DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AIE6_LEIBR

TriTrypDb:

LbrM.20.5130 , LBRM2903_200065700 , LBRM2903_200065800

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.613
CLV_C14_Caspase3-7	468	472	PF00656	0.766
CLV_C14_Caspase3-7	512	516	PF00656	0.571
CLV_C14_Caspase3-7	518	522	PF00656	0.544
CLV_NRD_NRD_1	2	4	PF00675	0.608
CLV_NRD_NRD_1	247	249	PF00675	0.694
CLV_NRD_NRD_1	26	28	PF00675	0.545
CLV_NRD_NRD_1	352	354	PF00675	0.715
CLV_NRD_NRD_1	382	384	PF00675	0.733
CLV_NRD_NRD_1	42	44	PF00675	0.499
CLV_NRD_NRD_1	490	492	PF00675	0.735
CLV_NRD_NRD_1	668	670	PF00675	0.685
CLV_NRD_NRD_1	675	677	PF00675	0.734
CLV_NRD_NRD_1	688	690	PF00675	0.676
CLV_NRD_NRD_1	717	719	PF00675	0.692
CLV_PCSK_FUR_1	380	384	PF00082	0.593
CLV_PCSK_FUR_1	673	677	PF00082	0.834
CLV_PCSK_KEX2_1	112	114	PF00082	0.286
CLV_PCSK_KEX2_1	2	4	PF00082	0.608
CLV_PCSK_KEX2_1	247	249	PF00082	0.694
CLV_PCSK_KEX2_1	26	28	PF00082	0.545
CLV_PCSK_KEX2_1	352	354	PF00082	0.715
CLV_PCSK_KEX2_1	382	384	PF00082	0.733
CLV_PCSK_KEX2_1	42	44	PF00082	0.499
CLV_PCSK_KEX2_1	490	492	PF00082	0.735
CLV_PCSK_KEX2_1	668	670	PF00082	0.681
CLV_PCSK_KEX2_1	675	677	PF00082	0.740
CLV_PCSK_KEX2_1	688	690	PF00082	0.685
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.286
CLV_PCSK_SKI1_1	20	24	PF00082	0.794
CLV_PCSK_SKI1_1	201	205	PF00082	0.696
CLV_PCSK_SKI1_1	212	216	PF00082	0.531
CLV_PCSK_SKI1_1	341	345	PF00082	0.681
CLV_PCSK_SKI1_1	353	357	PF00082	0.606
CLV_PCSK_SKI1_1	367	371	PF00082	0.679
CLV_PCSK_SKI1_1	392	396	PF00082	0.594
CLV_PCSK_SKI1_1	613	617	PF00082	0.570
CLV_PCSK_SKI1_1	724	728	PF00082	0.691
DEG_APCC_DBOX_1	211	219	PF00400	0.626
DEG_APCC_DBOX_1	290	298	PF00400	0.519
DEG_COP1_1	77	86	PF00400	0.512
DEG_Nend_UBRbox_1	1	4	PF02207	0.615
DEG_SPOP_SBC_1	35	39	PF00917	0.702
DEG_SPOP_SBC_1	637	641	PF00917	0.825
DOC_CKS1_1	270	275	PF01111	0.514
DOC_CKS1_1	393	398	PF01111	0.493
DOC_CKS1_1	504	509	PF01111	0.831
DOC_CYCLIN_RxL_1	338	347	PF00134	0.794
DOC_MAPK_gen_1	673	681	PF00069	0.797
DOC_MAPK_MEF2A_6	257	265	PF00069	0.758
DOC_MAPK_MEF2A_6	64	73	PF00069	0.614
DOC_PP1_RVXF_1	190	197	PF00149	0.527
DOC_PP2B_LxvP_1	316	319	PF13499	0.524
DOC_PP2B_LxvP_1	679	682	PF13499	0.738
DOC_PP4_FxxP_1	214	217	PF00568	0.511
DOC_PP4_FxxP_1	711	714	PF00568	0.728
DOC_USP7_MATH_1	13	17	PF00917	0.521
DOC_USP7_MATH_1	142	146	PF00917	0.747
DOC_USP7_MATH_1	210	214	PF00917	0.665
DOC_USP7_MATH_1	287	291	PF00917	0.677
DOC_USP7_MATH_1	361	365	PF00917	0.576
DOC_USP7_MATH_1	410	414	PF00917	0.652
DOC_USP7_MATH_1	415	419	PF00917	0.611
DOC_USP7_MATH_1	637	641	PF00917	0.828
DOC_USP7_MATH_1	65	69	PF00917	0.676
DOC_USP7_MATH_1	661	665	PF00917	0.644
DOC_USP7_MATH_1	700	704	PF00917	0.821
DOC_WW_Pin1_4	224	229	PF00397	0.527
DOC_WW_Pin1_4	269	274	PF00397	0.511
DOC_WW_Pin1_4	324	329	PF00397	0.711
DOC_WW_Pin1_4	344	349	PF00397	0.733
DOC_WW_Pin1_4	36	41	PF00397	0.533
DOC_WW_Pin1_4	392	397	PF00397	0.774
DOC_WW_Pin1_4	417	422	PF00397	0.587
DOC_WW_Pin1_4	473	478	PF00397	0.670
DOC_WW_Pin1_4	491	496	PF00397	0.789
DOC_WW_Pin1_4	503	508	PF00397	0.650
DOC_WW_Pin1_4	727	732	PF00397	0.760
LIG_14-3-3_CanoR_1	113	119	PF00244	0.418
LIG_14-3-3_CanoR_1	3	9	PF00244	0.617
LIG_14-3-3_CanoR_1	613	621	PF00244	0.543
LIG_14-3-3_CanoR_1	64	70	PF00244	0.477
LIG_14-3-3_CanoR_1	668	677	PF00244	0.655
LIG_14-3-3_CanoR_1	678	682	PF00244	0.662
LIG_CSL_BTD_1	195	198	PF09270	0.618
LIG_FHA_1	151	157	PF00498	0.502
LIG_FHA_1	189	195	PF00498	0.536
LIG_FHA_1	200	206	PF00498	0.641
LIG_FHA_1	26	32	PF00498	0.653
LIG_FHA_1	36	42	PF00498	0.577
LIG_FHA_1	393	399	PF00498	0.751
LIG_FHA_1	61	67	PF00498	0.787
LIG_FHA_1	615	621	PF00498	0.544
LIG_FHA_1	650	656	PF00498	0.778
LIG_FHA_1	98	104	PF00498	0.512
LIG_FHA_2	136	142	PF00498	0.512
LIG_FHA_2	163	169	PF00498	0.565
LIG_FHA_2	296	302	PF00498	0.491
LIG_FHA_2	363	369	PF00498	0.453
LIG_FHA_2	510	516	PF00498	0.628
LIG_FHA_2	549	555	PF00498	0.824
LIG_GBD_Chelix_1	335	343	PF00786	0.531
LIG_LIR_Apic_2	213	217	PF02991	0.513
LIG_LIR_Apic_2	709	714	PF02991	0.603
LIG_LIR_Gen_1	420	429	PF02991	0.603
LIG_LIR_LC3C_4	100	104	PF02991	0.244
LIG_LIR_Nem_3	239	243	PF02991	0.590
LIG_LIR_Nem_3	420	426	PF02991	0.602
LIG_Pex14_1	423	427	PF04695	0.653
LIG_SH2_CRK	535	539	PF00017	0.554
LIG_SH2_NCK_1	223	227	PF00017	0.539
LIG_SH2_PTP2	439	442	PF00017	0.679
LIG_SH2_SRC	439	442	PF00017	0.720
LIG_SH2_STAT5	374	377	PF00017	0.707
LIG_SH2_STAT5	439	442	PF00017	0.620
LIG_SH2_STAT5	447	450	PF00017	0.621
LIG_SH3_2	714	719	PF14604	0.731
LIG_SH3_3	267	273	PF00018	0.509
LIG_SH3_3	325	331	PF00018	0.658
LIG_SH3_3	390	396	PF00018	0.543
LIG_SH3_3	486	492	PF00018	0.804
LIG_SH3_3	539	545	PF00018	0.810
LIG_SH3_3	70	76	PF00018	0.548
LIG_SH3_3	711	717	PF00018	0.730
LIG_TRAF2_1	227	230	PF00917	0.686
LIG_TRAF2_1	551	554	PF00917	0.696
LIG_TYR_ITIM	533	538	PF00017	0.557
LIG_ULM_U2AF65_1	2	7	PF00076	0.529
MOD_CDC14_SPxK_1	39	42	PF00782	0.532
MOD_CDK_SPK_2	269	274	PF00069	0.511
MOD_CDK_SPxK_1	36	42	PF00069	0.536
MOD_CDK_SPxxK_3	36	43	PF00069	0.538
MOD_CDK_SPxxK_3	491	498	PF00069	0.830
MOD_CK1_1	184	190	PF00069	0.525
MOD_CK1_1	290	296	PF00069	0.793
MOD_CK1_1	347	353	PF00069	0.751
MOD_CK1_1	357	363	PF00069	0.492
MOD_CK1_1	402	408	PF00069	0.633
MOD_CK1_1	60	66	PF00069	0.753
MOD_CK1_1	600	606	PF00069	0.771
MOD_CK1_1	7	13	PF00069	0.562
MOD_CK2_1	135	141	PF00069	0.563
MOD_CK2_1	151	157	PF00069	0.713
MOD_CK2_1	224	230	PF00069	0.574
MOD_CK2_1	362	368	PF00069	0.460
MOD_CK2_1	384	390	PF00069	0.768
MOD_CK2_1	462	468	PF00069	0.751
MOD_CK2_1	548	554	PF00069	0.748
MOD_CK2_1	616	622	PF00069	0.594
MOD_CK2_1	630	636	PF00069	0.746
MOD_CK2_1	659	665	PF00069	0.502
MOD_CK2_1	92	98	PF00069	0.512
MOD_DYRK1A_RPxSP_1	491	495	PF00069	0.813
MOD_GlcNHglycan	141	145	PF01048	0.717
MOD_GlcNHglycan	146	149	PF01048	0.719
MOD_GlcNHglycan	15	18	PF01048	0.634
MOD_GlcNHglycan	207	210	PF01048	0.718
MOD_GlcNHglycan	224	227	PF01048	0.498
MOD_GlcNHglycan	281	284	PF01048	0.805
MOD_GlcNHglycan	405	408	PF01048	0.580
MOD_GlcNHglycan	413	416	PF01048	0.586
MOD_GlcNHglycan	432	435	PF01048	0.665
MOD_GlcNHglycan	441	445	PF01048	0.583
MOD_GlcNHglycan	521	524	PF01048	0.691
MOD_GlcNHglycan	527	530	PF01048	0.665
MOD_GlcNHglycan	553	558	PF01048	0.816
MOD_GlcNHglycan	59	62	PF01048	0.581
MOD_GlcNHglycan	622	625	PF01048	0.600
MOD_GlcNHglycan	701	705	PF01048	0.744
MOD_GlcNHglycan	731	734	PF01048	0.754
MOD_GSK3_1	140	147	PF00069	0.732
MOD_GSK3_1	158	165	PF00069	0.682
MOD_GSK3_1	184	191	PF00069	0.528
MOD_GSK3_1	277	284	PF00069	0.528
MOD_GSK3_1	353	360	PF00069	0.625
MOD_GSK3_1	399	406	PF00069	0.594
MOD_GSK3_1	411	418	PF00069	0.558
MOD_GSK3_1	421	428	PF00069	0.484
MOD_GSK3_1	44	51	PF00069	0.711
MOD_GSK3_1	469	476	PF00069	0.779
MOD_GSK3_1	597	604	PF00069	0.595
MOD_GSK3_1	616	623	PF00069	0.765
MOD_GSK3_1	649	656	PF00069	0.780
MOD_GSK3_1	727	734	PF00069	0.633
MOD_N-GLC_1	134	139	PF02516	0.496
MOD_N-GLC_1	384	389	PF02516	0.503
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	151	156	PF00069	0.687
MOD_NEK2_1	162	167	PF00069	0.546
MOD_NEK2_1	279	284	PF00069	0.577
MOD_NEK2_1	509	514	PF00069	0.633
MOD_NEK2_1	620	625	PF00069	0.590
MOD_NEK2_1	659	664	PF00069	0.768
MOD_NEK2_1	677	682	PF00069	0.675
MOD_NEK2_2	362	367	PF00069	0.729
MOD_NEK2_2	384	389	PF00069	0.503
MOD_NEK2_2	65	70	PF00069	0.468
MOD_PIKK_1	399	405	PF00454	0.536
MOD_PIKK_1	475	481	PF00454	0.696
MOD_PKA_1	42	48	PF00069	0.549
MOD_PKA_1	525	531	PF00069	0.561
MOD_PKA_1	668	674	PF00069	0.597
MOD_PKA_2	1	7	PF00069	0.594
MOD_PKA_2	105	111	PF00069	0.478
MOD_PKA_2	158	164	PF00069	0.419
MOD_PKA_2	25	31	PF00069	0.603
MOD_PKA_2	290	296	PF00069	0.793
MOD_PKA_2	311	317	PF00069	0.750
MOD_PKA_2	42	48	PF00069	0.500
MOD_PKA_2	430	436	PF00069	0.698
MOD_PKA_2	667	673	PF00069	0.711
MOD_PKA_2	677	683	PF00069	0.577
MOD_PKB_1	611	619	PF00069	0.525
MOD_Plk_1	384	390	PF00069	0.653
MOD_Plk_1	97	103	PF00069	0.512
MOD_Plk_4	480	486	PF00069	0.827
MOD_Plk_4	616	622	PF00069	0.655
MOD_Plk_4	98	104	PF00069	0.415
MOD_ProDKin_1	224	230	PF00069	0.526
MOD_ProDKin_1	269	275	PF00069	0.513
MOD_ProDKin_1	324	330	PF00069	0.712
MOD_ProDKin_1	344	350	PF00069	0.732
MOD_ProDKin_1	36	42	PF00069	0.536
MOD_ProDKin_1	392	398	PF00069	0.767
MOD_ProDKin_1	417	423	PF00069	0.588
MOD_ProDKin_1	473	479	PF00069	0.669
MOD_ProDKin_1	491	497	PF00069	0.789
MOD_ProDKin_1	503	509	PF00069	0.653
MOD_ProDKin_1	727	733	PF00069	0.757
MOD_SUMO_for_1	726	729	PF00179	0.570
MOD_SUMO_rev_2	386	394	PF00179	0.516
TRG_DiLeu_BaEn_1	98	103	PF01217	0.512
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.690
TRG_ENDOCYTIC_2	374	377	PF00928	0.606
TRG_ENDOCYTIC_2	535	538	PF00928	0.557
TRG_ER_diArg_1	1	3	PF00400	0.619
TRG_ER_diArg_1	246	248	PF00400	0.692
TRG_ER_diArg_1	25	27	PF00400	0.535
TRG_ER_diArg_1	351	353	PF00400	0.579
TRG_ER_diArg_1	380	383	PF00400	0.580
TRG_ER_diArg_1	41	43	PF00400	0.496
TRG_ER_diArg_1	489	491	PF00400	0.737
TRG_ER_diArg_1	673	676	PF00400	0.752
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYJ6	Leptomonas seymouri	36%	90%
A0A3Q8IEV0	Leishmania donovani	69%	100%
A4HYT7	Leishmania infantum	69%	100%
E9AUN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QCV1	Leishmania major	70%	98%