Phosphopantetheinyl transferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantetheinyl transferase-like protein

Species:

Leishmania braziliensis

UniProt:

E9AID4_LEIBR

TriTrypDb:

LbrM.20.5010 , LBRM2903_200064500

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AID4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AID4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006553	lysine metabolic process	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008652	amino acid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009066	aspartate family amino acid metabolic process	5	1
GO:0009067	aspartate family amino acid biosynthetic process	6	1
GO:0009085	lysine biosynthetic process	7	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0019878	lysine biosynthetic process via aminoadipic acid	8	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1
GO:1901607	alpha-amino acid biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0008897	holo-[acyl-carrier-protein] synthase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.338
CLV_C14_Caspase3-7	70	74	PF00656	0.402
CLV_NRD_NRD_1	156	158	PF00675	0.295
CLV_NRD_NRD_1	27	29	PF00675	0.449
CLV_PCSK_KEX2_1	83	85	PF00082	0.588
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.589
CLV_PCSK_PC7_1	79	85	PF00082	0.497
CLV_PCSK_SKI1_1	20	24	PF00082	0.346
CLV_PCSK_SKI1_1	62	66	PF00082	0.412
CLV_PCSK_SKI1_1	95	99	PF00082	0.425
CLV_Separin_Metazoa	148	152	PF03568	0.418
DEG_APCC_DBOX_1	19	27	PF00400	0.318
DEG_APCC_DBOX_1	61	69	PF00400	0.269
DOC_CYCLIN_RxL_1	171	184	PF00134	0.474
DOC_CYCLIN_RxL_1	56	70	PF00134	0.423
DOC_MAPK_gen_1	157	164	PF00069	0.418
DOC_MAPK_gen_1	83	90	PF00069	0.323
DOC_MAPK_MEF2A_6	217	224	PF00069	0.447
DOC_MAPK_MEF2A_6	83	90	PF00069	0.329
DOC_MAPK_NFAT4_5	217	225	PF00069	0.303
DOC_PP1_RVXF_1	77	83	PF00149	0.372
DOC_PP4_FxxP_1	237	240	PF00568	0.428
DOC_PP4_FxxP_1	264	267	PF00568	0.423
DOC_USP7_MATH_1	134	138	PF00917	0.494
DOC_USP7_MATH_1	35	39	PF00917	0.546
DOC_WW_Pin1_4	117	122	PF00397	0.316
DOC_WW_Pin1_4	263	268	PF00397	0.439
LIG_14-3-3_CanoR_1	231	240	PF00244	0.275
LIG_BIR_II_1	1	5	PF00653	0.324
LIG_BRCT_BRCA1_1	136	140	PF00533	0.526
LIG_FHA_1	150	156	PF00498	0.424
LIG_FHA_1	209	215	PF00498	0.421
LIG_FHA_2	167	173	PF00498	0.526
LIG_FHA_2	40	46	PF00498	0.439
LIG_FHA_2	68	74	PF00498	0.338
LIG_IRF3_LxIS_1	86	91	PF10401	0.324
LIG_LIR_Apic_2	235	240	PF02991	0.424
LIG_LIR_Apic_2	261	267	PF02991	0.435
LIG_LIR_Apic_2	91	96	PF02991	0.412
LIG_LIR_Gen_1	137	144	PF02991	0.418
LIG_LIR_Gen_1	233	240	PF02991	0.383
LIG_LIR_Nem_3	137	143	PF02991	0.418
LIG_LIR_Nem_3	233	237	PF02991	0.375
LIG_Pex14_1	160	164	PF04695	0.436
LIG_Pex14_2	164	168	PF04695	0.474
LIG_SH2_CRK	93	97	PF00017	0.398
LIG_SH2_STAP1	234	238	PF00017	0.267
LIG_SH3_3	118	124	PF00018	0.287
LIG_SH3_3	237	243	PF00018	0.452
LIG_SH3_3	83	89	PF00018	0.325
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.477
LIG_TRAF2_1	145	148	PF00917	0.526
LIG_UBA3_1	162	171	PF00899	0.375
LIG_UBA3_1	65	71	PF00899	0.291
MOD_CK1_1	202	208	PF00069	0.378
MOD_CK1_1	266	272	PF00069	0.371
MOD_CK1_1	72	78	PF00069	0.441
MOD_CK2_1	142	148	PF00069	0.311
MOD_CK2_1	166	172	PF00069	0.383
MOD_CK2_1	72	78	PF00069	0.411
MOD_GlcNHglycan	20	23	PF01048	0.453
MOD_GlcNHglycan	37	40	PF01048	0.360
MOD_GSK3_1	134	141	PF00069	0.352
MOD_GSK3_1	166	173	PF00069	0.264
MOD_GSK3_1	241	248	PF00069	0.294
MOD_GSK3_1	35	42	PF00069	0.531
MOD_GSK3_1	48	55	PF00069	0.374
MOD_N-GLC_1	199	204	PF02516	0.383
MOD_NEK2_1	166	171	PF00069	0.383
MOD_NEK2_1	180	185	PF00069	0.310
MOD_NEK2_1	220	225	PF00069	0.450
MOD_NEK2_1	97	102	PF00069	0.480
MOD_NEK2_2	232	237	PF00069	0.412
MOD_PIKK_1	72	78	PF00454	0.516
MOD_PK_1	28	34	PF00069	0.480
MOD_PKA_1	28	34	PF00069	0.329
MOD_PKA_2	230	236	PF00069	0.280
MOD_Plk_1	189	195	PF00069	0.275
MOD_Plk_1	199	205	PF00069	0.358
MOD_Plk_4	128	134	PF00069	0.246
MOD_Plk_4	170	176	PF00069	0.249
MOD_Plk_4	245	251	PF00069	0.371
MOD_ProDKin_1	117	123	PF00069	0.313
MOD_ProDKin_1	263	269	PF00069	0.440
MOD_SUMO_rev_2	51	57	PF00179	0.453
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.233
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.361
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.405
TRG_ENDOCYTIC_2	234	237	PF00928	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I553	Leptomonas seymouri	39%	100%
A0A3S7WW00	Leishmania donovani	64%	100%
A4HYS5	Leishmania infantum	64%	100%
E9AUM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QCW3	Leishmania major	63%	100%