WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIA9_LEIBR

TriTrypDb:

LbrM.20.4760 , LBRM2903_200061500 , LBRM2903_200061600

Length:

947

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.527
CLV_C14_Caspase3-7	138	142	PF00656	0.657
CLV_C14_Caspase3-7	159	163	PF00656	0.703
CLV_C14_Caspase3-7	630	634	PF00656	0.486
CLV_NRD_NRD_1	131	133	PF00675	0.586
CLV_NRD_NRD_1	19	21	PF00675	0.656
CLV_NRD_NRD_1	373	375	PF00675	0.555
CLV_NRD_NRD_1	391	393	PF00675	0.539
CLV_NRD_NRD_1	432	434	PF00675	0.577
CLV_NRD_NRD_1	569	571	PF00675	0.825
CLV_NRD_NRD_1	69	71	PF00675	0.698
CLV_NRD_NRD_1	785	787	PF00675	0.749
CLV_PCSK_KEX2_1	19	21	PF00082	0.715
CLV_PCSK_KEX2_1	373	375	PF00082	0.565
CLV_PCSK_KEX2_1	390	392	PF00082	0.543
CLV_PCSK_KEX2_1	432	434	PF00082	0.585
CLV_PCSK_KEX2_1	569	571	PF00082	0.725
CLV_PCSK_KEX2_1	631	633	PF00082	0.650
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.650
CLV_PCSK_SKI1_1	127	131	PF00082	0.527
CLV_PCSK_SKI1_1	189	193	PF00082	0.548
CLV_PCSK_SKI1_1	391	395	PF00082	0.581
CLV_PCSK_SKI1_1	751	755	PF00082	0.633
CLV_PCSK_SKI1_1	871	875	PF00082	0.457
CLV_PCSK_SKI1_1	888	892	PF00082	0.348
CLV_Separin_Metazoa	370	374	PF03568	0.376
CLV_Separin_Metazoa	92	96	PF03568	0.617
DEG_SCF_FBW7_1	302	309	PF00400	0.776
DEG_SPOP_SBC_1	182	186	PF00917	0.535
DEG_SPOP_SBC_1	274	278	PF00917	0.583
DEG_SPOP_SBC_1	735	739	PF00917	0.764
DEG_SPOP_SBC_1	809	813	PF00917	0.738
DOC_CDC14_PxL_1	37	45	PF14671	0.515
DOC_CKS1_1	333	338	PF01111	0.600
DOC_CYCLIN_RxL_1	883	892	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	679	685	PF00134	0.714
DOC_MAPK_DCC_7	71	81	PF00069	0.445
DOC_MAPK_gen_1	132	139	PF00069	0.795
DOC_MAPK_gen_1	390	396	PF00069	0.550
DOC_MAPK_gen_1	688	696	PF00069	0.644
DOC_MAPK_gen_1	70	78	PF00069	0.699
DOC_MAPK_gen_1	762	771	PF00069	0.727
DOC_MAPK_MEF2A_6	132	139	PF00069	0.795
DOC_PP1_RVXF_1	824	830	PF00149	0.541
DOC_PP2B_LxvP_1	503	506	PF13499	0.812
DOC_PP2B_LxvP_1	663	666	PF13499	0.411
DOC_USP7_MATH_1	178	182	PF00917	0.702
DOC_USP7_MATH_1	252	256	PF00917	0.567
DOC_USP7_MATH_1	274	278	PF00917	0.532
DOC_USP7_MATH_1	306	310	PF00917	0.577
DOC_USP7_MATH_1	434	438	PF00917	0.476
DOC_USP7_MATH_1	701	705	PF00917	0.753
DOC_USP7_MATH_1	722	726	PF00917	0.807
DOC_USP7_MATH_1	809	813	PF00917	0.746
DOC_USP7_UBL2_3	930	934	PF12436	0.323
DOC_WW_Pin1_4	143	148	PF00397	0.637
DOC_WW_Pin1_4	161	166	PF00397	0.657
DOC_WW_Pin1_4	248	253	PF00397	0.657
DOC_WW_Pin1_4	302	307	PF00397	0.788
DOC_WW_Pin1_4	323	328	PF00397	0.611
DOC_WW_Pin1_4	332	337	PF00397	0.638
DOC_WW_Pin1_4	354	359	PF00397	0.516
DOC_WW_Pin1_4	501	506	PF00397	0.792
DOC_WW_Pin1_4	620	625	PF00397	0.725
DOC_WW_Pin1_4	708	713	PF00397	0.682
DOC_WW_Pin1_4	801	806	PF00397	0.620
LIG_14-3-3_CanoR_1	411	419	PF00244	0.430
LIG_14-3-3_CanoR_1	51	55	PF00244	0.618
LIG_14-3-3_CanoR_1	614	624	PF00244	0.836
LIG_14-3-3_CanoR_1	70	74	PF00244	0.585
LIG_AP2alpha_2	269	271	PF02296	0.534
LIG_APCC_ABBAyCdc20_2	119	125	PF00400	0.776
LIG_BRCT_BRCA1_1	591	595	PF00533	0.800
LIG_BRCT_BRCA1_1	919	923	PF00533	0.389
LIG_deltaCOP1_diTrp_1	927	933	PF00928	0.467
LIG_eIF4E_1	26	32	PF01652	0.426
LIG_FHA_1	11	17	PF00498	0.629
LIG_FHA_1	202	208	PF00498	0.595
LIG_FHA_1	315	321	PF00498	0.571
LIG_FHA_1	603	609	PF00498	0.559
LIG_FHA_1	621	627	PF00498	0.768
LIG_FHA_1	665	671	PF00498	0.604
LIG_FHA_1	735	741	PF00498	0.712
LIG_FHA_1	83	89	PF00498	0.658
LIG_FHA_2	111	117	PF00498	0.554
LIG_FHA_2	208	214	PF00498	0.719
LIG_FHA_2	218	224	PF00498	0.701
LIG_FHA_2	365	371	PF00498	0.482
LIG_FHA_2	457	463	PF00498	0.401
LIG_FHA_2	548	554	PF00498	0.545
LIG_FHA_2	649	655	PF00498	0.512
LIG_FHA_2	794	800	PF00498	0.695
LIG_FHA_2	930	936	PF00498	0.494
LIG_GBD_Chelix_1	547	555	PF00786	0.545
LIG_LIR_Apic_2	24	28	PF02991	0.587
LIG_LIR_Apic_2	72	77	PF02991	0.586
LIG_LIR_Gen_1	309	316	PF02991	0.522
LIG_LIR_Nem_3	13	18	PF02991	0.600
LIG_LIR_Nem_3	309	313	PF02991	0.528
LIG_MAD2	515	523	PF02301	0.531
LIG_OCRL_FandH_1	17	29	PF00620	0.481
LIG_PDZ_Class_1	942	947	PF00595	0.626
LIG_Pex14_1	929	933	PF04695	0.466
LIG_Pex14_2	648	652	PF04695	0.411
LIG_Pex14_2	863	867	PF04695	0.290
LIG_PTAP_UEV_1	37	42	PF05743	0.512
LIG_PTB_Apo_2	57	64	PF02174	0.448
LIG_RPA_C_Fungi	406	418	PF08784	0.669
LIG_SH2_CRK	576	580	PF00017	0.698
LIG_SH2_CRK	943	947	PF00017	0.576
LIG_SH2_CRK	98	102	PF00017	0.665
LIG_SH2_STAP1	316	320	PF00017	0.526
LIG_SH2_STAP1	466	470	PF00017	0.571
LIG_SH2_STAP1	897	901	PF00017	0.427
LIG_SH2_STAP1	943	947	PF00017	0.576
LIG_SH2_STAP1	98	102	PF00017	0.788
LIG_SH2_STAT3	767	770	PF00017	0.608
LIG_SH2_STAT5	128	131	PF00017	0.527
LIG_SH2_STAT5	15	18	PF00017	0.611
LIG_SH2_STAT5	316	319	PF00017	0.525
LIG_SH2_STAT5	445	448	PF00017	0.543
LIG_SH2_STAT5	729	732	PF00017	0.564
LIG_SH2_STAT5	767	770	PF00017	0.608
LIG_SH2_STAT5	776	779	PF00017	0.556
LIG_SH2_STAT5	835	838	PF00017	0.498
LIG_SH2_STAT5	859	862	PF00017	0.411
LIG_SH2_STAT5	904	907	PF00017	0.472
LIG_SH2_STAT5	943	946	PF00017	0.556
LIG_SH3_2	2	7	PF14604	0.768
LIG_SH3_3	321	327	PF00018	0.584
LIG_SH3_3	346	352	PF00018	0.763
LIG_SH3_3	35	41	PF00018	0.685
LIG_SH3_3	517	523	PF00018	0.575
LIG_SH3_3	619	625	PF00018	0.691
LIG_SH3_3	760	766	PF00018	0.650
LIG_SUMO_SIM_par_1	263	269	PF11976	0.599
LIG_SUMO_SIM_par_1	623	630	PF11976	0.558
LIG_SUMO_SIM_par_1	661	668	PF11976	0.512
LIG_SUMO_SIM_par_1	744	749	PF11976	0.515
LIG_TRAF2_1	108	111	PF00917	0.550
LIG_TRAF2_1	704	707	PF00917	0.581
LIG_WW_1	505	508	PF00397	0.688
LIG_WW_3	611	615	PF00397	0.845
MOD_CDC14_SPxK_1	711	714	PF00782	0.591
MOD_CDK_SPK_2	161	166	PF00069	0.562
MOD_CDK_SPxK_1	708	714	PF00069	0.591
MOD_CDK_SPxxK_3	332	339	PF00069	0.600
MOD_CK1_1	118	124	PF00069	0.754
MOD_CK1_1	146	152	PF00069	0.760
MOD_CK1_1	157	163	PF00069	0.740
MOD_CK1_1	181	187	PF00069	0.639
MOD_CK1_1	343	349	PF00069	0.765
MOD_CK1_1	39	45	PF00069	0.602
MOD_CK1_1	497	503	PF00069	0.642
MOD_CK1_1	593	599	PF00069	0.725
MOD_CK1_1	664	670	PF00069	0.705
MOD_CK1_1	69	75	PF00069	0.412
MOD_CK1_1	690	696	PF00069	0.601
MOD_CK1_1	713	719	PF00069	0.789
MOD_CK1_1	725	731	PF00069	0.721
MOD_CK1_1	810	816	PF00069	0.741
MOD_CK2_1	105	111	PF00069	0.544
MOD_CK2_1	207	213	PF00069	0.607
MOD_CK2_1	234	240	PF00069	0.705
MOD_CK2_1	244	250	PF00069	0.582
MOD_CK2_1	364	370	PF00069	0.489
MOD_CK2_1	455	461	PF00069	0.397
MOD_CK2_1	648	654	PF00069	0.512
MOD_CK2_1	701	707	PF00069	0.670
MOD_CK2_1	793	799	PF00069	0.726
MOD_CK2_1	896	902	PF00069	0.325
MOD_GlcNHglycan	148	151	PF01048	0.765
MOD_GlcNHglycan	234	237	PF01048	0.520
MOD_GlcNHglycan	288	291	PF01048	0.763
MOD_GlcNHglycan	38	41	PF01048	0.513
MOD_GlcNHglycan	496	499	PF01048	0.796
MOD_GlcNHglycan	544	547	PF01048	0.754
MOD_GlcNHglycan	560	563	PF01048	0.564
MOD_GlcNHglycan	618	621	PF01048	0.714
MOD_GlcNHglycan	697	700	PF01048	0.812
MOD_GlcNHglycan	724	727	PF01048	0.566
MOD_GlcNHglycan	782	785	PF01048	0.600
MOD_GlcNHglycan	796	799	PF01048	0.772
MOD_GlcNHglycan	815	818	PF01048	0.657
MOD_GSK3_1	105	112	PF00069	0.545
MOD_GSK3_1	139	146	PF00069	0.639
MOD_GSK3_1	156	163	PF00069	0.587
MOD_GSK3_1	165	172	PF00069	0.731
MOD_GSK3_1	178	185	PF00069	0.544
MOD_GSK3_1	189	196	PF00069	0.580
MOD_GSK3_1	202	209	PF00069	0.809
MOD_GSK3_1	244	251	PF00069	0.764
MOD_GSK3_1	252	259	PF00069	0.827
MOD_GSK3_1	274	281	PF00069	0.705
MOD_GSK3_1	302	309	PF00069	0.728
MOD_GSK3_1	39	46	PF00069	0.630
MOD_GSK3_1	456	463	PF00069	0.399
MOD_GSK3_1	485	492	PF00069	0.680
MOD_GSK3_1	497	504	PF00069	0.744
MOD_GSK3_1	547	554	PF00069	0.707
MOD_GSK3_1	558	565	PF00069	0.584
MOD_GSK3_1	585	592	PF00069	0.808
MOD_GSK3_1	612	619	PF00069	0.603
MOD_GSK3_1	661	668	PF00069	0.411
MOD_GSK3_1	708	715	PF00069	0.823
MOD_GSK3_1	725	732	PF00069	0.668
MOD_GSK3_1	734	741	PF00069	0.763
MOD_GSK3_1	807	814	PF00069	0.769
MOD_N-GLC_1	490	495	PF02516	0.552
MOD_N-GLC_1	58	63	PF02516	0.430
MOD_N-GLC_1	593	598	PF02516	0.541
MOD_N-GLC_1	616	621	PF02516	0.565
MOD_NEK2_1	139	144	PF00069	0.635
MOD_NEK2_1	169	174	PF00069	0.556
MOD_NEK2_1	275	280	PF00069	0.556
MOD_NEK2_1	551	556	PF00069	0.546
MOD_NEK2_1	616	621	PF00069	0.732
MOD_NEK2_1	64	69	PF00069	0.409
MOD_NEK2_1	648	653	PF00069	0.512
MOD_NEK2_1	808	813	PF00069	0.522
MOD_NEK2_1	97	102	PF00069	0.518
MOD_NEK2_2	58	63	PF00069	0.441
MOD_NEK2_2	929	934	PF00069	0.484
MOD_PIKK_1	234	240	PF00454	0.572
MOD_PIKK_1	314	320	PF00454	0.788
MOD_PIKK_1	564	570	PF00454	0.556
MOD_PIKK_1	634	640	PF00454	0.623
MOD_PIKK_1	702	708	PF00454	0.709
MOD_PKA_2	165	171	PF00069	0.543
MOD_PKA_2	217	223	PF00069	0.768
MOD_PKA_2	232	238	PF00069	0.604
MOD_PKA_2	410	416	PF00069	0.494
MOD_PKA_2	50	56	PF00069	0.616
MOD_PKA_2	551	557	PF00069	0.671
MOD_PKA_2	589	595	PF00069	0.807
MOD_PKA_2	687	693	PF00069	0.762
MOD_PKA_2	69	75	PF00069	0.579
MOD_PKA_2	713	719	PF00069	0.616
MOD_Plk_1	193	199	PF00069	0.543
MOD_Plk_1	460	466	PF00069	0.406
MOD_Plk_1	58	64	PF00069	0.428
MOD_Plk_4	11	17	PF00069	0.629
MOD_Plk_4	165	171	PF00069	0.543
MOD_Plk_4	183	189	PF00069	0.486
MOD_Plk_4	202	208	PF00069	0.562
MOD_Plk_4	58	64	PF00069	0.565
MOD_Plk_4	69	75	PF00069	0.579
MOD_Plk_4	692	698	PF00069	0.567
MOD_Plk_4	831	837	PF00069	0.501
MOD_Plk_4	97	103	PF00069	0.623
MOD_ProDKin_1	143	149	PF00069	0.640
MOD_ProDKin_1	161	167	PF00069	0.657
MOD_ProDKin_1	248	254	PF00069	0.657
MOD_ProDKin_1	302	308	PF00069	0.786
MOD_ProDKin_1	323	329	PF00069	0.604
MOD_ProDKin_1	332	338	PF00069	0.637
MOD_ProDKin_1	354	360	PF00069	0.511
MOD_ProDKin_1	501	507	PF00069	0.791
MOD_ProDKin_1	620	626	PF00069	0.726
MOD_ProDKin_1	708	714	PF00069	0.683
MOD_ProDKin_1	801	807	PF00069	0.620
MOD_SUMO_rev_2	121	129	PF00179	0.540
MOD_SUMO_rev_2	747	753	PF00179	0.660
TRG_DiLeu_BaEn_4	402	408	PF01217	0.665
TRG_ENDOCYTIC_2	15	18	PF00928	0.611
TRG_ENDOCYTIC_2	310	313	PF00928	0.526
TRG_ENDOCYTIC_2	849	852	PF00928	0.464
TRG_ENDOCYTIC_2	943	946	PF00928	0.556
TRG_ENDOCYTIC_2	98	101	PF00928	0.789
TRG_ER_diArg_1	18	20	PF00400	0.696
TRG_ER_diArg_1	228	231	PF00400	0.642
TRG_ER_diArg_1	372	374	PF00400	0.568
TRG_ER_diArg_1	390	392	PF00400	0.542
TRG_ER_diArg_1	404	407	PF00400	0.566
TRG_ER_diArg_1	416	419	PF00400	0.571
TRG_ER_diArg_1	826	829	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	195	200	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V3	Leptomonas seymouri	39%	94%
A0A3Q8IBI8	Leishmania donovani	68%	98%
A4HYQ9	Leishmania infantum	68%	98%
E9AUJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	98%
Q4QCY8	Leishmania major	67%	100%