Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIB6_LEIBR

TriTrypDb:

LbrM.20.4830 , LBRM2903_200062400

Length:

606

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.604
CLV_C14_Caspase3-7	216	220	PF00656	0.659
CLV_C14_Caspase3-7	383	387	PF00656	0.666
CLV_C14_Caspase3-7	575	579	PF00656	0.622
CLV_NRD_NRD_1	24	26	PF00675	0.442
CLV_NRD_NRD_1	32	34	PF00675	0.516
CLV_NRD_NRD_1	38	40	PF00675	0.502
CLV_NRD_NRD_1	516	518	PF00675	0.476
CLV_PCSK_KEX2_1	24	26	PF00082	0.442
CLV_PCSK_KEX2_1	32	34	PF00082	0.516
CLV_PCSK_KEX2_1	38	40	PF00082	0.502
CLV_PCSK_KEX2_1	515	517	PF00082	0.477
CLV_PCSK_SKI1_1	477	481	PF00082	0.375
CLV_PCSK_SKI1_1	487	491	PF00082	0.389
DEG_Nend_Nbox_1	1	3	PF02207	0.312
DEG_SPOP_SBC_1	190	194	PF00917	0.646
DOC_ANK_TNKS_1	37	44	PF00023	0.650
DOC_CDC14_PxL_1	127	135	PF14671	0.590
DOC_CDC14_PxL_1	479	487	PF14671	0.559
DOC_CKS1_1	204	209	PF01111	0.613
DOC_MAPK_gen_1	409	417	PF00069	0.602
DOC_MAPK_MEF2A_6	409	417	PF00069	0.602
DOC_MAPK_RevD_3	10	25	PF00069	0.280
DOC_PP4_FxxP_1	201	204	PF00568	0.624
DOC_PP4_FxxP_1	480	483	PF00568	0.557
DOC_USP7_MATH_1	196	200	PF00917	0.752
DOC_USP7_MATH_1	289	293	PF00917	0.651
DOC_USP7_MATH_1	353	357	PF00917	0.777
DOC_USP7_MATH_1	367	371	PF00917	0.614
DOC_USP7_MATH_1	466	470	PF00917	0.534
DOC_USP7_MATH_1	588	592	PF00917	0.733
DOC_USP7_MATH_1	598	602	PF00917	0.657
DOC_USP7_MATH_1	67	71	PF00917	0.563
DOC_USP7_UBL2_3	252	256	PF12436	0.645
DOC_WW_Pin1_4	200	205	PF00397	0.667
DOC_WW_Pin1_4	260	265	PF00397	0.760
DOC_WW_Pin1_4	271	276	PF00397	0.666
DOC_WW_Pin1_4	292	297	PF00397	0.681
DOC_WW_Pin1_4	441	446	PF00397	0.616
DOC_WW_Pin1_4	81	86	PF00397	0.751
LIG_14-3-3_CanoR_1	380	385	PF00244	0.577
LIG_14-3-3_CanoR_1	430	436	PF00244	0.545
LIG_14-3-3_CanoR_1	77	86	PF00244	0.667
LIG_Actin_WH2_2	418	434	PF00022	0.581
LIG_Actin_WH2_2	479	494	PF00022	0.566
LIG_BIR_III_4	341	345	PF00653	0.641
LIG_BIR_III_4	555	559	PF00653	0.688
LIG_BRCT_BRCA1_1	393	397	PF00533	0.537
LIG_BRCT_BRCA1_1	99	103	PF00533	0.691
LIG_FHA_1	1	7	PF00498	0.231
LIG_FHA_1	241	247	PF00498	0.634
LIG_FHA_1	377	383	PF00498	0.657
LIG_FHA_1	42	48	PF00498	0.632
LIG_FHA_1	544	550	PF00498	0.765
LIG_FHA_1	85	91	PF00498	0.643
LIG_FHA_2	214	220	PF00498	0.661
LIG_GBD_Chelix_1	11	19	PF00786	0.318
LIG_LIR_Apic_2	199	204	PF02991	0.626
LIG_LIR_Apic_2	269	275	PF02991	0.698
LIG_LIR_Apic_2	478	483	PF02991	0.558
LIG_LIR_Gen_1	155	161	PF02991	0.545
LIG_LIR_Gen_1	3	13	PF02991	0.231
LIG_LIR_Gen_1	581	592	PF02991	0.675
LIG_LIR_Nem_3	155	159	PF02991	0.544
LIG_LIR_Nem_3	3	8	PF02991	0.231
LIG_LIR_Nem_3	478	482	PF02991	0.570
LIG_NRBOX	14	20	PF00104	0.312
LIG_Pex14_1	46	50	PF04695	0.678
LIG_Pex14_2	463	467	PF04695	0.543
LIG_Pex14_2	489	493	PF04695	0.562
LIG_REV1ctd_RIR_1	486	496	PF16727	0.566
LIG_SH2_NCK_1	272	276	PF00017	0.632
LIG_SH2_NCK_1	437	441	PF00017	0.593
LIG_SH2_PTP2	416	419	PF00017	0.568
LIG_SH2_SRC	437	440	PF00017	0.593
LIG_SH2_STAT5	175	178	PF00017	0.653
LIG_SH2_STAT5	412	415	PF00017	0.539
LIG_SH2_STAT5	416	419	PF00017	0.523
LIG_SH2_STAT5	450	453	PF00017	0.568
LIG_SH3_3	201	207	PF00018	0.724
LIG_SH3_3	439	445	PF00018	0.614
LIG_SH3_3	567	573	PF00018	0.636
LIG_SH3_3	88	94	PF00018	0.731
LIG_SUMO_SIM_anti_2	381	386	PF11976	0.600
LIG_TRAF2_1	307	310	PF00917	0.621
LIG_TRAF2_1	560	563	PF00917	0.627
LIG_TRAF2_2	275	280	PF00917	0.629
LIG_UBA3_1	15	22	PF00899	0.312
LIG_UBA3_1	548	553	PF00899	0.626
LIG_WRC_WIRS_1	153	158	PF05994	0.602
LIG_WRC_WIRS_1	2	7	PF05994	0.231
MOD_CDK_SPxxK_3	203	210	PF00069	0.618
MOD_CK1_1	106	112	PF00069	0.729
MOD_CK1_1	120	126	PF00069	0.605
MOD_CK1_1	183	189	PF00069	0.698
MOD_CK1_1	197	203	PF00069	0.704
MOD_CK1_1	214	220	PF00069	0.637
MOD_CK1_1	263	269	PF00069	0.723
MOD_CK1_1	292	298	PF00069	0.630
MOD_CK1_1	357	363	PF00069	0.694
MOD_CK1_1	400	406	PF00069	0.475
MOD_CK1_1	469	475	PF00069	0.541
MOD_CK1_1	501	507	PF00069	0.651
MOD_CK1_1	510	516	PF00069	0.671
MOD_CK1_1	543	549	PF00069	0.661
MOD_CK1_1	561	567	PF00069	0.736
MOD_CK1_1	81	87	PF00069	0.729
MOD_CK2_1	119	125	PF00069	0.741
MOD_CK2_1	270	276	PF00069	0.636
MOD_CK2_1	303	309	PF00069	0.719
MOD_CK2_1	588	594	PF00069	0.678
MOD_Cter_Amidation	537	540	PF01082	0.437
MOD_GlcNHglycan	105	108	PF01048	0.558
MOD_GlcNHglycan	122	125	PF01048	0.520
MOD_GlcNHglycan	144	147	PF01048	0.469
MOD_GlcNHglycan	182	185	PF01048	0.498
MOD_GlcNHglycan	188	191	PF01048	0.531
MOD_GlcNHglycan	196	199	PF01048	0.586
MOD_GlcNHglycan	243	246	PF01048	0.494
MOD_GlcNHglycan	265	268	PF01048	0.459
MOD_GlcNHglycan	291	294	PF01048	0.528
MOD_GlcNHglycan	306	309	PF01048	0.457
MOD_GlcNHglycan	332	335	PF01048	0.560
MOD_GlcNHglycan	338	341	PF01048	0.507
MOD_GlcNHglycan	392	396	PF01048	0.357
MOD_GlcNHglycan	451	454	PF01048	0.404
MOD_GlcNHglycan	524	527	PF01048	0.515
MOD_GlcNHglycan	533	536	PF01048	0.533
MOD_GlcNHglycan	542	545	PF01048	0.472
MOD_GlcNHglycan	562	566	PF01048	0.391
MOD_GlcNHglycan	59	62	PF01048	0.370
MOD_GlcNHglycan	600	603	PF01048	0.512
MOD_GlcNHglycan	69	72	PF01048	0.426
MOD_GlcNHglycan	98	102	PF01048	0.557
MOD_GSK3_1	185	192	PF00069	0.680
MOD_GSK3_1	196	203	PF00069	0.664
MOD_GSK3_1	256	263	PF00069	0.709
MOD_GSK3_1	266	273	PF00069	0.753
MOD_GSK3_1	294	301	PF00069	0.679
MOD_GSK3_1	353	360	PF00069	0.682
MOD_GSK3_1	362	369	PF00069	0.690
MOD_GSK3_1	372	379	PF00069	0.725
MOD_GSK3_1	391	398	PF00069	0.528
MOD_GSK3_1	499	506	PF00069	0.625
MOD_N-GLC_1	241	246	PF02516	0.485
MOD_N-GLC_1	395	400	PF02516	0.324
MOD_N-GLC_1	522	527	PF02516	0.427
MOD_N-GLC_1	540	545	PF02516	0.434
MOD_N-GLC_1	96	101	PF02516	0.434
MOD_NEK2_1	1	6	PF00069	0.312
MOD_NEK2_1	103	108	PF00069	0.627
MOD_NEK2_1	240	245	PF00069	0.652
MOD_NEK2_1	270	275	PF00069	0.748
MOD_NEK2_1	330	335	PF00069	0.738
MOD_NEK2_1	397	402	PF00069	0.526
MOD_NEK2_1	467	472	PF00069	0.573
MOD_NEK2_1	493	498	PF00069	0.619
MOD_NEK2_1	57	62	PF00069	0.566
MOD_PIKK_1	256	262	PF00454	0.684
MOD_PIKK_1	469	475	PF00454	0.541
MOD_PIKK_1	499	505	PF00454	0.662
MOD_PK_1	380	386	PF00069	0.610
MOD_PKA_2	304	310	PF00069	0.645
MOD_PKA_2	31	37	PF00069	0.685
MOD_PKA_2	367	373	PF00069	0.651
MOD_PKA_2	431	437	PF00069	0.564
MOD_PKA_2	498	504	PF00069	0.632
MOD_PKA_2	588	594	PF00069	0.732
MOD_PKB_1	371	379	PF00069	0.628
MOD_Plk_1	322	328	PF00069	0.628
MOD_Plk_1	395	401	PF00069	0.523
MOD_Plk_2-3	438	444	PF00069	0.606
MOD_Plk_4	1	7	PF00069	0.312
MOD_Plk_4	294	300	PF00069	0.729
MOD_Plk_4	354	360	PF00069	0.624
MOD_Plk_4	380	386	PF00069	0.610
MOD_Plk_4	41	47	PF00069	0.634
MOD_ProDKin_1	200	206	PF00069	0.667
MOD_ProDKin_1	260	266	PF00069	0.761
MOD_ProDKin_1	271	277	PF00069	0.667
MOD_ProDKin_1	292	298	PF00069	0.683
MOD_ProDKin_1	441	447	PF00069	0.613
MOD_ProDKin_1	81	87	PF00069	0.754
MOD_SUMO_rev_2	145	153	PF00179	0.622
TRG_ENDOCYTIC_2	412	415	PF00928	0.542
TRG_ENDOCYTIC_2	416	419	PF00928	0.516
TRG_ER_diArg_1	24	27	PF00400	0.631
TRG_ER_diArg_1	409	412	PF00400	0.582
TRG_ER_diArg_1	429	432	PF00400	0.531
TRG_ER_diArg_1	515	517	PF00400	0.690
TRG_NES_CRM1_1	129	142	PF08389	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B3	Leptomonas seymouri	46%	98%
A0A3S7WVW3	Leishmania donovani	72%	99%
A4HYQ2	Leishmania infantum	73%	99%
E9AUK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QCY1	Leishmania major	73%	100%