RWD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RWD domain-containing protein

Species:

Leishmania braziliensis

UniProt:

E9AIB1_LEIBR

TriTrypDb:

LbrM.20.4780 , LBRM2903_200061800

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005844	polysome	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

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Expansion

Sequence features

E9AIB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIB1

Function

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Biological processes
Term	Name	Level	Count
GO:0002181	cytoplasmic translation	5	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.568
CLV_PCSK_KEX2_1	123	125	PF00082	0.525
CLV_PCSK_KEX2_1	134	136	PF00082	0.548
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.608
CLV_PCSK_SKI1_1	153	157	PF00082	0.507
CLV_PCSK_SKI1_1	177	181	PF00082	0.640
DOC_CYCLIN_RxL_1	150	158	PF00134	0.536
DOC_MAPK_gen_1	171	181	PF00069	0.668
DOC_USP7_UBL2_3	176	180	PF12436	0.530
LIG_CaM_NSCaTE_8	192	199	PF13499	0.591

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT1	Leptomonas seymouri	77%	100%
A0A0S4IZT9	Bodo saltans	46%	97%
A0A1X0NWI2	Trypanosomatidae	60%	97%
A0A3Q8IA02	Leishmania donovani	85%	100%
A0A422NCD6	Trypanosoma rangeli	50%	100%
A4HYQ7	Leishmania infantum	85%	100%
C9ZI71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AUJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QCY6	Leishmania major	83%	100%
Q99ND9	Rattus norvegicus	29%	95%

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