rRNA biogenesis protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rRNA biogenesis protein-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIC1_LEIBR

TriTrypDb:

LbrM.20.4880 , LBRM2903_200063000 , LBRM2903_200063100

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AIC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIC1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.374
CLV_C14_Caspase3-7	442	446	PF00656	0.508
CLV_C14_Caspase3-7	735	739	PF00656	0.663
CLV_NRD_NRD_1	101	103	PF00675	0.490
CLV_NRD_NRD_1	108	110	PF00675	0.448
CLV_NRD_NRD_1	437	439	PF00675	0.519
CLV_NRD_NRD_1	536	538	PF00675	0.425
CLV_NRD_NRD_1	559	561	PF00675	0.385
CLV_NRD_NRD_1	580	582	PF00675	0.442
CLV_NRD_NRD_1	643	645	PF00675	0.528
CLV_NRD_NRD_1	665	667	PF00675	0.494
CLV_PCSK_FUR_1	434	438	PF00082	0.607
CLV_PCSK_KEX2_1	101	103	PF00082	0.505
CLV_PCSK_KEX2_1	436	438	PF00082	0.516
CLV_PCSK_KEX2_1	536	538	PF00082	0.362
CLV_PCSK_KEX2_1	54	56	PF00082	0.528
CLV_PCSK_KEX2_1	580	582	PF00082	0.434
CLV_PCSK_KEX2_1	595	597	PF00082	0.307
CLV_PCSK_KEX2_1	600	602	PF00082	0.391
CLV_PCSK_KEX2_1	611	613	PF00082	0.404
CLV_PCSK_KEX2_1	648	650	PF00082	0.547
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.525
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.391
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.406
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.420
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.523
CLV_PCSK_PC7_1	596	602	PF00082	0.393
CLV_PCSK_PC7_1	644	650	PF00082	0.526
CLV_PCSK_SKI1_1	110	114	PF00082	0.480
CLV_PCSK_SKI1_1	284	288	PF00082	0.392
CLV_PCSK_SKI1_1	390	394	PF00082	0.577
CLV_PCSK_SKI1_1	464	468	PF00082	0.410
CLV_PCSK_SKI1_1	570	574	PF00082	0.479
CLV_PCSK_SKI1_1	601	605	PF00082	0.425
CLV_PCSK_SKI1_1	636	640	PF00082	0.360
CLV_PCSK_SKI1_1	677	681	PF00082	0.356
CLV_PCSK_SKI1_1	80	84	PF00082	0.551
CLV_Separin_Metazoa	98	102	PF03568	0.535
DEG_SCF_FBW7_1	240	247	PF00400	0.619
DEG_SPOP_SBC_1	378	382	PF00917	0.645
DOC_CYCLIN_RxL_1	696	704	PF00134	0.432
DOC_MAPK_gen_1	106	116	PF00069	0.482
DOC_MAPK_gen_1	560	568	PF00069	0.373
DOC_MAPK_gen_1	580	588	PF00069	0.201
DOC_MAPK_gen_1	611	619	PF00069	0.368
DOC_MAPK_MEF2A_6	109	116	PF00069	0.493
DOC_MAPK_MEF2A_6	214	221	PF00069	0.340
DOC_MAPK_MEF2A_6	337	345	PF00069	0.337
DOC_MAPK_MEF2A_6	359	366	PF00069	0.477
DOC_MAPK_MEF2A_6	581	590	PF00069	0.418
DOC_MAPK_MEF2A_6	63	71	PF00069	0.348
DOC_PP1_RVXF_1	697	704	PF00149	0.433
DOC_USP7_MATH_1	129	133	PF00917	0.630
DOC_USP7_MATH_1	157	161	PF00917	0.598
DOC_USP7_MATH_1	282	286	PF00917	0.638
DOC_USP7_MATH_1	335	339	PF00917	0.426
DOC_USP7_MATH_1	372	376	PF00917	0.728
DOC_USP7_MATH_1	406	410	PF00917	0.525
DOC_USP7_MATH_1	470	474	PF00917	0.416
DOC_USP7_MATH_1	647	651	PF00917	0.378
DOC_USP7_MATH_1	669	673	PF00917	0.483
DOC_USP7_MATH_1	70	74	PF00917	0.522
DOC_USP7_MATH_1	8	12	PF00917	0.588
DOC_USP7_UBL2_3	600	604	PF12436	0.427
DOC_WW_Pin1_4	196	201	PF00397	0.513
DOC_WW_Pin1_4	240	245	PF00397	0.486
DOC_WW_Pin1_4	367	372	PF00397	0.714
DOC_WW_Pin1_4	379	384	PF00397	0.780
DOC_WW_Pin1_4	455	460	PF00397	0.466
LIG_14-3-3_CanoR_1	139	146	PF00244	0.631
LIG_14-3-3_CanoR_1	20	30	PF00244	0.432
LIG_14-3-3_CanoR_1	284	289	PF00244	0.410
LIG_14-3-3_CanoR_1	41	47	PF00244	0.498
LIG_14-3-3_CanoR_1	55	61	PF00244	0.386
LIG_14-3-3_CanoR_1	699	704	PF00244	0.370
LIG_14-3-3_CanoR_1	80	85	PF00244	0.473
LIG_Actin_WH2_2	584	602	PF00022	0.446
LIG_BIR_II_1	1	5	PF00653	0.755
LIG_BIR_III_4	75	79	PF00653	0.581
LIG_BRCT_BRCA1_1	35	39	PF00533	0.373
LIG_BRCT_BRCA1_1	531	535	PF00533	0.405
LIG_Clathr_ClatBox_1	81	85	PF01394	0.552
LIG_DLG_GKlike_1	699	706	PF00625	0.495
LIG_FHA_1	264	270	PF00498	0.389
LIG_FHA_1	285	291	PF00498	0.559
LIG_FHA_1	320	326	PF00498	0.576
LIG_FHA_1	42	48	PF00498	0.416
LIG_FHA_1	500	506	PF00498	0.386
LIG_FHA_1	614	620	PF00498	0.398
LIG_FHA_1	671	677	PF00498	0.494
LIG_FHA_1	696	702	PF00498	0.438
LIG_FHA_1	81	87	PF00498	0.528
LIG_FHA_2	22	28	PF00498	0.346
LIG_FHA_2	241	247	PF00498	0.498
LIG_FHA_2	425	431	PF00498	0.640
LIG_FHA_2	455	461	PF00498	0.571
LIG_FHA_2	600	606	PF00498	0.531
LIG_FHA_2	653	659	PF00498	0.486
LIG_FHA_2	707	713	PF00498	0.467
LIG_FHA_2	720	726	PF00498	0.265
LIG_FHA_2	728	734	PF00498	0.384
LIG_FHA_2	93	99	PF00498	0.603
LIG_GBD_Chelix_1	52	60	PF00786	0.472
LIG_Integrin_isoDGR_2	634	636	PF01839	0.363
LIG_LIR_Apic_2	95	99	PF02991	0.488
LIG_LIR_Gen_1	332	341	PF02991	0.618
LIG_LIR_Gen_1	400	406	PF02991	0.403
LIG_LIR_Gen_1	460	470	PF02991	0.411
LIG_LIR_Gen_1	698	706	PF02991	0.370
LIG_LIR_Gen_1	88	97	PF02991	0.490
LIG_LIR_LC3C_4	322	327	PF02991	0.396
LIG_LIR_Nem_3	332	336	PF02991	0.626
LIG_LIR_Nem_3	36	42	PF02991	0.516
LIG_LIR_Nem_3	460	465	PF02991	0.410
LIG_LIR_Nem_3	473	479	PF02991	0.336
LIG_LIR_Nem_3	650	656	PF02991	0.350
LIG_LIR_Nem_3	698	703	PF02991	0.346
LIG_LIR_Nem_3	88	93	PF02991	0.510
LIG_OCRL_FandH_1	702	714	PF00620	0.287
LIG_PCNA_PIPBox_1	694	703	PF02747	0.442
LIG_PCNA_yPIPBox_3	506	515	PF02747	0.420
LIG_PCNA_yPIPBox_3	691	701	PF02747	0.408
LIG_Pex14_1	398	402	PF04695	0.608
LIG_Pex14_2	329	333	PF04695	0.316
LIG_SH2_CRK	79	83	PF00017	0.424
LIG_SH2_GRB2like	518	521	PF00017	0.304
LIG_SH2_SRC	518	521	PF00017	0.398
LIG_SH2_SRC	723	726	PF00017	0.402
LIG_SH2_STAP1	224	228	PF00017	0.553
LIG_SH2_STAP1	402	406	PF00017	0.634
LIG_SH2_STAT3	656	659	PF00017	0.360
LIG_SH2_STAT5	304	307	PF00017	0.385
LIG_SH2_STAT5	518	521	PF00017	0.398
LIG_SH2_STAT5	556	559	PF00017	0.267
LIG_SH2_STAT5	656	659	PF00017	0.360
LIG_SH2_STAT5	723	726	PF00017	0.397
LIG_SH3_3	276	282	PF00018	0.397
LIG_SH3_3	28	34	PF00018	0.398
LIG_SH3_3	380	386	PF00018	0.634
LIG_SH3_3	453	459	PF00018	0.458
LIG_SH3_3	731	737	PF00018	0.423
LIG_SUMO_SIM_anti_2	322	328	PF11976	0.501
LIG_SUMO_SIM_anti_2	616	621	PF11976	0.421
LIG_SUMO_SIM_par_1	264	274	PF11976	0.420
LIG_SUMO_SIM_par_1	285	295	PF11976	0.693
LIG_SUMO_SIM_par_1	587	592	PF11976	0.391
LIG_SUMO_SIM_par_1	80	85	PF11976	0.518
LIG_TRAF2_1	458	461	PF00917	0.445
LIG_TRAF2_1	657	660	PF00917	0.420
LIG_TYR_ITIM	516	521	PF00017	0.304
LIG_UBA3_1	29	37	PF00899	0.369
LIG_UBA3_1	638	645	PF00899	0.429
LIG_WRC_WIRS_1	158	163	PF05994	0.657
LIG_WRC_WIRS_1	700	705	PF05994	0.377
MOD_CK1_1	132	138	PF00069	0.558
MOD_CK1_1	179	185	PF00069	0.787
MOD_CK1_1	199	205	PF00069	0.443
MOD_CK1_1	2	8	PF00069	0.635
MOD_CK1_1	409	415	PF00069	0.526
MOD_CK1_1	59	65	PF00069	0.513
MOD_CK1_1	654	660	PF00069	0.327
MOD_CK2_1	454	460	PF00069	0.479
MOD_CK2_1	58	64	PF00069	0.587
MOD_CK2_1	654	660	PF00069	0.421
MOD_CK2_1	708	714	PF00069	0.469
MOD_CK2_1	719	725	PF00069	0.420
MOD_CK2_1	92	98	PF00069	0.651
MOD_Cter_Amidation	593	596	PF01082	0.511
MOD_GlcNHglycan	1	4	PF01048	0.608
MOD_GlcNHglycan	10	13	PF01048	0.557
MOD_GlcNHglycan	127	130	PF01048	0.660
MOD_GlcNHglycan	154	157	PF01048	0.721
MOD_GlcNHglycan	161	164	PF01048	0.708
MOD_GlcNHglycan	181	184	PF01048	0.478
MOD_GlcNHglycan	201	204	PF01048	0.619
MOD_GlcNHglycan	294	297	PF01048	0.686
MOD_GlcNHglycan	332	336	PF01048	0.354
MOD_GlcNHglycan	372	375	PF01048	0.776
MOD_GlcNHglycan	531	534	PF01048	0.407
MOD_GlcNHglycan	688	691	PF01048	0.403
MOD_GlcNHglycan	90	93	PF01048	0.521
MOD_GSK3_1	125	132	PF00069	0.579
MOD_GSK3_1	159	166	PF00069	0.710
MOD_GSK3_1	240	247	PF00069	0.578
MOD_GSK3_1	263	270	PF00069	0.398
MOD_GSK3_1	292	299	PF00069	0.618
MOD_GSK3_1	3	10	PF00069	0.630
MOD_GSK3_1	331	338	PF00069	0.526
MOD_GSK3_1	362	369	PF00069	0.638
MOD_GSK3_1	377	384	PF00069	0.646
MOD_GSK3_1	450	457	PF00069	0.560
MOD_GSK3_1	470	477	PF00069	0.359
MOD_GSK3_1	55	62	PF00069	0.418
MOD_GSK3_1	647	654	PF00069	0.371
MOD_GSK3_1	695	702	PF00069	0.394
MOD_GSK3_1	88	95	PF00069	0.482
MOD_LATS_1	169	175	PF00433	0.511
MOD_N-GLC_1	231	236	PF02516	0.432
MOD_N-GLC_1	406	411	PF02516	0.684
MOD_N-GLC_1	470	475	PF02516	0.351
MOD_N-GLC_1	686	691	PF02516	0.438
MOD_NEK2_1	1	6	PF00069	0.760
MOD_NEK2_1	116	121	PF00069	0.485
MOD_NEK2_1	290	295	PF00069	0.582
MOD_NEK2_1	56	61	PF00069	0.564
MOD_NEK2_1	599	604	PF00069	0.526
MOD_NEK2_1	686	691	PF00069	0.533
MOD_NEK2_1	706	711	PF00069	0.524
MOD_NEK2_2	253	258	PF00069	0.509
MOD_PIKK_1	474	480	PF00454	0.452
MOD_PKA_2	125	131	PF00069	0.630
MOD_PKA_2	138	144	PF00069	0.600
MOD_PKA_2	362	368	PF00069	0.695
MOD_PKA_2	40	46	PF00069	0.439
MOD_Plk_1	331	337	PF00069	0.623
MOD_Plk_1	470	476	PF00069	0.348
MOD_Plk_1	527	533	PF00069	0.513
MOD_Plk_1	613	619	PF00069	0.503
MOD_Plk_4	129	135	PF00069	0.540
MOD_Plk_4	263	269	PF00069	0.422
MOD_Plk_4	296	302	PF00069	0.471
MOD_Plk_4	470	476	PF00069	0.372
MOD_ProDKin_1	196	202	PF00069	0.510
MOD_ProDKin_1	240	246	PF00069	0.489
MOD_ProDKin_1	367	373	PF00069	0.716
MOD_ProDKin_1	379	385	PF00069	0.776
MOD_ProDKin_1	455	461	PF00069	0.462
MOD_SUMO_for_1	235	238	PF00179	0.480
MOD_SUMO_rev_2	307	313	PF00179	0.590
TRG_DiLeu_BaEn_1	461	466	PF01217	0.436
TRG_DiLeu_BaEn_1	507	512	PF01217	0.465
TRG_DiLeu_BaEn_1	660	665	PF01217	0.335
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.588
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.455
TRG_DiLeu_LyEn_5	461	466	PF01217	0.411
TRG_ENDOCYTIC_2	402	405	PF00928	0.584
TRG_ENDOCYTIC_2	518	521	PF00928	0.304
TRG_ENDOCYTIC_2	79	82	PF00928	0.405
TRG_ER_diArg_1	100	102	PF00400	0.501
TRG_ER_diArg_1	434	437	PF00400	0.549
TRG_ER_diArg_1	535	537	PF00400	0.451
TRG_ER_diArg_1	71	74	PF00400	0.517
TRG_NES_CRM1_1	510	522	PF08389	0.310
TRG_Pf-PMV_PEXEL_1	220	225	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	636	640	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	677	681	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	699	704	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9P1	Leptomonas seymouri	68%	100%
A0A0S4J3E1	Bodo saltans	42%	100%
A0A1X0NXS8	Trypanosomatidae	48%	100%
A0A3Q8IBQ3	Leishmania donovani	84%	100%
A0A3R7KD39	Trypanosoma rangeli	55%	100%
A4HYP7	Leishmania infantum	83%	100%
C9ZI84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AUK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QCX6	Leishmania major	84%	100%
V5BQT5	Trypanosoma cruzi	53%	100%