Putative serine/threonine protein phosphatase 2A regulatory subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase 2A regulatory subunit, putative

Species:

Leishmania braziliensis

UniProt:

E9AIC2_LEIBR

TriTrypDb:

LbrM.20.4890 , LBRM2903_200063200

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	1
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

E9AIC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIC2

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.684
CLV_C14_Caspase3-7	229	233	PF00656	0.393
CLV_C14_Caspase3-7	581	585	PF00656	0.441
CLV_C14_Caspase3-7	9	13	PF00656	0.524
CLV_NRD_NRD_1	148	150	PF00675	0.484
CLV_NRD_NRD_1	196	198	PF00675	0.350
CLV_PCSK_KEX2_1	148	150	PF00082	0.484
CLV_PCSK_KEX2_1	196	198	PF00082	0.350
CLV_PCSK_SKI1_1	333	337	PF00082	0.272
CLV_PCSK_SKI1_1	390	394	PF00082	0.345
CLV_PCSK_SKI1_1	505	509	PF00082	0.319
CLV_PCSK_SKI1_1	568	572	PF00082	0.460
CLV_PCSK_SKI1_1	583	587	PF00082	0.435
CLV_Separin_Metazoa	58	62	PF03568	0.369
DEG_APCC_DBOX_1	176	184	PF00400	0.502
DEG_APCC_DBOX_1	504	512	PF00400	0.441
DEG_Nend_UBRbox_2	1	3	PF02207	0.616
DEG_ODPH_VHL_1	409	420	PF01847	0.417
DEG_SPOP_SBC_1	116	120	PF00917	0.673
DOC_ANK_TNKS_1	147	154	PF00023	0.524
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.433
DOC_MAPK_DCC_7	539	547	PF00069	0.476
DOC_MAPK_gen_1	40	49	PF00069	0.463
DOC_MAPK_gen_1	425	433	PF00069	0.390
DOC_MAPK_MEF2A_6	40	49	PF00069	0.502
DOC_MAPK_MEF2A_6	539	547	PF00069	0.422
DOC_MAPK_NFAT4_5	42	50	PF00069	0.503
DOC_PP2B_LxvP_1	287	290	PF13499	0.384
DOC_PP2B_LxvP_1	83	86	PF13499	0.465
DOC_USP7_MATH_1	102	106	PF00917	0.325
DOC_USP7_MATH_1	260	264	PF00917	0.421
DOC_USP7_MATH_1	276	280	PF00917	0.311
DOC_USP7_MATH_1	392	396	PF00917	0.387
DOC_USP7_MATH_1	421	425	PF00917	0.527
DOC_USP7_MATH_1	469	473	PF00917	0.355
DOC_USP7_MATH_1	525	529	PF00917	0.361
DOC_USP7_MATH_1	588	592	PF00917	0.627
DOC_USP7_MATH_1	594	598	PF00917	0.685
DOC_WW_Pin1_4	285	290	PF00397	0.356
DOC_WW_Pin1_4	400	405	PF00397	0.493
LIG_14-3-3_CanoR_1	158	165	PF00244	0.333
LIG_14-3-3_CanoR_1	22	27	PF00244	0.379
LIG_14-3-3_CanoR_1	262	272	PF00244	0.420
LIG_14-3-3_CanoR_1	341	350	PF00244	0.384
LIG_14-3-3_CanoR_1	351	355	PF00244	0.384
LIG_14-3-3_CanoR_1	457	465	PF00244	0.457
LIG_14-3-3_CanoR_1	572	580	PF00244	0.544
LIG_Actin_WH2_2	347	362	PF00022	0.334
LIG_APCC_ABBA_1	535	540	PF00400	0.521
LIG_BIR_III_4	328	332	PF00653	0.420
LIG_Clathr_ClatBox_1	84	88	PF01394	0.239
LIG_eIF4E_1	79	85	PF01652	0.256
LIG_FHA_1	338	344	PF00498	0.420
LIG_FHA_1	370	376	PF00498	0.377
LIG_FHA_1	377	383	PF00498	0.350
LIG_FHA_1	457	463	PF00498	0.474
LIG_FHA_1	48	54	PF00498	0.396
LIG_FHA_1	565	571	PF00498	0.407
LIG_FHA_1	78	84	PF00498	0.483
LIG_FHA_2	174	180	PF00498	0.491
LIG_FHA_2	39	45	PF00498	0.384
LIG_FHA_2	522	528	PF00498	0.259
LIG_FHA_2	7	13	PF00498	0.580
LIG_FHA_2	95	101	PF00498	0.384
LIG_LIR_Gen_1	142	150	PF02991	0.348
LIG_LIR_Gen_1	2	11	PF02991	0.461
LIG_LIR_Gen_1	395	404	PF02991	0.438
LIG_LIR_Nem_3	2	7	PF02991	0.455
LIG_LIR_Nem_3	528	534	PF02991	0.454
LIG_MYND_1	411	415	PF01753	0.396
LIG_Pex14_1	270	274	PF04695	0.299
LIG_PTB_Apo_2	108	115	PF02174	0.274
LIG_SH2_CRK	295	299	PF00017	0.420
LIG_SH2_CRK	512	516	PF00017	0.407
LIG_SH2_STAP1	79	83	PF00017	0.461
LIG_SH2_STAT5	438	441	PF00017	0.495
LIG_SH2_STAT5	48	51	PF00017	0.391
LIG_SH2_STAT5	502	505	PF00017	0.344
LIG_SH2_STAT5	52	55	PF00017	0.387
LIG_SH2_STAT5	79	82	PF00017	0.490
LIG_SH3_3	207	213	PF00018	0.427
LIG_SH3_3	494	500	PF00018	0.431
LIG_SUMO_SIM_par_1	257	263	PF11976	0.479
LIG_SUMO_SIM_par_1	492	499	PF11976	0.257
LIG_UBA3_1	553	561	PF00899	0.420
MOD_CDK_SPxxK_3	400	407	PF00069	0.489
MOD_CK1_1	123	129	PF00069	0.713
MOD_CK1_1	163	169	PF00069	0.367
MOD_CK1_1	172	178	PF00069	0.250
MOD_CK1_1	263	269	PF00069	0.346
MOD_CK1_1	353	359	PF00069	0.420
MOD_CK1_1	495	501	PF00069	0.361
MOD_CK1_1	6	12	PF00069	0.456
MOD_CK2_1	304	310	PF00069	0.355
MOD_CK2_1	38	44	PF00069	0.391
MOD_CK2_1	521	527	PF00069	0.434
MOD_CK2_1	570	576	PF00069	0.409
MOD_CK2_1	89	95	PF00069	0.419
MOD_Cter_Amidation	330	333	PF01082	0.420
MOD_GlcNHglycan	122	125	PF01048	0.732
MOD_GlcNHglycan	126	129	PF01048	0.692
MOD_GlcNHglycan	223	226	PF01048	0.470
MOD_GlcNHglycan	254	257	PF01048	0.440
MOD_GlcNHglycan	355	358	PF01048	0.324
MOD_GlcNHglycan	394	397	PF01048	0.400
MOD_GlcNHglycan	527	530	PF01048	0.501
MOD_GSK3_1	115	122	PF00069	0.592
MOD_GSK3_1	156	163	PF00069	0.425
MOD_GSK3_1	169	176	PF00069	0.470
MOD_GSK3_1	262	269	PF00069	0.389
MOD_GSK3_1	337	344	PF00069	0.391
MOD_GSK3_1	392	399	PF00069	0.404
MOD_GSK3_1	521	528	PF00069	0.340
MOD_GSK3_1	588	595	PF00069	0.579
MOD_NEK2_1	164	169	PF00069	0.377
MOD_NEK2_1	252	257	PF00069	0.492
MOD_NEK2_1	31	36	PF00069	0.417
MOD_NEK2_1	369	374	PF00069	0.370
MOD_NEK2_1	521	526	PF00069	0.295
MOD_NEK2_1	554	559	PF00069	0.442
MOD_NEK2_1	592	597	PF00069	0.616
MOD_PIKK_1	431	437	PF00454	0.231
MOD_PKA_2	157	163	PF00069	0.336
MOD_PKA_2	21	27	PF00069	0.416
MOD_PKA_2	350	356	PF00069	0.420
MOD_PKA_2	456	462	PF00069	0.455
MOD_PKA_2	564	570	PF00069	0.469
MOD_Plk_1	266	272	PF00069	0.299
MOD_Plk_1	345	351	PF00069	0.381
MOD_Plk_1	94	100	PF00069	0.375
MOD_Plk_2-3	94	100	PF00069	0.383
MOD_Plk_4	160	166	PF00069	0.323
MOD_Plk_4	241	247	PF00069	0.410
MOD_Plk_4	370	376	PF00069	0.389
MOD_Plk_4	409	415	PF00069	0.508
MOD_Plk_4	492	498	PF00069	0.409
MOD_Plk_4	6	12	PF00069	0.435
MOD_Plk_4	66	72	PF00069	0.357
MOD_Plk_4	79	85	PF00069	0.339
MOD_ProDKin_1	285	291	PF00069	0.356
MOD_ProDKin_1	400	406	PF00069	0.487
MOD_SUMO_for_1	227	230	PF00179	0.519
MOD_SUMO_rev_2	399	409	PF00179	0.575
TRG_ENDOCYTIC_2	512	515	PF00928	0.339
TRG_ER_diArg_1	147	149	PF00400	0.500
TRG_ER_diArg_1	195	197	PF00400	0.341
TRG_ER_diArg_1	270	273	PF00400	0.299
TRG_ER_diArg_1	426	429	PF00400	0.365
TRG_NES_CRM1_1	88	101	PF08389	0.453
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHR7	Leptomonas seymouri	25%	82%
A0A0N1IM26	Leptomonas seymouri	83%	100%
A0A0S4IUU5	Bodo saltans	26%	95%
A0A0S4J1S0	Bodo saltans	23%	97%
A0A0S4J2C5	Bodo saltans	52%	100%
A0A1X0NWU2	Trypanosomatidae	59%	100%
A0A3Q8IBL0	Leishmania donovani	91%	100%
A0A3R7MGY7	Trypanosoma rangeli	58%	100%
A0A3S7WUV3	Leishmania donovani	25%	84%
A4H9H6	Leishmania braziliensis	25%	84%
A4HXU2	Leishmania infantum	25%	84%
A4HYP6	Leishmania infantum	91%	100%
C9ZI85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AUK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P30153	Homo sapiens	36%	100%
P30154	Homo sapiens	34%	100%
P31383	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	94%
P36179	Drosophila melanogaster	33%	100%
P54612	Sus scrofa	36%	100%
P54613	Sus scrofa	34%	100%
Q09543	Caenorhabditis elegans	33%	100%
Q32PI5	Bos taurus	36%	100%
Q38845	Arabidopsis thaliana	34%	100%
Q38950	Arabidopsis thaliana	34%	100%
Q38951	Arabidopsis thaliana	33%	100%
Q4QCX5	Leishmania major	90%	100%
Q4QDX5	Leishmania major	24%	84%
Q4QQT4	Rattus norvegicus	34%	100%
Q54QR9	Dictyostelium discoideum	33%	100%
Q76MZ3	Mus musculus	36%	100%
Q7TNP2	Mus musculus	34%	100%
Q9UT08	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
V5C089	Trypanosoma cruzi	57%	100%