Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIE2_LEIBR

TriTrypDb:

LbrM.20.5090 , LBRM2903_200065300

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.518
CLV_C14_Caspase3-7	247	251	PF00656	0.688
CLV_MEL_PAP_1	30	36	PF00089	0.360
CLV_NRD_NRD_1	212	214	PF00675	0.581
CLV_NRD_NRD_1	230	232	PF00675	0.595
CLV_NRD_NRD_1	5	7	PF00675	0.497
CLV_NRD_NRD_1	75	77	PF00675	0.384
CLV_PCSK_FUR_1	101	105	PF00082	0.379
CLV_PCSK_KEX2_1	103	105	PF00082	0.496
CLV_PCSK_KEX2_1	214	216	PF00082	0.614
CLV_PCSK_KEX2_1	223	225	PF00082	0.587
CLV_PCSK_KEX2_1	230	232	PF00082	0.532
CLV_PCSK_KEX2_1	5	7	PF00082	0.497
CLV_PCSK_KEX2_1	75	77	PF00082	0.384
CLV_PCSK_KEX2_1	84	86	PF00082	0.408
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.654
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.545
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.587
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.408
CLV_PCSK_PC7_1	226	232	PF00082	0.529
CLV_PCSK_SKI1_1	200	204	PF00082	0.535
CLV_PCSK_SKI1_1	81	85	PF00082	0.389
DEG_SPOP_SBC_1	155	159	PF00917	0.510
DEG_SPOP_SBC_1	179	183	PF00917	0.671
DOC_CDC14_PxL_1	54	62	PF14671	0.430
DOC_MAPK_MEF2A_6	55	62	PF00069	0.406
DOC_USP7_MATH_1	135	139	PF00917	0.595
DOC_USP7_MATH_1	180	184	PF00917	0.644
DOC_USP7_MATH_1	192	196	PF00917	0.685
DOC_USP7_MATH_1	244	248	PF00917	0.727
DOC_WW_Pin1_4	107	112	PF00397	0.499
DOC_WW_Pin1_4	240	245	PF00397	0.645
LIG_14-3-3_CanoR_1	31	40	PF00244	0.399
LIG_14-3-3_CanoR_1	75	81	PF00244	0.289
LIG_FHA_1	111	117	PF00498	0.423
LIG_FHA_1	157	163	PF00498	0.507
LIG_FHA_1	255	261	PF00498	0.760
LIG_FHA_1	89	95	PF00498	0.395
LIG_LIR_Gen_1	26	34	PF02991	0.395
LIG_LIR_Nem_3	26	30	PF02991	0.394
LIG_LIR_Nem_3	79	83	PF02991	0.325
LIG_SH2_CRK	80	84	PF00017	0.395
LIG_SH2_STAT3	109	112	PF00017	0.464
LIG_SH2_STAT3	69	72	PF00017	0.366
LIG_SH2_STAT5	24	27	PF00017	0.353
LIG_SH2_STAT5	78	81	PF00017	0.445
LIG_SH3_3	182	188	PF00018	0.658
LIG_SUMO_SIM_par_1	13	19	PF11976	0.340
LIG_SUMO_SIM_par_1	58	65	PF11976	0.384
LIG_TRAF2_1	207	210	PF00917	0.542
LIG_WRC_WIRS_1	24	29	PF05994	0.369
MOD_CK1_1	107	113	PF00069	0.423
MOD_CK1_1	138	144	PF00069	0.598
MOD_CK1_1	178	184	PF00069	0.630
MOD_CK1_1	243	249	PF00069	0.664
MOD_CK1_1	61	67	PF00069	0.394
MOD_CK2_1	141	147	PF00069	0.608
MOD_CK2_1	204	210	PF00069	0.559
MOD_CK2_1	255	261	PF00069	0.542
MOD_GlcNHglycan	132	136	PF01048	0.584
MOD_GlcNHglycan	140	143	PF01048	0.621
MOD_GlcNHglycan	177	180	PF01048	0.605
MOD_GlcNHglycan	182	185	PF01048	0.601
MOD_GlcNHglycan	194	197	PF01048	0.617
MOD_GlcNHglycan	257	260	PF01048	0.693
MOD_GSK3_1	131	138	PF00069	0.770
MOD_GSK3_1	171	178	PF00069	0.632
MOD_GSK3_1	179	186	PF00069	0.619
MOD_GSK3_1	205	212	PF00069	0.567
MOD_GSK3_1	240	247	PF00069	0.624
MOD_GSK3_1	32	39	PF00069	0.429
MOD_N-GLC_1	175	180	PF02516	0.707
MOD_N-GLC_1	226	231	PF02516	0.588
MOD_N-GLC_1	253	258	PF02516	0.504
MOD_NEK2_1	116	121	PF00069	0.428
MOD_NEK2_1	25	30	PF00069	0.403
MOD_NEK2_1	88	93	PF00069	0.370
MOD_PIKK_1	183	189	PF00454	0.523
MOD_PIKK_1	68	74	PF00454	0.381
MOD_PKA_2	121	127	PF00069	0.562
MOD_PKA_2	130	136	PF00069	0.563
MOD_PKA_2	32	38	PF00069	0.375
MOD_PKB_1	224	232	PF00069	0.534
MOD_Plk_4	116	122	PF00069	0.436
MOD_Plk_4	135	141	PF00069	0.585
MOD_Plk_4	58	64	PF00069	0.380
MOD_ProDKin_1	107	113	PF00069	0.500
MOD_ProDKin_1	240	246	PF00069	0.645
MOD_SUMO_for_1	83	86	PF00179	0.398
MOD_SUMO_rev_2	194	202	PF00179	0.545
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.443
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.419
TRG_ENDOCYTIC_2	24	27	PF00928	0.353
TRG_ENDOCYTIC_2	80	83	PF00928	0.391
TRG_ER_diArg_1	29	32	PF00400	0.375
TRG_ER_diArg_1	5	7	PF00400	0.497
TRG_ER_diArg_1	75	77	PF00400	0.384
TRG_ER_diArg_1	94	97	PF00400	0.424
TRG_NLS_Bipartite_1	213	227	PF00514	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P637	Leptomonas seymouri	48%	100%
A0A3Q8IBK6	Leishmania donovani	68%	95%
A4HYT3	Leishmania infantum	68%	95%
E9AUM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4QCV5	Leishmania major	66%	100%