Transcription elongation factor 1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transcription elongation factor 1 domain-containing protein

Species:

Leishmania braziliensis

UniProt:

E9AIE0_LEIBR

TriTrypDb:

LbrM.20.5070 , LBRM2903_200065100

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AIE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIE0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.552
CLV_C14_Caspase3-7	3	7	PF00656	0.660
CLV_NRD_NRD_1	11	13	PF00675	0.729
CLV_NRD_NRD_1	156	158	PF00675	0.685
CLV_NRD_NRD_1	17	19	PF00675	0.689
CLV_NRD_NRD_1	172	174	PF00675	0.657
CLV_NRD_NRD_1	46	48	PF00675	0.608
CLV_PCSK_KEX2_1	11	13	PF00082	0.729
CLV_PCSK_KEX2_1	158	160	PF00082	0.696
CLV_PCSK_KEX2_1	172	174	PF00082	0.657
CLV_PCSK_KEX2_1	228	230	PF00082	0.650
CLV_PCSK_KEX2_1	46	48	PF00082	0.623
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.696
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.556
DOC_CKS1_1	230	235	PF01111	0.692
DOC_MAPK_MEF2A_6	71	78	PF00069	0.385
DOC_PP4_FxxP_1	63	66	PF00568	0.385
DOC_USP7_MATH_1	103	107	PF00917	0.478
DOC_USP7_MATH_1	147	151	PF00917	0.547
DOC_USP7_MATH_1	152	156	PF00917	0.519
DOC_USP7_MATH_1	31	35	PF00917	0.518
DOC_USP7_UBL2_3	158	162	PF12436	0.673
DOC_WW_Pin1_4	229	234	PF00397	0.694
LIG_14-3-3_CanoR_1	229	233	PF00244	0.553
LIG_14-3-3_CanoR_1	75	79	PF00244	0.385
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_eIF4E_1	187	193	PF01652	0.473
LIG_FHA_1	188	194	PF00498	0.582
LIG_FHA_1	203	209	PF00498	0.566
LIG_FHA_1	71	77	PF00498	0.250
LIG_FHA_2	253	259	PF00498	0.593
LIG_HCF-1_HBM_1	40	43	PF13415	0.632
LIG_LIR_Apic_2	62	66	PF02991	0.385
LIG_LIR_Gen_1	126	136	PF02991	0.624
LIG_LIR_Gen_1	245	254	PF02991	0.686
LIG_LIR_Nem_3	101	107	PF02991	0.421
LIG_LIR_Nem_3	119	124	PF02991	0.339
LIG_LIR_Nem_3	126	131	PF02991	0.391
LIG_LIR_Nem_3	178	184	PF02991	0.521
LIG_LIR_Nem_3	245	251	PF02991	0.691
LIG_LYPXL_yS_3	104	107	PF13949	0.385
LIG_MYND_3	111	115	PF01753	0.385
LIG_REV1ctd_RIR_1	119	127	PF16727	0.385
LIG_SH2_STAP1	128	132	PF00017	0.487
LIG_SH2_STAT5	184	187	PF00017	0.474
LIG_SH2_STAT5	91	94	PF00017	0.527
LIG_SH3_3	227	233	PF00018	0.571
LIG_TYR_ITIM	102	107	PF00017	0.385
LIG_WRC_WIRS_1	60	65	PF05994	0.385
LIG_WW_3	234	238	PF00397	0.668
MOD_CDC14_SPxK_1	234	237	PF00782	0.668
MOD_CDK_SPxK_1	231	237	PF00069	0.670
MOD_CK1_1	231	237	PF00069	0.722
MOD_CK1_1	252	258	PF00069	0.506
MOD_CK1_1	32	38	PF00069	0.582
MOD_CK1_1	70	76	PF00069	0.385
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.553
MOD_GlcNHglycan	149	152	PF01048	0.559
MOD_GlcNHglycan	29	32	PF01048	0.573
MOD_GlcNHglycan	34	37	PF01048	0.551
MOD_GSK3_1	141	148	PF00069	0.662
MOD_GSK3_1	164	171	PF00069	0.645
MOD_GSK3_1	187	194	PF00069	0.473
MOD_GSK3_1	243	250	PF00069	0.531
MOD_GSK3_1	27	34	PF00069	0.689
MOD_GSK3_1	70	77	PF00069	0.385
MOD_GSK3_1	83	90	PF00069	0.264
MOD_NEK2_1	249	254	PF00069	0.503
MOD_NEK2_2	91	96	PF00069	0.385
MOD_PKA_1	228	234	PF00069	0.553
MOD_PKA_2	228	234	PF00069	0.659
MOD_PKA_2	32	38	PF00069	0.587
MOD_PKA_2	74	80	PF00069	0.372
MOD_Plk_1	39	45	PF00069	0.618
MOD_Plk_4	249	255	PF00069	0.632
MOD_ProDKin_1	229	235	PF00069	0.692
MOD_SUMO_rev_2	113	118	PF00179	0.326
MOD_SUMO_rev_2	64	73	PF00179	0.320
TRG_ENDOCYTIC_2	104	107	PF00928	0.421
TRG_ENDOCYTIC_2	128	131	PF00928	0.603
TRG_ER_diArg_1	10	12	PF00400	0.715
TRG_ER_diArg_1	172	175	PF00400	0.571
TRG_ER_diArg_1	46	48	PF00400	0.602
TRG_NLS_MonoExtC_3	17	23	PF00514	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBM0	Leishmania donovani	69%	94%
A4HYT1	Leishmania infantum	69%	94%
E9AUM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	95%
Q4QCV7	Leishmania major	69%	99%