DNA-directed RNA polymerase I, II, and III subunit RPABC4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AIA6_LEIBR

TriTrypDb:

LbrM.20.4730 , LBRM2903_200061200

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	1
GO:0030880	RNA polymerase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AIA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIA6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0034062	5'-3' RNA polymerase activity	5	2
GO:0097747	RNA polymerase activity	4	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	8	12	PF00082	0.543
DOC_USP7_MATH_1	70	74	PF00917	0.463
DOC_USP7_UBL2_3	7	11	PF12436	0.681
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BRCT_BRCA1_1	78	82	PF00533	0.459
LIG_BRCT_BRCA1_2	78	84	PF00533	0.517
LIG_FHA_1	46	52	PF00498	0.541
LIG_FHA_1	54	60	PF00498	0.485
LIG_FHA_2	34	40	PF00498	0.729
LIG_FHA_2	4	10	PF00498	0.541
LIG_FHA_2	88	94	PF00498	0.550
LIG_LIR_Gen_1	90	95	PF02991	0.528
LIG_LIR_Nem_3	35	40	PF02991	0.504
LIG_LIR_Nem_3	79	85	PF02991	0.506
LIG_LIR_Nem_3	90	95	PF02991	0.528
LIG_PDZ_Class_3	90	95	PF00595	0.564
LIG_SH2_STAP1	17	21	PF00017	0.551
LIG_SH2_STAT5	50	53	PF00017	0.410
LIG_SH2_STAT5	60	63	PF00017	0.492
LIG_TRAF2_1	22	25	PF00917	0.790
LIG_TYR_ITSM	88	95	PF00017	0.561
MOD_CK1_1	73	79	PF00069	0.485
MOD_CK2_1	3	9	PF00069	0.540
MOD_GlcNHglycan	1	4	PF01048	0.796
MOD_GSK3_1	73	80	PF00069	0.485
MOD_GSK3_1	87	94	PF00069	0.408
MOD_N-GLC_1	53	58	PF02516	0.491
MOD_NEK2_2	77	82	PF00069	0.480
MOD_PIKK_1	20	26	PF00454	0.686
MOD_PIKK_1	30	36	PF00454	0.667
MOD_Plk_4	45	51	PF00069	0.495
MOD_Plk_4	77	83	PF00069	0.517
MOD_Plk_4	87	93	PF00069	0.402
MOD_SUMO_for_1	10	13	PF00179	0.686
MOD_SUMO_rev_2	9	18	PF00179	0.580
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.408
TRG_ENDOCYTIC_2	92	95	PF00928	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9P5	Leptomonas seymouri	75%	100%
A4HYR2	Leishmania infantum	78%	67%
E9AUJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%