Chaperone protein DNAJ-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DNAJ-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIB2_LEIBR

TriTrypDb:

LbrM.20.4790 , LBRM2903_200061900

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 20
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AIB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIB2

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	22
GO:0009987	cellular process	1	22
GO:0006950	response to stress	2	10
GO:0009266	response to temperature stimulus	3	10
GO:0009408	response to heat	3	10
GO:0009628	response to abiotic stimulus	2	10
GO:0050896	response to stimulus	1	10
GO:0006458	'de novo' protein folding	3	2
GO:0042026	protein refolding	3	3
GO:0051084	'de novo' post-translational protein folding	4	2
GO:0051085	chaperone cofactor-dependent protein refolding	4	2
GO:0061077	chaperone-mediated protein folding	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	22
GO:0005515	protein binding	2	22
GO:0031072	heat shock protein binding	3	22
GO:0043167	ion binding	2	21
GO:0043169	cation binding	3	20
GO:0046872	metal ion binding	4	20
GO:0051082	unfolded protein binding	3	22
GO:0000166	nucleotide binding	3	10
GO:0005524	ATP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0030544	Hsp70 protein binding	4	1
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	75	79	PF00656	0.314
CLV_NRD_NRD_1	10	12	PF00675	0.514
CLV_NRD_NRD_1	250	252	PF00675	0.220
CLV_NRD_NRD_1	273	275	PF00675	0.309
CLV_NRD_NRD_1	43	45	PF00675	0.436
CLV_NRD_NRD_1	55	57	PF00675	0.457
CLV_PCSK_KEX2_1	10	12	PF00082	0.514
CLV_PCSK_KEX2_1	273	275	PF00082	0.309
CLV_PCSK_KEX2_1	43	45	PF00082	0.453
CLV_PCSK_KEX2_1	55	57	PF00082	0.489
CLV_PCSK_KEX2_1	71	73	PF00082	0.442
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.530
CLV_PCSK_SKI1_1	175	179	PF00082	0.524
CLV_PCSK_SKI1_1	235	239	PF00082	0.309
CLV_PCSK_SKI1_1	442	446	PF00082	0.427
CLV_PCSK_SKI1_1	50	54	PF00082	0.471
DEG_COP1_1	159	167	PF00400	0.420
DOC_CKS1_1	247	252	PF01111	0.393
DOC_CKS1_1	478	483	PF01111	0.478
DOC_CYCLIN_yCln2_LP_2	363	369	PF00134	0.327
DOC_PP1_RVXF_1	28	34	PF00149	0.481
DOC_PP2B_LxvP_1	363	366	PF13499	0.291
DOC_PP2B_LxvP_1	465	468	PF13499	0.444
DOC_USP7_MATH_1	187	191	PF00917	0.587
DOC_USP7_MATH_1	23	27	PF00917	0.618
DOC_USP7_MATH_1	353	357	PF00917	0.263
DOC_USP7_MATH_1	481	485	PF00917	0.778
DOC_USP7_MATH_1	499	503	PF00917	0.567
DOC_USP7_UBL2_3	501	505	PF12436	0.432
DOC_WW_Pin1_4	246	251	PF00397	0.393
DOC_WW_Pin1_4	477	482	PF00397	0.579
LIG_14-3-3_CanoR_1	157	165	PF00244	0.442
LIG_14-3-3_CanoR_1	214	218	PF00244	0.213
LIG_14-3-3_CanoR_1	412	416	PF00244	0.601
LIG_14-3-3_CanoR_1	43	53	PF00244	0.402
LIG_14-3-3_CanoR_1	89	97	PF00244	0.412
LIG_BIR_III_4	199	203	PF00653	0.419
LIG_BIR_III_4	402	406	PF00653	0.149
LIG_EH1_1	424	432	PF00400	0.218
LIG_EVH1_2	467	471	PF00568	0.451
LIG_FHA_1	208	214	PF00498	0.320
LIG_FHA_1	266	272	PF00498	0.427
LIG_FHA_1	338	344	PF00498	0.267
LIG_FHA_1	44	50	PF00498	0.353
LIG_FHA_2	123	129	PF00498	0.714
LIG_FHA_2	456	462	PF00498	0.720
LIG_LIR_Apic_2	402	407	PF02991	0.193
LIG_LIR_Gen_1	26	34	PF02991	0.371
LIG_LIR_Gen_1	78	88	PF02991	0.466
LIG_LIR_Nem_3	26	31	PF02991	0.369
LIG_LIR_Nem_3	78	83	PF02991	0.388
LIG_PTB_Apo_2	313	320	PF02174	0.381
LIG_SH2_CRK	28	32	PF00017	0.416
LIG_SH2_CRK	425	429	PF00017	0.334
LIG_SH2_CRK	80	84	PF00017	0.354
LIG_SH2_SRC	126	129	PF00017	0.673
LIG_SH2_STAP1	92	96	PF00017	0.372
LIG_SH2_STAT5	126	129	PF00017	0.673
LIG_SH2_STAT5	277	280	PF00017	0.419
LIG_SH2_STAT5	80	83	PF00017	0.419
LIG_SH2_STAT5	92	95	PF00017	0.472
LIG_SH3_2	285	290	PF14604	0.509
LIG_SH3_3	259	265	PF00018	0.514
LIG_SH3_3	281	287	PF00018	0.470
LIG_SH3_3	300	306	PF00018	0.151
LIG_SH3_3	373	379	PF00018	0.259
LIG_SH3_3	384	390	PF00018	0.225
LIG_SH3_3	426	432	PF00018	0.353
LIG_SH3_3	461	467	PF00018	0.474
LIG_SH3_3	61	67	PF00018	0.354
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.164
LIG_SUMO_SIM_anti_2	368	373	PF11976	0.327
LIG_SUMO_SIM_par_1	339	345	PF11976	0.310
LIG_TYR_ITIM	423	428	PF00017	0.331
MOD_CDK_SPK_2	246	251	PF00069	0.220
MOD_CDK_SPxK_1	246	252	PF00069	0.220
MOD_CK1_1	135	141	PF00069	0.549
MOD_CK1_1	143	149	PF00069	0.536
MOD_CK1_1	159	165	PF00069	0.598
MOD_CK1_1	185	191	PF00069	0.563
MOD_CK1_1	411	417	PF00069	0.599
MOD_CK1_1	483	489	PF00069	0.492
MOD_CK2_1	157	163	PF00069	0.567
MOD_CK2_1	42	48	PF00069	0.385
MOD_CK2_1	455	461	PF00069	0.579
MOD_GlcNHglycan	137	140	PF01048	0.577
MOD_GlcNHglycan	145	148	PF01048	0.576
MOD_GlcNHglycan	151	154	PF01048	0.545
MOD_GlcNHglycan	184	187	PF01048	0.556
MOD_GlcNHglycan	241	244	PF01048	0.290
MOD_GlcNHglycan	265	268	PF01048	0.221
MOD_GlcNHglycan	394	397	PF01048	0.328
MOD_GlcNHglycan	437	440	PF01048	0.439
MOD_GlcNHglycan	483	486	PF01048	0.743
MOD_GlcNHglycan	508	511	PF01048	0.475
MOD_GSK3_1	145	152	PF00069	0.626
MOD_GSK3_1	159	166	PF00069	0.634
MOD_GSK3_1	182	189	PF00069	0.533
MOD_GSK3_1	213	220	PF00069	0.223
MOD_GSK3_1	310	317	PF00069	0.294
MOD_GSK3_1	337	344	PF00069	0.381
MOD_GSK3_1	407	414	PF00069	0.489
MOD_GSK3_1	453	460	PF00069	0.509
MOD_GSK3_1	477	484	PF00069	0.747
MOD_GSK3_1	87	94	PF00069	0.482
MOD_N-GLC_1	175	180	PF02516	0.531
MOD_N-GLC_1	182	187	PF02516	0.549
MOD_N-GLC_1	190	195	PF02516	0.518
MOD_N-GLC_1	204	209	PF02516	0.413
MOD_N-GLC_1	90	95	PF02516	0.453
MOD_NEK2_1	217	222	PF00069	0.247
MOD_NEK2_1	314	319	PF00069	0.300
MOD_NEK2_1	493	498	PF00069	0.382
MOD_NEK2_1	500	505	PF00069	0.367
MOD_NEK2_2	23	28	PF00069	0.521
MOD_NEK2_2	258	263	PF00069	0.409
MOD_PKA_1	43	49	PF00069	0.377
MOD_PKA_2	132	138	PF00069	0.628
MOD_PKA_2	156	162	PF00069	0.455
MOD_PKA_2	213	219	PF00069	0.214
MOD_PKA_2	239	245	PF00069	0.304
MOD_PKA_2	258	264	PF00069	0.288
MOD_PKA_2	411	417	PF00069	0.644
MOD_PKA_2	42	48	PF00069	0.439
MOD_Plk_1	140	146	PF00069	0.662
MOD_Plk_1	190	196	PF00069	0.682
MOD_Plk_1	207	213	PF00069	0.274
MOD_Plk_1	217	223	PF00069	0.240
MOD_Plk_4	2	8	PF00069	0.509
MOD_Plk_4	23	29	PF00069	0.426
MOD_Plk_4	314	320	PF00069	0.381
MOD_Plk_4	337	343	PF00069	0.296
MOD_ProDKin_1	246	252	PF00069	0.220
MOD_ProDKin_1	477	483	PF00069	0.578
MOD_SUMO_rev_2	58	63	PF00179	0.468
MOD_SUMO_rev_2	66	73	PF00179	0.421
TRG_ENDOCYTIC_2	28	31	PF00928	0.412
TRG_ENDOCYTIC_2	425	428	PF00928	0.402
TRG_ENDOCYTIC_2	80	83	PF00928	0.412
TRG_ER_diArg_1	42	44	PF00400	0.467
TRG_ER_diArg_1	54	56	PF00400	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS2	Leptomonas seymouri	62%	96%
A0A0N1I257	Leptomonas seymouri	27%	100%
A0A0S4J3B2	Bodo saltans	34%	100%
A0A1X0NLD4	Trypanosomatidae	27%	100%
A0A1X0NWP1	Trypanosomatidae	45%	100%
A0A3Q8IET3	Leishmania donovani	85%	94%
A0A3R7KX88	Trypanosoma rangeli	43%	100%
A0A3S7WNT6	Leishmania donovani	27%	100%
A0A422N924	Trypanosoma rangeli	27%	100%
A4H3Y7	Leishmania braziliensis	28%	100%
A4HS91	Leishmania infantum	27%	100%
A4HYQ6	Leishmania infantum	85%	94%
C9ZI72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
C9ZY84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AK75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AUJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	94%
O97016	Leishmania major	28%	100%
Q493S6	Blochmannia pennsylvanicus (strain BPEN)	25%	100%
Q4Q9Y3	Leishmania major	26%	100%
Q4QCY5	Leishmania major	84%	100%
V5AY81	Trypanosoma cruzi	27%	100%