Tubulin_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin/FtsZ family, putative

Species:

Leishmania braziliensis

UniProt:

E9AIC9_LEIBR

TriTrypDb:

LbrM.20.4960 , LBRM2903_200064000

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.480
CLV_C14_Caspase3-7	693	697	PF00656	0.571
CLV_C14_Caspase3-7	74	78	PF00656	0.589
CLV_C14_Caspase3-7	91	95	PF00656	0.715
CLV_NRD_NRD_1	109	111	PF00675	0.494
CLV_NRD_NRD_1	141	143	PF00675	0.539
CLV_NRD_NRD_1	197	199	PF00675	0.659
CLV_NRD_NRD_1	206	208	PF00675	0.570
CLV_NRD_NRD_1	277	279	PF00675	0.517
CLV_NRD_NRD_1	347	349	PF00675	0.381
CLV_PCSK_FUR_1	345	349	PF00082	0.512
CLV_PCSK_KEX2_1	109	111	PF00082	0.623
CLV_PCSK_KEX2_1	141	143	PF00082	0.539
CLV_PCSK_KEX2_1	197	199	PF00082	0.532
CLV_PCSK_KEX2_1	206	208	PF00082	0.424
CLV_PCSK_KEX2_1	277	279	PF00082	0.517
CLV_PCSK_KEX2_1	347	349	PF00082	0.381
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.514
CLV_PCSK_SKI1_1	134	138	PF00082	0.580
CLV_PCSK_SKI1_1	141	145	PF00082	0.644
CLV_PCSK_SKI1_1	207	211	PF00082	0.530
CLV_PCSK_SKI1_1	557	561	PF00082	0.435
CLV_PCSK_SKI1_1	61	65	PF00082	0.349
CLV_PCSK_SKI1_1	614	618	PF00082	0.502
CLV_PCSK_SKI1_1	666	670	PF00082	0.447
DEG_APCC_DBOX_1	613	621	PF00400	0.541
DEG_SPOP_SBC_1	101	105	PF00917	0.497
DOC_CDC14_PxL_1	480	488	PF14671	0.596
DOC_CKS1_1	316	321	PF01111	0.515
DOC_CYCLIN_RxL_1	201	212	PF00134	0.507
DOC_CYCLIN_RxL_1	58	66	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	460	466	PF00134	0.299
DOC_MAPK_gen_1	345	354	PF00069	0.420
DOC_MAPK_gen_1	362	372	PF00069	0.236
DOC_MAPK_gen_1	443	453	PF00069	0.485
DOC_MAPK_MEF2A_6	365	374	PF00069	0.378
DOC_MAPK_MEF2A_6	446	453	PF00069	0.487
DOC_MAPK_MEF2A_6	5	12	PF00069	0.330
DOC_MAPK_NFAT4_5	5	13	PF00069	0.471
DOC_PP2B_LxvP_1	65	68	PF13499	0.384
DOC_PP4_FxxP_1	588	591	PF00568	0.536
DOC_USP7_MATH_1	101	105	PF00917	0.687
DOC_USP7_MATH_1	249	253	PF00917	0.484
DOC_USP7_MATH_1	447	451	PF00917	0.427
DOC_USP7_MATH_1	493	497	PF00917	0.610
DOC_USP7_MATH_1	68	72	PF00917	0.590
DOC_WW_Pin1_4	102	107	PF00397	0.763
DOC_WW_Pin1_4	111	116	PF00397	0.599
DOC_WW_Pin1_4	214	219	PF00397	0.488
DOC_WW_Pin1_4	315	320	PF00397	0.511
DOC_WW_Pin1_4	388	393	PF00397	0.624
DOC_WW_Pin1_4	520	525	PF00397	0.449
DOC_WW_Pin1_4	95	100	PF00397	0.710
LIG_14-3-3_CanoR_1	109	115	PF00244	0.597
LIG_14-3-3_CanoR_1	265	272	PF00244	0.440
LIG_14-3-3_CanoR_1	365	374	PF00244	0.419
LIG_14-3-3_CanoR_1	403	409	PF00244	0.526
LIG_14-3-3_CanoR_1	563	568	PF00244	0.488
LIG_Actin_WH2_2	405	423	PF00022	0.404
LIG_Actin_WH2_2	541	559	PF00022	0.441
LIG_APCC_ABBA_1	673	678	PF00400	0.509
LIG_APCC_ABBAyCdc20_2	206	212	PF00400	0.526
LIG_BRCT_BRCA1_1	104	108	PF00533	0.490
LIG_BRCT_BRCA1_1	578	582	PF00533	0.382
LIG_Clathr_ClatBox_1	62	66	PF01394	0.351
LIG_deltaCOP1_diTrp_1	378	383	PF00928	0.439
LIG_deltaCOP1_diTrp_1	469	473	PF00928	0.374
LIG_FHA_1	222	228	PF00498	0.549
LIG_FHA_1	316	322	PF00498	0.479
LIG_FHA_1	358	364	PF00498	0.369
LIG_FHA_1	365	371	PF00498	0.410
LIG_FHA_1	403	409	PF00498	0.370
LIG_FHA_2	70	76	PF00498	0.467
LIG_LIR_Apic_2	585	591	PF02991	0.408
LIG_LIR_Gen_1	217	227	PF02991	0.533
LIG_LIR_Gen_1	377	387	PF02991	0.472
LIG_LIR_Gen_1	439	449	PF02991	0.499
LIG_LIR_Gen_1	468	479	PF02991	0.376
LIG_LIR_Gen_1	677	684	PF02991	0.540
LIG_LIR_Gen_1	71	80	PF02991	0.620
LIG_LIR_Nem_3	116	121	PF02991	0.491
LIG_LIR_Nem_3	217	223	PF02991	0.549
LIG_LIR_Nem_3	368	374	PF02991	0.430
LIG_LIR_Nem_3	377	382	PF02991	0.470
LIG_LIR_Nem_3	439	444	PF02991	0.509
LIG_LIR_Nem_3	468	474	PF02991	0.365
LIG_LIR_Nem_3	564	570	PF02991	0.342
LIG_LIR_Nem_3	677	682	PF02991	0.361
LIG_LIR_Nem_3	71	76	PF02991	0.611
LIG_LIR_Nem_3	9	15	PF02991	0.407
LIG_NRBOX	353	359	PF00104	0.321
LIG_Pex14_1	379	383	PF04695	0.357
LIG_Pex14_1	79	83	PF04695	0.631
LIG_PTB_Apo_2	332	339	PF02174	0.537
LIG_PTB_Phospho_1	332	338	PF10480	0.291
LIG_SH2_CRK	118	122	PF00017	0.486
LIG_SH2_CRK	15	19	PF00017	0.313
LIG_SH2_CRK	558	562	PF00017	0.350
LIG_SH2_NCK_1	183	187	PF00017	0.453
LIG_SH2_NCK_1	522	526	PF00017	0.325
LIG_SH2_NCK_1	630	634	PF00017	0.419
LIG_SH2_NCK_1	679	683	PF00017	0.540
LIG_SH2_PTP2	371	374	PF00017	0.385
LIG_SH2_SRC	371	374	PF00017	0.368
LIG_SH2_STAP1	15	19	PF00017	0.313
LIG_SH2_STAP1	69	73	PF00017	0.593
LIG_SH2_STAT5	222	225	PF00017	0.420
LIG_SH2_STAT5	259	262	PF00017	0.602
LIG_SH2_STAT5	371	374	PF00017	0.327
LIG_SH2_STAT5	512	515	PF00017	0.539
LIG_SH2_STAT5	567	570	PF00017	0.326
LIG_SH2_STAT5	630	633	PF00017	0.237
LIG_SH2_STAT5	654	657	PF00017	0.446
LIG_SH2_STAT5	658	661	PF00017	0.436
LIG_SH3_3	313	319	PF00018	0.526
LIG_SH3_3	330	336	PF00018	0.320
LIG_SH3_3	367	373	PF00018	0.308
LIG_SH3_3	441	447	PF00018	0.463
LIG_SH3_3	475	481	PF00018	0.526
LIG_SH3_3	54	60	PF00018	0.572
LIG_SH3_3	571	577	PF00018	0.426
LIG_SUMO_SIM_par_1	157	170	PF11976	0.482
LIG_SUMO_SIM_par_1	61	66	PF11976	0.340
LIG_TRAF2_1	124	127	PF00917	0.721
LIG_TRAF2_2	237	242	PF00917	0.614
LIG_UBA3_1	635	642	PF00899	0.413
LIG_WRC_WIRS_1	250	255	PF05994	0.397
MOD_CDK_SPxxK_3	102	109	PF00069	0.624
MOD_CK1_1	100	106	PF00069	0.749
MOD_CK1_1	113	119	PF00069	0.697
MOD_CK1_1	231	237	PF00069	0.511
MOD_CK1_1	364	370	PF00069	0.331
MOD_CK1_1	424	430	PF00069	0.561
MOD_CK1_1	465	471	PF00069	0.526
MOD_CK1_1	503	509	PF00069	0.628
MOD_CK1_1	518	524	PF00069	0.570
MOD_CK1_1	609	615	PF00069	0.582
MOD_CK1_1	628	634	PF00069	0.239
MOD_CK2_1	121	127	PF00069	0.652
MOD_CK2_1	388	394	PF00069	0.603
MOD_CK2_1	682	688	PF00069	0.497
MOD_GlcNHglycan	123	126	PF01048	0.735
MOD_GlcNHglycan	190	193	PF01048	0.643
MOD_GlcNHglycan	367	370	PF01048	0.370
MOD_GlcNHglycan	42	45	PF01048	0.715
MOD_GlcNHglycan	426	429	PF01048	0.620
MOD_GlcNHglycan	464	467	PF01048	0.534
MOD_GlcNHglycan	495	498	PF01048	0.731
MOD_GlcNHglycan	502	505	PF01048	0.661
MOD_GlcNHglycan	51	54	PF01048	0.419
MOD_GlcNHglycan	608	611	PF01048	0.515
MOD_GlcNHglycan	99	102	PF01048	0.713
MOD_GSK3_1	110	117	PF00069	0.551
MOD_GSK3_1	188	195	PF00069	0.640
MOD_GSK3_1	32	39	PF00069	0.598
MOD_GSK3_1	357	364	PF00069	0.343
MOD_GSK3_1	423	430	PF00069	0.521
MOD_GSK3_1	499	506	PF00069	0.649
MOD_GSK3_1	513	520	PF00069	0.401
MOD_GSK3_1	612	619	PF00069	0.564
MOD_GSK3_1	625	632	PF00069	0.338
MOD_GSK3_1	97	104	PF00069	0.695
MOD_N-GLC_1	13	18	PF02516	0.406
MOD_N-GLC_1	24	29	PF02516	0.377
MOD_N-GLC_2	54	56	PF02516	0.431
MOD_NEK2_1	357	362	PF00069	0.339
MOD_NEK2_1	47	52	PF00069	0.428
MOD_NEK2_1	515	520	PF00069	0.434
MOD_NEK2_1	562	567	PF00069	0.440
MOD_PIKK_1	428	434	PF00454	0.543
MOD_PKA_1	110	116	PF00069	0.481
MOD_PKA_2	121	127	PF00069	0.590
MOD_PKA_2	264	270	PF00069	0.437
MOD_PKA_2	361	367	PF00069	0.466
MOD_PKA_2	402	408	PF00069	0.493
MOD_PKA_2	562	568	PF00069	0.483
MOD_Plk_1	13	19	PF00069	0.423
MOD_Plk_2-3	86	92	PF00069	0.619
MOD_Plk_4	14	20	PF00069	0.326
MOD_Plk_4	33	39	PF00069	0.568
MOD_Plk_4	544	550	PF00069	0.507
MOD_Plk_4	563	569	PF00069	0.486
MOD_Plk_4	631	637	PF00069	0.375
MOD_ProDKin_1	102	108	PF00069	0.764
MOD_ProDKin_1	111	117	PF00069	0.601
MOD_ProDKin_1	214	220	PF00069	0.489
MOD_ProDKin_1	315	321	PF00069	0.504
MOD_ProDKin_1	388	394	PF00069	0.622
MOD_ProDKin_1	520	526	PF00069	0.448
MOD_ProDKin_1	95	101	PF00069	0.710
TRG_DiLeu_BaEn_1	169	174	PF01217	0.483
TRG_DiLeu_BaEn_2	468	474	PF01217	0.489
TRG_DiLeu_BaEn_4	127	133	PF01217	0.532
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.405
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.488
TRG_ENDOCYTIC_2	118	121	PF00928	0.488
TRG_ENDOCYTIC_2	15	18	PF00928	0.314
TRG_ENDOCYTIC_2	371	374	PF00928	0.307
TRG_ENDOCYTIC_2	512	515	PF00928	0.427
TRG_ENDOCYTIC_2	567	570	PF00928	0.326
TRG_ENDOCYTIC_2	679	682	PF00928	0.302
TRG_ER_diArg_1	108	110	PF00400	0.495
TRG_ER_diArg_1	141	143	PF00400	0.539
TRG_ER_diArg_1	276	278	PF00400	0.510
TRG_ER_diArg_1	347	349	PF00400	0.426
TRG_NLS_MonoExtC_3	205	211	PF00514	0.624
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U7	Leptomonas seymouri	53%	95%
A0A0S4J688	Bodo saltans	33%	100%
A0A1X0NWM5	Trypanosomatidae	42%	100%
A0A3R7MKD9	Trypanosoma rangeli	40%	100%
A0A3S7WVZ9	Leishmania donovani	79%	100%
A4HYP0	Leishmania infantum	79%	100%
C9ZI95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AUL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QCW8	Leishmania major	78%	98%
V5C080	Trypanosoma cruzi	40%	100%