LeishMANIAdb
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DUF4198 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4198 domain-containing protein
Gene product:
conserved protein, unknown function
Species:
Leishmania braziliensis
UniProt:
E9AIB0_LEIBR
TriTrypDb:
LbrM.20.4770 , LBRM2903_200061700
Length:
144

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AIB0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIB0

PDB structure(s): 7aih_J , 7am2_J , 7ane_J

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 74 78 PF00656 0.479
CLV_PCSK_SKI1_1 10 14 PF00082 0.490
DOC_PP2B_LxvP_1 102 105 PF13499 0.469
DOC_USP7_MATH_1 118 122 PF00917 0.583
DOC_USP7_UBL2_3 40 44 PF12436 0.616
DOC_USP7_UBL2_3 86 90 PF12436 0.491
DOC_WW_Pin1_4 53 58 PF00397 0.612
LIG_CSL_BTD_1 102 105 PF09270 0.469
LIG_FHA_2 72 78 PF00498 0.474
LIG_LIR_Nem_3 121 125 PF02991 0.497
LIG_REV1ctd_RIR_1 10 20 PF16727 0.469
LIG_SH2_STAT5 125 128 PF00017 0.516
LIG_SH2_STAT5 3 6 PF00017 0.501
LIG_SH2_STAT5 48 51 PF00017 0.460
LIG_SH3_3 51 57 PF00018 0.390
MOD_CK1_1 56 62 PF00069 0.584
MOD_GlcNHglycan 116 119 PF01048 0.610
MOD_GSK3_1 1 8 PF00069 0.493
MOD_GSK3_1 114 121 PF00069 0.513
MOD_GSK3_1 77 84 PF00069 0.495
MOD_NEK2_1 12 17 PF00069 0.593
MOD_NEK2_1 71 76 PF00069 0.463
MOD_Plk_1 80 86 PF00069 0.511
MOD_Plk_2-3 77 83 PF00069 0.495
MOD_Plk_4 71 77 PF00069 0.469
MOD_ProDKin_1 53 59 PF00069 0.613
MOD_SUMO_for_1 111 114 PF00179 0.531
TRG_DiLeu_BaEn_3 96 102 PF01217 0.505
TRG_DiLeu_BaLyEn_6 67 72 PF01217 0.476
TRG_ER_diArg_1 140 143 PF00400 0.516
TRG_Pf-PMV_PEXEL_1 31 36 PF00026 0.505

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7H3 Leptomonas seymouri 94% 100%
A0A0S4J6A6 Bodo saltans 74% 100%
A0A1X0NX43 Trypanosomatidae 88% 100%
A0A3S7WVT6 Leishmania donovani 97% 100%
A0A422NCH2 Trypanosoma rangeli 88% 100%
A4HYQ8 Leishmania infantum 97% 100%
C9ZI70 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 88% 100%
E9AUJ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QCY7 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS