Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AID7_LEIBR

TriTrypDb:

LbrM.20.5040 , LBRM2903_200064800

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AID7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AID7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.685
CLV_C14_Caspase3-7	215	219	PF00656	0.534
CLV_NRD_NRD_1	15	17	PF00675	0.493
CLV_NRD_NRD_1	325	327	PF00675	0.365
CLV_NRD_NRD_1	45	47	PF00675	0.432
CLV_PCSK_FUR_1	13	17	PF00082	0.382
CLV_PCSK_FUR_1	43	47	PF00082	0.496
CLV_PCSK_KEX2_1	15	17	PF00082	0.507
CLV_PCSK_KEX2_1	234	236	PF00082	0.621
CLV_PCSK_KEX2_1	240	242	PF00082	0.573
CLV_PCSK_KEX2_1	302	304	PF00082	0.436
CLV_PCSK_KEX2_1	45	47	PF00082	0.400
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.621
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.573
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.495
CLV_PCSK_PC7_1	11	17	PF00082	0.536
CLV_PCSK_SKI1_1	46	50	PF00082	0.381
CLV_PCSK_SKI1_1	73	77	PF00082	0.452
DEG_APCC_DBOX_1	317	325	PF00400	0.439
DEG_Nend_UBRbox_3	1	3	PF02207	0.505
DEG_SCF_FBW7_1	176	183	PF00400	0.532
DEG_SPOP_SBC_1	196	200	PF00917	0.635
DOC_CDC14_PxL_1	85	93	PF14671	0.378
DOC_CYCLIN_RxL_1	42	53	PF00134	0.482
DOC_CYCLIN_RxL_1	82	94	PF00134	0.374
DOC_MAPK_gen_1	13	22	PF00069	0.430
DOC_MAPK_gen_1	316	324	PF00069	0.509
DOC_MAPK_gen_1	326	332	PF00069	0.380
DOC_MAPK_gen_1	59	69	PF00069	0.513
DOC_PP2B_LxvP_1	150	153	PF13499	0.493
DOC_PP4_FxxP_1	185	188	PF00568	0.525
DOC_PP4_FxxP_1	279	282	PF00568	0.368
DOC_USP7_MATH_1	212	216	PF00917	0.506
DOC_USP7_MATH_1	242	246	PF00917	0.385
DOC_WW_Pin1_4	104	109	PF00397	0.414
DOC_WW_Pin1_4	143	148	PF00397	0.421
DOC_WW_Pin1_4	15	20	PF00397	0.333
DOC_WW_Pin1_4	176	181	PF00397	0.597
DOC_WW_Pin1_4	278	283	PF00397	0.403
DOC_WW_Pin1_4	50	55	PF00397	0.549
LIG_14-3-3_CanoR_1	186	196	PF00244	0.533
LIG_14-3-3_CanoR_1	308	317	PF00244	0.524
LIG_CtBP_PxDLS_1	147	151	PF00389	0.350
LIG_eIF4E_1	85	91	PF01652	0.381
LIG_FHA_1	154	160	PF00498	0.453
LIG_FHA_1	250	256	PF00498	0.390
LIG_FHA_2	111	117	PF00498	0.418
LIG_FHA_2	143	149	PF00498	0.480
LIG_FHA_2	187	193	PF00498	0.626
LIG_FHA_2	249	255	PF00498	0.363
LIG_LIR_Apic_2	143	147	PF02991	0.335
LIG_LIR_Apic_2	182	188	PF02991	0.520
LIG_LIR_Gen_1	273	284	PF02991	0.468
LIG_LIR_Gen_1	340	346	PF02991	0.312
LIG_LIR_Gen_1	4	12	PF02991	0.498
LIG_LIR_Gen_1	74	83	PF02991	0.393
LIG_LIR_Gen_1	96	106	PF02991	0.402
LIG_LIR_Nem_3	139	144	PF02991	0.411
LIG_LIR_Nem_3	164	169	PF02991	0.259
LIG_LIR_Nem_3	273	279	PF02991	0.448
LIG_LIR_Nem_3	36	42	PF02991	0.429
LIG_LIR_Nem_3	4	9	PF02991	0.497
LIG_LIR_Nem_3	74	78	PF02991	0.386
LIG_PCNA_yPIPBox_3	239	250	PF02747	0.352
LIG_REV1ctd_RIR_1	138	146	PF16727	0.458
LIG_SH2_CRK	6	10	PF00017	0.507
LIG_SH2_CRK	85	89	PF00017	0.412
LIG_SH2_NCK_1	144	148	PF00017	0.335
LIG_SH2_NCK_1	333	337	PF00017	0.440
LIG_SH2_SRC	341	344	PF00017	0.424
LIG_SH2_STAP1	341	345	PF00017	0.447
LIG_SH2_STAP1	6	10	PF00017	0.507
LIG_SH2_STAT5	144	147	PF00017	0.475
LIG_SH3_3	105	111	PF00018	0.477
LIG_SH3_3	55	61	PF00018	0.497
LIG_TRAF2_1	146	149	PF00917	0.587
LIG_TRAF2_1	189	192	PF00917	0.628
LIG_TRFH_1	85	89	PF08558	0.379
LIG_UBA3_1	321	327	PF00899	0.384
LIG_WRC_WIRS_1	162	167	PF05994	0.277
LIG_WRC_WIRS_1	72	77	PF05994	0.448
MOD_CDK_SPxK_1	15	21	PF00069	0.332
MOD_CK1_1	107	113	PF00069	0.452
MOD_CK1_1	198	204	PF00069	0.681
MOD_CK1_1	226	232	PF00069	0.579
MOD_CK2_1	142	148	PF00069	0.425
MOD_CK2_1	186	192	PF00069	0.625
MOD_CK2_1	202	208	PF00069	0.645
MOD_CK2_1	288	294	PF00069	0.465
MOD_CK2_1	307	313	PF00069	0.357
MOD_CK2_1	90	96	PF00069	0.433
MOD_GlcNHglycan	208	212	PF01048	0.640
MOD_GSK3_1	176	183	PF00069	0.577
MOD_GSK3_1	195	202	PF00069	0.637
MOD_GSK3_1	222	229	PF00069	0.641
MOD_GSK3_1	230	237	PF00069	0.581
MOD_N-GLC_1	226	231	PF02516	0.511
MOD_N-GLC_1	242	247	PF02516	0.334
MOD_NEK2_1	230	235	PF00069	0.724
MOD_NEK2_2	180	185	PF00069	0.510
MOD_PIKK_1	117	123	PF00454	0.545
MOD_PIKK_1	259	265	PF00454	0.434
MOD_PK_1	288	294	PF00069	0.465
MOD_PKA_1	234	240	PF00069	0.495
MOD_PKA_2	125	131	PF00069	0.457
MOD_PKA_2	234	240	PF00069	0.495
MOD_PKA_2	307	313	PF00069	0.559
MOD_Plk_1	242	248	PF00069	0.329
MOD_Plk_4	161	167	PF00069	0.275
MOD_Plk_4	180	186	PF00069	0.470
MOD_Plk_4	280	286	PF00069	0.368
MOD_Plk_4	71	77	PF00069	0.443
MOD_ProDKin_1	104	110	PF00069	0.413
MOD_ProDKin_1	143	149	PF00069	0.418
MOD_ProDKin_1	15	21	PF00069	0.332
MOD_ProDKin_1	176	182	PF00069	0.602
MOD_ProDKin_1	278	284	PF00069	0.408
MOD_ProDKin_1	50	56	PF00069	0.546
TRG_DiLeu_BaEn_2	293	299	PF01217	0.437
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.309
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.367
TRG_ENDOCYTIC_2	276	279	PF00928	0.391
TRG_ENDOCYTIC_2	333	336	PF00928	0.430
TRG_ENDOCYTIC_2	343	346	PF00928	0.464
TRG_ENDOCYTIC_2	6	9	PF00928	0.503
TRG_ENDOCYTIC_2	72	75	PF00928	0.404
TRG_ENDOCYTIC_2	85	88	PF00928	0.321
TRG_ER_diArg_1	12	15	PF00400	0.398
TRG_ER_diArg_1	315	318	PF00400	0.566
TRG_ER_diArg_1	42	45	PF00400	0.466
TRG_ER_FFAT_2	139	149	PF00635	0.326
TRG_NES_CRM1_1	313	328	PF08389	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD57	Leptomonas seymouri	48%	100%
A0A1X0NWC4	Trypanosomatidae	33%	100%
A0A3S7WVX4	Leishmania donovani	80%	100%
A4HYS8	Leishmania infantum	80%	100%
E9AUM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QCW0	Leishmania major	80%	100%