AATF-Che1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AATF protein, putative

Species:

Leishmania braziliensis

UniProt:

E9AIE3_LEIBR

TriTrypDb:

LbrM.20.5100 , LBRM2903_200065400

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AIE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.784
CLV_C14_Caspase3-7	185	189	PF00656	0.713
CLV_C14_Caspase3-7	334	338	PF00656	0.257
CLV_C14_Caspase3-7	343	347	PF00656	0.278
CLV_C14_Caspase3-7	384	388	PF00656	0.457
CLV_C14_Caspase3-7	63	67	PF00656	0.641
CLV_NRD_NRD_1	191	193	PF00675	0.587
CLV_NRD_NRD_1	195	197	PF00675	0.554
CLV_NRD_NRD_1	213	215	PF00675	0.412
CLV_NRD_NRD_1	216	218	PF00675	0.536
CLV_NRD_NRD_1	526	528	PF00675	0.404
CLV_NRD_NRD_1	553	555	PF00675	0.406
CLV_NRD_NRD_1	9	11	PF00675	0.645
CLV_PCSK_FUR_1	214	218	PF00082	0.489
CLV_PCSK_KEX2_1	195	197	PF00082	0.569
CLV_PCSK_KEX2_1	215	217	PF00082	0.484
CLV_PCSK_KEX2_1	526	528	PF00082	0.331
CLV_PCSK_KEX2_1	9	11	PF00082	0.606
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.478
CLV_PCSK_PC7_1	522	528	PF00082	0.321
CLV_PCSK_SKI1_1	195	199	PF00082	0.669
CLV_PCSK_SKI1_1	307	311	PF00082	0.416
CLV_PCSK_SKI1_1	402	406	PF00082	0.442
CLV_PCSK_SKI1_1	490	494	PF00082	0.416
CLV_PCSK_SKI1_1	537	541	PF00082	0.463
CLV_PCSK_SKI1_1	544	548	PF00082	0.410
CLV_PCSK_SKI1_1	594	598	PF00082	0.538
CLV_PCSK_SKI1_1	83	87	PF00082	0.670
CLV_Separin_Metazoa	523	527	PF03568	0.396
DEG_SPOP_SBC_1	270	274	PF00917	0.565
DOC_CYCLIN_RxL_1	538	551	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.658
DOC_CYCLIN_yCln2_LP_2	261	267	PF00134	0.460
DOC_MAPK_gen_1	108	117	PF00069	0.486
DOC_MAPK_gen_1	402	412	PF00069	0.442
DOC_MAPK_gen_1	472	482	PF00069	0.498
DOC_MAPK_gen_1	6	16	PF00069	0.686
DOC_MAPK_MEF2A_6	110	119	PF00069	0.472
DOC_PP1_RVXF_1	571	578	PF00149	0.321
DOC_PP2B_LxvP_1	410	413	PF13499	0.442
DOC_PP4_FxxP_1	577	580	PF00568	0.341
DOC_USP7_MATH_1	104	108	PF00917	0.749
DOC_USP7_MATH_1	270	274	PF00917	0.653
DOC_USP7_MATH_1	340	344	PF00917	0.442
DOC_USP7_MATH_1	356	360	PF00917	0.215
DOC_USP7_MATH_1	380	384	PF00917	0.492
DOC_USP7_MATH_1	398	402	PF00917	0.427
DOC_USP7_MATH_1	491	495	PF00917	0.563
DOC_USP7_MATH_1	530	534	PF00917	0.467
DOC_USP7_UBL2_3	540	544	PF12436	0.215
DOC_USP7_UBL2_3	90	94	PF12436	0.774
LIG_14-3-3_CanoR_1	223	229	PF00244	0.715
LIG_14-3-3_CanoR_1	255	263	PF00244	0.640
LIG_14-3-3_CanoR_1	427	436	PF00244	0.229
LIG_14-3-3_CanoR_1	490	497	PF00244	0.534
LIG_14-3-3_CanoR_1	83	92	PF00244	0.664
LIG_APCC_ABBA_1	326	331	PF00400	0.215
LIG_BIR_III_4	148	152	PF00653	0.708
LIG_BIR_III_4	188	192	PF00653	0.731
LIG_BIR_III_4	40	44	PF00653	0.507
LIG_BRCT_BRCA1_1	66	70	PF00533	0.727
LIG_CtBP_PxDLS_1	114	118	PF00389	0.668
LIG_eIF4E_1	323	329	PF01652	0.438
LIG_eIF4E_1	435	441	PF01652	0.365
LIG_FHA_1	204	210	PF00498	0.622
LIG_FHA_1	217	223	PF00498	0.672
LIG_FHA_1	287	293	PF00498	0.626
LIG_FHA_1	313	319	PF00498	0.440
LIG_FHA_1	95	101	PF00498	0.590
LIG_FHA_2	199	205	PF00498	0.582
LIG_FHA_2	24	30	PF00498	0.652
LIG_FHA_2	332	338	PF00498	0.215
LIG_FHA_2	379	385	PF00498	0.300
LIG_FHA_2	429	435	PF00498	0.442
LIG_FHA_2	491	497	PF00498	0.633
LIG_LIR_Gen_1	359	369	PF02991	0.431
LIG_LIR_Gen_1	59	70	PF02991	0.687
LIG_LIR_Nem_3	136	142	PF02991	0.552
LIG_LIR_Nem_3	359	365	PF02991	0.409
LIG_LIR_Nem_3	414	418	PF02991	0.280
LIG_LIR_Nem_3	59	65	PF02991	0.665
LIG_NRBOX	305	311	PF00104	0.421
LIG_PCNA_yPIPBox_3	360	373	PF02747	0.440
LIG_Pex14_1	224	228	PF04695	0.505
LIG_SH2_CRK	300	304	PF00017	0.315
LIG_SH2_CRK	324	328	PF00017	0.336
LIG_SH2_NCK_1	377	381	PF00017	0.417
LIG_SH2_NCK_1	515	519	PF00017	0.510
LIG_SH2_NCK_1	62	66	PF00017	0.593
LIG_SH2_SRC	51	54	PF00017	0.726
LIG_SH2_SRC	515	518	PF00017	0.495
LIG_SH2_SRC	62	65	PF00017	0.729
LIG_SH2_STAP1	155	159	PF00017	0.650
LIG_SH2_STAP1	205	209	PF00017	0.596
LIG_SH2_STAT5	205	208	PF00017	0.502
LIG_SH2_STAT5	51	54	PF00017	0.503
LIG_Sin3_3	275	282	PF02671	0.436
LIG_SUMO_SIM_anti_2	478	484	PF11976	0.526
LIG_SUMO_SIM_par_1	113	118	PF11976	0.544
LIG_TRAF2_1	201	204	PF00917	0.631
MOD_CK1_1	102	108	PF00069	0.752
MOD_CK1_1	12	18	PF00069	0.707
MOD_CK1_1	396	402	PF00069	0.334
MOD_CK1_1	411	417	PF00069	0.220
MOD_CK1_1	464	470	PF00069	0.645
MOD_CK1_1	586	592	PF00069	0.397
MOD_CK2_1	115	121	PF00069	0.603
MOD_CK2_1	198	204	PF00069	0.590
MOD_CK2_1	23	29	PF00069	0.632
MOD_CK2_1	342	348	PF00069	0.336
MOD_CK2_1	378	384	PF00069	0.364
MOD_CK2_1	411	417	PF00069	0.378
MOD_CK2_1	428	434	PF00069	0.407
MOD_CK2_1	530	536	PF00069	0.442
MOD_Cter_Amidation	190	193	PF01082	0.640
MOD_GlcNHglycan	102	105	PF01048	0.654
MOD_GlcNHglycan	232	235	PF01048	0.655
MOD_GlcNHglycan	273	276	PF01048	0.646
MOD_GlcNHglycan	280	283	PF01048	0.653
MOD_GlcNHglycan	33	36	PF01048	0.609
MOD_GlcNHglycan	396	399	PF01048	0.479
MOD_GlcNHglycan	444	447	PF01048	0.579
MOD_GlcNHglycan	463	466	PF01048	0.622
MOD_GlcNHglycan	493	496	PF01048	0.537
MOD_GlcNHglycan	86	89	PF01048	0.729
MOD_GSK3_1	19	26	PF00069	0.577
MOD_GSK3_1	265	272	PF00069	0.665
MOD_GSK3_1	392	399	PF00069	0.446
MOD_GSK3_1	464	471	PF00069	0.554
MOD_GSK3_1	5	12	PF00069	0.630
MOD_GSK3_1	542	549	PF00069	0.263
MOD_GSK3_1	579	586	PF00069	0.336
MOD_GSK3_1	77	84	PF00069	0.739
MOD_GSK3_1	90	97	PF00069	0.620
MOD_GSK3_1	98	105	PF00069	0.735
MOD_LATS_1	488	494	PF00433	0.637
MOD_N-GLC_1	31	36	PF02516	0.634
MOD_N-GLC_1	475	480	PF02516	0.539
MOD_N-GLC_2	430	432	PF02516	0.215
MOD_NEK2_1	100	105	PF00069	0.651
MOD_NEK2_1	115	120	PF00069	0.539
MOD_NEK2_1	23	28	PF00069	0.438
MOD_NEK2_1	254	259	PF00069	0.627
MOD_NEK2_1	31	36	PF00069	0.617
MOD_NEK2_1	392	397	PF00069	0.246
MOD_NEK2_1	4	9	PF00069	0.633
MOD_NEK2_1	542	547	PF00069	0.280
MOD_NEK2_1	583	588	PF00069	0.230
MOD_PIKK_1	254	260	PF00454	0.599
MOD_PIKK_1	530	536	PF00454	0.485
MOD_PIKK_1	583	589	PF00454	0.336
MOD_PK_1	9	15	PF00069	0.585
MOD_PKA_1	19	25	PF00069	0.563
MOD_PKA_1	216	222	PF00069	0.536
MOD_PKA_1	9	15	PF00069	0.599
MOD_PKA_1	90	96	PF00069	0.613
MOD_PKA_1	98	104	PF00069	0.626
MOD_PKA_2	216	222	PF00069	0.603
MOD_PKA_2	254	260	PF00069	0.616
MOD_PKA_2	558	564	PF00069	0.315
MOD_PKA_2	9	15	PF00069	0.654
MOD_PKB_1	214	222	PF00069	0.454
MOD_Plk_1	115	121	PF00069	0.554
MOD_Plk_1	155	161	PF00069	0.656
MOD_Plk_1	203	209	PF00069	0.621
MOD_Plk_1	31	37	PF00069	0.476
MOD_Plk_1	475	481	PF00069	0.543
MOD_Plk_2-3	331	337	PF00069	0.215
MOD_Plk_4	257	263	PF00069	0.638
MOD_Plk_4	372	378	PF00069	0.404
MOD_Plk_4	542	548	PF00069	0.336
MOD_Plk_4	9	15	PF00069	0.722
MOD_SUMO_for_1	404	407	PF00179	0.447
MOD_SUMO_rev_2	116	125	PF00179	0.671
MOD_SUMO_rev_2	281	289	PF00179	0.648
MOD_SUMO_rev_2	494	499	PF00179	0.508
MOD_SUMO_rev_2	533	539	PF00179	0.442
TRG_DiLeu_BaEn_4	243	249	PF01217	0.586
TRG_ENDOCYTIC_2	300	303	PF00928	0.328
TRG_ENDOCYTIC_2	323	326	PF00928	0.225
TRG_ENDOCYTIC_2	362	365	PF00928	0.438
TRG_ENDOCYTIC_2	415	418	PF00928	0.396
TRG_ENDOCYTIC_2	62	65	PF00928	0.629
TRG_ER_diArg_1	109	112	PF00400	0.665
TRG_ER_diArg_1	214	217	PF00400	0.559
TRG_ER_diArg_1	304	307	PF00400	0.327
TRG_ER_diArg_1	525	527	PF00400	0.396
TRG_NLS_Bipartite_1	9	23	PF00514	0.488
TRG_NLS_MonoCore_2	213	218	PF00514	0.440
TRG_NLS_MonoExtC_3	191	196	PF00514	0.616
TRG_NLS_MonoExtC_3	213	218	PF00514	0.477
TRG_NLS_MonoExtC_3	401	407	PF00514	0.439
TRG_NLS_MonoExtN_4	17	23	PF00514	0.599
TRG_NLS_MonoExtN_4	212	219	PF00514	0.512
TRG_NLS_MonoExtN_4	400	406	PF00514	0.441
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P4	Leptomonas seymouri	60%	99%
A0A0S4JJ09	Bodo saltans	29%	100%
A0A1X0NXQ8	Trypanosomatidae	37%	100%
A0A3Q8IA20	Leishmania donovani	78%	100%
A0A3R7KQ11	Trypanosoma rangeli	40%	100%
A4HYT4	Leishmania infantum	79%	85%
C9ZIB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AUN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QCV4	Leishmania major	77%	99%
V5BQR9	Trypanosoma cruzi	39%	100%