Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AID3_LEIBR

TriTrypDb:

LbrM.20.5000 , LBRM2903_200064400

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AID3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AID3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.539
CLV_C14_Caspase3-7	272	276	PF00656	0.441
CLV_NRD_NRD_1	31	33	PF00675	0.507
CLV_PCSK_KEX2_1	266	268	PF00082	0.526
CLV_PCSK_KEX2_1	31	33	PF00082	0.532
CLV_PCSK_KEX2_1	82	84	PF00082	0.453
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.526
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.525
CLV_PCSK_SKI1_1	196	200	PF00082	0.373
CLV_PCSK_SKI1_1	7	11	PF00082	0.558
DOC_CYCLIN_RxL_1	111	123	PF00134	0.409
DOC_CYCLIN_RxL_1	193	201	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.614
DOC_PP1_RVXF_1	139	145	PF00149	0.495
DOC_PP1_RVXF_1	194	200	PF00149	0.469
DOC_USP7_MATH_1	122	126	PF00917	0.545
DOC_USP7_MATH_1	44	48	PF00917	0.570
DOC_USP7_MATH_2	121	127	PF00917	0.423
DOC_USP7_UBL2_3	252	256	PF12436	0.261
DOC_WW_Pin1_4	157	162	PF00397	0.404
DOC_WW_Pin1_4	215	220	PF00397	0.610
DOC_WW_Pin1_4	7	12	PF00397	0.676
LIG_14-3-3_CanoR_1	196	206	PF00244	0.456
LIG_14-3-3_CanoR_1	267	273	PF00244	0.509
LIG_14-3-3_CanoR_1	308	317	PF00244	0.381
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_deltaCOP1_diTrp_1	100	109	PF00928	0.328
LIG_FHA_1	125	131	PF00498	0.433
LIG_FHA_1	216	222	PF00498	0.611
LIG_FHA_1	236	242	PF00498	0.245
LIG_FHA_1	277	283	PF00498	0.401
LIG_FHA_1	309	315	PF00498	0.321
LIG_FHA_2	167	173	PF00498	0.449
LIG_FHA_2	177	183	PF00498	0.590
LIG_FHA_2	270	276	PF00498	0.447
LIG_LIR_Gen_1	286	295	PF02991	0.388
LIG_LIR_Gen_1	299	309	PF02991	0.291
LIG_LIR_Gen_1	49	60	PF02991	0.476
LIG_LIR_Nem_3	286	290	PF02991	0.410
LIG_LIR_Nem_3	299	305	PF02991	0.303
LIG_LIR_Nem_3	49	55	PF02991	0.477
LIG_Pex14_2	109	113	PF04695	0.396
LIG_Pex14_2	144	148	PF04695	0.397
LIG_SH2_CRK	287	291	PF00017	0.315
LIG_SH2_SRC	328	331	PF00017	0.583
LIG_SH2_STAT5	155	158	PF00017	0.330
LIG_SH2_STAT5	192	195	PF00017	0.487
LIG_SH3_1	21	27	PF00018	0.616
LIG_SH3_3	21	27	PF00018	0.463
LIG_SH3_3	225	231	PF00018	0.578
LIG_SH3_3	252	258	PF00018	0.353
LIG_SH3_3	6	12	PF00018	0.615
LIG_Sin3_3	52	59	PF02671	0.519
LIG_SUMO_SIM_par_1	123	131	PF11976	0.502
LIG_TRAF2_1	121	124	PF00917	0.664
MOD_CK1_1	176	182	PF00069	0.504
MOD_CK1_1	2	8	PF00069	0.664
MOD_CK1_1	269	275	PF00069	0.652
MOD_CK1_1	72	78	PF00069	0.621
MOD_CK2_1	166	172	PF00069	0.596
MOD_CK2_1	75	81	PF00069	0.715
MOD_CMANNOS	307	310	PF00535	0.400
MOD_GlcNHglycan	137	140	PF01048	0.513
MOD_GlcNHglycan	16	19	PF01048	0.709
MOD_GlcNHglycan	182	185	PF01048	0.649
MOD_GlcNHglycan	225	228	PF01048	0.469
MOD_GlcNHglycan	75	78	PF01048	0.767
MOD_GSK3_1	124	131	PF00069	0.536
MOD_GSK3_1	143	150	PF00069	0.303
MOD_GSK3_1	173	180	PF00069	0.578
MOD_GSK3_1	197	204	PF00069	0.372
MOD_GSK3_1	235	242	PF00069	0.484
MOD_GSK3_1	3	10	PF00069	0.687
MOD_GSK3_1	69	76	PF00069	0.737
MOD_N-GLC_1	177	182	PF02516	0.484
MOD_N-GLC_1	44	49	PF02516	0.375
MOD_NEK2_1	135	140	PF00069	0.417
MOD_NEK2_1	147	152	PF00069	0.284
MOD_NEK2_1	3	8	PF00069	0.673
MOD_OFUCOSY	152	159	PF10250	0.405
MOD_PIKK_1	308	314	PF00454	0.278
MOD_PKA_1	266	272	PF00069	0.452
MOD_PKA_2	266	272	PF00069	0.565
MOD_PKA_2	69	75	PF00069	0.483
MOD_Plk_1	123	129	PF00069	0.469
MOD_Plk_1	269	275	PF00069	0.450
MOD_Plk_1	44	50	PF00069	0.373
MOD_Plk_4	124	130	PF00069	0.456
MOD_Plk_4	143	149	PF00069	0.331
MOD_Plk_4	201	207	PF00069	0.344
MOD_Plk_4	240	246	PF00069	0.418
MOD_ProDKin_1	157	163	PF00069	0.408
MOD_ProDKin_1	215	221	PF00069	0.601
MOD_ProDKin_1	7	13	PF00069	0.677
TRG_ENDOCYTIC_2	287	290	PF00928	0.292
TRG_ER_diArg_1	30	32	PF00400	0.442
TRG_NES_CRM1_1	108	123	PF08389	0.553
TRG_NES_CRM1_1	46	61	PF08389	0.422
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P7	Leptomonas seymouri	51%	100%
A0A1X0NWT5	Trypanosomatidae	31%	100%
A0A3R7NTG5	Trypanosoma rangeli	31%	100%
A0A3S7WW35	Leishmania donovani	73%	100%
A4HYS4	Leishmania infantum	73%	100%
E9AUM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4QCW4	Leishmania major	75%	100%
V5BA94	Trypanosoma cruzi	33%	91%