Putative ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

E9AID8_LEIBR

TriTrypDb:

LbrM.20.5050 , LBRM2903_200064900

Length:

793

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AID8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AID8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016787	hydrolase activity	2	9
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004386	helicase activity	2	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9
GO:0140657	ATP-dependent activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	658	662	PF00656	0.653
CLV_C14_Caspase3-7	749	753	PF00656	0.748
CLV_MEL_PAP_1	148	154	PF00089	0.636
CLV_NRD_NRD_1	145	147	PF00675	0.497
CLV_NRD_NRD_1	269	271	PF00675	0.362
CLV_NRD_NRD_1	365	367	PF00675	0.623
CLV_NRD_NRD_1	435	437	PF00675	0.546
CLV_NRD_NRD_1	530	532	PF00675	0.259
CLV_NRD_NRD_1	711	713	PF00675	0.589
CLV_NRD_NRD_1	761	763	PF00675	0.683
CLV_NRD_NRD_1	790	792	PF00675	0.514
CLV_PCSK_KEX2_1	145	147	PF00082	0.497
CLV_PCSK_KEX2_1	269	271	PF00082	0.362
CLV_PCSK_KEX2_1	435	437	PF00082	0.548
CLV_PCSK_KEX2_1	529	531	PF00082	0.258
CLV_PCSK_KEX2_1	620	622	PF00082	0.534
CLV_PCSK_KEX2_1	711	713	PF00082	0.589
CLV_PCSK_KEX2_1	763	765	PF00082	0.705
CLV_PCSK_KEX2_1	79	81	PF00082	0.212
CLV_PCSK_KEX2_1	790	792	PF00082	0.514
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.559
CLV_PCSK_PC1ET2_1	763	765	PF00082	0.705
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.212
CLV_PCSK_PC7_1	141	147	PF00082	0.561
CLV_PCSK_SKI1_1	146	150	PF00082	0.460
CLV_PCSK_SKI1_1	229	233	PF00082	0.318
CLV_PCSK_SKI1_1	530	534	PF00082	0.272
CLV_PCSK_SKI1_1	636	640	PF00082	0.496
CLV_PCSK_SKI1_1	776	780	PF00082	0.502
CLV_Separin_Metazoa	142	146	PF03568	0.552
DEG_Nend_UBRbox_2	1	3	PF02207	0.441
DEG_SPOP_SBC_1	654	658	PF00917	0.681
DOC_CKS1_1	212	217	PF01111	0.458
DOC_CYCLIN_RxL_1	220	232	PF00134	0.519
DOC_CYCLIN_RxL_1	528	538	PF00134	0.489
DOC_CYCLIN_RxL_1	85	95	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.319
DOC_MAPK_gen_1	108	117	PF00069	0.526
DOC_MAPK_gen_1	226	235	PF00069	0.538
DOC_MAPK_gen_1	342	351	PF00069	0.617
DOC_MAPK_gen_1	591	600	PF00069	0.559
DOC_MAPK_MEF2A_6	203	212	PF00069	0.562
DOC_MAPK_MEF2A_6	229	237	PF00069	0.538
DOC_MAPK_MEF2A_6	413	420	PF00069	0.374
DOC_MAPK_MEF2A_6	594	602	PF00069	0.435
DOC_PP2B_LxvP_1	55	58	PF13499	0.458
DOC_PP4_FxxP_1	395	398	PF00568	0.391
DOC_USP7_MATH_1	166	170	PF00917	0.745
DOC_USP7_MATH_1	291	295	PF00917	0.532
DOC_USP7_MATH_1	385	389	PF00917	0.548
DOC_USP7_MATH_1	423	427	PF00917	0.508
DOC_USP7_MATH_1	44	48	PF00917	0.506
DOC_USP7_MATH_1	475	479	PF00917	0.640
DOC_USP7_MATH_1	512	516	PF00917	0.559
DOC_USP7_MATH_1	58	62	PF00917	0.396
DOC_USP7_MATH_1	654	658	PF00917	0.714
DOC_USP7_MATH_1	666	670	PF00917	0.787
DOC_USP7_MATH_2	575	581	PF00917	0.538
DOC_WW_Pin1_4	128	133	PF00397	0.568
DOC_WW_Pin1_4	211	216	PF00397	0.458
DOC_WW_Pin1_4	289	294	PF00397	0.540
DOC_WW_Pin1_4	301	306	PF00397	0.565
DOC_WW_Pin1_4	673	678	PF00397	0.702
DOC_WW_Pin1_4	728	733	PF00397	0.557
DOC_WW_Pin1_4	737	742	PF00397	0.660
LIG_14-3-3_CanoR_1	229	234	PF00244	0.562
LIG_14-3-3_CanoR_1	352	357	PF00244	0.447
LIG_14-3-3_CanoR_1	427	433	PF00244	0.517
LIG_14-3-3_CanoR_1	585	595	PF00244	0.458
LIG_14-3-3_CanoR_1	621	627	PF00244	0.546
LIG_14-3-3_CanoR_1	640	648	PF00244	0.604
LIG_14-3-3_CanoR_1	711	717	PF00244	0.568
LIG_14-3-3_CterR_2	790	793	PF00244	0.516
LIG_Actin_WH2_2	215	231	PF00022	0.538
LIG_CaM_NSCaTE_8	713	720	PF13499	0.585
LIG_Clathr_ClatBox_1	235	239	PF01394	0.489
LIG_deltaCOP1_diTrp_1	692	701	PF00928	0.614
LIG_DLG_GKlike_1	352	359	PF00625	0.536
LIG_EH_1	305	309	PF12763	0.381
LIG_eIF4E_1	412	418	PF01652	0.392
LIG_FHA_1	223	229	PF00498	0.489
LIG_FHA_1	230	236	PF00498	0.489
LIG_FHA_1	488	494	PF00498	0.511
LIG_FHA_1	627	633	PF00498	0.526
LIG_FHA_1	93	99	PF00498	0.465
LIG_FHA_2	131	137	PF00498	0.602
LIG_FHA_2	398	404	PF00498	0.470
LIG_FHA_2	4	10	PF00498	0.549
LIG_FHA_2	496	502	PF00498	0.489
LIG_FHA_2	536	542	PF00498	0.465
LIG_FHA_2	608	614	PF00498	0.394
LIG_FHA_2	656	662	PF00498	0.595
LIG_Integrin_isoDGR_2	680	682	PF01839	0.528
LIG_LIR_Apic_2	26	30	PF02991	0.598
LIG_LIR_Apic_2	393	398	PF02991	0.436
LIG_LIR_Apic_2	64	70	PF02991	0.458
LIG_LIR_Gen_1	519	527	PF02991	0.474
LIG_LIR_Nem_3	355	359	PF02991	0.539
LIG_LIR_Nem_3	478	484	PF02991	0.636
LIG_LIR_Nem_3	519	523	PF02991	0.474
LIG_LIR_Nem_3	635	641	PF02991	0.538
LIG_LYPXL_S_1	480	484	PF13949	0.394
LIG_LYPXL_yS_3	481	484	PF13949	0.600
LIG_PCNA_yPIPBox_3	269	282	PF02747	0.545
LIG_PTB_Apo_2	350	357	PF02174	0.530
LIG_PTB_Phospho_1	350	356	PF10480	0.532
LIG_REV1ctd_RIR_1	636	644	PF16727	0.658
LIG_RPA_C_Fungi	422	434	PF08784	0.557
LIG_RPA_C_Fungi	498	510	PF08784	0.423
LIG_SH2_CRK	619	623	PF00017	0.545
LIG_SH2_SRC	67	70	PF00017	0.456
LIG_SH2_STAP1	260	264	PF00017	0.423
LIG_SH2_STAP1	386	390	PF00017	0.668
LIG_SH2_STAP1	634	638	PF00017	0.426
LIG_SH2_STAT5	204	207	PF00017	0.423
LIG_SH2_STAT5	357	360	PF00017	0.553
LIG_SH2_STAT5	582	585	PF00017	0.328
LIG_SH2_STAT5	67	70	PF00017	0.303
LIG_SH3_3	144	150	PF00018	0.537
LIG_SH3_3	209	215	PF00018	0.354
LIG_SUMO_SIM_anti_2	206	214	PF11976	0.384
LIG_SUMO_SIM_par_1	234	240	PF11976	0.331
LIG_SUMO_SIM_par_1	89	95	PF11976	0.311
LIG_TRAF2_1	400	403	PF00917	0.498
LIG_TRAF2_1	498	501	PF00917	0.354
LIG_TRFH_1	395	399	PF08558	0.407
LIG_UBA3_1	74	79	PF00899	0.279
LIG_WRC_WIRS_1	1	6	PF05994	0.402
MOD_CDK_SPxK_1	211	217	PF00069	0.311
MOD_CDK_SPxxK_3	728	735	PF00069	0.501
MOD_CK1_1	287	293	PF00069	0.441
MOD_CK1_1	294	300	PF00069	0.411
MOD_CK1_1	3	9	PF00069	0.572
MOD_CK1_1	547	553	PF00069	0.411
MOD_CK1_1	61	67	PF00069	0.316
MOD_CK1_1	657	663	PF00069	0.743
MOD_CK1_1	669	675	PF00069	0.713
MOD_CK1_1	767	773	PF00069	0.735
MOD_CK1_1	782	788	PF00069	0.743
MOD_CK2_1	128	134	PF00069	0.582
MOD_CK2_1	173	179	PF00069	0.688
MOD_CK2_1	358	364	PF00069	0.560
MOD_CK2_1	397	403	PF00069	0.476
MOD_CK2_1	495	501	PF00069	0.331
MOD_CK2_1	513	519	PF00069	0.256
MOD_CK2_1	522	528	PF00069	0.268
MOD_CK2_1	535	541	PF00069	0.311
MOD_CK2_1	712	718	PF00069	0.535
MOD_Cter_Amidation	760	763	PF01082	0.782
MOD_GlcNHglycan	175	178	PF01048	0.642
MOD_GlcNHglycan	289	292	PF01048	0.327
MOD_GlcNHglycan	296	299	PF01048	0.355
MOD_GlcNHglycan	313	316	PF01048	0.426
MOD_GlcNHglycan	335	338	PF01048	0.218
MOD_GlcNHglycan	387	390	PF01048	0.554
MOD_GlcNHglycan	46	49	PF01048	0.311
MOD_GlcNHglycan	60	63	PF01048	0.258
MOD_GlcNHglycan	607	610	PF01048	0.521
MOD_GlcNHglycan	649	652	PF01048	0.736
MOD_GlcNHglycan	668	671	PF01048	0.740
MOD_GlcNHglycan	677	680	PF01048	0.737
MOD_GlcNHglycan	689	692	PF01048	0.555
MOD_GlcNHglycan	718	721	PF01048	0.541
MOD_GlcNHglycan	759	762	PF01048	0.645
MOD_GlcNHglycan	781	784	PF01048	0.706
MOD_GSK3_1	107	114	PF00069	0.331
MOD_GSK3_1	280	287	PF00069	0.416
MOD_GSK3_1	289	296	PF00069	0.397
MOD_GSK3_1	333	340	PF00069	0.319
MOD_GSK3_1	371	378	PF00069	0.589
MOD_GSK3_1	380	387	PF00069	0.485
MOD_GSK3_1	518	525	PF00069	0.322
MOD_GSK3_1	540	547	PF00069	0.361
MOD_GSK3_1	620	627	PF00069	0.434
MOD_GSK3_1	630	637	PF00069	0.505
MOD_GSK3_1	639	646	PF00069	0.654
MOD_GSK3_1	649	656	PF00069	0.660
MOD_GSK3_1	668	675	PF00069	0.729
MOD_GSK3_1	712	719	PF00069	0.542
MOD_GSK3_1	782	789	PF00069	0.531
MOD_N-GLC_1	311	316	PF02516	0.203
MOD_N-GLC_1	352	357	PF02516	0.504
MOD_N-GLC_1	770	775	PF02516	0.516
MOD_NEK2_1	222	227	PF00069	0.419
MOD_NEK2_1	311	316	PF00069	0.321
MOD_NEK2_1	371	376	PF00069	0.742
MOD_NEK2_1	534	539	PF00069	0.311
MOD_NEK2_1	600	605	PF00069	0.519
MOD_NEK2_1	622	627	PF00069	0.540
MOD_NEK2_1	702	707	PF00069	0.514
MOD_NEK2_1	756	761	PF00069	0.627
MOD_NEK2_2	476	481	PF00069	0.440
MOD_NEK2_2	634	639	PF00069	0.426
MOD_PIKK_1	248	254	PF00454	0.360
MOD_PIKK_1	291	297	PF00454	0.203
MOD_PIKK_1	371	377	PF00454	0.776
MOD_PIKK_1	390	396	PF00454	0.638
MOD_PIKK_1	577	583	PF00454	0.376
MOD_PIKK_1	607	613	PF00454	0.453
MOD_PIKK_1	620	626	PF00454	0.435
MOD_PIKK_1	702	708	PF00454	0.516
MOD_PIKK_1	92	98	PF00454	0.368
MOD_PK_1	111	117	PF00069	0.384
MOD_PK_1	712	718	PF00069	0.627
MOD_PK_1	764	770	PF00069	0.772
MOD_PKA_1	620	626	PF00069	0.551
MOD_PKA_2	107	113	PF00069	0.317
MOD_PKA_2	197	203	PF00069	0.553
MOD_PKA_2	344	350	PF00069	0.461
MOD_PKA_2	535	541	PF00069	0.203
MOD_PKA_2	620	626	PF00069	0.551
MOD_PKA_2	639	645	PF00069	0.582
MOD_PKB_1	762	770	PF00069	0.741
MOD_Plk_1	352	358	PF00069	0.508
MOD_Plk_1	408	414	PF00069	0.544
MOD_Plk_1	459	465	PF00069	0.465
MOD_Plk_1	51	57	PF00069	0.423
MOD_Plk_1	518	524	PF00069	0.331
MOD_Plk_1	634	640	PF00069	0.436
MOD_Plk_1	764	770	PF00069	0.608
MOD_Plk_4	197	203	PF00069	0.457
MOD_Plk_4	352	358	PF00069	0.537
MOD_Plk_4	37	43	PF00069	0.456
MOD_Plk_4	476	482	PF00069	0.427
MOD_Plk_4	513	519	PF00069	0.423
MOD_Plk_4	712	718	PF00069	0.627
MOD_ProDKin_1	128	134	PF00069	0.565
MOD_ProDKin_1	211	217	PF00069	0.311
MOD_ProDKin_1	289	295	PF00069	0.425
MOD_ProDKin_1	301	307	PF00069	0.461
MOD_ProDKin_1	673	679	PF00069	0.700
MOD_ProDKin_1	728	734	PF00069	0.561
MOD_ProDKin_1	737	743	PF00069	0.659
TRG_DiLeu_BaEn_1	139	144	PF01217	0.454
TRG_DiLeu_BaEn_2	402	408	PF01217	0.392
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.306
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.247
TRG_ENDOCYTIC_2	103	106	PF00928	0.320
TRG_ENDOCYTIC_2	356	359	PF00928	0.544
TRG_ENDOCYTIC_2	481	484	PF00928	0.600
TRG_ENDOCYTIC_2	619	622	PF00928	0.548
TRG_ER_diArg_1	144	146	PF00400	0.484
TRG_ER_diArg_1	268	270	PF00400	0.203
TRG_ER_diArg_1	424	427	PF00400	0.531
TRG_ER_diArg_1	529	531	PF00400	0.331
TRG_ER_diArg_1	711	713	PF00400	0.615
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	442	447	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKF6	Leptomonas seymouri	63%	100%
A0A0S4JIC9	Bodo saltans	38%	100%
A0A3R7NJH7	Trypanosoma rangeli	42%	100%
A0A3S7WVZ5	Leishmania donovani	79%	100%
A4HYS9	Leishmania infantum	79%	100%
A4QX49	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	24%	96%
C9ZIA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AUM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QCV9	Leishmania major	79%	97%
V5DS01	Trypanosoma cruzi	41%	100%