Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIC3_LEIBR

TriTrypDb:

LbrM.20.4900 , LBRM2903_200063300

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AIC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIC3

PDB structure(s): 7aih_Ap , 7am2_Ap , 7ane_Ap

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.597
CLV_PCSK_KEX2_1	157	159	PF00082	0.659
CLV_PCSK_KEX2_1	165	167	PF00082	0.555
CLV_PCSK_KEX2_1	3	5	PF00082	0.597
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.685
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.707
CLV_PCSK_SKI1_1	111	115	PF00082	0.506
CLV_PCSK_SKI1_1	50	54	PF00082	0.510
CLV_PCSK_SKI1_1	79	83	PF00082	0.489
CLV_Separin_Metazoa	71	75	PF03568	0.464
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DOC_CYCLIN_RxL_1	84	94	PF00134	0.560
DOC_MAPK_gen_1	108	116	PF00069	0.463
DOC_MAPK_gen_1	19	28	PF00069	0.579
DOC_MAPK_MEF2A_6	108	116	PF00069	0.517
DOC_MAPK_MEF2A_6	74	82	PF00069	0.470
DOC_PP1_RVXF_1	77	84	PF00149	0.469
DOC_PP2B_LxvP_1	26	29	PF13499	0.545
DOC_PP4_FxxP_1	53	56	PF00568	0.514
DOC_PP4_FxxP_1	83	86	PF00568	0.470
DOC_USP7_MATH_1	103	107	PF00917	0.506
DOC_USP7_MATH_1	29	33	PF00917	0.546
LIG_14-3-3_CanoR_1	25	29	PF00244	0.508
LIG_14-3-3_CanoR_1	3	12	PF00244	0.564
LIG_CaM_IQ_9	143	159	PF13499	0.549
LIG_EH1_1	143	151	PF00400	0.668
LIG_eIF4E_1	76	82	PF01652	0.457
LIG_FHA_1	128	134	PF00498	0.525
LIG_FHA_2	205	211	PF00498	0.514
LIG_LIR_Apic_2	51	56	PF02991	0.523
LIG_LIR_Nem_3	131	137	PF02991	0.704
LIG_LRP6_Inhibitor_1	57	63	PF00058	0.549
LIG_MYND_1	16	20	PF01753	0.528
LIG_PCNA_yPIPBox_3	43	53	PF02747	0.526
LIG_PDZ_Class_1	243	248	PF00595	0.760
LIG_Pex14_2	204	208	PF04695	0.560
LIG_SH2_STAT3	137	140	PF00017	0.538
LIG_SH2_STAT5	137	140	PF00017	0.511
LIG_SH2_STAT5	214	217	PF00017	0.542
LIG_SH2_STAT5	76	79	PF00017	0.472
LIG_SH3_3	9	15	PF00018	0.554
LIG_SUMO_SIM_par_1	88	94	PF11976	0.483
LIG_TRAF2_1	234	237	PF00917	0.659
LIG_TYR_ITIM	133	138	PF00017	0.542
LIG_UBA3_1	89	97	PF00899	0.560
MOD_CK1_1	32	38	PF00069	0.519
MOD_CK2_1	237	243	PF00069	0.639
MOD_GlcNHglycan	105	108	PF01048	0.503
MOD_GlcNHglycan	217	220	PF01048	0.553
MOD_GSK3_1	204	211	PF00069	0.669
MOD_GSK3_1	232	239	PF00069	0.597
MOD_N-GLC_1	127	132	PF02516	0.503
MOD_NEK2_1	190	195	PF00069	0.546
MOD_NEK2_1	2	7	PF00069	0.530
MOD_NEK2_1	208	213	PF00069	0.468
MOD_PIKK_1	232	238	PF00454	0.461
MOD_PKA_2	2	8	PF00069	0.557
MOD_PKA_2	24	30	PF00069	0.502
MOD_Plk_1	32	38	PF00069	0.527
MOD_Plk_2-3	179	185	PF00069	0.487
MOD_Plk_4	190	196	PF00069	0.544
MOD_Plk_4	204	210	PF00069	0.672
MOD_Plk_4	32	38	PF00069	0.509
MOD_SUMO_rev_2	205	213	PF00179	0.643
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.548
TRG_ENDOCYTIC_2	135	138	PF00928	0.509
TRG_ER_diArg_1	2	4	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.507
TRG_PTS1	245	248	PF00515	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG2	Leptomonas seymouri	29%	100%
A0A0N1PDB1	Leptomonas seymouri	74%	99%
A0A0S4IZI9	Bodo saltans	51%	100%
A0A0S4JXP9	Bodo saltans	33%	81%
A0A1X0NWE3	Trypanosomatidae	67%	100%
A0A1X0P2D2	Trypanosomatidae	29%	100%
A0A3S7WW24	Leishmania donovani	87%	100%
A0A3S7X2W2	Leishmania donovani	30%	100%
A0A422N627	Trypanosoma rangeli	31%	99%
A0A422NJN4	Trypanosoma rangeli	68%	98%
A4HHV1	Leishmania braziliensis	29%	100%
A4HYP5	Leishmania infantum	87%	100%
A4I501	Leishmania infantum	30%	100%
C9ZI86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
C9ZQF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	82%
E9AUL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B0D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q7V3	Leishmania major	28%	100%
Q4QCX4	Leishmania major	86%	100%
V5BCA8	Trypanosoma cruzi	32%	99%
V5BVG0	Trypanosoma cruzi	69%	100%