.691
LIG_14-3-3_CanoR_1	81	89	PF00244	0.525
LIG_BIR_III_2	461	465	PF00653	0.548
LIG_BIR_III_4	505	509	PF00653	0.555
LIG_BRCT_BRCA1_1	62	66	PF00533	0.532
LIG_BRCT_BRCA1_1	668	672	PF00533	0.579
LIG_CSL_BTD_1	408	411	PF09270	0.566
LIG_FHA_1	20	26	PF00498	0.439
LIG_FHA_1	258	264	PF00498	0.662
LIG_FHA_1	314	320	PF00498	0.634
LIG_FHA_1	507	513	PF00498	0.692
LIG_FHA_1	544	550	PF00498	0.810
LIG_FHA_1	572	578	PF00498	0.733
LIG_FHA_1	639	645	PF00498	0.711
LIG_FHA_2	396	402	PF00498	0.721
LIG_FHA_2	469	475	PF00498	0.725
LIG_FHA_2	571	577	PF00498	0.598
LIG_FHA_2	700	706	PF00498	0.679
LIG_LIR_Apic_2	233	238	PF02991	0.597
LIG_NRBOX	27	33	PF00104	0.514
LIG_PTB_Apo_2	229	236	PF02174	0.535
LIG_RPA_C_Fungi	587	599	PF08784	0.579
LIG_SH2_GRB2like	579	582	PF00017	0.749
LIG_SH2_STAT5	38	41	PF00017	0.470
LIG_SH2_STAT5	723	726	PF00017	0.679
LIG_SH2_STAT5	94	97	PF00017	0.562
LIG_SH3_2	481	486	PF14604	0.657
LIG_SH3_3	115	121	PF00018	0.619
LIG_SH3_3	133	139	PF00018	0.496
LIG_SH3_3	401	407	PF00018	0.717
LIG_SH3_3	478	484	PF00018	0.749
LIG_SH3_3	513	519	PF00018	0.811
LIG_SH3_3	547	553	PF00018	0.673
LIG_SH3_3	599	605	PF00018	0.589
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.543
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.569
LIG_TRAF2_1	220	223	PF00917	0.667
LIG_TRAF2_1	246	249	PF00917	0.749
LIG_TRAF2_1	251	254	PF00917	0.693
LIG_TRAF2_1	295	298	PF00917	0.776
LIG_TRAF2_1	398	401	PF00917	0.564
MOD_CDK_SPxK_1	535	541	PF00069	0.563
MOD_CDK_SPxxK_3	623	630	PF00069	0.667
MOD_CK1_1	168	174	PF00069	0.549
MOD_CK1_1	199	205	PF00069	0.585
MOD_CK1_1	257	263	PF00069	0.566
MOD_CK1_1	338	344	PF00069	0.667
MOD_CK1_1	379	385	PF00069	0.650
MOD_CK1_1	417	423	PF00069	0.700
MOD_CK1_1	468	474	PF00069	0.671
MOD_CK1_1	477	483	PF00069	0.630
MOD_CK1_1	488	494	PF00069	0.583
MOD_CK1_1	496	502	PF00069	0.593
MOD_CK1_1	523	529	PF00069	0.630
MOD_CK1_1	565	571	PF00069	0.730
MOD_CK1_1	580	586	PF00069	0.587
MOD_CK1_1	593	599	PF00069	0.644
MOD_CK1_1	626	632	PF00069	0.734
MOD_CK1_1	638	644	PF00069	0.588
MOD_CK1_1	657	663	PF00069	0.526
MOD_CK1_1	714	720	PF00069	0.644
MOD_CK2_1	144	150	PF00069	0.707
MOD_CK2_1	242	248	PF00069	0.734
MOD_CK2_1	395	401	PF00069	0.565
MOD_CK2_1	418	424	PF00069	0.726
MOD_CK2_1	699	705	PF00069	0.675
MOD_CK2_1	709	715	PF00069	0.579
MOD_Cter_Amidation	388	391	PF01082	0.732
MOD_GlcNHglycan	128	131	PF01048	0.754
MOD_GlcNHglycan	167	170	PF01048	0.631
MOD_GlcNHglycan	179	182	PF01048	0.605
MOD_GlcNHglycan	186	189	PF01048	0.565
MOD_GlcNHglycan	280	283	PF01048	0.656
MOD_GlcNHglycan	284	287	PF01048	0.611
MOD_GlcNHglycan	350	353	PF01048	0.709
MOD_GlcNHglycan	452	455	PF01048	0.683
MOD_GlcNHglycan	476	479	PF01048	0.700
MOD_GlcNHglycan	491	494	PF01048	0.565
MOD_GlcNHglycan	495	498	PF01048	0.524
MOD_GlcNHglycan	525	528	PF01048	0.712
MOD_GlcNHglycan	560	563	PF01048	0.675
MOD_GlcNHglycan	60	63	PF01048	0.604
MOD_GlcNHglycan	621	624	PF01048	0.730
MOD_GlcNHglycan	637	640	PF01048	0.598
MOD_GlcNHglycan	661	665	PF01048	0.639
MOD_GlcNHglycan	717	720	PF01048	0.679
MOD_GSK3_1	122	129	PF00069	0.680
MOD_GSK3_1	141	148	PF00069	0.541
MOD_GSK3_1	179	186	PF00069	0.630
MOD_GSK3_1	278	285	PF00069	0.577
MOD_GSK3_1	335	342	PF00069	0.706
MOD_GSK3_1	375	382	PF00069	0.659
MOD_GSK3_1	395	402	PF00069	0.691
MOD_GSK3_1	414	421	PF00069	0.644
MOD_GSK3_1	423	430	PF00069	0.622
MOD_GSK3_1	450	457	PF00069	0.693
MOD_GSK3_1	468	475	PF00069	0.531
MOD_GSK3_1	485	492	PF00069	0.552
MOD_GSK3_1	49	56	PF00069	0.608
MOD_GSK3_1	496	503	PF00069	0.601
MOD_GSK3_1	506	513	PF00069	0.674
MOD_GSK3_1	537	544	PF00069	0.776
MOD_GSK3_1	545	552	PF00069	0.685
MOD_GSK3_1	558	565	PF00069	0.597
MOD_GSK3_1	577	584	PF00069	0.695
MOD_GSK3_1	58	65	PF00069	0.558
MOD_GSK3_1	590	597	PF00069	0.605
MOD_GSK3_1	619	626	PF00069	0.728
MOD_GSK3_1	635	642	PF00069	0.553
MOD_GSK3_1	705	712	PF00069	0.599
MOD_GSK3_1	714	721	PF00069	0.497
MOD_N-GLC_1	231	236	PF02516	0.535
MOD_N-GLC_1	330	335	PF02516	0.554
MOD_N-GLC_1	558	563	PF02516	0.589
MOD_N-GLC_1	58	63	PF02516	0.522
MOD_N-GLC_1	580	585	PF02516	0.742
MOD_N-GLC_1	635	640	PF02516	0.647
MOD_NEK2_1	142	147	PF00069	0.596
MOD_NEK2_1	230	235	PF00069	0.694
MOD_NEK2_1	418	423	PF00069	0.669
MOD_NEK2_1	466	471	PF00069	0.589
MOD_NEK2_1	48	53	PF00069	0.772
MOD_NEK2_1	694	699	PF00069	0.674
MOD_PIKK_1	128	134	PF00454	0.665
MOD_PIKK_1	299	305	PF00454	0.515
MOD_PIKK_1	376	382	PF00454	0.731
MOD_PIKK_1	427	433	PF00454	0.593
MOD_PIKK_1	610	616	PF00454	0.590
MOD_PIKK_1	628	634	PF00454	0.622
MOD_PIKK_1	694	700	PF00454	0.675
MOD_PK_1	75	81	PF00069	0.577
MOD_PKA_1	212	218	PF00069	0.702
MOD_PKA_1	313	319	PF00069	0.686
MOD_PKA_1	489	495	PF00069	0.728
MOD_PKA_1	591	597	PF00069	0.583
MOD_PKA_1	75	81	PF00069	0.577
MOD_PKA_2	257	263	PF00069	0.681
MOD_PKA_2	282	288	PF00069	0.551
MOD_PKA_2	472	478	PF00069	0.626
MOD_PKA_2	485	491	PF00069	0.730
MOD_PKA_2	581	587	PF00069	0.739
MOD_PKA_2	590	596	PF00069	0.647
MOD_PKA_2	75	81	PF00069	0.577
MOD_PKB_1	204	212	PF00069	0.547
MOD_PKB_1	344	352	PF00069	0.574
MOD_Plk_1	157	163	PF00069	0.557
MOD_Plk_1	231	237	PF00069	0.532
MOD_Plk_1	399	405	PF00069	0.568
MOD_Plk_1	558	564	PF00069	0.590
MOD_Plk_1	705	711	PF00069	0.688
MOD_Plk_2-3	442	448	PF00069	0.555
MOD_Plk_2-3	705	711	PF00069	0.688
MOD_Plk_4	131	137	PF00069	0.645
MOD_Plk_4	231	237	PF00069	0.532
MOD_Plk_4	259	265	PF00069	0.684
MOD_Plk_4	400	406	PF00069	0.569
MOD_Plk_4	414	420	PF00069	0.532
MOD_Plk_4	545	551	PF00069	0.580
MOD_Plk_4	640	646	PF00069	0.720
MOD_Plk_4	75	81	PF00069	0.577
MOD_ProDKin_1	117	123	PF00069	0.569
MOD_ProDKin_1	134	140	PF00069	0.619
MOD_ProDKin_1	236	242	PF00069	0.741
MOD_ProDKin_1	423	429	PF00069	0.705
MOD_ProDKin_1	477	483	PF00069	0.744
MOD_ProDKin_1	514	520	PF00069	0.677
MOD_ProDKin_1	535	541	PF00069	0.708
MOD_ProDKin_1	549	555	PF00069	0.656
MOD_ProDKin_1	562	568	PF00069	0.725
MOD_ProDKin_1	571	577	PF00069	0.673
MOD_ProDKin_1	623	629	PF00069	0.737
MOD_ProDKin_1	647	653	PF00069	0.802
MOD_ProDKin_1	654	660	PF00069	0.705
MOD_ProDKin_1	688	694	PF00069	0.682
MOD_SUMO_for_1	106	109	PF00179	0.515
MOD_SUMO_rev_2	262	270	PF00179	0.541
TRG_DiLeu_BaEn_4	400	406	PF01217	0.569
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.618
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.554
TRG_DiLeu_BaLyEn_6	648	653	PF01217	0.675
TRG_ENDOCYTIC_2	101	104	PF00928	0.475
TRG_ER_diArg_1	270	272	PF00400	0.540
TRG_NLS_MonoExtC_3	485	490	PF00514	0.668
TRG_NLS_MonoExtN_4	312	317	PF00514	0.672
TRG_NLS_MonoExtN_4	388	394	PF00514	0.730
TRG_NLS_MonoExtN_4	43	48	PF00514	0.580
TRG_NLS_MonoExtN_4	483	490	PF00514	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WW49	Leishmania donovani	61%	100%
A4HYU1	Leishmania infantum	61%	100%
E9AUN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QCU6	Leishmania major	61%	97%