DUF775 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF775), putative

Species:

Leishmania braziliensis

UniProt:

E9AIC4_LEIBR

TriTrypDb:

LbrM.20.4910 , LBRM2903_200063400

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIC4

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0061608	nuclear import signal receptor activity	3	1
GO:0140104	molecular carrier activity	1	1
GO:0140142	nucleocytoplasmic carrier activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	115	119	PF00082	0.268
CLV_PCSK_SKI1_1	167	171	PF00082	0.358
CLV_PCSK_SKI1_1	206	210	PF00082	0.232
DEG_MDM2_SWIB_1	195	203	PF02201	0.468
DEG_Nend_UBRbox_3	1	3	PF02207	0.685
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.432
DOC_MAPK_MEF2A_6	115	122	PF00069	0.524
DOC_MAPK_MEF2A_6	46	53	PF00069	0.519
DOC_MAPK_NFAT4_5	115	123	PF00069	0.534
DOC_PP2B_LxvP_1	10	13	PF13499	0.630
DOC_USP7_MATH_1	17	21	PF00917	0.620
DOC_WW_Pin1_4	20	25	PF00397	0.568
LIG_14-3-3_CanoR_1	167	172	PF00244	0.501
LIG_14-3-3_CanoR_1	46	50	PF00244	0.500
LIG_BRCT_BRCA1_1	103	107	PF00533	0.486
LIG_BRCT_BRCA1_1	22	26	PF00533	0.391
LIG_FHA_1	112	118	PF00498	0.455
LIG_FHA_1	13	19	PF00498	0.558
LIG_FHA_1	166	172	PF00498	0.530
LIG_FHA_1	175	181	PF00498	0.488
LIG_FHA_1	46	52	PF00498	0.442
LIG_FHA_2	61	67	PF00498	0.534
LIG_GBD_Chelix_1	150	158	PF00786	0.285
LIG_LIR_Gen_1	187	196	PF02991	0.534
LIG_LIR_Gen_1	56	64	PF02991	0.558
LIG_LIR_Gen_1	83	92	PF02991	0.456
LIG_LIR_Nem_3	156	162	PF02991	0.468
LIG_LIR_Nem_3	23	29	PF02991	0.229
LIG_LIR_Nem_3	56	61	PF02991	0.508
LIG_LIR_Nem_3	83	89	PF02991	0.456
LIG_PDZ_Class_2	210	215	PF00595	0.447
LIG_Pex14_2	195	199	PF04695	0.468
LIG_SH2_CRK	14	18	PF00017	0.651
LIG_SH2_CRK	159	163	PF00017	0.468
LIG_SH2_STAP1	165	169	PF00017	0.512
LIG_SH2_STAT3	33	36	PF00017	0.488
LIG_SH2_STAT5	14	17	PF00017	0.549
LIG_SH2_STAT5	188	191	PF00017	0.489
LIG_SH2_STAT5	88	91	PF00017	0.496
LIG_SH3_3	1	7	PF00018	0.535
LIG_SH3_3	186	192	PF00018	0.468
LIG_SH3_3	25	31	PF00018	0.502
LIG_SH3_3	64	70	PF00018	0.486
LIG_SUMO_SIM_anti_2	37	44	PF11976	0.377
MOD_CK1_1	111	117	PF00069	0.377
MOD_CK1_1	175	181	PF00069	0.533
MOD_CK1_1	20	26	PF00069	0.477
MOD_CK2_1	178	184	PF00069	0.534
MOD_CK2_1	60	66	PF00069	0.534
MOD_GlcNHglycan	103	106	PF01048	0.222
MOD_GlcNHglycan	174	177	PF01048	0.322
MOD_GlcNHglycan	19	22	PF01048	0.536
MOD_GSK3_1	107	114	PF00069	0.499
MOD_GSK3_1	12	19	PF00069	0.695
MOD_GSK3_1	139	146	PF00069	0.567
MOD_GSK3_1	161	168	PF00069	0.494
MOD_GSK3_1	174	181	PF00069	0.551
MOD_GSK3_1	37	44	PF00069	0.521
MOD_N-GLC_1	108	113	PF02516	0.314
MOD_N-GLC_1	37	42	PF02516	0.309
MOD_NEK2_1	139	144	PF00069	0.567
MOD_NEK2_1	161	166	PF00069	0.445
MOD_NEK2_1	41	46	PF00069	0.478
MOD_PIKK_1	131	137	PF00454	0.496
MOD_PIKK_1	139	145	PF00454	0.503
MOD_PIKK_1	90	96	PF00454	0.507
MOD_PKA_2	45	51	PF00069	0.405
MOD_PKB_1	200	208	PF00069	0.507
MOD_Plk_1	37	43	PF00069	0.465
MOD_Plk_1	80	86	PF00069	0.534
MOD_Plk_4	191	197	PF00069	0.467
MOD_Plk_4	37	43	PF00069	0.526
MOD_Plk_4	54	60	PF00069	0.454
MOD_ProDKin_1	20	26	PF00069	0.550
TRG_DiLeu_BaEn_4	126	132	PF01217	0.534
TRG_ENDOCYTIC_2	159	162	PF00928	0.455
TRG_ENDOCYTIC_2	188	191	PF00928	0.509
TRG_ER_diArg_1	199	202	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS8	Leptomonas seymouri	70%	93%
A0A0S4J2E1	Bodo saltans	36%	100%
A0A1X0NWD7	Trypanosomatidae	42%	91%
A0A3Q8IBJ8	Leishmania donovani	83%	100%
A0A422NJN3	Trypanosoma rangeli	47%	100%
A4HYP4	Leishmania infantum	83%	100%
C9ZI87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AUL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
O60175	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q4QCX3	Leishmania major	82%	100%