Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIE9_LEIBR

TriTrypDb:

LbrM.20.5160 , LBRM2903_200066100

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.406
CLV_NRD_NRD_1	186	188	PF00675	0.454
CLV_NRD_NRD_1	316	318	PF00675	0.441
CLV_NRD_NRD_1	319	321	PF00675	0.469
CLV_NRD_NRD_1	466	468	PF00675	0.662
CLV_NRD_NRD_1	530	532	PF00675	0.573
CLV_NRD_NRD_1	77	79	PF00675	0.414
CLV_PCSK_FUR_1	317	321	PF00082	0.429
CLV_PCSK_FUR_1	528	532	PF00082	0.469
CLV_PCSK_KEX2_1	155	157	PF00082	0.406
CLV_PCSK_KEX2_1	316	318	PF00082	0.440
CLV_PCSK_KEX2_1	319	321	PF00082	0.472
CLV_PCSK_KEX2_1	400	402	PF00082	0.714
CLV_PCSK_KEX2_1	416	418	PF00082	0.713
CLV_PCSK_KEX2_1	466	468	PF00082	0.662
CLV_PCSK_KEX2_1	530	532	PF00082	0.450
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.490
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.445
CLV_PCSK_PC7_1	396	402	PF00082	0.614
CLV_PCSK_SKI1_1	30	34	PF00082	0.513
CLV_PCSK_SKI1_1	332	336	PF00082	0.465
CLV_PCSK_SKI1_1	445	449	PF00082	0.473
CLV_PCSK_SKI1_1	53	57	PF00082	0.309
CLV_PCSK_SKI1_1	6	10	PF00082	0.405
CLV_Separin_Metazoa	190	194	PF03568	0.408
DEG_APCC_DBOX_1	416	424	PF00400	0.547
DEG_APCC_DBOX_1	444	452	PF00400	0.466
DEG_Nend_UBRbox_2	1	3	PF02207	0.306
DEG_SCF_TRCP1_1	349	354	PF00400	0.439
DEG_SPOP_SBC_1	379	383	PF00917	0.547
DOC_CKS1_1	506	511	PF01111	0.559
DOC_CYCLIN_RxL_1	27	36	PF00134	0.482
DOC_CYCLIN_RxL_1	329	338	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.450
DOC_MAPK_gen_1	205	214	PF00069	0.430
DOC_MAPK_gen_1	256	264	PF00069	0.411
DOC_MAPK_gen_1	495	503	PF00069	0.576
DOC_MAPK_MEF2A_6	495	503	PF00069	0.576
DOC_PP1_RVXF_1	247	254	PF00149	0.500
DOC_PP1_RVXF_1	28	35	PF00149	0.476
DOC_PP2B_LxvP_1	212	215	PF13499	0.589
DOC_PP4_FxxP_1	45	48	PF00568	0.407
DOC_USP7_MATH_1	145	149	PF00917	0.572
DOC_USP7_MATH_1	347	351	PF00917	0.626
DOC_USP7_MATH_1	361	365	PF00917	0.458
DOC_USP7_MATH_1	379	383	PF00917	0.728
DOC_USP7_MATH_1	394	398	PF00917	0.577
DOC_USP7_MATH_1	89	93	PF00917	0.442
DOC_WW_Pin1_4	132	137	PF00397	0.536
DOC_WW_Pin1_4	216	221	PF00397	0.679
DOC_WW_Pin1_4	380	385	PF00397	0.654
DOC_WW_Pin1_4	400	405	PF00397	0.644
DOC_WW_Pin1_4	436	441	PF00397	0.479
DOC_WW_Pin1_4	479	484	PF00397	0.749
DOC_WW_Pin1_4	505	510	PF00397	0.644
DOC_WW_Pin1_4	536	541	PF00397	0.600
DOC_WW_Pin1_4	84	89	PF00397	0.290
LIG_14-3-3_CanoR_1	299	303	PF00244	0.532
LIG_14-3-3_CanoR_1	417	427	PF00244	0.547
LIG_14-3-3_CanoR_1	6	16	PF00244	0.412
LIG_BRCT_BRCA1_1	73	77	PF00533	0.463
LIG_BRCT_BRCA1_2	73	79	PF00533	0.469
LIG_CaM_IQ_9	180	195	PF13499	0.336
LIG_CaM_IQ_9	514	530	PF13499	0.551
LIG_FHA_1	165	171	PF00498	0.452
LIG_FHA_1	235	241	PF00498	0.334
LIG_FHA_1	261	267	PF00498	0.323
LIG_FHA_1	289	295	PF00498	0.636
LIG_FHA_1	480	486	PF00498	0.724
LIG_FHA_2	255	261	PF00498	0.560
LIG_FHA_2	272	278	PF00498	0.456
LIG_FHA_2	301	307	PF00498	0.482
LIG_FHA_2	408	414	PF00498	0.481
LIG_FHA_2	441	447	PF00498	0.488
LIG_FHA_2	473	479	PF00498	0.750
LIG_HCF-1_HBM_1	2	5	PF13415	0.430
LIG_HCF-1_HBM_1	66	69	PF13415	0.283
LIG_LIR_Apic_2	42	48	PF02991	0.424
LIG_LIR_Apic_2	534	540	PF02991	0.419
LIG_LIR_Gen_1	124	134	PF02991	0.344
LIG_LIR_Gen_1	186	196	PF02991	0.459
LIG_LIR_Gen_1	277	285	PF02991	0.450
LIG_LIR_Gen_1	92	101	PF02991	0.502
LIG_LIR_Nem_3	124	129	PF02991	0.487
LIG_LIR_Nem_3	186	192	PF02991	0.459
LIG_LIR_Nem_3	2	8	PF02991	0.375
LIG_LIR_Nem_3	217	221	PF02991	0.444
LIG_LIR_Nem_3	314	318	PF02991	0.434
LIG_LIR_Nem_3	74	80	PF02991	0.423
LIG_LIR_Nem_3	92	97	PF02991	0.305
LIG_MYND_1	132	136	PF01753	0.464
LIG_NRBOX	330	336	PF00104	0.508
LIG_Pex14_1	58	62	PF04695	0.357
LIG_Rb_LxCxE_1	243	260	PF01857	0.399
LIG_SH2_CRK	178	182	PF00017	0.461
LIG_SH2_CRK	315	319	PF00017	0.317
LIG_SH2_CRK	5	9	PF00017	0.496
LIG_SH2_NCK_1	324	328	PF00017	0.430
LIG_SH2_STAP1	110	114	PF00017	0.346
LIG_SH2_STAP1	25	29	PF00017	0.309
LIG_SH2_STAT5	62	65	PF00017	0.333
LIG_SH2_STAT5	69	72	PF00017	0.313
LIG_SH2_STAT5	96	99	PF00017	0.300
LIG_SH3_3	13	19	PF00018	0.398
LIG_SH3_3	323	329	PF00018	0.508
LIG_SUMO_SIM_par_1	219	224	PF11976	0.425
LIG_SUMO_SIM_par_1	450	455	PF11976	0.313
LIG_TRAF2_1	303	306	PF00917	0.509
LIG_TRAF2_1	40	43	PF00917	0.452
LIG_TRAF2_1	431	434	PF00917	0.484
LIG_UBA3_1	180	188	PF00899	0.482
LIG_WRC_WIRS_1	261	266	PF05994	0.353
MOD_CK1_1	350	356	PF00069	0.667
MOD_CK1_1	382	388	PF00069	0.720
MOD_CK1_1	419	425	PF00069	0.713
MOD_CK1_1	479	485	PF00069	0.690
MOD_CK1_1	507	513	PF00069	0.654
MOD_CK2_1	221	227	PF00069	0.671
MOD_CK2_1	254	260	PF00069	0.381
MOD_CK2_1	300	306	PF00069	0.424
MOD_CK2_1	350	356	PF00069	0.421
MOD_CK2_1	428	434	PF00069	0.720
MOD_CK2_1	436	442	PF00069	0.602
MOD_CK2_1	472	478	PF00069	0.737
MOD_Cter_Amidation	398	401	PF01082	0.492
MOD_Cter_Amidation	414	417	PF01082	0.445
MOD_GlcNHglycan	349	352	PF01048	0.599
MOD_GlcNHglycan	370	373	PF01048	0.564
MOD_GlcNHglycan	423	426	PF01048	0.745
MOD_GlcNHglycan	478	482	PF01048	0.627
MOD_GlcNHglycan	487	490	PF01048	0.513
MOD_GlcNHglycan	512	515	PF01048	0.659
MOD_GlcNHglycan	71	74	PF01048	0.459
MOD_GlcNHglycan	91	94	PF01048	0.245
MOD_GSK3_1	179	186	PF00069	0.458
MOD_GSK3_1	297	304	PF00069	0.440
MOD_GSK3_1	347	354	PF00069	0.736
MOD_GSK3_1	375	382	PF00069	0.650
MOD_GSK3_1	436	443	PF00069	0.445
MOD_GSK3_1	472	479	PF00069	0.775
MOD_GSK3_1	481	488	PF00069	0.736
MOD_GSK3_1	504	511	PF00069	0.457
MOD_N-GLC_1	476	481	PF02516	0.642
MOD_NEK2_1	183	188	PF00069	0.361
MOD_NEK2_1	240	245	PF00069	0.468
MOD_NEK2_1	311	316	PF00069	0.572
MOD_NEK2_1	32	37	PF00069	0.513
MOD_NEK2_1	368	373	PF00069	0.666
MOD_NEK2_1	476	481	PF00069	0.736
MOD_NEK2_1	485	490	PF00069	0.667
MOD_NEK2_1	68	73	PF00069	0.459
MOD_PIKK_1	159	165	PF00454	0.451
MOD_PKA_1	416	422	PF00069	0.470
MOD_PKA_2	255	261	PF00069	0.468
MOD_PKA_2	298	304	PF00069	0.624
MOD_PKA_2	416	422	PF00069	0.560
MOD_PKA_2	455	461	PF00069	0.556
MOD_Plk_1	375	381	PF00069	0.578
MOD_Plk_1	428	434	PF00069	0.605
MOD_Plk_4	240	246	PF00069	0.468
MOD_Plk_4	260	266	PF00069	0.305
MOD_Plk_4	306	312	PF00069	0.379
MOD_Plk_4	407	413	PF00069	0.612
MOD_Plk_4	455	461	PF00069	0.640
MOD_Plk_4	481	487	PF00069	0.483
MOD_Plk_4	71	77	PF00069	0.380
MOD_ProDKin_1	132	138	PF00069	0.544
MOD_ProDKin_1	216	222	PF00069	0.678
MOD_ProDKin_1	380	386	PF00069	0.656
MOD_ProDKin_1	400	406	PF00069	0.645
MOD_ProDKin_1	436	442	PF00069	0.472
MOD_ProDKin_1	479	485	PF00069	0.749
MOD_ProDKin_1	505	511	PF00069	0.643
MOD_ProDKin_1	536	542	PF00069	0.603
MOD_ProDKin_1	84	90	PF00069	0.284
MOD_SUMO_rev_2	115	120	PF00179	0.260
TRG_DiLeu_BaEn_1	306	311	PF01217	0.491
TRG_DiLeu_BaEn_2	259	265	PF01217	0.552
TRG_DiLeu_BaEn_4	42	48	PF01217	0.380
TRG_DiLeu_BaEn_4	524	530	PF01217	0.536
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.216
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.418
TRG_ENDOCYTIC_2	178	181	PF00928	0.442
TRG_ENDOCYTIC_2	25	28	PF00928	0.311
TRG_ENDOCYTIC_2	315	318	PF00928	0.306
TRG_ENDOCYTIC_2	5	8	PF00928	0.433
TRG_ENDOCYTIC_2	62	65	PF00928	0.293
TRG_ER_diArg_1	155	157	PF00400	0.385
TRG_ER_diArg_1	283	286	PF00400	0.370
TRG_ER_diArg_1	315	317	PF00400	0.471
TRG_ER_diArg_1	318	320	PF00400	0.487
TRG_ER_diArg_1	466	468	PF00400	0.774
TRG_ER_diArg_1	528	531	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P3	Leptomonas seymouri	55%	74%
A0A0S4JGL0	Bodo saltans	30%	100%
A0A1X0NTL4	Trypanosomatidae	40%	98%
A0A3S7WW17	Leishmania donovani	80%	79%
A0A422N5G0	Trypanosoma rangeli	39%	100%
A4HYU0	Leishmania infantum	80%	79%
C9ZQ69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	94%
E9AUN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	79%
Q4QCU8	Leishmania major	78%	100%
V5D7X2	Trypanosoma cruzi	39%	91%