CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIA7_LEIBR

TriTrypDb:

LbrM.20.4740 , LBRM2903_200061300

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIA7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0009058	biosynthetic process	2	4
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009435	NAD biosynthetic process	8	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019359	nicotinamide nucleotide biosynthetic process	7	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019363	pyridine nucleotide biosynthetic process	6	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:0072525	pyridine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	6	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0070566	adenylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.549
CLV_C14_Caspase3-7	209	213	PF00656	0.535
CLV_C14_Caspase3-7	293	297	PF00656	0.458
CLV_NRD_NRD_1	30	32	PF00675	0.517
CLV_NRD_NRD_1	349	351	PF00675	0.431
CLV_NRD_NRD_1	419	421	PF00675	0.292
CLV_NRD_NRD_1	499	501	PF00675	0.292
CLV_NRD_NRD_1	547	549	PF00675	0.532
CLV_NRD_NRD_1	552	554	PF00675	0.573
CLV_NRD_NRD_1	72	74	PF00675	0.307
CLV_PCSK_FUR_1	545	549	PF00082	0.488
CLV_PCSK_KEX2_1	30	32	PF00082	0.517
CLV_PCSK_KEX2_1	419	421	PF00082	0.292
CLV_PCSK_KEX2_1	547	549	PF00082	0.484
CLV_PCSK_KEX2_1	552	554	PF00082	0.522
CLV_PCSK_KEX2_1	72	74	PF00082	0.307
CLV_PCSK_PC7_1	548	554	PF00082	0.488
CLV_PCSK_SKI1_1	219	223	PF00082	0.595
CLV_PCSK_SKI1_1	279	283	PF00082	0.506
CLV_PCSK_SKI1_1	30	34	PF00082	0.474
CLV_PCSK_SKI1_1	377	381	PF00082	0.228
CLV_PCSK_SKI1_1	422	426	PF00082	0.228
CLV_PCSK_SKI1_1	521	525	PF00082	0.251
DEG_APCC_DBOX_1	278	286	PF00400	0.561
DEG_APCC_DBOX_1	90	98	PF00400	0.410
DOC_CDC14_PxL_1	94	102	PF14671	0.466
DOC_MAPK_gen_1	127	137	PF00069	0.438
DOC_PP1_RVXF_1	81	88	PF00149	0.557
DOC_PP2B_LxvP_1	514	517	PF13499	0.492
DOC_USP7_MATH_1	262	266	PF00917	0.647
DOC_USP7_MATH_1	288	292	PF00917	0.641
DOC_USP7_MATH_1	295	299	PF00917	0.582
DOC_USP7_MATH_1	346	350	PF00917	0.680
DOC_USP7_MATH_1	36	40	PF00917	0.442
DOC_USP7_UBL2_3	405	409	PF12436	0.492
DOC_WW_Pin1_4	10	15	PF00397	0.378
DOC_WW_Pin1_4	152	157	PF00397	0.717
LIG_14-3-3_CanoR_1	16	20	PF00244	0.354
LIG_14-3-3_CanoR_1	244	252	PF00244	0.670
LIG_14-3-3_CanoR_1	257	262	PF00244	0.530
LIG_14-3-3_CanoR_1	430	440	PF00244	0.576
LIG_14-3-3_CanoR_1	500	508	PF00244	0.576
LIG_14-3-3_CanoR_1	51	58	PF00244	0.560
LIG_14-3-3_CanoR_1	552	556	PF00244	0.509
LIG_Actin_WH2_2	298	315	PF00022	0.415
LIG_APCC_ABBA_1	317	322	PF00400	0.425
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_BIR_III_4	504	508	PF00653	0.428
LIG_Clathr_ClatBox_1	452	456	PF01394	0.492
LIG_EH1_1	187	195	PF00400	0.304
LIG_eIF4E_1	366	372	PF01652	0.576
LIG_EVH1_1	104	108	PF00568	0.473
LIG_FHA_1	116	122	PF00498	0.341
LIG_FHA_1	200	206	PF00498	0.551
LIG_FHA_1	251	257	PF00498	0.544
LIG_FHA_1	367	373	PF00498	0.576
LIG_FHA_1	374	380	PF00498	0.508
LIG_FHA_1	397	403	PF00498	0.492
LIG_FHA_1	433	439	PF00498	0.546
LIG_FHA_1	483	489	PF00498	0.576
LIG_FHA_1	99	105	PF00498	0.632
LIG_FHA_2	207	213	PF00498	0.537
LIG_FHA_2	291	297	PF00498	0.672
LIG_FHA_2	39	45	PF00498	0.402
LIG_LIR_Gen_1	131	142	PF02991	0.298
LIG_LIR_Gen_1	506	516	PF02991	0.428
LIG_LIR_Nem_3	131	137	PF02991	0.297
LIG_LIR_Nem_3	360	364	PF02991	0.492
LIG_LIR_Nem_3	506	511	PF02991	0.421
LIG_PCNA_PIPBox_1	418	427	PF02747	0.421
LIG_RPA_C_Plants	542	553	PF08784	0.580
LIG_SH2_PTP2	134	137	PF00017	0.300
LIG_SH2_SRC	400	403	PF00017	0.492
LIG_SH2_STAP1	340	344	PF00017	0.654
LIG_SH2_STAP1	400	404	PF00017	0.492
LIG_SH2_STAT5	134	137	PF00017	0.300
LIG_SH2_STAT5	494	497	PF00017	0.492
LIG_SH3_3	102	108	PF00018	0.547
LIG_SH3_3	315	321	PF00018	0.423
LIG_SH3_3	458	464	PF00018	0.492
LIG_SH3_3	522	528	PF00018	0.508
LIG_Sin3_3	222	229	PF02671	0.582
LIG_SUMO_SIM_anti_2	179	186	PF11976	0.432
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.527
LIG_SUMO_SIM_anti_2	510	515	PF11976	0.428
LIG_SUMO_SIM_par_1	394	399	PF11976	0.519
LIG_SUMO_SIM_par_1	410	416	PF11976	0.410
MOD_CDC14_SPxK_1	13	16	PF00782	0.389
MOD_CDK_SPxK_1	10	16	PF00069	0.378
MOD_CK1_1	126	132	PF00069	0.604
MOD_CK1_1	149	155	PF00069	0.699
MOD_CK1_1	206	212	PF00069	0.715
MOD_CK1_1	243	249	PF00069	0.617
MOD_CK1_1	260	266	PF00069	0.545
MOD_CK1_1	287	293	PF00069	0.505
MOD_CK1_1	503	509	PF00069	0.449
MOD_CK2_1	126	132	PF00069	0.604
MOD_CK2_1	171	177	PF00069	0.648
MOD_CK2_1	225	231	PF00069	0.643
MOD_CK2_1	262	268	PF00069	0.692
MOD_CK2_1	38	44	PF00069	0.399
MOD_CK2_1	465	471	PF00069	0.576
MOD_CK2_1	534	540	PF00069	0.492
MOD_Cter_Amidation	498	501	PF01082	0.292
MOD_GlcNHglycan	118	121	PF01048	0.407
MOD_GlcNHglycan	227	230	PF01048	0.640
MOD_GlcNHglycan	246	249	PF01048	0.468
MOD_GlcNHglycan	264	267	PF01048	0.683
MOD_GlcNHglycan	273	277	PF01048	0.508
MOD_GlcNHglycan	286	289	PF01048	0.489
MOD_GlcNHglycan	290	293	PF01048	0.520
MOD_GlcNHglycan	314	317	PF01048	0.556
MOD_GlcNHglycan	337	340	PF01048	0.568
MOD_GlcNHglycan	341	345	PF01048	0.605
MOD_GlcNHglycan	66	69	PF01048	0.440
MOD_GSK3_1	116	123	PF00069	0.418
MOD_GSK3_1	199	206	PF00069	0.690
MOD_GSK3_1	238	245	PF00069	0.633
MOD_GSK3_1	262	269	PF00069	0.605
MOD_GSK3_1	284	291	PF00069	0.477
MOD_NEK2_1	100	105	PF00069	0.495
MOD_NEK2_1	312	317	PF00069	0.540
MOD_NEK2_1	373	378	PF00069	0.428
MOD_NEK2_2	295	300	PF00069	0.554
MOD_PIKK_1	51	57	PF00454	0.564
MOD_PKA_1	30	36	PF00069	0.533
MOD_PKA_1	500	506	PF00069	0.576
MOD_PKA_2	126	132	PF00069	0.486
MOD_PKA_2	15	21	PF00069	0.354
MOD_PKA_2	243	249	PF00069	0.653
MOD_PKA_2	30	36	PF00069	0.415
MOD_PKA_2	312	318	PF00069	0.468
MOD_PKA_2	50	56	PF00069	0.299
MOD_PKA_2	551	557	PF00069	0.507
MOD_Plk_1	340	346	PF00069	0.518
MOD_Plk_1	396	402	PF00069	0.509
MOD_Plk_1	509	515	PF00069	0.492
MOD_Plk_4	434	440	PF00069	0.519
MOD_Plk_4	509	515	PF00069	0.421
MOD_ProDKin_1	10	16	PF00069	0.378
MOD_ProDKin_1	152	158	PF00069	0.716
TRG_DiLeu_BaEn_1	180	185	PF01217	0.473
TRG_DiLeu_BaEn_1	413	418	PF01217	0.519
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.414
TRG_ENDOCYTIC_2	134	137	PF00928	0.300
TRG_ENDOCYTIC_2	166	169	PF00928	0.537
TRG_ENDOCYTIC_2	494	497	PF00928	0.493
TRG_ER_diArg_1	29	31	PF00400	0.522
TRG_ER_diArg_1	418	420	PF00400	0.494
TRG_ER_diArg_1	545	548	PF00400	0.481
TRG_ER_diArg_1	72	74	PF00400	0.307
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H4	Leptomonas seymouri	52%	100%
A0A3S7WVU1	Leishmania donovani	79%	100%
A4HYR1	Leishmania infantum	79%	100%
E9AUJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QCZ0	Leishmania major	78%	100%