Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AIB4_LEIBR

TriTrypDb:

LbrM.20.4810 , LBRM2903_200062100

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AIB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.648
CLV_C14_Caspase3-7	469	473	PF00656	0.629
CLV_C14_Caspase3-7	502	506	PF00656	0.717
CLV_NRD_NRD_1	377	379	PF00675	0.389
CLV_NRD_NRD_1	459	461	PF00675	0.436
CLV_NRD_NRD_1	87	89	PF00675	0.487
CLV_PCSK_FUR_1	85	89	PF00082	0.489
CLV_PCSK_KEX2_1	459	461	PF00082	0.442
CLV_PCSK_KEX2_1	85	87	PF00082	0.489
CLV_PCSK_SKI1_1	201	205	PF00082	0.476
CLV_PCSK_SKI1_1	213	217	PF00082	0.379
CLV_PCSK_SKI1_1	468	472	PF00082	0.431
CLV_Separin_Metazoa	465	469	PF03568	0.628
DEG_APCC_DBOX_1	212	220	PF00400	0.560
DEG_APCC_DBOX_1	459	467	PF00400	0.630
DEG_Nend_UBRbox_2	1	3	PF02207	0.715
DEG_SPOP_SBC_1	413	417	PF00917	0.582
DOC_CDC14_PxL_1	193	201	PF14671	0.678
DOC_MAPK_gen_1	545	555	PF00069	0.639
DOC_MAPK_MEF2A_6	352	359	PF00069	0.371
DOC_MAPK_NFAT4_5	352	360	PF00069	0.231
DOC_MAPK_RevD_3	75	88	PF00069	0.598
DOC_PP2B_LxvP_1	142	145	PF13499	0.648
DOC_PP2B_LxvP_1	270	273	PF13499	0.700
DOC_PP2B_LxvP_1	333	336	PF13499	0.363
DOC_PP4_FxxP_1	441	444	PF00568	0.723
DOC_USP7_MATH_1	127	131	PF00917	0.670
DOC_USP7_MATH_1	153	157	PF00917	0.684
DOC_USP7_MATH_1	170	174	PF00917	0.632
DOC_USP7_MATH_1	296	300	PF00917	0.514
DOC_USP7_MATH_1	337	341	PF00917	0.454
DOC_USP7_MATH_1	430	434	PF00917	0.665
DOC_USP7_MATH_1	445	449	PF00917	0.593
DOC_USP7_MATH_1	571	575	PF00917	0.633
DOC_USP7_MATH_2	145	151	PF00917	0.644
DOC_USP7_UBL2_3	148	152	PF12436	0.648
LIG_14-3-3_CanoR_1	201	209	PF00244	0.617
LIG_14-3-3_CanoR_1	378	387	PF00244	0.629
LIG_14-3-3_CanoR_1	411	421	PF00244	0.633
LIG_14-3-3_CanoR_1	446	452	PF00244	0.623
LIG_14-3-3_CanoR_1	548	554	PF00244	0.732
LIG_Actin_WH2_2	301	319	PF00022	0.307
LIG_BRCT_BRCA1_1	204	208	PF00533	0.634
LIG_BRCT_BRCA1_1	360	364	PF00533	0.385
LIG_BRCT_BRCA1_1	437	441	PF00533	0.627
LIG_deltaCOP1_diTrp_1	226	231	PF00928	0.660
LIG_deltaCOP1_diTrp_1	246	254	PF00928	0.536
LIG_eIF4E_1	310	316	PF01652	0.243
LIG_FHA_1	130	136	PF00498	0.649
LIG_FHA_1	202	208	PF00498	0.679
LIG_FHA_1	345	351	PF00498	0.422
LIG_FHA_1	379	385	PF00498	0.535
LIG_FHA_1	542	548	PF00498	0.760
LIG_FHA_1	7	13	PF00498	0.728
LIG_FHA_2	103	109	PF00498	0.721
LIG_FHA_2	221	227	PF00498	0.579
LIG_FHA_2	554	560	PF00498	0.635
LIG_FHA_2	562	568	PF00498	0.633
LIG_LIR_Apic_2	118	124	PF02991	0.645
LIG_LIR_Apic_2	438	444	PF02991	0.723
LIG_LIR_Gen_1	226	235	PF02991	0.652
LIG_LIR_Gen_1	328	337	PF02991	0.363
LIG_LIR_Gen_1	340	350	PF02991	0.350
LIG_LIR_Gen_1	361	372	PF02991	0.385
LIG_LIR_Nem_3	226	231	PF02991	0.657
LIG_LIR_Nem_3	328	332	PF02991	0.364
LIG_LIR_Nem_3	340	346	PF02991	0.349
LIG_LIR_Nem_3	361	367	PF02991	0.385
LIG_NRBOX	311	317	PF00104	0.385
LIG_NRBOX	322	328	PF00104	0.352
LIG_Pex14_2	364	368	PF04695	0.243
LIG_SH2_NCK_1	63	67	PF00017	0.693
LIG_SH2_SRC	484	487	PF00017	0.790
LIG_SH2_SRC	61	64	PF00017	0.696
LIG_SH2_STAP1	329	333	PF00017	0.367
LIG_SH2_STAP1	380	384	PF00017	0.629
LIG_SH2_STAP1	63	67	PF00017	0.693
LIG_SH2_STAT3	240	243	PF00017	0.666
LIG_SH2_STAT3	29	32	PF00017	0.638
LIG_SH2_STAT5	19	22	PF00017	0.733
LIG_SH2_STAT5	198	201	PF00017	0.692
LIG_SH2_STAT5	380	383	PF00017	0.604
LIG_SH2_STAT5	484	487	PF00017	0.790
LIG_SH2_STAT5	61	64	PF00017	0.696
LIG_SH3_3	174	180	PF00018	0.632
LIG_SH3_3	298	304	PF00018	0.506
LIG_SUMO_SIM_anti_2	356	361	PF11976	0.243
LIG_SUMO_SIM_par_1	100	105	PF11976	0.697
LIG_SUMO_SIM_par_1	9	17	PF11976	0.678
LIG_TRAF2_1	115	118	PF00917	0.693
LIG_TRAF2_1	54	57	PF00917	0.598
LIG_TRAF2_1	556	559	PF00917	0.636
LIG_TYR_ITIM	327	332	PF00017	0.363
LIG_UBA3_1	332	338	PF00899	0.422
LIG_ULM_U2AF65_1	85	90	PF00076	0.677
MOD_CK1_1	182	188	PF00069	0.590
MOD_CK1_1	250	256	PF00069	0.682
MOD_CK1_1	289	295	PF00069	0.671
MOD_CK1_1	328	334	PF00069	0.366
MOD_CK1_1	344	350	PF00069	0.307
MOD_CK1_1	433	439	PF00069	0.722
MOD_CK1_1	448	454	PF00069	0.610
MOD_CK1_1	492	498	PF00069	0.765
MOD_CK1_1	503	509	PF00069	0.676
MOD_CK1_1	561	567	PF00069	0.632
MOD_CK1_1	78	84	PF00069	0.662
MOD_CK2_1	220	226	PF00069	0.628
MOD_CK2_1	51	57	PF00069	0.613
MOD_CK2_1	553	559	PF00069	0.638
MOD_CK2_1	561	567	PF00069	0.632
MOD_CMANNOS	251	254	PF00535	0.471
MOD_GlcNHglycan	149	152	PF01048	0.463
MOD_GlcNHglycan	181	184	PF01048	0.488
MOD_GlcNHglycan	257	261	PF01048	0.519
MOD_GlcNHglycan	273	276	PF01048	0.414
MOD_GlcNHglycan	298	301	PF01048	0.307
MOD_GlcNHglycan	417	420	PF01048	0.490
MOD_GlcNHglycan	432	435	PF01048	0.457
MOD_GlcNHglycan	437	440	PF01048	0.415
MOD_GlcNHglycan	448	451	PF01048	0.396
MOD_GlcNHglycan	452	455	PF01048	0.413
MOD_GlcNHglycan	505	508	PF01048	0.542
MOD_GlcNHglycan	516	519	PF01048	0.499
MOD_GlcNHglycan	53	56	PF01048	0.407
MOD_GlcNHglycan	549	552	PF01048	0.439
MOD_GlcNHglycan	80	83	PF01048	0.502
MOD_GSK3_1	109	116	PF00069	0.680
MOD_GSK3_1	182	189	PF00069	0.583
MOD_GSK3_1	246	253	PF00069	0.644
MOD_GSK3_1	271	278	PF00069	0.677
MOD_GSK3_1	282	289	PF00069	0.578
MOD_GSK3_1	292	299	PF00069	0.553
MOD_GSK3_1	337	344	PF00069	0.450
MOD_GSK3_1	420	427	PF00069	0.671
MOD_GSK3_1	430	437	PF00069	0.659
MOD_GSK3_1	446	453	PF00069	0.665
MOD_GSK3_1	489	496	PF00069	0.704
MOD_GSK3_1	501	508	PF00069	0.762
MOD_GSK3_1	549	556	PF00069	0.751
MOD_N-GLC_1	127	132	PF02516	0.448
MOD_N-GLC_1	186	191	PF02516	0.478
MOD_N-GLC_1	430	435	PF02516	0.449
MOD_N-GLC_1	541	546	PF02516	0.482
MOD_NEK2_1	109	114	PF00069	0.732
MOD_NEK2_1	358	363	PF00069	0.385
MOD_NEK2_1	48	53	PF00069	0.673
MOD_NEK2_1	521	526	PF00069	0.634
MOD_NEK2_2	153	158	PF00069	0.659
MOD_NEK2_2	235	240	PF00069	0.649
MOD_NEK2_2	454	459	PF00069	0.632
MOD_PIKK_1	113	119	PF00454	0.651
MOD_PIKK_1	220	226	PF00454	0.581
MOD_PIKK_1	43	49	PF00454	0.669
MOD_PIKK_1	493	499	PF00454	0.653
MOD_PKA_1	378	384	PF00069	0.590
MOD_PKA_2	413	419	PF00069	0.590
MOD_PKA_2	445	451	PF00069	0.618
MOD_PKA_2	500	506	PF00069	0.693
MOD_PKA_2	547	553	PF00069	0.731
MOD_PKB_1	376	384	PF00069	0.630
MOD_Plk_1	107	113	PF00069	0.631
MOD_Plk_1	137	143	PF00069	0.668
MOD_Plk_1	226	232	PF00069	0.620
MOD_Plk_1	478	484	PF00069	0.630
MOD_Plk_1	509	515	PF00069	0.715
MOD_Plk_4	116	122	PF00069	0.642
MOD_Plk_4	235	241	PF00069	0.656
MOD_Plk_4	247	253	PF00069	0.597
MOD_Plk_4	304	310	PF00069	0.385
MOD_Plk_4	328	334	PF00069	0.422
MOD_Plk_4	337	343	PF00069	0.437
MOD_Plk_4	478	484	PF00069	0.672
MOD_Plk_4	489	495	PF00069	0.621
MOD_Plk_4	549	555	PF00069	0.639
TRG_DiLeu_BaEn_1	211	216	PF01217	0.656
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.243
TRG_ENDOCYTIC_2	329	332	PF00928	0.369
TRG_ER_diArg_1	408	411	PF00400	0.638
TRG_ER_diArg_1	458	460	PF00400	0.635
TRG_ER_diArg_1	84	87	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WVX7	Leishmania donovani	55%	67%
A4HYQ4	Leishmania infantum	56%	67%
E9AUK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	68%
Q4QCY3	Leishmania major	56%	100%