PPIase cyclophilin-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 15, putative

Species:

Leishmania braziliensis

UniProt:

E9AIE5_LEIBR

TriTrypDb:

LbrM.20.5120 , LBRM2903_200065600

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIE5

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018208	peptidyl-proline modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.610
CLV_C14_Caspase3-7	282	286	PF00656	0.505
CLV_C14_Caspase3-7	63	67	PF00656	0.337
CLV_NRD_NRD_1	163	165	PF00675	0.492
CLV_NRD_NRD_1	258	260	PF00675	0.752
CLV_NRD_NRD_1	317	319	PF00675	0.669
CLV_NRD_NRD_1	430	432	PF00675	0.516
CLV_PCSK_FUR_1	255	259	PF00082	0.755
CLV_PCSK_KEX2_1	163	165	PF00082	0.581
CLV_PCSK_KEX2_1	183	185	PF00082	0.555
CLV_PCSK_KEX2_1	242	244	PF00082	0.667
CLV_PCSK_KEX2_1	257	259	PF00082	0.744
CLV_PCSK_KEX2_1	315	317	PF00082	0.596
CLV_PCSK_KEX2_1	430	432	PF00082	0.637
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.575
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.575
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.596
CLV_PCSK_SKI1_1	303	307	PF00082	0.650
CLV_PCSK_SKI1_1	98	102	PF00082	0.405
DEG_Nend_UBRbox_3	1	3	PF02207	0.384
DEG_SPOP_SBC_1	392	396	PF00917	0.725
DEG_SPOP_SBC_1	61	65	PF00917	0.326
DOC_CKS1_1	157	162	PF01111	0.578
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.535
DOC_MAPK_gen_1	28	37	PF00069	0.381
DOC_MAPK_gen_1	83	92	PF00069	0.397
DOC_PP2B_LxvP_1	140	143	PF13499	0.565
DOC_PP2B_LxvP_1	43	46	PF13499	0.525
DOC_PP4_FxxP_1	20	23	PF00568	0.394
DOC_USP7_MATH_1	125	129	PF00917	0.523
DOC_USP7_MATH_1	222	226	PF00917	0.728
DOC_USP7_MATH_1	273	277	PF00917	0.673
DOC_USP7_MATH_1	288	292	PF00917	0.760
DOC_USP7_MATH_1	390	394	PF00917	0.714
DOC_USP7_MATH_1	413	417	PF00917	0.724
DOC_USP7_MATH_2	232	238	PF00917	0.550
DOC_USP7_UBL2_3	380	384	PF12436	0.457
DOC_USP7_UBL2_3	421	425	PF12436	0.778
DOC_WW_Pin1_4	156	161	PF00397	0.546
DOC_WW_Pin1_4	309	314	PF00397	0.506
LIG_14-3-3_CanoR_1	184	193	PF00244	0.583
LIG_14-3-3_CanoR_1	28	33	PF00244	0.387
LIG_14-3-3_CanoR_1	296	302	PF00244	0.473
LIG_14-3-3_CanoR_1	333	339	PF00244	0.703
LIG_Actin_WH2_2	168	185	PF00022	0.541
LIG_BIR_III_2	285	289	PF00653	0.538
LIG_BRCT_BRCA1_1	290	294	PF00533	0.694
LIG_BRCT_BRCA1_1	297	301	PF00533	0.635
LIG_BRCT_BRCA1_1	5	9	PF00533	0.473
LIG_FHA_1	174	180	PF00498	0.458
LIG_FHA_1	332	338	PF00498	0.631
LIG_FHA_1	85	91	PF00498	0.414
LIG_FHA_1	95	101	PF00498	0.379
LIG_FHA_2	10	16	PF00498	0.313
LIG_FHA_2	156	162	PF00498	0.552
LIG_FHA_2	270	276	PF00498	0.752
LIG_FHA_2	54	60	PF00498	0.532
LIG_FHA_2	61	67	PF00498	0.497
LIG_LIR_Apic_2	19	23	PF02991	0.482
LIG_LIR_Nem_3	134	140	PF02991	0.458
LIG_LIR_Nem_3	165	169	PF02991	0.496
LIG_LIR_Nem_3	19	24	PF02991	0.456
LIG_LIR_Nem_3	212	216	PF02991	0.616
LIG_LIR_Nem_3	99	104	PF02991	0.395
LIG_PTB_Apo_2	31	38	PF02174	0.343
LIG_REV1ctd_RIR_1	292	300	PF16727	0.711
LIG_REV1ctd_RIR_1	352	360	PF16727	0.634
LIG_SH2_CRK	137	141	PF00017	0.532
LIG_SH2_CRK	213	217	PF00017	0.485
LIG_SH2_PTP2	151	154	PF00017	0.392
LIG_SH2_STAT5	151	154	PF00017	0.392
LIG_SH2_STAT5	62	65	PF00017	0.323
LIG_SH3_1	242	248	PF00018	0.710
LIG_SH3_3	103	109	PF00018	0.431
LIG_SH3_3	154	160	PF00018	0.503
LIG_SH3_3	242	248	PF00018	0.710
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.390
LIG_SUMO_SIM_par_1	87	97	PF11976	0.412
LIG_TYR_ITIM	135	140	PF00017	0.512
LIG_TYR_ITIM	211	216	PF00017	0.603
MOD_CDC14_SPxK_1	312	315	PF00782	0.506
MOD_CDK_SPxK_1	309	315	PF00069	0.507
MOD_CDK_SPxxK_3	156	163	PF00069	0.478
MOD_CDK_SPxxK_3	309	316	PF00069	0.505
MOD_CK1_1	156	162	PF00069	0.421
MOD_CK1_1	345	351	PF00069	0.457
MOD_CK1_1	393	399	PF00069	0.707
MOD_CK1_1	408	414	PF00069	0.532
MOD_CK1_1	416	422	PF00069	0.656
MOD_CK1_1	94	100	PF00069	0.398
MOD_CK2_1	155	161	PF00069	0.516
MOD_CK2_1	215	221	PF00069	0.533
MOD_CK2_1	269	275	PF00069	0.568
MOD_CK2_1	53	59	PF00069	0.501
MOD_CK2_1	85	91	PF00069	0.499
MOD_CK2_1	9	15	PF00069	0.497
MOD_Cter_Amidation	240	243	PF01082	0.782
MOD_Cter_Amidation	381	384	PF01082	0.439
MOD_GlcNHglycan	176	179	PF01048	0.434
MOD_GlcNHglycan	224	227	PF01048	0.767
MOD_GlcNHglycan	281	284	PF01048	0.666
MOD_GlcNHglycan	297	300	PF01048	0.602
MOD_GlcNHglycan	307	310	PF01048	0.727
MOD_GlcNHglycan	39	42	PF01048	0.499
MOD_GlcNHglycan	408	411	PF01048	0.738
MOD_GlcNHglycan	422	425	PF01048	0.771
MOD_GlcNHglycan	78	81	PF01048	0.423
MOD_GSK3_1	119	126	PF00069	0.544
MOD_GSK3_1	265	272	PF00069	0.727
MOD_GSK3_1	305	312	PF00069	0.646
MOD_GSK3_1	413	420	PF00069	0.683
MOD_GSK3_1	92	99	PF00069	0.387
MOD_N-GLC_1	279	284	PF02516	0.726
MOD_NEK2_1	153	158	PF00069	0.432
MOD_NEK2_1	174	179	PF00069	0.452
MOD_NEK2_1	289	294	PF00069	0.649
MOD_NEK2_1	295	300	PF00069	0.556
MOD_NEK2_1	332	337	PF00069	0.624
MOD_NEK2_1	37	42	PF00069	0.392
MOD_NEK2_1	391	396	PF00069	0.626
MOD_NEK2_1	76	81	PF00069	0.406
MOD_PIKK_1	142	148	PF00454	0.509
MOD_PIKK_1	184	190	PF00454	0.578
MOD_PIKK_1	234	240	PF00454	0.690
MOD_PIKK_1	384	390	PF00454	0.557
MOD_PIKK_1	400	406	PF00454	0.773
MOD_PK_1	119	125	PF00069	0.556
MOD_PKA_1	384	390	PF00069	0.531
MOD_PKA_2	295	301	PF00069	0.605
MOD_PKA_2	332	338	PF00069	0.618
MOD_PKA_2	406	412	PF00069	0.652
MOD_PKA_2	416	422	PF00069	0.580
MOD_Plk_1	119	125	PF00069	0.352
MOD_Plk_1	3	9	PF00069	0.456
MOD_Plk_1	84	90	PF00069	0.385
MOD_Plk_2-3	85	91	PF00069	0.511
MOD_Plk_4	131	137	PF00069	0.415
MOD_Plk_4	16	22	PF00069	0.445
MOD_Plk_4	192	198	PF00069	0.467
MOD_Plk_4	3	9	PF00069	0.439
MOD_Plk_4	85	91	PF00069	0.450
MOD_Plk_4	96	102	PF00069	0.334
MOD_ProDKin_1	156	162	PF00069	0.548
MOD_ProDKin_1	309	315	PF00069	0.507
MOD_SUMO_rev_2	177	185	PF00179	0.538
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.267
TRG_ENDOCYTIC_2	137	140	PF00928	0.475
TRG_ENDOCYTIC_2	150	153	PF00928	0.313
TRG_ENDOCYTIC_2	213	216	PF00928	0.620
TRG_ER_diArg_1	255	258	PF00400	0.690
TRG_ER_diArg_1	316	318	PF00400	0.732
TRG_ER_diArg_1	374	377	PF00400	0.518
TRG_ER_diArg_1	429	431	PF00400	0.507
TRG_NLS_Bipartite_1	183	203	PF00514	0.580
TRG_NLS_MonoCore_2	314	319	PF00514	0.668
TRG_NLS_MonoCore_2	382	387	PF00514	0.541
TRG_NLS_MonoExtC_3	314	320	PF00514	0.608
TRG_NLS_MonoExtN_4	198	203	PF00514	0.567
TRG_NLS_MonoExtN_4	313	319	PF00514	0.644
TRG_NLS_MonoExtN_4	380	387	PF00514	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC45	Leptomonas seymouri	58%	100%
A0A0S4KRJ3	Bodo saltans	30%	100%
A0A1X0NWC9	Trypanosomatidae	32%	100%
A0A3S7WVY2	Leishmania donovani	76%	100%
A0A422NPI7	Trypanosoma rangeli	37%	100%
A4HYT6	Leishmania infantum	76%	94%
C9ZIB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AUN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4QCV2	Leishmania major	77%	100%
V5DRZ7	Trypanosoma cruzi	37%	100%